Study Evaluating Long-Term Safety of MOA-728 in Participants With Opioid-Induced Constipation
Public ClinicalTrials.gov record NCT00804141. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
An Open-Label Study to Evaluate the Long-Term Safety of Subcutaneous MOA-728 for Treatment of Opioid-Induced Constipation in Subjects With Nonmalignant Pain
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study is designed to evaluate the long-term safety and tolerability of the subcutaneous (SC) injection form of N-methylnaltrexone bromide (MOA-728) for the treatment of opioid-induced constipation in participants with nonmalignant pain. The study consists of a 2-week screening period, a 48-week open-label treatment period and a 2 week follow-up period. Participants will need to agree to self-administer SC injections, complete daily diaries, and check-in via a daily telephone call during the study.
Study identification
- NCT ID
- NCT00804141
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 1,040 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 3, 2008 (Actual)
- Primary completion
- Sep 20, 2010 (Actual)
- Completion
- Sep 20, 2010 (Actual)
- Last update posted
- Oct 18, 2019
2008 – 2010
United States locations
- U.S. sites
- 94
- U.S. states
- 33
- U.S. cities
- 79
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Pfizer Investigational Site | Birmingham | Alabama | 35242 | — |
| Pfizer Investigational Site | Chandler | Arizona | 85224 | — |
| Pfizer Investigational Site | Mesa | Arizona | 85206 | — |
| Pfizer Investigational Site | Mesa | Arizona | 85213 | — |
| Pfizer Investigational Site | Phoenix | Arizona | 85028 | — |
| Pfizer Investigational Site | Phoenix | Arizona | 85029 | — |
| Pfizer Investigational Site | Tempe | Arizona | 85282 | — |
| Pfizer Investigational Site | Tucson | Arizona | 85710 | — |
| Pfizer Investigational Site | Tucson | Arizona | 85741 | — |
| Pfizer Investigational Site | Hot Springs | Arkansas | 71913 | — |
| Pfizer Investigational Site | Garden Grove | California | 92843 | — |
| Pfizer Investigational Site | Laguna Hills | California | 92653 | — |
| Pfizer Investigational Site | Los Gatos | California | 95032 | — |
| Pfizer Investigational Site | Newport Beach | California | 92660 | — |
| Pfizer Investigational Site | Newport Beach | California | 92663 | — |
| Pfizer Investigational Site | Colorado Springs | Colorado | 80904 | — |
| Pfizer Investigational Site | Boca Raton | Florida | 33432 | — |
| Pfizer Investigational Site | Brandon | Florida | 33511 | — |
| Pfizer Investigational Site | Chiefland | Florida | 32626 | — |
| Pfizer Investigational Site | Clearwater | Florida | 33756 | — |
| Pfizer Investigational Site | Daytona Beach | Florida | 32117 | — |
| Pfizer Investigational Site | Fort Myers | Florida | 33916 | — |
| Pfizer Investigational Site | Gainesville | Florida | 32607 | — |
| Pfizer Investigational Site | Jacksonville | Florida | 32216 | — |
| Pfizer Investigational Site | Jacksonville | Florida | 32257 | — |
| Pfizer Investigational Site | Jupiter | Florida | 33458 | — |
| Pfizer Investigational Site | Miami | Florida | 33180 | — |
| Pfizer Investigational Site | Miami | Florida | 33183 | — |
| Pfizer Investigational Site | Ocala | Florida | 34471-2106 | — |
| Pfizer Investigational Site | Ocala | Florida | 34471 | — |
| Pfizer Investigational Site | Ocala | Florida | 34474 | — |
| Pfizer Investigational Site | Orlando | Florida | 32806 | — |
| Pfizer Investigational Site | Ormond Beach | Florida | 32174 | — |
| Pfizer Investigational Site | Port Orange | Florida | 32129 | — |
| Pfizer Investigational Site | Sarasota | Florida | 34231 | — |
| Pfizer Investigational Site | Sarasota | Florida | 34239 | — |
| Pfizer Investigational Site | Tampa | Florida | 33603 | — |
| Pfizer Investigational Site | Tampa | Florida | 33613 | — |
| Pfizer Investigational Site | Vero Beach | Florida | 32960 | — |
