Biomarkers of Risk of Parkinson Disease
Public ClinicalTrials.gov record NCT00775853. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study (https://pdrisk.ninds.nih.gov) will determine if people who have risk factors for Parkinson disease (PD) have biomarkers (objective ways to measure a disease process) that show that the disease process is actually going on, and if people who have abnormal biomarkers go on to develop PD during several years of follow-up. Biomarkers of Parkinson disease (PD) might identify people who are healthy now but may develop the disease later in life. Healthy volunteers and people who have certain risk factors for developing PD who are between 18 and 70 years of age may be eligible for this study. People with the following risk factors are included: * Family history of PD * Loss of sense of smell * Fall in blood pressure when standing up * REM behavior disorder (a type of sleep disturbance) Participants undergo the following tests and procedures: * Screening examination * Medical and neurological history and physical examination * Tests or rating scales for movement, sense of smell, mood, attention, fatigue, pain, and thinking. * Measurement of blood pressure and pulse rate while lying down and then standing up * Blood draw for genetic testing * Inpatient testing at the NIH Clinical Center for 2-3 days, including: * Measurements while blowing against a resistance * Measurements of blood pressure and pulse rate * Blood draws for levels of various chemicals * PET and MRI scanning * Lumbar puncture (spinal tap) * Electrocardiogram * Skin electrical conduction test (test of sweat production) * Skin and core temperature measurements * Transcranial ultrasound (sound-wave test of the head) * Follow-up testing (up to five visits in 18-month intervals) to repeat some of the tests listed above, excluding the genetic testing and spinal tap
Study identification
- NCT ID
- NCT00775853
- Recruitment status
- Completed
- Study type
- Observational
- Phase
- Not listed
- Enrollment
- 89 participants
Conditions and interventions
Eligibility (public fields only)
- Age range
- 18 Years to 70 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- May 26, 2009
- Primary completion
- Jan 10, 2023
- Completion
- Jan 10, 2023
- Last update posted
- Sep 18, 2025
2009 – 2023
United States locations
- U.S. sites
- 1
- U.S. states
- 1
- U.S. cities
- 1
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| National Institutes of Health Clinical Center | Bethesda | Maryland | 20892 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00775853, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 18, 2025 · Synced Sep 5, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT00775853 live on ClinicalTrials.gov.