ClinicalTrials.gov record
Vorinostat, Rituximab, and Combination Chemotherapy in Treating Patients With Newly Diagnosed Stage II, Stage III, or Stage IV Diffuse Large B-Cell Lymphoma
ClinicalTrials.gov ID: NCT00972478
Public ClinicalTrials.gov record NCT00972478. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase I/II Trial of Vorinostat (SAHA) (NSC-701852) in Combination With Rituximab-CHOP in Patients With Newly Diagnosed Advanced Stage Diffuse Large B-Cell Lymphoma (DLBCL)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This phase I/II trial is studying the side effects and best dose of vorinostat when given together with rituximab and combination chemotherapy and to see how well it works in treating patients with newly diagnosed stage II, stage III, or stage IV diffuse large B-cell lymphoma. Vorinostat may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the cancer. Monoclonal antibodies, such as rituximab, can block cancer cell growth in different ways. Some block the ability of cancer cells to grow and spread. Others find cancer cells and help kill them or carry cell-killing substances to them. Drugs used in chemotherapy, such as cyclophosphamide, doxorubicin hydrochloride, vincristine sulfate, and prednisone, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Giving vorinostat together with rituximab and combination chemotherapy may kill more cancer cells.
Study identification
- NCT ID
- NCT00972478
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 1, Phase 2
- Enrollment
- 83 participants
Conditions and interventions
Conditions
Interventions
- Cyclophosphamide Drug
- Doxorubicin Hydrochloride Drug
- Laboratory Biomarker Analysis Other
- Prednisone Drug
- Rituximab Biological
- Vincristine Sulfate Drug
- Vorinostat Drug
Drug · Other · Biological
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Nov 15, 2010 (Actual)
- Primary completion
- Dec 30, 2015 (Actual)
- Completion
- Mar 6, 2027 (Estimated)
- Last update posted
- Sep 9, 2026
2010 – 2027
United States locations
- U.S. sites
- 190
- U.S. states
- 23
- U.S. cities
- 135
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Providence Hospital | Mobile | Alabama | 36608 | — |
| University of Arizona Cancer Center-Orange Grove Campus | Tucson | Arizona | 85704 | — |
| Banner University Medical Center - Tucson | Tucson | Arizona | 85719 | — |
| University of Arizona Cancer Center-North Campus | Tucson | Arizona | 85719 | — |
| Mercy Hospital Fort Smith | Fort Smith | Arkansas | 72903 | — |
| NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro | Jonesboro | Arkansas | 72401 | — |
| NEA Baptist Memorial Hospital | Jonesboro | Arkansas | 72401 | — |
| Kaiser Permanente-Deer Valley Medical Center | Antioch | California | 94531 | — |
| City of Hope Comprehensive Cancer Center | Duarte | California | 91010 | — |
| Kaiser Permanente-Fremont | Fremont | California | 94538 | — |
| Kaiser Permanente-Fresno | Fresno | California | 93720 | — |
| USC / Norris Comprehensive Cancer Center | Los Angeles | California | 90033 | — |
| Kaiser Permanente-Modesto | Modesto | California | 95356 | — |
| Kaiser Permanente-Oakland | Oakland | California | 94611 | — |
| Kaiser Permanente-Redwood City | Redwood City | California | 94063 | — |
| Kaiser Permanente-Richmond | Richmond | California | 94801 | — |
| Kaiser Permanente-Roseville | Roseville | California | 95661 | — |
| Kaiser Permanente-South Sacramento | Sacramento | California | 95823 | — |
| Kaiser Permanente Sacramento Medical Center | Sacramento | California | 95825 | — |
| Kaiser Permanente-San Francisco | San Francisco | California | 94115 | — |
| Kaiser Permanente-Santa Teresa-San Jose | San Jose | California | 95119 | — |
| Kaiser Permanente San Leandro | San Leandro | California | 94577 | — |
| Kaiser Permanente-San Rafael | San Rafael | California | 94903 | — |
| Kaiser Permanente Medical Center - Santa Clara | Santa Clara | California | 95051 | — |
| Kaiser Permanente-Santa Rosa | Santa Rosa | California | 95403 | — |
| Kaiser Permanente-South San Francisco | South San Francisco | California | 94080 | — |
| Kaiser Permanente-Stockton | Stockton | California | 95210 | — |
| Kaiser Permanente Medical Center-Vacaville | Vacaville | California | 95688 | — |
