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ClinicalTrials.gov record
Terminated Phase 3 Interventional Results available

Pemetrexed Disodium or Erlotinib Hydrochloride as Second-Line Therapy in Treating Patients With Advanced Non-small Cell Lung Cancer

ClinicalTrials.gov ID: NCT00738881

Public ClinicalTrials.gov record NCT00738881. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

ClinicalTrials.gov public records Last synced Oct 9, 2026, 2:55 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

MARVEL: Marker Validation of Erlotinib in Lung Cancer- A Phase III Biomarker Validation Study of Second-Line Therapy in Patients With Advanced Non-small Cell Lung Cancer (NSCLC) Randomized to Pemetrexed Versus Erlotinib

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

This randomized phase III trial studies pemetrexed disodium to see how well it works compared with erlotinib hydrochloride as second-line therapy in treating patients with non-small cell lung cancer that has spread to other places in the body. Pemetrexed disodium and erlotinib hydrochloride may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. It is not yet known whether pemetrexed disodium is more effective than erlotinib hydrochloride in treating advanced non-small cell lung cancer.

Study identification

NCT ID
NCT00738881
Recruitment status
Terminated
Study type
Interventional
Phase
Phase 3
Enrollment
23 participants

Conditions and interventions

Eligibility (public fields only)

Age range
18 Years and older
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Oct 2008 (Type not available)
Primary completion
Dec 2011 (Actual)
Completion
Dec 2014 (Actual)
Last update posted
Oct 29, 2015

