Safety and Efficacy Study of Eculizumab in Patients With Refractory Generalized Myasthenia Gravis
Public ClinicalTrials.gov record NCT00727194. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Double-Blind, Placebo-Controlled, Cross-Over, Multi-Center Study of Eculizumab in Patients With Generalized Myasthenia Gravis (gMG) Who Have Moderate to Severe Muscle Weakness Despite Treatment With Immunosuppressants
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to determine whether eculizumab is safe and effective in the treatment of patients with generalized myasthenia gravis despite treatment with various immunosuppressants, such as prednisone, methotrexate, Cellcept, cyclosporine, and cyclophosphamide, that are currently available.
Study identification
- NCT ID
- NCT00727194
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 14 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 80 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Oct 2008 (Type not available)
- Primary completion
- Mar 2011 (Actual)
- Completion
- Jul 2011 (Actual)
- Last update posted
- Sep 24, 2019
2008 – 2011
United States locations
- U.S. sites
- 21
- U.S. states
- 17
- U.S. cities
- 20
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham | Birmingham | Alabama | 35233 | — |
| University of California, Irvine | Orange | California | 92868 | — |
| University of California - Davis | Sacramento | California | 95817 | — |
| University of Florida & Shands Neuroscience Institute | Jacksonville | Florida | 32209 | — |
| Emory University | Atlanta | Georgia | 30322 | — |
| Wishard Hospital | Indianapolis | Indiana | 46202 | — |
| University of Kansas Medical Center | Kansas City | Kansas | 66160 | — |
| Johns Hopkins University School of Medicine | Baltimore | Maryland | 21287 | — |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | — |
| Caritas St. Elizabeths' Medical Center | Boston | Massachusetts | 02135 | — |
| Wayne State University | Detroit | Michigan | 48201 | — |
| Mount Sinai School of Medicine | New York | New York | 10029-6574 | — |
| University of North Carolina at Chapel Hill | Chapel Hill | North Carolina | 27599-1651 | — |
| Duke University Medical Center | Durham | North Carolina | 27710 | — |
| University Hospitals - Case Medical Center | Cleveland | Ohio | 44106-5098 | — |
| The Ohio State University | Columbus | Ohio | 43210 | — |
| The Warren Alpert Medical School of Brown University | Providence | Rhode Island | 02905 | — |
| Vanderbilt University Medical Center | Nashville | Tennessee | 37232 | — |
| University of Texas Southwestern Medical School | Dallas | Texas | 75390 | — |
| The University of Vermont College of Medicine | Burlington | Vermont | 05405 | — |
| University of Virginia | Charlottesville | Virginia | 22908-0394 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 4 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00727194, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 24, 2019 · Synced Oct 26, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00727194 live on ClinicalTrials.gov.