ClinicalTrials.gov record
S0802 - Topotecan With or Without Aflibercept in Treating Patients With Extensive-Stage Small Cell Lung Cancer
ClinicalTrials.gov ID: NCT00828139
Public ClinicalTrials.gov record NCT00828139. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized Phase II Trial of Weekly Topotecan With and Without AVE0005 (Aflibercept; NSC-724770) in Patients With Platinum Treated Extensive Stage Small Cell Lung Cancer (E-SCLC)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This randomized phase II trial is studying topotecan to see how well it works when given with or without aflibercept in treating patients with extensive-stage small cell lung cancer. Drugs used in chemotherapy, such as topotecan, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Combinations of biological substances in aflibercept may be able to carry tumor-killing substances directly to small cell lung cancer cells. Aflibercept may also stop the growth of small cell lung cancer by blocking blood flow to the tumor. It is not yet known whether topotecan is more effective with or without aflibercept in treating patients with small cell lung cancer.
Study identification
- NCT ID
- NCT00828139
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 189 participants
Conditions and interventions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- May 2009 (Type not available)
- Primary completion
- Sep 2012 (Actual)
- Completion
- Sep 2012 (Actual)
- Last update posted
- Aug 21, 2017
2009 – 2012
United States locations
- U.S. sites
- 257
- U.S. states
- 32
- U.S. cities
- 177
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Northeast Alabama Regional Medical Center | Anniston | Alabama | 36202 | — |
| Providence Hospital | Mobile | Alabama | 36608 | — |
| Arizona Cancer Center at UMC Orange Grove | Tucson | Arizona | 85704 | — |
| Arizona Cancer Center at University Medical Center North | Tucson | Arizona | 85719 | — |
| University of Arizona Health Sciences Center | Tucson | Arizona | 85724 | — |
| NEA Baptist Memorial Hospital | Jonesboro | Arkansas | 72401 | — |
| University of Arkansas for Medical Sciences | Little Rock | Arkansas | 72205 | — |
| Highlands Oncology Group-Rogers | Rogers | Arkansas | 72758 | — |
| East Bay Radiation Oncology Center | Castro Valley | California | 94546 | — |
| Eden Hospital Medical Center | Castro Valley | California | 94546 | — |
| Valley Medical Oncology Consultants-Castro Valley | Castro Valley | California | 94546 | — |
| City of Hope Medical Center | Duarte | California | 91010 | — |
| Valley Medical Oncology Consultants-Fremont | Fremont | California | 94538 | — |
| Contra Costa Regional Medical Center | Martinez | California | 94553-3156 | — |
| Fremont - Rideout Cancer Center | Marysville | California | 95901 | — |
| El Camino Hospital | Mountain View | California | 94040 | — |
| Highland General Hospital | Oakland | California | 94602 | — |
| Alta Bates Summit Medical Center - Summit Campus | Oakland | California | 94609 | — |
| Bay Area Breast Surgeons Inc | Oakland | California | 94609 | — |
| Bay Area Tumor Institute CCOP | Oakland | California | 94609 | — |
| Larry G Strieff MD Medical Corporation | Oakland | California | 94609 | — |
| Tom K Lee Inc | Oakland | California | 94609 | — |
| Valley Care Health System - Pleasanton | Pleasanton | California | 94588 | — |
| Valley Medical Oncology Consultants | Pleasanton | California | 94588 | — |
| University of California at Davis Cancer Center | Sacramento | California | 95817 | — |
| Doctors Medical Center- JC Robinson Regional Cancer Center | San Pablo | California | 94806 | — |
| San Luis Valley Regional Medical Center | Alamosa | Colorado | 81101 | — |
| University of Colorado Cancer Center - Anschutz Cancer Pavilion | Aurora | Colorado | 80045 | — |
| The Shaw Regional Cancer Center | Edwards | Colorado | 81632 | — |
| Valley View Hospital Cancer Center | Glenwood Springs | Colorado | 81601 | — |
| Saint Mary's Hospital and Regional Medical Center | Grand Junction | Colorado | 81502 | — |
