Study Evaluating Changes In Bone Mineral Density (BMD), And Safety Of Rhbmp-2/CPM In Subjects With Decreased BMD
Public ClinicalTrials.gov record NCT00752557. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A PHASE 2, MULTICENTER, RANDOMIZED, ACTIVE-CONTROLLED, PARALLEL-GROUP, DOSE-FINDING AND SAFETY STUDY OF RECOMBINANT HUMAN BONE MORPHOGENETIC PROTEIN-2 (RHBMP-2)/CALCIUM PHOSPHATE MATRIX(CPM) IN SUBJECTS WITH DECREASED BONE MINERAL DENSITY
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The main purpose of this study is to assess whether a locally-administered rhBMP-2/CPM injection can rapidly increase bone mass in subjects at high risk for osteoporotic fractures of the hip. All subjects will receive standard treatment for low bone mass, consisting of bisphosphonates, calcium, and vitamin D (all taken by mouth). Subjects that are randomly selected to receive treatment with rhBMP-2 will receive an injection directly into the hip. The injection is given in a surgery room using a light anesthesia.
Study identification
- NCT ID
- NCT00752557
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 50 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 65 Years to 85 Years
- Sex
- Female
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 3, 2008 (Actual)
- Primary completion
- Apr 24, 2015 (Actual)
- Completion
- Apr 24, 2015 (Actual)
- Last update posted
- Mar 20, 2020
2008 – 2015
United States locations
- U.S. sites
- 28
- U.S. states
- 10
- U.S. cities
- 18
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Arizona Research Center, Inc. | Phoenix | Arizona | 85023 | — |
| John C. Lincoln Hospital - Deer Valley | Phoenix | Arizona | 85027 | — |
| Tucson Orthopaedic Institute | Tucson | Arizona | 85712 | — |
| UC Davis Medical Center | Sacramento | California | 95817 | — |
| Florida Hospital Deland | DeLand | Florida | 32720 | — |
| Florida Orthopaedic Associates, P.A. | DeLand | Florida | 32720 | — |
| Florida Research Associates, LLC | DeLand | Florida | 32720 | — |
| Victoria Park Imaging | DeLand | Florida | 32724 | — |
| Diagnostic Professionals, Inc. | Fort Lauderdale | Florida | 33311 | — |
| Shrock Orthopedic Research | Fort Lauderdale | Florida | 33316 | — |
| Suncoast Clinical Research Inc | New Port Richey | Florida | 34652 | — |
| Coastal orthopedic and Sports Medicine | New Port Richey | Florida | 34653 | — |
| Westside Regional Medical Center | Plantation | Florida | 33324 | — |
| Florida Arthritis & Osteoporosis Center | Port Richey | Florida | 34668 | — |
| Medical Center of Trinity | Trinity | Florida | 34655 | — |
| Intensive Research Unit | St Louis | Missouri | 63110 | — |
| Washington University School of Medicine | St Louis | Missouri | 63110 | — |
| Center for Advanced Medicine | St Louis | Missouri | 63310 | — |
| Creighton University Medical Center | Omaha | Nebraska | 68131 | — |
| Creighton University Osteoporosis Research Center | Omaha | Nebraska | 68131 | — |
| Columbia University Medical Center | New York | New York | 10032 | — |
| Duke University Medical Center | Durham | North Carolina | 27710 | — |
| University Orthopedics Center | Altoona | Pennsylvania | 16602 | — |
| University Orthopedics Center | State College | Pennsylvania | 16801 | — |
| Prairie Lakes Healthcare Systems | Watertown | South Dakota | 57201G | — |
| Brown Clinic | Watertown | South Dakota | 57201 | — |
| Cool Spring Interventional, PLLC | Franklin | Tennessee | 37067 | — |
| Center for Women's Health Research at Meharry Medical College | Nashville | Tennessee | 37208-3599 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 7 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00752557, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Mar 20, 2020 · Synced Oct 19, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00752557 live on ClinicalTrials.gov.