A Study to Evaluate Ocrelizumab in Combination With Methotrexate Compared With Infliximab Plus Methotrexate in Patients With Active Rheumatoid Arthritis Currently Responding Inadequately to Etanercept or Adalimumab
Public ClinicalTrials.gov record NCT00808210. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
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Official title
A PHASE II RANDOMIZED, DOUBLE-BLIND, PARALLEL GROUP STUDY TO EVALUATE THE EFFICACY AND SAFETY OF OCRELIZUMAB IN COMBINATION WITH METHOTREXATE, COMPARED TO INFLIXIMAB PLUS METHOTREXATE IN PATIENTS WITH ACTIVE RHEUMATOID ARTHRITIS CURRENTLY RESPONDING INADEQUATELY TO ETANERCEPT OR ADALIMUMAB
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is a Phase II, randomized, active-controlled, double-blind, double-dummy, parallel-group, multicenter study in the United States enrolling patients with active RA. The study will enroll approximately 290 patients at approximately 130 sites.
Study identification
- NCT ID
- NCT00808210
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 28 participants
Conditions and interventions
Conditions
Interventions
- Infliximab Drug
- Methotrexate Drug
- Methylprednisolone Drug
- Ocrelizumab Drug
- Placebo Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 5, 2009 (Actual)
- Primary completion
- Nov 14, 2012 (Actual)
- Completion
- Nov 14, 2012 (Actual)
- Last update posted
- Nov 6, 2020
2009 – 2012
United States locations
- U.S. sites
- 53
- U.S. states
- 27
- U.S. cities
- 52
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Rheumatology Associates | Birmingham | Alabama | 35205 | — |
| NEA Baptist Clinic | Jonesboro | Arkansas | 72401 | — |
| Dr. Brigid Freyne, MD | Murrieta | California | 92563 | — |
| Agilence Arthritis and Osteoporosis Medical Center, Inc. | Whittier | California | 90606 | — |
| Arthritis Assoc & Osteoporosis; Ctr of Colorado Springs | Colorado Springs | Colorado | 80920 | — |
| RASF-Clinical Research Center | Boca Raton | Florida | 33486 | — |
| Robert W. Levin MD - PP | Dunedin | Florida | 34698 | — |
| Science and Research Institute, Inc. | Jupiter | Florida | 33458 | — |
| Rheumatology Associates of Central Florida | Orlando | Florida | 32806 | — |
| Lovelace Scientific Resources | Sarasota | Florida | 34292 | — |
| Arthritis Res & Treatment | Macon | Georgia | 30281 | — |
| Harbin Clinic | Rome | Georgia | 30165 | — |
| Institute of Arthritis Research | Idaho Falls | Idaho | 83404 | — |
| Illinois Bone & Joint Inst. | Morton Grove | Illinois | 60053 | — |
| Springfield Clinic | Springfield | Illinois | 62703 | — |
| University of Kansas Medical Center | Kansas City | Kansas | 66160 | — |
| Graves Gilbert Clinic | Bowling Green | Kentucky | 42101 | — |
| Clinical Pharmacology Study Group | Worcester | Massachusetts | 01610 | — |
| Hurley Medical Center | Flint | Michigan | 48503 | — |
| Rheumatology, P.C.; Medical Arts Building | Kalamazoo | Michigan | 49009 | — |
| Fiechtner Research Inc | Lansing | Michigan | 48910 | — |
| Shores Rheumatology | Saint Clair Shores | Michigan | 48081 | — |
| Jackson Arthritis Clinic | Flowood | Mississippi | 39232 | — |
| Arthritis Associates of Mississippi | Jackson | Mississippi | 39202 | — |
| Private Practice - Rosenberg | Florissant | Missouri | 63031 | — |
| Clayton Medical Research | St Louis | Missouri | 63117 | — |
| Billings Clinic; Research Center | Billings | Montana | 59101 | — |
| Billings Clinic | Billings | Montana | 59102 | — |
| Westroads Medical Group | Omaha | Nebraska | 68114 | — |
| Arthritis Center of Reno | Reno | Nevada | 89502 | — |
| Dartmouth-Hitchcock Medical Center, Rheumatology 5C | Lebanon | New Hampshire | 03756 | — |
| Regional Clinical Research | Binghamton | New York | 13905 | — |
| Arthritis & Osteoporosis Center | Brooklyn | New York | 11201 | — |
| Southern Tier Arthritis & Rheumatism | Olean | New York | 14760 | — |
| Buffalo Rheumatology Associates | Orchard Park | New York | 14127 | — |
| Barada,Harrell,Toohey&Bellhorn | Durham | North Carolina | 27704 | — |
| Physicians East Pa | Greenville | North Carolina | 27834 | — |
| Ohio State Univ Med Center | Columbus | Ohio | 43210 | — |
| Oklahoma Medical Research Foundation | Oklahoma City | Oklahoma | 73104 | — |
| Healthcare Research Consultants | Tulsa | Oklahoma | 74135 | — |
| Providence Arthritis Center | Portland | Oregon | 97213 | — |
| Lehigh Valley Physicians Group | Allentown | Pennsylvania | 18103 | — |
| Arthritis Associates | Erie | Pennsylvania | 16508 | — |
| Columbia Arthritis Center (Partnership Practice) | Columbia | South Carolina | 29204 | — |
| Piedmont Arthritis Clinic | Greenville | South Carolina | 29601 | — |
| South Carolina Research Center | Myrtle Beach | South Carolina | 29572 | — |
| Arthritis Associates | Hixson | Tennessee | 37343 | — |
| Ramesh Gupta - PP | Memphis | Tennessee | 38119 | — |
| Ctr for Inflammatory Disease | Nashville | Tennessee | 37205 | — |
| Amarillo Center For Clinical Research | Amarillo | Texas | 79124 | — |
| Phillip A Waller MD, PA | Houston | Texas | 77034 | — |
| Southwest Rheumatology | Mesquite | Texas | 75150 | — |
| Texas Arthritis Research Center | San Antonio | Texas | 78217 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00808210, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Nov 6, 2020 · Synced Nov 8, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00808210 live on ClinicalTrials.gov.