ClinicalTrials.gov record
Trial of Linaclotide Administered to Patients With Irritable Bowel Syndrome With Constipation
ClinicalTrials.gov ID: NCT00948818
Public ClinicalTrials.gov record NCT00948818. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase III, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Trial of Linaclotide Administered Orally for 12 Weeks Followed by a 4-Week Randomized Withdrawal Period in Patients With Irritable Bowel Syndrome With Constipation
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The objective of this trial is to determine the efficacy and safety of linaclotide administered to patients with irritable bowel syndrome with constipation (IBS-C). The primary efficacy parameter is the percentage of patients in each treatment group that meet the protocol definition for Abdominal Pain and Complete Spontaneous Bowel Movement (APC) Responder.
Study identification
- NCT ID
- NCT00948818
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 803 participants
Conditions and interventions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 30, 2009
- Primary completion
- Jun 30, 2010
- Completion
- Jul 31, 2010
- Last update posted
- Jan 29, 2013
2009 – 2010
United States locations
- U.S. sites
- 111
- U.S. states
- 33
- U.S. cities
- 97
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Forest Investigative Site 037 | Birmingham | Alabama | 35209 | — |
| Forest Investigative Site 036 | Birmingham | Alabama | 35215 | — |
| Forest Investigative Site 135 | Hueytown | Alabama | 35023 | — |
| Forest Investigative Site 014 | Huntsville | Alabama | 35801 | — |
| Forest Investigative Site 080 | Chandler | Arizona | 85225 | — |
| Forest Investigative Site 053 | Mesa | Arizona | 85210 | — |
| Forest Investigative Site 078 | Peoria | Arizona | 85381 | — |
| Forest Investigative Site 101 | Phoenix | Arizona | 85012 | — |
| Forest Investigative Site 128 | Phoenix | Arizona | 85018 | — |
| Forest Investigative Site 051 | Scottsdale | Arizona | 85251 | — |
| Forest Investigative Site 136 | Tucson | Arizona | 85712 | — |
| Forest Investigative Site 087 | Tucson | Arizona | 85741 | — |
| Forest Investigative Site 094 | Burbank | California | 91505 | — |
| Forest Investigative Site 026 | Encinitas | California | 92024 | — |
| Forest Investigative Site 096 | Foothill Ranch | California | 92610 | — |
| Forest Investigative Site 057 | Los Angeles | California | 90036 | — |
| Forest Investigative Site 097 | Mission Hills | California | 91345 | — |
| Forest Investigative Site 005 | Orange | California | 92869 | — |
| Forest Investigative Site 024 | Westlake Village | California | 91361 | — |
| Forest Investigative Site 021 | Boulder | Colorado | 80304 | — |
| Forest Investigative Site 019 | Colorado Springs | Colorado | 80907 | — |
| Forest Investigative Site 034 | Denver | Colorado | 80205 | — |
| Forest Investigative Site 074 | Longmont | Colorado | 80501 | — |
| Forest Investigative Site 010 | Wheat Ridge | Colorado | 80033 | — |
| Forest Investigative Site 058 | Waterbury | Connecticut | 06708 | — |
| Forest Investigative Site 042 | Boca Raton | Florida | 33486 | — |
| Forest Investigative Site 003 | Bradenton | Florida | 34203 | — |
| Forest Investigative Site 137 | Brandon | Florida | 33511 | — |
| Forest Investigative Site 070 | Brooksville | Florida | 34613 | — |
| Forest Investigative Site 018 | Fort Myers | Florida | 33916 | — |
| Forest Investigative Site 030 | Jupiter | Florida | 33458 | — |
| Forest Investigative Site 077 | Kissimmee | Florida | 34741 | — |
| Forest Investigative Site 133 | Miami | Florida | 33126 | — |
| Forest Investigative Site 031 | Miami | Florida | 33143 | — |
| Forest Investigative Site 129 | New Smyrna Beach | Florida | 32168 | — |
| Forest Investigative Site 108 | Ocala | Florida | 34471 | — |
| Forest Investigative Site 092 | Orlando | Florida | 32806 | — |
| Forest Investigative Site 038 | Panama City | Florida | 32405 | — |
| Forest Investigative Site 027 | Pembroke Pines | Florida | 33024 | — |
| Forest Investigative Site 045 | St. Petersburg | Florida | 33709 | — |
| Forest Investigative Site 015 | Tampa | Florida | 33606 | — |
| Forest Investigative Site 104 | Trinity | Florida | 34655 | — |
| Forest Investigative Site 068 | Zephyrhills | Florida | 33542 | — |
| Forest Investigative Site 032 | Atlanta | Georgia | 30342 | — |
| Forest Investigative Site 103 | Atlanta | Georgia | 30342 | — |
| Forest Investigative Site 033 | Marietta | Georgia | 30060 | — |
| Forest Investigative Site 020 | Marietta | Georgia | 30067 | — |
| Forest Investigative Site 040 | Woodstock | Georgia | 30189 | — |