| Montrose Memorial Hospital | Montrose | Colorado | 81401 | — |
| Saint Francis Hospital and Medical Center | Hartford | Connecticut | 06105 | — |
| Piedmont Hospital | Atlanta | Georgia | 30309 | — |
| Atlanta Regional CCOP | Atlanta | Georgia | 30342 | — |
| Northside Hospital | Atlanta | Georgia | 30342 | — |
| Saint Joseph's Hospital of Atlanta | Atlanta | Georgia | 30342 | — |
| Well Star Cobb Hospital | Austell | Georgia | 30106 | — |
| John B Amos Cancer Center | Columbus | Georgia | 31904 | — |
| Dekalb Medical Center | Decatur | Georgia | 30033 | — |
| Piedmont Fayette Hospital | Fayetteville | Georgia | 30214 | — |
| Gwinnett Medical Center | Lawrenceville | Georgia | 30045 | — |
| Wellstar Kennestone Hospital | Marietta | Georgia | 30060 | — |
| Southern Regional Medical Center | Riverdale | Georgia | 30274 | — |
| Harbin Clinic Medical Oncology and Clinical Research | Rome | Georgia | 30165 | — |
| Memorial Health University Medical Center | Savannah | Georgia | 31403 | — |
| South Georgia Medical Center | Valdosta | Georgia | 31603 | — |
| Saint Alphonsus Regional Medical Center | Boise | Idaho | 83706 | — |
| Saint Anthony's Health | Alton | Illinois | 62002 | — |
| Cancer Care Center of Decatur | Decatur | Illinois | 62526 | — |
| Decatur Memorial Hospital | Decatur | Illinois | 62526 | — |
| Loyola University Medical Center | Maywood | Illinois | 60153 | — |
| Good Samaritan Regional Health Center | Mount Vernon | Illinois | 62864 | — |
| Memorial Medical Center | Springfield | Illinois | 62781-0001 | — |
| Saint Francis Hospital and Health Centers | Beech Grove | Indiana | 46107 | — |
| Reid Hospital and Health Care Services | Richmond | Indiana | 47374 | — |
| Genesis Medical Center - East Campus | Davenport | Iowa | 52803 | — |
| Genesis Medical Center - West Campus | Davenport | Iowa | 52804 | — |
| Hospital District Sixth of Harper County | Anthony | Kansas | 67003 | — |
| Cancer Center of Kansas - Chanute | Chanute | Kansas | 66720 | — |
| Cancer Center of Kansas - Dodge City | Dodge City | Kansas | 67801 | — |
| Cancer Center of Kansas - El Dorado | El Dorado | Kansas | 67042 | — |
| Cancer Center of Kansas - Fort Scott | Fort Scott | Kansas | 66701 | — |
| Hays Medical Center | Hays | Kansas | 67601 | — |
| Promise Regional Medical Center-Hutchinson | Hutchinson | Kansas | 65702 | — |
| Cancer Center of Kansas-Independence | Independence | Kansas | 67301 | — |
| Kansas City Cancer Center-West | Kansas City | Kansas | 66112 | — |
| University of Kansas Medical Center | Kansas City | Kansas | 66160 | — |
| Cancer Center of Kansas-Kingman | Kingman | Kansas | 67068 | — |
| Lawrence Memorial Hospital | Lawrence | Kansas | 66044 | — |
| Cancer Center of Kansas-Liberal | Liberal | Kansas | 67901 | — |
| Cancer Center of Kansas - Newton | Newton | Kansas | 67114 | — |
| Olathe Cancer Center | Olathe | Kansas | 66061 | — |
| Cancer Center of Kansas - Parsons | Parsons | Kansas | 67357 | — |
| Via Christi Hospital-Pittsburg | Pittsburg | Kansas | 66762 | — |
| Cancer Center of Kansas - Pratt | Pratt | Kansas | 67124 | — |
| Cancer Center of Kansas - Salina | Salina | Kansas | 67401 | — |
| Salina Regional Health Center | Salina | Kansas | 67401 | — |
| Stormont-Vail Regional Health Center | Topeka | Kansas | 66604 | — |
| Saint Francis Hospital and Medical Center - Topeka | Topeka | Kansas | 66606 | — |
| Cancer Center of Kansas - Wellington | Wellington | Kansas | 67152 | — |
| Associates In Womens Health | Wichita | Kansas | 67208 | — |
| Cancer Center of Kansas-Wichita Medical Arts Tower | Wichita | Kansas | 67208 | — |
| Cancer Center of Kansas - Main Office | Wichita | Kansas | 67214 | — |
| Via Christi Regional Medical Center | Wichita | Kansas | 67214 | — |
| Wichita CCOP | Wichita | Kansas | 67214 | — |
| Cancer Center of Kansas - Winfield | Winfield | Kansas | 67156 | — |
| University of Kentucky | Lexington | Kentucky | 40536 | — |