2008 – 2014

United States locations

U.S. sites
268
U.S. states
27
U.S. cities
179
Facility City State ZIP Site status
Mayo Clinic in Arizona Scottsdale Arizona 85259 —
Sparks Regional Medical Center Fort Smith Arkansas 72901 —
Kaiser Permanente-Deer Valley Medical Center Antioch California 94531 —
Kaiser Permanente-Fremont Fremont California 94538 —
Fremont - Rideout Cancer Center Marysville California 95901 —
Kaiser Permanente-Oakland Oakland California 94611 —
Valley Care Health System - Pleasanton Pleasanton California 94588 —
Kaiser Permanente-Redwood City Redwood City California 94063 —
Kaiser Permanente-Richmond Richmond California 94801 —
Kaiser Permanente-Roseville Roseville California 95661 —
University of California Davis Comprehensive Cancer Center Sacramento California 95817 —
Kaiser Permanente-South Sacramento Sacramento California 95823 —
Kaiser Permanente - Sacramento Sacramento California 95825 —
Kaiser Permanente-San Francisco San Francisco California 94115 —
Kaiser Permanente-Santa Teresa-San Jose San Jose California 95119 —
Kaiser Permanente San Leandro San Leandro California 94577 —
Kaiser Permanente-San Rafael San Rafael California 94903 —
Kaiser Permanente Medical Center - Santa Clara Santa Clara California 95051 —
Kaiser Permanente-Santa Rosa Santa Rosa California 95403 —
Kaiser Permanente-South San Francisco South San Francisco California 94080 —
Kaiser Permanente-Stockton Stockton California 95210 —
Tahoe Forest Cancer Center Truckee California 96161 —
Kaiser Permanente Medical Center-Vacaville Vacaville California 95688 —
Kaiser Permanente-Vallejo Vallejo California 94589 —
Kaiser Permanente-Walnut Creek Walnut Creek California 94596 —
The Medical Center of Aurora Aurora Colorado 80012 —
Boulder Community Hospital Boulder Colorado 80301 —
Penrose-Saint Francis Healthcare Colorado Springs Colorado 80907 —
Porter Adventist Hospital Denver Colorado 80210 —
Exempla Saint Joseph Hospital Denver Colorado 80218 —
Presbyterian - Saint Lukes Medical Center - Health One Denver Colorado 80218 —
Rose Medical Center Denver Colorado 80220 —
Colorado Cancer Research Program CCOP Denver Colorado 80224-2522 —
Swedish Medical Center Englewood Colorado 80113 —
Saint Mary's Hospital and Regional Medical Center Grand Junction Colorado 81502 —
North Colorado Medical Center Greeley Colorado 80631 —
Saint Anthony Hospital Lakewood Colorado 80228 —
Sky Ridge Medical Center Lone Tree Colorado 80124 —
Longmont United Hospital Longmont Colorado 80501 —
McKee Medical Center Loveland Colorado 80539 —
Saint Mary Corwin Medical Center Pueblo Colorado 81004 —
North Suburban Medical Center Thornton Colorado 80229 —
SCL Health Lutheran Medical Center Wheat Ridge Colorado 80033 —
Bristol Hospital Bristol Connecticut 06011 —
Middlesex Hospital Middletown Connecticut 06457 —
Lynn Regional Cancer Center - West Boca Raton Florida 33428 —
Boca Raton Comprehensive Cancer Center Boca Raton Florida 33486 —
Mayo Clinic in Florida Jacksonville Florida 32224-9980 —
MacNeal Hospital and Cancer Center Berwyn Illinois 60402 —
Saint Joseph Medical Center Bloomington Illinois 61701 —
Illinois CancerCare-Bloomington Bloomington Illinois 61704 —
Graham Hospital Association Canton Illinois 61520 —
Illinois CancerCare-Canton Canton Illinois 61520 —
Illinois CancerCare-Carthage Carthage Illinois 62321 —
Memorial Hospital Carthage Illinois 62321 —
Hematology and Oncology Associates Chicago Illinois 60611 —
Northwestern University Chicago Illinois 60611 —
University of Chicago Comprehensive Cancer Center Chicago Illinois 60637 —
Decatur Memorial Hospital Decatur Illinois 62526 —
Eureka Hospital Eureka Illinois 61530 —
Illinois CancerCare-Eureka Eureka Illinois 61530 —
Galesburg Cottage Hospital Galesburg Illinois 61401 —
Illinois CancerCare Galesburg Galesburg Illinois 61401 —
Illinois CancerCare-Cottage Galesburg Illinois 61401 —
Illinois CancerCare-Havana Havana Illinois 62644 —
Mason District Hospital Havana Illinois 62644 —
Hematology Oncology Associates of Illinois-Highland Park Highland Park Illinois 60035 —