| Kaiser Permanente-Vallejo | Vallejo | California | 94589 | — |
| Kaiser Permanente-Walnut Creek | Walnut Creek | California | 94596 | — |
| Poudre Valley Hospital | Fort Collins | Colorado | 80524 | — |
| Yale University | New Haven | Connecticut | 06520 | — |
| Memorial Health University Medical Center | Savannah | Georgia | 31404 | — |
| Hawaii Cancer Care Inc - Waterfront Plaza | Honolulu | Hawaii | 96813 | — |
| Queen's Medical Center | Honolulu | Hawaii | 96813 | — |
| Straub Clinic and Hospital | Honolulu | Hawaii | 96813 | — |
| University of Hawaii Cancer Center | Honolulu | Hawaii | 96813 | — |
| Hawaii Cancer Care Inc-Liliha | Honolulu | Hawaii | 96817 | — |
| Kuakini Medical Center | Honolulu | Hawaii | 96817 | — |
| Queen's Cancer Center - Kuakini | Honolulu | Hawaii | 96817 | — |
| Kaiser Permanente Moanalua Medical Center | Honolulu | Hawaii | 96819 | — |
| Kapiolani Medical Center for Women and Children | Honolulu | Hawaii | 96826 | — |
| Tripler Army Medical Center | Honolulu | Hawaii | 96859 | — |
| Castle Medical Center | Kailua | Hawaii | 96734 | — |
| Wilcox Memorial Hospital and Kauai Medical Clinic | Lihue | Hawaii | 96766 | — |
| Pali Momi Medical Center | ‘Aiea | Hawaii | 96701 | — |
| Queen's Cancer Center - Pearlridge | ‘Aiea | Hawaii | 96701 | — |
| Northwestern Medicine Cancer Center Delnor | Geneva | Illinois | 60134 | — |
| Loyola University Medical Center | Maywood | Illinois | 60153 | — |
| SSM Health Good Samaritan | Mount Vernon | Illinois | 62864 | — |
| Northwestern Medicine Cancer Center Warrenville | Warrenville | Illinois | 60555 | — |
| Franciscan Saint Francis Health-Beech Grove | Beech Grove | Indiana | 46107 | — |
| Franciscan Health Indianapolis | Indianapolis | Indiana | 46237 | — |
| Reid Health | Richmond | Indiana | 47374 | — |
| Cancer Center of Kansas - Chanute | Chanute | Kansas | 66720 | — |
| Cancer Center of Kansas - Dodge City | Dodge City | Kansas | 67801 | — |
| Cancer Center of Kansas - El Dorado | El Dorado | Kansas | 67042 | — |
| Cancer Center of Kansas - Fort Scott | Fort Scott | Kansas | 66701 | — |
| Saint Rose Ambulatory and Surgery Center | Great Bend | Kansas | 67530 | — |
| HaysMed | Hays | Kansas | 67601 | — |
| Hutchinson Regional Medical Center | Hutchinson | Kansas | 67502 | — |
| Cancer Center of Kansas-Independence | Independence | Kansas | 67301 | — |
| Providence Medical Center | Kansas City | Kansas | 66112 | — |
| University of Kansas Cancer Center | Kansas City | Kansas | 66160 | — |
| Cancer Center of Kansas-Kingman | Kingman | Kansas | 67068 | — |
| Lawrence Memorial Hospital | Lawrence | Kansas | 66044 | — |
| Cancer Center of Kansas-Liberal | Liberal | Kansas | 67905 | — |
| Cancer Center of Kansas - Newton | Newton | Kansas | 67114 | — |
| Menorah Medical Center | Overland Park | Kansas | 66209 | — |
| Saint Luke's South Hospital | Overland Park | Kansas | 66213 | — |
| Cancer Center of Kansas - Parsons | Parsons | Kansas | 67357 | — |
| Mercy Hospital Pittsburg | Pittsburg | Kansas | 66762 | — |
| Kansas City NCI Community Oncology Research Program | Prairie Village | Kansas | 66208 | — |
| Cancer Center of Kansas - Pratt | Pratt | Kansas | 67124 | — |
| Cancer Center of Kansas - Salina | Salina | Kansas | 67401 | — |
| Salina Regional Health Center | Salina | Kansas | 67401 | — |
| University of Kansas Health System Saint Francis Campus | Topeka | Kansas | 66606 | — |
| Cancer Center of Kansas - Wellington | Wellington | Kansas | 67152 | — |
| Associates In Womens Health | Wichita | Kansas | 67208 | — |
| Cancer Center of Kansas-Wichita Medical Arts Tower | Wichita | Kansas | 67208 | — |
| Ascension Via Christi Hospitals Wichita | Wichita | Kansas | 67214 | — |
| Cancer Center of Kansas - Wichita | Wichita | Kansas | 67214 | — |
| Wichita NCI Community Oncology Research Program | Wichita | Kansas | 67214 | — |
| Cancer Center of Kansas - Winfield | Winfield | Kansas | 67156 | — |
| Christus Saint Frances Cabrini Hospital | Alexandria | Louisiana | 71301 | — |
| DeSoto Regional Health System | Mansfield | Louisiana | 71052 | — |
| Ochsner LSU Health Monroe Medical Center | Monroe | Louisiana | 71202 | — |
| Overton Brooks Veteran's Administration Medical Center | Shreveport | Louisiana | 71101 | — |
| LSU Health Sciences Center at Shreveport | Shreveport | Louisiana | 71103 | — |