| Baton Rouge General Medical Center | Baton Rouge | Louisiana | 70806 | — |
| Mary Bird Perkins Cancer Center | Baton Rouge | Louisiana | 70809 | — |
| Interim LSU Public Hospital | New Orleans | Louisiana | 70112 | — |
| Louisiana State University Health Science Center | New Orleans | Louisiana | 70112 | — |
| Sinai Hospital of Baltimore | Baltimore | Maryland | 21215 | — |
| Boston Medical Center | Boston | Massachusetts | 02118 | — |
| Lahey Hospital and Medical Center | Burlington | Massachusetts | 01805 | — |
| Holy Family Hospital | Methuen | Massachusetts | 01844 | — |
| Saint Joseph Mercy Hospital | Ann Arbor | Michigan | 48106-0995 | — |
| Michigan Cancer Research Consortium Community Clinical Oncology Program | Ann Arbor | Michigan | 48106 | — |
| University of Michigan | Ann Arbor | Michigan | 48109 | — |
| Bronson Battle Creek | Battle Creek | Michigan | 49017 | — |
| Spectrum Health Big Rapids Hospital | Big Rapids | Michigan | 49307 | — |
| Oakwood Hospital | Dearborn | Michigan | 48124 | — |
| Wayne State University/Karmanos Cancer Institute | Detroit | Michigan | 48201 | — |
| Saint John Hospital and Medical Center | Detroit | Michigan | 48236 | — |
| Hurley Medical Center | Flint | Michigan | 48502 | — |
| Genesys Regional Medical Center-West Flint Campus | Flint | Michigan | 48532 | — |
| Grand Rapids Clinical Oncology Program | Grand Rapids | Michigan | 49503 | — |
| Mercy Health Saint Mary's | Grand Rapids | Michigan | 49503 | — |
| Spectrum Health at Butterworth Campus | Grand Rapids | Michigan | 49503 | — |
| Allegiance Health | Jackson | Michigan | 49201 | — |
| Sparrow Hospital | Lansing | Michigan | 48912 | — |
| Saint Mary Mercy Hospital | Livonia | Michigan | 48154 | — |
| Mercy Health Mercy Campus | Muskegon | Michigan | 49444 | — |
| Saint Joseph Mercy Oakland | Pontiac | Michigan | 48341-2985 | — |
| Saint Joseph Mercy Port Huron | Port Huron | Michigan | 48060 | — |
| Saint Mary's of Michigan | Saginaw | Michigan | 48601 | — |
| Munson Medical Center | Traverse City | Michigan | 49684 | — |
| Saint John Macomb-Oakland Hospital | Warren | Michigan | 48093 | — |
| Metro Health Hospital | Wyoming | Michigan | 49519 | — |
| Gulfport Memorial Hospital | Gulfport | Mississippi | 39502 | — |
| University of Mississippi Medical Center | Jackson | Mississippi | 39216 | — |
| Singing River Hospital | Pascagoula | Mississippi | 39581 | — |
| Saint Francis Medical Center | Cape Girardeau | Missouri | 63703 | — |
| Truman Medical Center | Kansas City | Missouri | 64108 | — |
| Kansas City Veterans Affairs Medical Center | Kansas City | Missouri | 64128 | — |
| Ozark Health Ventures LLC dba Cancer Research for The Ozarks Springfield | Springfield | Missouri | 65802 | — |
| Mercy Hospital Springfield | Springfield | Missouri | 65804 | — |
| CoxHealth South Hospital | Springfield | Missouri | 65807 | — |
| Saint Louis Cancer and Breast Institute-South City | St Louis | Missouri | 63109 | — |
| Saint Louis University Hospital | St Louis | Missouri | 63110 | — |
| Saint John's Mercy Medical Center | St Louis | Missouri | 63141 | — |
| Saint Louis-Cape Girardeau CCOP | St Louis | Missouri | 63141 | — |
| Montana Cancer Consortium CCOP | Billings | Montana | 59101 | — |
| Northern Rockies Radiation Oncology Center | Billings | Montana | 59101 | — |
| Saint Vincent Healthcare | Billings | Montana | 59101 | — |
| Hematology-Oncology Centers of the Northern Rockies PC | Billings | Montana | 59102 | — |
| Billings Clinic | Billings | Montana | 59107-7000 | — |
| Bozeman Deaconess Cancer Center | Bozeman | Montana | 59715 | — |
| Bozeman Deaconess Hospital | Bozeman | Montana | 59715 | — |
| Saint James Community Hospital and Cancer Treatment Center | Butte | Montana | 59701 | — |
| Benefis Healthcare- Sletten Cancer Institute | Great Falls | Montana | 59405 | — |
| Berdeaux, Donald MD (UIA Investigator) | Great Falls | Montana | 59405 | — |
| Big Sky Oncology | Great Falls | Montana | 59405 | — |
| Great Falls Clinic | Great Falls | Montana | 59405 | — |
