ClinicalTrials.gov record
S0919 Idarubicin, Cytarabine, and Pravastatin in Treating Patients With Relapsed Acute Myeloid Leukemia
ClinicalTrials.gov ID: NCT00840177
Public ClinicalTrials.gov record NCT00840177. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
S0919, A Phase II Study of Idarubicin and Ara-C in Combination With Pravastatin for Poor-Risk Acute Myelogenous Leukemia
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
RATIONALE: Drugs used in chemotherapy, such as idarubicin and cytarabine, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Pravastatin may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Pravastatin may also help idarubicin and cytarabine work better by making cancer cells more sensitive to the drugs. Giving idarubicin and cytarabine together with pravastatin may kill more cancer cells. PURPOSE: This phase II trial is studying how well giving idarubicin and cytarabine together with pravastatin works in treating patients with relapsed acute myeloid leukemia (AML). ADDITIONAL BACKGROUND: S0919 was initially designed for patients with relapsed acute myeloid leukemia (AML), where the patient's preceding remission had lasted ≥ 3 months. The null response rate was 30%. The study closed to accrual on Nov 1, 2012 after meeting the defined criterion for a positive study; and the results are being submitted to the American Society of Clinical Oncology meeting. Based on the promising results from this trial, the trial has now been amended to evaluate this therapeutic regimen in poor-risk patients (patients with newly diagnosed acute myeloid leukemia (AML) arising out of myelodysplastic syndrome (MDS), primary refractory acute myeloid leukemia (AML), and relapsed acute myeloid leukemia (AML) with the patient's preceding remission lasting \< 6 months).
Study identification
- NCT ID
- NCT00840177
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 115 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 9, 2009
- Primary completion
- Nov 30, 2018
- Completion
- Oct 20, 2021
- Last update posted
- May 2, 2023
2009 – 2021
United States locations
- U.S. sites
- 185
- U.S. states
- 24
- U.S. cities
- 126
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham Cancer Center | Birmingham | Alabama | 35233 | — |
| University of Arkansas for Medical Sciences | Little Rock | Arkansas | 72205 | — |
| Stanford Cancer Institute | Palo Alto | California | 94304 | — |
| University of Colorado Cancer Center - Anschutz Cancer Pavilion | Aurora | Colorado | 80045 | — |
| Smilow Cancer Hospital Care Center at Saint Francis | Hartford | Connecticut | 06105 | — |
| Moffitt Cancer Center | Tampa | Florida | 33612 | — |
| Saint Alphonsus Cancer Care Center-Boise | Boise | Idaho | 83706 | — |
| Saint Alphonsus Cancer Care Center-Caldwell | Caldwell | Idaho | 83605 | — |
| Kootenai Medical Center | Coeur d'Alene | Idaho | 83814 | — |
| Walter Knox Memorial Hospital | Emmett | Idaho | 83617 | — |
| Idaho Urologic Institute-Meridian | Meridian | Idaho | 83642 | — |
| Saint Alphonsus Medical Center-Nampa | Nampa | Idaho | 83686 | — |
| Kootenai Cancer Center | Post Falls | Idaho | 83854 | — |
| Kootenai Cancer Clinic | Sandpoint | Idaho | 83864 | — |
| Saint Joseph Medical Center | Bloomington | Illinois | 61701 | — |
| Illinois CancerCare-Bloomington | Bloomington | Illinois | 61704 | — |
| Illinois CancerCare-Canton | Canton | Illinois | 61520 | — |
| Memorial Hospital of Carbondale | Carbondale | Illinois | 62902 | — |
| SIH Cancer Institute | Carterville | Illinois | 62918 | — |
| Illinois CancerCare-Carthage | Carthage | Illinois | 62321 | — |
| Centralia Oncology Clinic | Centralia | Illinois | 62801 | — |
| Cancer Care Center of Decatur | Decatur | Illinois | 62526 | — |
| Decatur Memorial Hospital | Decatur | Illinois | 62526 | — |
| Crossroads Cancer Center | Effingham | Illinois | 62401 | — |
| Illinois CancerCare-Eureka | Eureka | Illinois | 61530 | — |
| Illinois CancerCare-Galesburg | Galesburg | Illinois | 61401 | — |
