Study Evaluating Neratinib Versus Lapatinib Plus Capecitabine For ErbB2 Positive Advanced Breast Cancer
Public ClinicalTrials.gov record NCT00777101. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2 Randomized Open-Label Study of Neratinib Versus Lapatinib Plus Capecitabine For The Treatment Of ErbB-2 Positive Locally Advanced Or Metastatic Breast Cancer
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is a study of an experimental drug (neratinib) versus a combination of drugs (lapatinib and capecitabine) in women who have erbB-2 (HER-2) positive metastatic or locally advanced breast cancer. The goal of this study is to compare the two regimens in shrinking tumors and extending the lives of women with erbB2 (HER2) positive breast cancer. The study will also compare the safety of the two regimens and to compare quality of life of patients taking the two regimens.
Study identification
- NCT ID
- NCT00777101
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 233 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- Female
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Feb 4, 2009 (Actual)
- Primary completion
- Mar 2011 (Actual)
- Completion
- Jun 3, 2018 (Actual)
- Last update posted
- Aug 9, 2018
2009 – 2018
United States locations
- U.S. sites
- 44
- U.S. states
- 16
- U.S. cities
- 43
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Arizona Oncology Associates HOPE | Tucson | Arizona | 85704-7891 | — |
| Southwest Cancer Care | Murrieta | California | 92562 | — |
| UC Irvine Medical Center | Orange | California | 92868-3298 | — |
| Aptium Oncology/Comprehensive Cancer Center at Desert Regional Medical Center | Palm Springs | California | 92262 | — |
| Redwood Regional Medical Group, Inc. | Santa Rosa | California | 95403 | — |
| Rocky Mountain Cancer Center | Denver | Colorado | 80220 | — |
| Hematology Oncology Associates, P.C. | Stamford | Connecticut | 06902 | — |
| Palm Beach Institute of Hematology & Oncology | Boynton Beach | Florida | 33435 | — |
| Robert R. Carroll, MD, PA | Gainesville | Florida | 32605 | — |
| University of Florida | Jacksonville | Florida | 32209 | — |
| Hematology Oncology Associates | Loxahatchee Groves | Florida | 33470 | — |
| Mercy Research Institute | Miami | Florida | 33133 | — |
| Cancer Centers of Florida | Orlando | Florida | 32806 | — |
| Hematology Oncology Associates of the Treasure Coast | Port Saint Lucie | Florida | 34952 | — |
| Cancer Care Specialists Of Central Illinois | Decatur | Illinois | 62526 | — |
| Oncology Specialists, SC | Park Ridge | Illinois | 60068 | — |
| Midwestern Regional Medical Center | Zion | Illinois | 60099 | — |
| Central Indiana Cancer Centers | Fishers | Indiana | 46037 | — |
| Hematology Oncology of Indiana | Indianapolis | Indiana | 46260-2082 | — |
| Floyd Memorial Cancer Center of Indiana | New Albany | Indiana | 47150 | — |
| Ashland-Bellefonte Cancer Center | Ashland | Kentucky | 41101 | — |
| Owsley Brown Frazier Cancer Center (OBFCC) | Louisville | Kentucky | 40245 | — |
| Purchase Cancer Group | Paducah | Kentucky | 42001 | — |
| Missouri Cancer Associates | Columbia | Missouri | 65201 | — |
| Capitol Comprehensive Cancer Care Clinic | Jefferson City | Missouri | 65109 | — |
| Arena Oncology Associates, PC | Lake Success | New York | 11042 | — |
| Weill Cornell Medical College New York-Presbyterian Hospital Weill, Cornell Breast Center | New York | New York | 10065 | — |
| New York Oncology Hematolgy, PC | Troy | New York | 12180 | — |
| Oncology Partners Network | Cincinnati | Ohio | 45247 | — |
| MetroHealth Medical Center, Cancer Care Center | Cleveland | Ohio | 44109 | — |
| University of Oklahoma Health Sciences Center Dept. of Hematology Oncology | Oklahoma City | Oklahoma | 73104 | — |
| Northwest Cancer Specialists, PC | Portland | Oregon | 97213 | — |
| Lancaster Cancer Center | Lancaster | Pennsylvania | 17605 | — |
| Allegheny General Hospital Allegheny Cancer Center | Pittsburgh | Pennsylvania | 15212 | — |
| Cookeville Regional Medical Center | Cookeville | Tennessee | 38501 | — |
| Center for Biomedical Research | Knoxville | Tennessee | 37909 | — |
| Thompson Cancer Survival Center Thompson Oncology Group | Knoxville | Tennessee | 37916 | — |
| University of Tennessee Cancer Institute | Memphis | Tennessee | 38104 | — |
| Texas Oncology, P.A. | Austin | Texas | 78731-4214 | — |
| El Paso Cancer Treatment Center - West | El Paso | Texas | 79902 | — |
| The Center for Cancer and Blood Disorders | Fort Worth | Texas | 76104 | — |
| HOPE Oncology | Richardson | Texas | 75080 | — |
| Cancer Care Network of South Texas-HOAST | San Antonio | Texas | 78229 | — |
| East Texas Medical Center Cancer Institute, Tyler Hematology Oncology | Tyler | Texas | 75701-2043 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 108 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00777101, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 9, 2018 · Synced Oct 19, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00777101 live on ClinicalTrials.gov.