Preventing Acute Chest Syndrome by Transfusion Feasibility Study
Public ClinicalTrials.gov record NCT00951808. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Preventing Acute Chest Syndrome by Transfusion Feasibility Study( PROACTIVE Feasibility Study)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
Acute chest syndrome (ACS) is similar to severe pneumonia and is a common cause of hospitalizations for people with sickle cell disease (SCD). Blood transfusions are one treatment option for ACS. High levels of an enzyme called secretory phospholipase A2 (sPLA2) may be present in people before they develop ACS. This study will determine how well sPLA2 levels can predict the onset of ACS and whether identifying high sPLA2 levels allows enough time to prevent ACS with blood transfusions. Results from this study will help to determine the feasibility of conducting a larger study that would further examine the use of sPLA2 levels and blood transfusions to prevent ACS in people with SCD.
Study identification
- NCT ID
- NCT00951808
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Not applicable
- Enrollment
- 237 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 2 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jul 2009 (Type not available)
- Primary completion
- Jun 2010 (Actual)
- Completion
- Jul 2010 (Actual)
- Last update posted
- Apr 24, 2013
2009 – 2010
United States locations
- U.S. sites
- 24
- U.S. states
- 14
- U.S. cities
- 17
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Children's Hospital and Research Center | Oakland | California | — | — |
| A.I. duPont Hospital for Children | Wilmington | Delaware | — | — |
| Children's National Medical Center | Washington D.C. | District of Columbia | — | — |
| Howard University Hospital | Washington D.C. | District of Columbia | — | — |
| Emory University School of Medicine | Atlanta | Georgia | — | — |
| Medical College of Georgia | Augusta | Georgia | — | — |
| Children's Memorial Hospital | Chicago | Illinois | — | — |
| University of Illinois Sickle Cell Center | Chicago | Illinois | — | — |
| Kosair Children's Hospital | Louisville | Kentucky | — | — |
| Johns Hopkins | Baltimore | Maryland | — | — |
| Boston Medical Center | Boston | Massachusetts | — | — |
| Brigham & Women's Hospital | Boston | Massachusetts | — | — |
| Children's Hospital Boston | Boston | Massachusetts | — | — |
| University of Mississippi Medical Center | Jackson | Mississippi | — | — |
| Interfaith Medical Center | Brooklyn | New York | — | — |
| New York Methodist Hospital | Brooklyn | New York | — | — |
| The University of North Carolina at Chapel Hill | Chapel Hill | North Carolina | — | — |
| Duke University Medical Center | Durham | North Carolina | — | — |
| Cincinnati Children's Hospital Medical Center | Cincinnati | Ohio | — | — |
| Nationwide Children's Hospital | Columbus | Ohio | — | — |
| Ohio State University | Columbus | Ohio | — | — |
| Children's Hospital of Philadelphia | Philadelphia | Pennsylvania | — | — |
| St. Christopher's Hospital for Children | Philadelphia | Pennsylvania | — | — |
| Virginia Commonwealth University Health Systems | Richmond | Virginia | — | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00951808, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 24, 2013 · Synced Oct 19, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00951808 live on ClinicalTrials.gov.