| Northern Montana Hospital | Havre | Montana | 59501 | — |
| Saint Peter's Community Hospital | Helena | Montana | 59601 | — |
| Glacier Oncology PLLC | Kalispell | Montana | 59901 | — |
| Kalispell Medical Oncology | Kalispell | Montana | 59901 | — |
| Kalispell Regional Medical Center | Kalispell | Montana | 59901 | — |
| Community Medical Hospital | Missoula | Montana | 59801 | — |
| Montana Cancer Specialists | Missoula | Montana | 59802 | — |
| Saint Patrick Hospital - Community Hospital | Missoula | Montana | 59802 | — |
| Guardian Oncology and Center for Wellness | Missoula | Montana | 59804 | — |
| University Medical Center of Southern Nevada | Las Vegas | Nevada | 89102 | — |
| Nevada Cancer Research Foundation CCOP | Las Vegas | Nevada | 89106 | — |
| Arnot Ogden Medical Center | Elmira | New York | 14905 | — |
| Adirondack Cancer Center | Glens Falls | New York | 12801 | — |
| Winthrop University Hospital | Mineola | New York | 11501 | — |
| Columbia University Medical Center | New York | New York | 10032 | — |
| Highland Hospital | Rochester | New York | 14620 | — |
| Interlakes Foundation Inc-Rochester | Rochester | New York | 14623 | — |
| University of Rochester | Rochester | New York | 14642 | — |
| Randolph Hospital | Asheboro | North Carolina | 27203 | — |
| Carolinas Medical Center | Charlotte | North Carolina | 28203 | — |
| Novant Health Presbyterian Medical Center | Charlotte | North Carolina | 28204 | — |
| Carolinas Medical Center - Northeast | Concord | North Carolina | 28025 | — |
| Gaston Memorial Hospital | Gastonia | North Carolina | 28054 | — |
| Wayne Memorial Hospital | Goldsboro | North Carolina | 27534 | — |
| Cone Health Cancer Center | Greensboro | North Carolina | 27403 | — |
| Margaret R Pardee Memorial Hospital | Hendersonville | North Carolina | 28791 | — |
| High Point Regional Hospital | High Point | North Carolina | 27261 | — |
| Annie Penn Memorial Hospital | Reidsville | North Carolina | 27320 | — |
| Rutherford Hospital | Rutherfordton | North Carolina | 28139 | — |
| Iredell Memorial Hospital | Statesville | North Carolina | 28677 | — |
| Akron General Medical Center | Akron | Ohio | 44307 | — |
| Mary Rutan Hospital | Bellefontaine | Ohio | 43311 | — |
| Adena Regional Medical Center | Chillicothe | Ohio | 45601 | — |
| University of Cincinnati | Cincinnati | Ohio | 45267 | — |
| Riverside Methodist Hospital | Columbus | Ohio | 43214 | — |
| Columbus CCOP | Columbus | Ohio | 43215 | — |
| Grant Medical Center | Columbus | Ohio | 43215 | — |
| Mount Carmel Health Center West | Columbus | Ohio | 43222 | — |
| Doctors Hospital | Columbus | Ohio | 43228 | — |
| Grandview Hospital | Dayton | Ohio | 45405 | — |
| Good Samaritan Hospital - Dayton | Dayton | Ohio | 45406 | — |
| Miami Valley Hospital | Dayton | Ohio | 45409 | — |
| Samaritan North Health Center | Dayton | Ohio | 45415 | — |
| Dayton CCOP | Dayton | Ohio | 45420 | — |
| Grady Memorial Hospital | Delaware | Ohio | 43015 | — |
| Blanchard Valley Hospital | Findlay | Ohio | 45840 | — |
| Atrium Medical Center-Middletown Regional Hospital | Franklin | Ohio | 45005-1066 | — |
| Wayne Hospital | Greenville | Ohio | 45331 | — |
| Kettering Medical Center | Kettering | Ohio | 45429 | — |
| Fairfield Medical Center | Lancaster | Ohio | 43130 | — |
| Marietta Memorial Hospital | Marietta | Ohio | 45750 | — |
| Knox Community Hospital | Mount Vernon | Ohio | 43050 | — |
| Licking Memorial Hospital | Newark | Ohio | 43055 | — |
| Southern Ohio Medical Center | Portsmouth | Ohio | 45662 | — |
| Springfield Regional Medical Center | Springfield | Ohio | 45505 | — |
| Upper Valley Medical Center | Troy | Ohio | 45373 | — |
| Saint Ann's Hospital | Westerville | Ohio | 43081 | — |
| Clinton Memorial Hospital | Wilmington | Ohio | 45177 | — |
| Wright-Patterson Medical Center | Wright-Patterson Air Force Base | Ohio | 45433-5529 | — |
| Greene Memorial Hospital | Xenia | Ohio | 45385 | — |
| Genesis HealthCare System | Zanesville | Ohio | 43701 | — |