Hopedale Medical Complex - Hospital Hopedale Illinois 61747 —
Midwest Center for Hematology Oncology Joliet Illinois 60432 —
Illinois CancerCare-Kewanee Clinic Kewanee Illinois 61443 —
NorthShore Hematology Oncology-Libertyville Libertyville Illinois 60048 —
Illinois CancerCare-Macomb Macomb Illinois 61455 —
Mcdonough District Hospital Macomb Illinois 61455 —
Loyola University Medical Center Maywood Illinois 60153 —
Holy Family Medical Center Monmouth Illinois 61462 —
Illinois CancerCare-Monmouth Monmouth Illinois 61462 —
DuPage Medical Group-Ogden Naperville Illinois 60563 —
Illinois Cancer Specialists-Niles Niles Illinois 60714 —
Bromenn Regional Medical Center Normal Illinois 61761 —
Community Cancer Center Foundation Normal Illinois 61761 —
Illinois CancerCare-Community Cancer Center Normal Illinois 61761 —
Illinois CancerCare-Ottawa Clinic Ottawa Illinois 61350 —
Ottawa Regional Hospital and Healthcare Center Ottawa Illinois 61350 —
Illinois CancerCare-Pekin Pekin Illinois 61554 —
Pekin Cancer Treatment Center Pekin Illinois 61554 —
Pekin Hospital Pekin Illinois 61554 —
Methodist Medical Center of Illinois Peoria Illinois 61603 —
Proctor Hospital Peoria Illinois 61614 —
OSF Saint Francis Medical Center Radiation Oncology Service at the Central Illinois Comprehensive CC Peoria Illinois 61615-7827 —
Illinois CancerCare-Peoria Peoria Illinois 61615 —
Illinois Oncology Research Association CCOP Peoria Illinois 61615 —
OSF Saint Francis Medical Center Peoria Illinois 61637 —
Illinois CancerCare-Peru Peru Illinois 61354 —
Illinois Valley Hospital Peru Illinois 61354 —
Illinois CancerCare-Princeton Princeton Illinois 61356 —
Perry Memorial Hospital Princeton Illinois 61356 —
Hematology Oncology Associates of Illinois - Skokie Skokie Illinois 60076 —
Illinois CancerCare-Spring Valley Spring Valley Illinois 61362 —
Saint Margaret's Hospital Spring Valley Illinois 61362 —
Memorial Medical Center Springfield Illinois 62781 —
Franciscan St. Francis Health-Beech Grove Beech Grove Indiana 46107 —
Reid Hospital and Health Care Services Richmond Indiana 47374 —
McFarland Clinic PC-William R Bliss Cancer Center Ames Iowa 50010 —
Hematology Oncology Associates-Quad Cities Bettendorf Iowa 52722 —
Cedar Rapids Oncology Association Cedar Rapids Iowa 52403 —
Mercy Hospital Cedar Rapids Iowa 52403 —
Oncology Associates at Mercy Medical Center Cedar Rapids Iowa 52403 —
Medical Oncology and Hematology Associates-West Des Moines Clive Iowa 50325 —
Genesis Medical Center - East Campus Davenport Iowa 52803 —
Genesis Medical Center - West Campus Davenport Iowa 52804 —
Mercy Capitol Des Moines Iowa 50307 —
Iowa Methodist Medical Center Des Moines Iowa 50309 —
Iowa Oncology Research Association CCOP Des Moines Iowa 50309 —
Medical Oncology and Hematology Associates-Des Moines Des Moines Iowa 50309 —
Medical Oncology and Hematology Associates-Laurel Des Moines Iowa 50314 —
Mercy Medical Center - Des Moines Des Moines Iowa 50314 —
Iowa Lutheran Hospital Des Moines Iowa 50316 —
Siouxland Regional Cancer Center Sioux City Iowa 51101 —
Mercy Medical Center-Sioux City Sioux City Iowa 51104 —
Saint Luke's Regional Medical Center Sioux City Iowa 51104 —
Covenant Medical Center Waterloo Iowa 50702 —
Hospital District Sixth of Harper County Anthony Kansas 67003 —
Menorah Medical Center Overland Park Kansas 66209 —
Saint Luke's South Hospital Overland Park Kansas 66213 —
Shawnee Mission Medical Center-KCCC Shawnee Mission Kansas 66204 —
Stormont-Vail Regional Health Center Topeka Kansas 66604 —
Greater Baltimore Medical Center Baltimore Maryland 21204 —
The Memorial Hospital at Easton Easton Maryland 21601 —
Cancer Trials Support Unit Rockville Maryland 20850-2062 —
Boston Medical Center Boston Massachusetts 02118 —
Steward Saint Elizabeth's Medical Center Brighton Massachusetts 02135-2997 —
Cape Cod Hospital Hyannis Massachusetts 02601 —
Bixby Medical Center Adrian Michigan 49221 —
Hickman Cancer Center Adrian Michigan 49221 —
Saint Joseph Mercy Hospital Ann Arbor Michigan 48106-0995 —
Michigan Cancer Research Consortium CCOP Ann Arbor Michigan 48106 —