| Forest Investigative Site 055 | Idaho Falls | Idaho | 83404 | — |
| Forest Investigative Site 043 | Rockford | Illinois | 61107 | — |
| Forest Investigative Site 047 | Evansville | Indiana | 47714 | — |
| Forest Investigative Site 046 | Iowa City | Iowa | 52242 | — |
| Forest Investigative Site 029 | Arkansas City | Kansas | 67005 | — |
| Forest Investigative Site 009 | Newton | Kansas | 67114 | — |
| Forest Investigative Site 023 | Wichita | Kansas | 67205 | — |
| Forest Investigative Site 093 | Wichita | Kansas | 67207 | — |
| Forest Investigative Site 067 | Lexington | Kentucky | 40509 | — |
| Forest Investigative Site 114 | Madisonville | Kentucky | 42431 | — |
| Forest Investigative Site 132 | Baton Rouge | Louisiana | 70808 | — |
| Forest Investigative Site 124 | Shreveport | Louisiana | 71101 | — |
| Forest Investigative Site 013 | Chevy Chase | Maryland | 20815 | — |
| Forest Investigative Site 006 | Hagerstown | Maryland | 21742 | — |
| Forest Investigative Site 073 | Lutherville | Maryland | 21093 | — |
| Forest Investigative Site 001 | Boston | Massachusetts | 02135 | — |
| Forest Investigative Site 125 | Kalamazoo | Michigan | 49048 | — |
| Forest Investigative Site 064 | Chaska | Minnesota | 55318 | — |
| Forest Investigative Site 004 | St Louis | Missouri | 63128 | — |
| Forest Investigative Site 085 | Vineland | New Jersey | 08360 | — |
| Forest Investigative Site 052 | Albuquerque | New Mexico | 87106 | — |
| Forest Investigative Site 035 | Brooklyn | New York | 11214 | — |
| Forest Investigative Site 017 | Great Neck | New York | 11021 | — |
| Forest Investigative Site 011 | Great Neck | New York | 11023 | — |
| Forest Investigative Site 134 | Setauket | New York | 11733 | — |
| Forest Investigative Site 122 | Boone | North Carolina | 28607 | — |
| Forest Investigative Site 072 | Fayetteville | North Carolina | 28304 | — |
| Forest Investigative Site 016 | Greensboro | North Carolina | 27403 | — |
| Forest Investigative Site 119 | Hickory | North Carolina | 28601 | — |
| Forest Investigative Site 088 | Raleigh | North Carolina | 27612 | — |
| Forest Investigative Site 056 | Wilmington | North Carolina | 28401 | — |
| Forest Investigative Site 065 | Winston-Salem | North Carolina | 27103 | — |
| Forest Investigative Site 028 | Cincinnati | Ohio | 45219 | — |
| Forest Investigative Site 044 | Cleveland | Ohio | 44122 | — |
| Forest Investigative Site 123 | Columbus | Ohio | 43215 | — |
| Forest Investigative Site 130 | Dayton | Ohio | 45432 | — |
| Forest Investigative Site 082 | Oklahoma City | Oklahoma | 73104 | — |
| Forest Investigative Site 102 | Tulsa | Oklahoma | 74135 | — |
| Forest Investigative Site 039 | Pittsburgh | Pennsylvania | 15206 | — |
| Forest Investigative Site 121 | Greenville | South Carolina | 29615 | — |
| Forest Investigative Site 069 | Greer | South Carolina | 29651 | — |
| Forest Investigative Site 131 | Greer | South Carolina | 29651 | — |
| Forest Investigative Site 025 | Nashville | Tennessee | 37205 | — |
| Forest Investigative Site 099 | Austin | Texas | 78705 | — |
| Forest Investigative Site 002 | Dallas | Texas | 75234 | — |
| Forest Investigative Site 041 | Houston | Texas | 77090 | — |
| Forest Investigative Site 110 | Houston | Texas | 77090 | — |
| Forest Investigative Site 063 | Lake Jackson | Texas | 77566 | — |
| Forest Investigative Site 095 | San Antonio | Texas | 78209 | — |
| Forest Investigative Site 076 | San Antonio | Texas | 78229 | — |
| Forest Investigative Site 089 | Salt Lake City | Utah | 84102 | — |
| Forest Investigative Site 091 | Salt Lake City | Utah | 84132 | — |
| Forest Investigative Site 100 | Salt Lake City | Utah | 84148 | — |
| Forest Investigative Site 054 | Charlottesville | Virginia | 22911 | — |
| Forest Investigative Site 061 | Christianburg | Virginia | 24073 | — |
| Forest Investigative Site 007 | Newport News | Virginia | 23606 | — |
| Forest Investigative Site 060 | Norfolk | Virginia | 23502 | — |
| Forest Investigative Site 075 | Norfolk | Virginia | 23507 | — |
| Forest Investigative Site 050 | Richmond | Virginia | 23294 | — |
| Forest Investigative Site 049 | Bellevue | Washington | 98402 | — |
| Forest Investigative Site 098 | Lakewood | Washington | 98499 | — |
| Forest Investigative Site 066 | Wenatchee | Washington | 98801 | — |
| Forest Investigative Site 083 | Milwaukee | Wisconsin | 53209 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 7 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00948818, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jan 29, 2013 · Synced Sep 4, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT00948818 live on ClinicalTrials.gov.