| Western Illinois Cancer Treatment Center | Galesburg | Illinois | 61401 | — |
| Illinois CancerCare-Kewanee Clinic | Kewanee | Illinois | 61443 | — |
| Illinois CancerCare-Macomb | Macomb | Illinois | 61455 | — |
| Loyola University Medical Center | Maywood | Illinois | 60153 | — |
| Illinois CancerCare-Ottawa Clinic | Ottawa | Illinois | 61350 | — |
| Radiation Oncology of Northern Illinois | Ottawa | Illinois | 61350 | — |
| Illinois CancerCare-Pekin | Pekin | Illinois | 61554 | — |
| OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center | Pekin | Illinois | 61554 | — |
| Methodist Medical Center of Illinois | Peoria | Illinois | 61603 | — |
| Illinois CancerCare-Peoria | Peoria | Illinois | 61615 | — |
| OSF Saint Francis Radiation Oncology at Peoria Cancer Center | Peoria | Illinois | 61615 | — |
| OSF Saint Francis Medical Center | Peoria | Illinois | 61637 | — |
| Illinois CancerCare-Peru | Peru | Illinois | 61354 | — |
| Valley Radiation Oncology | Peru | Illinois | 61354 | — |
| Illinois CancerCare-Princeton | Princeton | Illinois | 61356 | — |
| Central Illinois Hematology Oncology Center | Springfield | Illinois | 62702 | — |
| Southern Illinois University School of Medicine | Springfield | Illinois | 62702 | — |
| Springfield Clinic | Springfield | Illinois | 62702 | — |
| Memorial Medical Center | Springfield | Illinois | 62781 | — |
| Cancer Care Specialists of Illinois-Swansea | Swansea | Illinois | 62226 | — |
| Memorial and Saint Elizabeth's Health Care Services LLP | Swansea | Illinois | 62226 | — |
| Hospital District Sixth of Harper County | Anthony | Kansas | 67003 | — |
| Cancer Center of Kansas - Chanute | Chanute | Kansas | 66720 | — |
| Cancer Center of Kansas - Dodge City | Dodge City | Kansas | 67801 | — |
| Cancer Center of Kansas - El Dorado | El Dorado | Kansas | 67042 | — |
| Cancer Center of Kansas - Fort Scott | Fort Scott | Kansas | 66701 | — |
| Cancer Center of Kansas-Independence | Independence | Kansas | 67301 | — |
| Cancer Center of Kansas-Kingman | Kingman | Kansas | 67068 | — |
| Lawrence Memorial Hospital | Lawrence | Kansas | 66044 | — |
| Cancer Center of Kansas-Liberal | Liberal | Kansas | 67905 | — |
| Cancer Center of Kansas-Manhattan | Manhattan | Kansas | 66502 | — |
| Cancer Center of Kansas - McPherson | McPherson | Kansas | 67460 | — |
| Cancer Center of Kansas - Newton | Newton | Kansas | 67114 | — |
| Cancer Center of Kansas - Parsons | Parsons | Kansas | 67357 | — |
| Cancer Center of Kansas - Pratt | Pratt | Kansas | 67124 | — |
| Cancer Center of Kansas - Salina | Salina | Kansas | 67401 | — |
| Cancer Center of Kansas - Wellington | Wellington | Kansas | 67152 | — |
| Associates In Womens Health | Wichita | Kansas | 67208 | — |
| Cancer Center of Kansas-Wichita Medical Arts Tower | Wichita | Kansas | 67208 | — |
| Cancer Center of Kansas - Wichita | Wichita | Kansas | 67214 | — |
| Via Christi Regional Medical Center | Wichita | Kansas | 67214 | — |
| Wesley Medical Center | Wichita | Kansas | 67214 | — |
| Wichita NCI Community Oncology Research Program | Wichita | Kansas | 67214 | — |
| Cancer Center of Kansas - Winfield | Winfield | Kansas | 67156 | — |
| Hematology/Oncology Clinic LLP | Baton Rouge | Louisiana | 70809 | — |
| Tulane University Health Sciences Center | New Orleans | Louisiana | 70112 | — |
| Louisiana State University Health Sciences Center Shreveport | Shreveport | Louisiana | 71103 | — |
| Saint Joseph Mercy Hospital | Ann Arbor | Michigan | 48106-0995 | — |
| Michigan Cancer Research Consortium NCORP | Ann Arbor | Michigan | 48106 | — |
| IHA Hematology Oncology Consultants-Brighton | Brighton | Michigan | 48114 | — |
| Saint Joseph Mercy Brighton | Brighton | Michigan | 48114 | — |
| IHA Hematology Oncology Consultants-Canton | Canton | Michigan | 48188 | — |
| Saint Joseph Mercy Canton Health Center | Canton | Michigan | 48188 | — |
| Caro Cancer Center | Caro | Michigan | 48723 | — |
| IHA Hematology Oncology Consultants-Chelsea | Chelsea | Michigan | 48118 | — |