| Clackamas Radiation Oncology Center | Clackamas | Oregon | 97015 | — |
| Providence Milwaukie Hospital | Milwaukie | Oregon | 97222 | — |
| Providence Newberg Medical Center | Newberg | Oregon | 97132 | — |
| Providence Willamette Falls Medical Center | Oregon City | Oregon | 97045 | — |
| Providence Portland Medical Center | Portland | Oregon | 97213 | — |
| Western Oncology Research Consortium | Portland | Oregon | 97213 | — |
| Adventist Medical Center | Portland | Oregon | 97216 | — |
| Providence Saint Vincent Medical Center | Portland | Oregon | 97225 | — |
| Oregon Health and Science University | Portland | Oregon | 97239 | — |
| Salem Hospital | Salem | Oregon | 97301 | — |
| AnMed Health Hospital | Anderson | South Carolina | 29621 | — |
| McLeod Regional Medical Center | Florence | South Carolina | 29506 | — |
| Spartanburg Regional Medical Center | Spartanburg | South Carolina | 29303 | — |
| Upstate Carolina CCOP | Spartanburg | South Carolina | 29303 | — |
| University of Tennessee - Knoxville | Knoxville | Tennessee | 37920 | — |
| Veterans Affairs Medical Center - Memphis | Memphis | Tennessee | 38104 | — |
| University of Tennessee - Memphis | Memphis | Tennessee | 38163 | — |
| University of Texas Medical Branch at Galveston | Galveston | Texas | 77555-0565 | — |
| Baylor College of Medicine | Houston | Texas | 77030 | — |
| Ben Taub General Hospital | Houston | Texas | 77030 | — |
| Methodist Hospital | Houston | Texas | 77030 | — |
| Saint Luke's Episcopal Hospital | Houston | Texas | 77030 | — |
| Veterans Administration Medical Center | Houston | Texas | 77030 | — |
| Texas Tech University Health Sciences Center | Lubbock | Texas | 79430 | — |
| Southwest Oncology Group | San Antonio | Texas | 78245 | — |
| Scott and White Memorial Hospital | Temple | Texas | 76508 | — |
| Huntsman Cancer Institute/University of Utah | Salt Lake City | Utah | 84112 | — |
| Danville Regional Medical Center | Danville | Virginia | 24541 | — |
| Memorial Hospital Of Martinsville | Martinsville | Virginia | 24115 | — |
| Cancer Care Center at Island Hospital | Anacortes | Washington | 98221 | — |
| PeaceHealth Saint Joseph Medical Center | Bellingham | Washington | 98225 | — |
| Harrison HealthPartners Hematology and Oncology-Bremerton | Bremerton | Washington | 98310 | — |
| Highline Medical Center-Main Campus | Burien | Washington | 98166 | — |
| Columbia Basin Hematology and Oncology PLLC | Kennewick | Washington | 99336 | — |
| Skagit Valley Hospital | Mount Vernon | Washington | 98274 | — |
| Harrison HealthPartners Hematology and Oncology-Poulsbo | Poulsbo | Washington | 98370 | — |
| Harborview Medical Center | Seattle | Washington | 98104 | — |
| Minor and James Medical PLLC | Seattle | Washington | 98104 | — |
| Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium | Seattle | Washington | 98109 | — |
| Group Health Cooperative-Seattle | Seattle | Washington | 98112 | — |
| Swedish Medical Center-First Hill | Seattle | Washington | 98122-4307 | — |
| The Polyclinic | Seattle | Washington | 98122 | — |
| University of Washington Medical Center | Seattle | Washington | 98195 | — |
| United General Hospital | Sedro-Woolley | Washington | 98284 | — |
| Cancer Care Northwest - Spokane South | Spokane | Washington | 99202 | — |
| Evergreen Hematology and Oncology PS | Spokane | Washington | 99218 | — |
| Rockwood Clinic | Spokane | Washington | 99220 | — |
| PeaceHealth Southwest Medical Center | Vancouver | Washington | 98664 | — |
| Compass Oncology Vancouver | Vancouver | Washington | 98684 | — |
| Wenatchee Valley Medical Center | Wenatchee | Washington | 98801 | — |
| Rocky Mountain Oncology | Casper | Wyoming | 82609 | — |
| Welch Cancer Center | Sheridan | Wyoming | 82801 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00828139, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 21, 2017 · Synced Nov 5, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00828139 live on ClinicalTrials.gov.