| Pfizer Investigational Site | Winter Park | Florida | 32789 | — |
| Pfizer Investigational Site | Chicago | Illinois | 60616 | — |
| Pfizer Investigational Site | Rockford | Illinois | 61107 | — |
| Pfizer Investigational Site | Avon | Indiana | 46123 | — |
| Pfizer Investigational Site | Evansville | Indiana | 47714 | — |
| Pfizer Investigational Site | Indianapolis | Indiana | 46205 | — |
| Pfizer Investigational Site | Indianapolis | Indiana | 46250 | — |
| Pfizer Investigational Site | West Des Moines | Iowa | 50265 | — |
| Pfizer Investigational Site | Madisonville | Kentucky | 42431 | — |
| Pfizer Investigational Site | Hagerstown | Maryland | 21742 | — |
| Pfizer Investigational Site | Hollywood | Maryland | 20636 | — |
| Pfizer Investigational Site | Boston | Massachusetts | 02115 | — |
| Pfizer Investigational Site | Brockton | Massachusetts | 02301 | — |
| Pfizer Investigational Site | Watertown | Massachusetts | 02472 | — |
| Pfizer Investigational Site | Bingham Farms | Michigan | 48025 | — |
| Pfizer Investigational Site | Chesterfield | Michigan | 48047 | — |
| Pfizer Investigational Site | Kalamazoo | Michigan | 49009 | — |
| Pfizer Investigational Site | Traverse City | Michigan | 49684 | — |
| Pfizer Investigational Site | Edina | Minnesota | 55435 | — |
| Pfizer Investigational Site | Biloxi | Mississippi | 39531 | — |
| Pfizer Investigational Site | Jackson | Mississippi | 39202 | — |
| Pfizer Investigational Site | Springfield | Missouri | 65807 | — |
| Pfizer Investigational Site | Omaha | Nebraska | 68131 | — |
| Pfizer Investigational Site | Henderson | Nevada | 89014 | — |
| Pfizer Investigational Site | Las Vegas | Nevada | 89119 | — |
| Pfizer Investigational Site | Las Vegas | Nevada | 89123 | — |
| Pfizer Investigational Site | Las Vegas | Nevada | 89146 | — |
| Pfizer Investigational Site | Elizabeth | New Jersey | 07202 | — |
| Pfizer Investigational Site | Albuquerque | New Mexico | 87102 | — |
| Pfizer Investigational Site | Great Neck | New York | 11023 | — |
| Pfizer Investigational Site | New York | New York | 10022 | — |
| Pfizer Investigational Site | Charlotte | North Carolina | 28204 | — |
| Pfizer Investigational Site | Raleigh | North Carolina | 27607 | — |
| Pfizer Investigational Site | Fargo | North Dakota | 58103 | — |
| Pfizer Investigational Site | Centerville | Ohio | 45459 | — |
| Pfizer Investigational Site | Dayton | Ohio | 45432 | — |
| Pfizer Investigational Site | Oklahoma City | Oklahoma | 73112 | — |
| Pfizer Investigational Site | Medford | Oregon | 97504 | — |
| Pfizer Investigational Site | Portland | Oregon | 97210 | — |
| Pfizer Investigational Site | Altoona | Pennsylvania | 16602 | — |
| Pfizer Investigational Site | Levittown | Pennsylvania | 19056 | — |
| Pfizer Investigational Site | Yardley | Pennsylvania | 19067 | — |
| Pfizer Investigational Site | Cranston | Rhode Island | 02920 | — |
| Pfizer Investigational Site | Huntingdon | Tennessee | 38344 | — |
| Pfizer Investigational Site | Austin | Texas | 78705 | — |
| Pfizer Investigational Site | Beaumont | Texas | 77701 | — |
| Pfizer Investigational Site | Dallas | Texas | 75230 | — |
| Pfizer Investigational Site | Dallas | Texas | 75234 | — |
| Pfizer Investigational Site | Houston | Texas | 77074 | — |
| Pfizer Investigational Site | Hurst | Texas | 76054 | — |
| Pfizer Investigational Site | San Antonio | Texas | 78215 | — |
| Pfizer Investigational Site | San Antonio | Texas | 78229 | — |
| Pfizer Investigational Site | Salt Lake City | Utah | 84106 | — |
| Pfizer Investigational Site | Christiansburg | Virginia | 24073 | — |
| Pfizer Investigational Site | Bellevue | Washington | 98007 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 26 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00804141, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 18, 2019 · Synced Oct 17, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00804141 live on ClinicalTrials.gov.