Bronson Battle Creek Battle Creek Michigan 49017 —
Spectrum Health Big Rapids Hospital Big Rapids Michigan 49307 —
Oakwood Hospital and Medical Center Dearborn Michigan 48124 —
Saint John Hospital and Medical Center Detroit Michigan 48236 —
Hurley Medical Center Flint Michigan 48502 —
Genesys Regional Medical Center-West Flint Campus Flint Michigan 48532 —
Grand Rapids Clinical Oncology Program Grand Rapids Michigan 49503 —
Mercy Health Saint Mary's Grand Rapids Michigan 49503 —
Spectrum Health at Butterworth Campus Grand Rapids Michigan 49503 —
Allegiance Health Jackson Michigan 49201 —
Sparrow Hospital Lansing Michigan 48912 —
Saint Mary Mercy Hospital Livonia Michigan 48154 —
Mercy Memorial Hospital Monroe Michigan 48162 —
Toledo Clinic Cancer Centers-Monroe Monroe Michigan 48162 —
Mercy Health Mercy Campus Muskegon Michigan 49444 —
Saint Joseph Mercy Oakland Pontiac Michigan 48341 —
Saint Joseph Mercy Port Huron Port Huron Michigan 48060 —
Saint Mary's of Michigan Saginaw Michigan 48601 —
Munson Medical Center Traverse City Michigan 49684 —
Saint John Macomb-Oakland Hospital Warren Michigan 48093 —
Metro Health Hospital Wyoming Michigan 49519 —
Essentia Health Cancer Center Duluth Minnesota 55805 —
Essentia Health Saint Mary's Medical Center Duluth Minnesota 55805 —
Miller-Dwan Hospital Duluth Minnesota 55805 —
Hutchinson Area Health Care Hutchinson Minnesota 55350 —
Meeker County Memorial Hospital Litchfield Minnesota 55355 —
Saint John's Hospital - Healtheast Maplewood Minnesota 55109 —
Minnesota Cooperative Group Outreach Program Minneapolis Minnesota 55407 —
Virginia Piper Cancer Institute Minneapolis Minnesota 55407 —
Hennepin County Medical Center Minneapolis Minnesota 55415 —
Mayo Clinic Rochester Minnesota 55905 —
Regions Hospital Saint Paul Minnesota 55101 —
Rice Memorial Hospital Willmar Minnesota 56201 —
Truman Medical Center Kansas City Missouri 64108 —
Saint Luke's Cancer Institute Kansas City Missouri 64111 —
Saint Luke's Hospital of Kansas City Kansas City Missouri 64111 —
Saint Joseph Health Center Kansas City Missouri 64114 —
North Kansas City Hospital Kansas City Missouri 64116 —
Research Medical Center Kansas City Missouri 64132 —
Saint Luke's East - Lee's Summit Lee's Summit Missouri 64086 —
Liberty Hospital Liberty Missouri 64068 —
Liberty Radiation Oncology Center Liberty Missouri 64068 —
Heartland Regional Medical Center Saint Joseph Missouri 64506 —
Saint Louis University Hospital St Louis Missouri 63110 —
Missouri Baptist Medical Center St Louis Missouri 63131 —
Center for Cancer Care and Research St Louis Missouri 63141 —
Montana Cancer Consortium NCORP Billings Montana 59101 —
Northern Rockies Radiation Oncology Center Billings Montana 59101 —
Saint Vincent Healthcare Billings Montana 59101 —
Frontier Cancer Center and Blood Institute-Billings Billings Montana 59102 —
Billings Clinic Cancer Center Billings Montana 59107 —
Bozeman Deaconess Cancer Center Bozeman Montana 59715 —
Bozeman Deaconess Hospital Bozeman Montana 59715 —
Saint James Community Hospital and Cancer Treatment Center Butte Montana 59701 —
Berdeaux, Donald MD (UIA Investigator) Great Falls Montana 59405 —
Great Falls Clinic Great Falls Montana 59405 —
Northern Montana Hospital Havre Montana 59501 —
Saint Peter's Community Hospital Helena Montana 59601 —
Glacier Oncology PLLC Kalispell Montana 59901 —
Kalispell Medical Oncology Kalispell Montana 59901 —
Kalispell Regional Medical Center Kalispell Montana 59901 —
Community Medical Hospital Missoula Montana 59801 —
Montana Cancer Specialists Missoula Montana 59802 —
Saint Patrick Hospital - Community Hospital Missoula Montana 59802 —
Guardian Oncology and Center for Wellness Missoula Montana 59804 —
CHI Health Good Samaritan Kearney Nebraska 68847 —
Veterans Adminstration New Jersey Health Care System East Orange New Jersey 07018-1095 —
Hunterdon Medical Center Flemington New Jersey 08822 —
Fox Chase Cancer Center at Virtua Memorial Hospital of Burlington County Mount Holly New Jersey 08060 —