| Saint Joseph Mercy Chelsea | Chelsea | Michigan | 48118 | — |
| Hematology Oncology Consultants-Clarkston | Clarkston | Michigan | 48346 | — |
| Newland Medical Associates-Clarkston | Clarkston | Michigan | 48346 | — |
| Beaumont Hospital-Dearborn | Dearborn | Michigan | 48124 | — |
| Saint John Hospital and Medical Center | Detroit | Michigan | 48236 | — |
| Great Lakes Cancer Management Specialists-Doctors Park | East China Township | Michigan | 48054 | — |
| Hurley Medical Center | Flint | Michigan | 48502 | — |
| Genesee Cancer and Blood Disease Treatment Center | Flint | Michigan | 48503 | — |
| Genesee Hematology Oncology PC | Flint | Michigan | 48503 | — |
| Genesys Hurley Cancer Institute | Flint | Michigan | 48503 | — |
| Great Lakes Cancer Management Specialists-Van Elslander Cancer Center | Grosse Pointe Woods | Michigan | 48236 | — |
| Lymphoma Clinic of Michigan | Grosse Pointe Woods | Michigan | 48236 | — |
| Michigan Breast Specialists-Grosse Pointe Woods | Grosse Pointe Woods | Michigan | 48236 | — |
| Allegiance Health | Jackson | Michigan | 49201 | — |
| Sparrow Hospital | Lansing | Michigan | 48912 | — |
| Hope Cancer Clinic | Livonia | Michigan | 48154 | — |
| Saint Mary Mercy Hospital | Livonia | Michigan | 48154 | — |
| Hematology Oncology Associates East PC | Macomb | Michigan | 48044 | — |
| Michigan Breast Specialists-Macomb Township | Macomb | Michigan | 48044 | — |
| 21st Century Oncology-Pontiac | Pontiac | Michigan | 48341 | — |
| Hope Cancer Center | Pontiac | Michigan | 48341 | — |
| Newland Medical Associates-Pontiac | Pontiac | Michigan | 48341 | — |
| Saint Joseph Mercy Oakland | Pontiac | Michigan | 48341 | — |
| Lake Huron Medical Center | Port Huron | Michigan | 48060 | — |
| Great Lakes Cancer Management Specialists-Rochester Hills | Rochester Hills | Michigan | 48309 | — |
| Saint Mary's of Michigan | Saginaw | Michigan | 48601 | — |
| Oncology Hematology Associates of Saginaw Valley PC | Saginaw | Michigan | 48604 | — |
| Bhadresh Nayak MD PC-Sterling Heights | Sterling Heights | Michigan | 48312 | — |
| Great Lakes Cancer Management Specialists-Macomb Professional Building | Warren | Michigan | 48093 | — |
| Macomb Hematology Oncology PC | Warren | Michigan | 48093 | — |
| Michigan Breast Specialists-Warren | Warren | Michigan | 48093 | — |
| Saint John Macomb-Oakland Hospital | Warren | Michigan | 48093 | — |
| Saint Mary's Oncology/Hematology Associates of West Branch | West Branch | Michigan | 48661 | — |
| Huron Gastroenterology PC | Ypsilanti | Michigan | 48106 | — |
| IHA Hematology Oncology Consultants-Ann Arbor | Ypsilanti | Michigan | 48197 | — |
| University of Mississippi Medical Center | Jackson | Mississippi | 39216 | — |
| Parkland Health Center-Bonne Terre | Bonne Terre | Missouri | 63628 | — |
| Saint Francis Medical Center | Cape Girardeau | Missouri | 63703 | — |
| Southeast Cancer Center | Cape Girardeau | Missouri | 63703 | — |
| Capital Region Medical Center-Goldschmidt Cancer Center | Jefferson City | Missouri | 65109 | — |
| Sainte Genevieve County Memorial Hospital | Sainte Genevieve | Missouri | 63670 | — |
| Missouri Baptist Medical Center | St Louis | Missouri | 63131 | — |
| Missouri Baptist Sullivan Hospital | Sullivan | Missouri | 63080 | — |
| Missouri Baptist Outpatient Center-Sunset Hills | Sunset Hills | Missouri | 63127 | — |
| Community Hospital of Anaconda | Anaconda | Montana | 59711 | — |
| Billings Clinic Cancer Center | Billings | Montana | 59101 | — |
| Saint Vincent Healthcare | Billings | Montana | 59101 | — |
| Frontier Cancer Center and Blood Institute-Billings | Billings | Montana | 59102 | — |
| Montana Cancer Consortium NCORP | Billings | Montana | 59102 | — |
| Bozeman Deaconess Hospital | Bozeman | Montana | 59715 | — |
| Saint James Community Hospital and Cancer Treatment Center | Butte | Montana | 59701 | — |
| Benefis Healthcare- Sletten Cancer Institute | Great Falls | Montana | 59405 | — |
| Great Falls Clinic | Great Falls | Montana | 59405 | — |
