Regional Rates of Cerebral Protein Synthesis: Effects of Sleep and Memory Consolidation
Public ClinicalTrials.gov record NCT00884702. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
Background: * The brain needs sleep to function normally, but the purpose of sleep is not understood. Brain activity decreases during sleep, so it may be that sleep is important to maintain, repair, or reorganize brain cells. In animals, the formation of brain proteins increases during sleep, and the same thing may happen in humans. * There is also evidence that learning and memory are helped by sleep, and that the synthesis of proteins in the brain are involved. Objectives: * To examine the formation of proteins in the brain while people are awake, deprived of sleep, and during sleep. * To look at the formation of proteins in the brain while awake or asleep and following learning a task. Eligibility: * Healthy volunteers between 18 and 28 years of age. * Volunteers must not have psychiatric, neurologic, or sleep disorders or certain types of vision problems, and must be able to undergo imaging studies. Design: * Study Part I (protein formation in waking, sleep deprivation, and sleep): * Participants will wear an actigraph (a unit to record motor activity) for 2 weeks prior to admission. * Participants will have physical and psychological examinations, along with a blood sample. * After admission participants will have three positron emission tomography (PET) scans to study protein formation and one magnetic resonance imaging (MRI) scan over the course of two days. * Participants may be asked to stay awake for as long as 20 hours and will be monitored throughout. * Participants will be able to sleep overnight after they complete the required scans and monitoring, and will be discharged the following morning. * Study Part II (protein formation in waking and sleep combined with a learning task): * Participants will wear an actigraph (a unit to record motor activity) for 2 weeks prior to admission. * Participants will have physical and psychological examinations, along with a blood sample. * After admission participants may be asked to stay awake for as long as 20 hours and will be monitored throughout. * The next morning, participants will be trained to perform a computerized visual discrimination task, and will be tested 8 hours later (after sleep or after remaining awake) on the visual discrimination task. * Some participants may have PET and MRI scans as part of the study. * Participants will be able to sleep overnight after they complete the required tests and scans, and will be discharged the following morning. * Participants will receive financial compensation for their participation in these studies.
Study identification
- NCT ID
- NCT00884702
- Recruitment status
- Completed
- Study type
- Observational
- Phase
- Not listed
- Enrollment
- 538 participants
Conditions and interventions
Conditions
Interventions
Not listed
Eligibility (public fields only)
- Age range
- 18 Years to 28 Years
- Sex
- All
- Healthy volunteers
- Accepts healthy volunteers
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Apr 15, 2009
- Primary completion
- Not listed
- Completion
- Apr 17, 2017
- Last update posted
- Oct 5, 2017
2009 – 2017
United States locations
- U.S. sites
- 1
- U.S. states
- 1
- U.S. cities
- 1
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| National Institutes of Health Clinical Center, 9000 Rockville Pike | Bethesda | Maryland | 20892 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00884702, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 5, 2017 · Synced Sep 25, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT00884702 live on ClinicalTrials.gov.