Exploratory Study of SPD489 in Adults With Major Depressive Disorder (MDD) as Augmentation Therapy to an Antidepressant
Public ClinicalTrials.gov record NCT00905424. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2, Multicenter, Randomized, Double-blind, Parallel-group, Placebo Controlled Exploratory Efficacy and Safety Study of SPD489 in Adults 18-55 Years With Major Depressive Disorder (MDD) as Augmentation Therapy to an Antidepressant
Study identification
- NCT ID
- NCT00905424
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Lead sponsor
- Shire
- Industry
- Enrollment
- 246 participants
Conditions and interventions
Conditions
Interventions
- Antidepressant + SPD489 (lisdexamfetamine dimesylate) Drug
- Antidepressant + placebo Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years to 55 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jul 29, 2009
- Primary completion
- Aug 3, 2010
- Completion
- Aug 3, 2010
- Last update posted
- Jun 13, 2021
2009 – 2010
United States locations
- U.S. sites
- 15
- U.S. states
- 10
- U.S. cities
- 15
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Pharmacology Research Institute (PRI) | Newport Beach | California | 92660 | — |
| Affiliated Research Institute | San Diego | California | 92108 | — |
| Florida Clinical Research Center, LLC | Bradenton | Florida | 34208 | — |
| Gulfcoast Clinical Research Center | Fort Myers | Florida | 33912 | — |
| Clinical Neuroscience Solutions, Inc. | Orlando | Florida | 32809 | — |
| Atlanta Institute of Medicine & Research | Atlanta | Georgia | 30328 | — |
| Carman Research | Smyrna | Georgia | 30080 | — |
| Vince & Associates Clinical Research | Overland Park | Kansas | 66212 | — |
| Duke University Medical Center | Durham | North Carolina | 27705 | — |
| North Star Medical Research, LLC | Middleburg Heights | Ohio | 44130 | — |
| IPS Research Company | Oklahoma City | Oklahoma | 73103 | — |
| Summit Research Network | Portland | Oregon | 97210 | — |
| FutureSearch Clinical Trials, LP | Austin | Texas | 78756 | — |
| Northwest Clinical Research Center | Bellevue | Washington | 98007 | — |
| Summit Research Network (Seattle), LLC | Seattle | Washington | 98104 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00905424, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jun 13, 2021 · Synced May 4, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT00905424 live on ClinicalTrials.gov.