Riverview Medical Center/Booker Cancer Center Red Bank New Jersey 07701 —
Virtua West Jersey Hospital Voorhees Voorhees Township New Jersey 08043 —
Roswell Park Cancer Institute Buffalo New York 14263 —
University of Rochester Rochester New York 14642 —
State University of New York Upstate Medical University Syracuse New York 13210 —
Syracuse Veterans Administration Medical Center Syracuse New York 13210 —
Wayne Memorial Hospital Goldsboro North Carolina 27534 —
Margaret R Pardee Memorial Hospital Hendersonville North Carolina 28791 —
Rutherford Hospital Rutherfordton North Carolina 28139 —
Southeast Cancer Consortium-Upstate NCORP Winston-Salem North Carolina 27104 —
Mid Dakota Clinic Bismarck North Dakota 58501 —
Saint Alexius Medical Center Bismarck North Dakota 58501 —
Sanford Bismarck Medical Center Bismarck North Dakota 58501 —
Altru Cancer Center Grand Forks North Dakota 58201 —
Toledo Clinic Cancer Centers-Bowling Green Bowling Green Ohio 43402 —
North Coast Cancer Care-Clyde Clyde Ohio 43410 —
Ohio State University Comprehensive Cancer Center Columbus Ohio 43210 —
Grandview Hospital Dayton Ohio 45405 —
Good Samaritan Hospital - Dayton Dayton Ohio 45406 —
Miami Valley Hospital Dayton Ohio 45409 —
Samaritan North Health Center Dayton Ohio 45415 —
Dayton CCOP Dayton Ohio 45420 —
Hematology Oncology Center Incorporated Elyria Ohio 44035 —
Blanchard Valley Hospital Findlay Ohio 45840 —
Atrium Medical Center-Middletown Regional Hospital Franklin Ohio 45005-1066 —
Wayne Hospital Greenville Ohio 45331 —
Kettering Medical Center Kettering Ohio 45429 —
Lima Memorial Hospital Lima Ohio 45804 —
Saint Luke's Hospital Maumee Ohio 43537 —
Toledo Clinic Cancer Centers-Maumee Maumee Ohio 43537 —
Toledo Radiation Oncology at Northwest Ohio Onocolgy Center Maumee Ohio 43537 —
Saint Charles Hospital Oregon Ohio 43616 —
Toledo Clinic Cancer Centers-Oregon Oregon Ohio 43616 —
North Coast Cancer Care Sandusky Ohio 44870 —
Flower Hospital Sylvania Ohio 43560 —
Mercy Hospital of Tiffin Tiffin Ohio 44883 —
The Toledo Hospital/Toledo Children's Hospital Toledo Ohio 43606 —
Saint Vincent Mercy Medical Center Toledo Ohio 43608 —
University of Toledo Toledo Ohio 43614 —
Toledo Community Hospital Oncology Program CCOP Toledo Ohio 43617 —
Mercy Saint Anne Hospital Toledo Ohio 43623 —
Toledo Clinic Cancer Centers-Toledo Toledo Ohio 43623 —
Upper Valley Medical Center Troy Ohio 45373 —
Fulton County Health Center Wauseon Ohio 43567 —
Clinton Memorial Hospital Wilmington Ohio 45177 —
Greene Memorial Hospital Xenia Ohio 45385 —
Geisinger Medical Center Danville Pennsylvania 17822 —
Geisinger Medical Center-Cancer Center Hazleton Hazleton Pennsylvania 18201 —
Thomas Jefferson University Hospital Philadelphia Pennsylvania 19107 —
Mercy Hospital Scranton Pennsylvania 18501 —
Scranton Hematology Oncology Scranton Pennsylvania 18510 —
Geisinger Medical Group State College Pennsylvania 16801 —
Mount Nittany Medical Center State College Pennsylvania 16803 —
Geisinger Wyoming Valley/Henry Cancer Center Wilkes-Barre Pennsylvania 18711 —
AnMed Health Hospital Anderson South Carolina 29621 —
Spartanburg Medical Center Spartanburg South Carolina 29303 —
Rapid City Regional Hospital Rapid City South Dakota 57701 —
Danville Regional Medical Center Danville Virginia 24541 —
Fredericksburg Oncology Inc Fredericksburg Virginia 22401 —
Memorial Hospital Of Martinsville Martinsville Virginia 24115 —
Virginia Commonwealth University/Massey Cancer Center Richmond Virginia 23298 —
Rocky Mountain Oncology Casper Wyoming 82609 —
Welch Cancer Center Sheridan Wyoming 82801 —

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 1 non-U.S. site.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT00738881, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Oct 29, 2015 · Synced Oct 9, 2026

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Open the official record

The complete public registry record, listed eligibility criteria, and available contact information for NCT00738881 live on ClinicalTrials.gov.

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