| Saint Peter's Community Hospital | Helena | Montana | 59601 | — |
| Glacier Oncology PLLC | Kalispell | Montana | 59901 | — |
| Kalispell Regional Medical Center | Kalispell | Montana | 59901 | — |
| Montana Cancer Specialists | Missoula | Montana | 59802 | — |
| Saint Patrick Hospital - Community Hospital | Missoula | Montana | 59802 | — |
| Community Medical Hospital | Missoula | Montana | 59804 | — |
| University of New Mexico Cancer Center | Albuquerque | New Mexico | 87102 | — |
| University of Rochester | Rochester | New York | 14642 | — |
| Southeastern Medical Oncology Center-Clinton | Clinton | North Carolina | 28328 | — |
| Southeastern Medical Oncology Center-Goldsboro | Goldsboro | North Carolina | 27534 | — |
| Wayne Memorial Hospital | Goldsboro | North Carolina | 27534 | — |
| Southeastern Medical Oncology Center-Jacksonville | Jacksonville | North Carolina | 28546 | — |
| Southeastern Medical Oncology Center-Wilson | Wilson | North Carolina | 27893 | — |
| Southeast Clinical Oncology Research (SCOR) Consortium NCORP | Winston-Salem | North Carolina | 27104 | — |
| Cleveland Clinic Foundation | Cleveland | Ohio | 44195 | — |
| Saint Alphonsus Medical Center-Baker City | Baker City | Oregon | 97814 | — |
| Saint Alphonsus Medical Center-Ontario | Ontario | Oregon | 97914 | — |
| Oregon Health and Science University | Portland | Oregon | 97239 | — |
| Lehigh Valley Hospital-Cedar Crest | Allentown | Pennsylvania | 18103 | — |
| Lehigh Valley Hospital - Muhlenberg | Bethlehem | Pennsylvania | 18017 | — |
| Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center | Houston | Texas | 77030 | — |
| Baylor Saint Luke's Medical Center | Houston | Texas | 77030 | — |
| Ben Taub General Hospital | Houston | Texas | 77030 | — |
| Michael E DeBakey VA Medical Center | Houston | Texas | 77030 | — |
| Cancer Care Center at Island Hospital | Anacortes | Washington | 98221 | — |
| PeaceHealth Saint Joseph Medical Center | Bellingham | Washington | 98225 | — |
| Harrison HealthPartners Hematology and Oncology-Bremerton | Bremerton | Washington | 98310 | — |
| Highline Medical Center-Main Campus | Burien | Washington | 98166 | — |
| Swedish Medical Center-Edmonds | Edmonds | Washington | 98026 | — |
| Swedish Cancer Institute-Issaquah | Issaquah | Washington | 98029 | — |
| Kadlec Clinic Hematology and Oncology | Kennewick | Washington | 99336 | — |
| Seattle Cancer Care Alliance at EvergreenHealth | Kirkland | Washington | 98034 | — |
| Skagit Valley Hospital | Mount Vernon | Washington | 98274 | — |
| Harrison HealthPartners Hematology and Oncology-Poulsbo | Poulsbo | Washington | 98370 | — |
| Harborview Medical Center | Seattle | Washington | 98104 | — |
| Minor and James Medical PLLC | Seattle | Washington | 98104 | — |
| Swedish Medical Center-Ballard Campus | Seattle | Washington | 98107 | — |
| Fred Hutchinson Cancer Research Center | Seattle | Washington | 98109 | — |
| Group Health Cooperative-Seattle | Seattle | Washington | 98112 | — |
| Swedish Medical Center-First Hill | Seattle | Washington | 98122-4307 | — |
| University of Washington Medical Center | Seattle | Washington | 98195 | — |
| United General Hospital | Sedro-Woolley | Washington | 98284 | — |
| Cancer Care Northwest - Spokane South | Spokane | Washington | 99202 | — |
| Evergreen Hematology and Oncology PS | Spokane | Washington | 99218 | — |
| Rockwood Clinic | Spokane | Washington | 99220 | — |
| Wenatchee Valley Hospital and Clinics | Wenatchee | Washington | 98801 | — |
| Froedtert and the Medical College of Wisconsin | Milwaukee | Wisconsin | 53226 | — |
| Rocky Mountain Oncology | Casper | Wyoming | 82609 | — |
| Big Horn Basin Cancer Center | Cody | Wyoming | 82414 | — |
| Billings Clinic-Cody | Cody | Wyoming | 82414 | — |
| Welch Cancer Center | Sheridan | Wyoming | 82801 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00840177, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 2, 2023 · Synced Sep 26, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT00840177 live on ClinicalTrials.gov.