| Highland Clinic | Shreveport | Louisiana | 71105 | — |
| Boston Medical Center | Boston | Massachusetts | 02118 | — |
| Lahey Clinic | Burlington | Massachusetts | 01805 | — |
| Bronson Battle Creek | Battle Creek | Michigan | 49017 | — |
| Spectrum Health Big Rapids Hospital | Big Rapids | Michigan | 49307 | — |
| Cancer Research Consortium of West Michigan NCORP | Grand Rapids | Michigan | 49503 | — |
| Corewell Health Grand Rapids Hospitals - Butterworth Hospital | Grand Rapids | Michigan | 49503 | — |
| Trinity Health Grand Rapids Hospital | Grand Rapids | Michigan | 49503 | — |
| Trinity Health Muskegon Hospital | Muskegon | Michigan | 49444 | — |
| Corewell Health Reed City Hospital | Reed City | Michigan | 49677 | — |
| Munson Medical Center | Traverse City | Michigan | 49684 | — |
| University Health Truman Medical Center | Kansas City | Missouri | 64108 | — |
| Saint Luke's Hospital of Kansas City | Kansas City | Missouri | 64111 | — |
| Saint Joseph Health Center | Kansas City | Missouri | 64114 | — |
| North Kansas City Hospital | Kansas City | Missouri | 64116 | — |
| Heartland Hematology and Oncology Associates Incorporated | Kansas City | Missouri | 64118 | — |
| Research Medical Center | Kansas City | Missouri | 64132 | — |
| Saint Luke's East - Lee's Summit | Lee's Summit | Missouri | 64086 | — |
| Liberty Hospital | Liberty | Missouri | 64068 | — |
| Mercy Clinic-Rolla-Cancer and Hematology | Rolla | Missouri | 65401 | — |
| Heartland Regional Medical Center | Saint Joseph | Missouri | 64506 | — |
| Cancer Research for the Ozarks NCORP | Springfield | Missouri | 65804 | — |
| Mercy Hospital Springfield | Springfield | Missouri | 65804 | — |
| Mercy Infusion Center - Chippewa | St Louis | Missouri | 63109 | — |
| Mercy Hospital Saint Louis | St Louis | Missouri | 63141 | — |
| Billings Clinic Cancer Center | Billings | Montana | 59101 | — |
| Saint Vincent Healthcare | Billings | Montana | 59101 | — |
| Montana Cancer Consortium NCORP | Billings | Montana | 59102 | — |
| Saint Vincent Frontier Cancer Center | Billings | Montana | 59102 | — |
| Bozeman Health Deaconess Hospital | Bozeman | Montana | 59715 | — |
| Saint James Community Hospital and Cancer Treatment Center | Butte | Montana | 59701 | — |
| Benefis Sletten Cancer Institute | Great Falls | Montana | 59405 | — |
| Great Falls Clinic | Great Falls | Montana | 59405 | — |
| Saint Peter's Community Hospital | Helena | Montana | 59601 | — |
| Glacier Oncology PLLC | Kalispell | Montana | 59901 | — |
| Logan Health Medical Center | Kalispell | Montana | 59901 | — |
| Montana Cancer Specialists | Missoula | Montana | 59802 | — |
| Saint Patrick Hospital - Community Hospital | Missoula | Montana | 59802 | — |
| Arnot Ogden Medical Center/Falck Cancer Center | Elmira | New York | 14905 | — |
| Interlakes Foundation Inc-Rochester | Rochester | New York | 14623 | — |
| University of Rochester | Rochester | New York | 14642 | — |
| Wayne Memorial Hospital | Goldsboro | North Carolina | 27534 | — |
| Margaret R Pardee Memorial Hospital | Hendersonville | North Carolina | 28791 | — |
| AdventHealth Hendersonville | Hendersonville | North Carolina | 28792 | — |
| Iredell Memorial Hospital | Statesville | North Carolina | 28677 | — |
| Southeast Clinical Oncology Research Consortium NCORP | Winston-Salem | North Carolina | 27104 | — |
| Mary Rutan Hospital | Bellefontaine | Ohio | 43311 | — |
| Adena Regional Medical Center | Chillicothe | Ohio | 45601 | — |
| University of Cincinnati Cancer Center-UC Medical Center | Cincinnati | Ohio | 45219 | — |
| Riverside Methodist Hospital | Columbus | Ohio | 43214 | — |
| Columbus NCI Community Oncology Research Program | Columbus | Ohio | 43215 | — |
| Grant Medical Center | Columbus | Ohio | 43215 | — |
| Mount Carmel Health Center West | Columbus | Ohio | 43222 | — |
| Doctors Hospital | Columbus | Ohio | 43228 | — |
| Grandview Hospital | Dayton | Ohio | 45405 | — |
| Good Samaritan Hospital - Dayton | Dayton | Ohio | 45406 | — |
| Miami Valley Hospital | Dayton | Ohio | 45409 | — |
| Miami Valley Hospital North | Dayton | Ohio | 45415 | — |
| Dayton NCI Community Oncology Research Program | Dayton | Ohio | 45459 | — |
| Grady Memorial Hospital | Delaware | Ohio | 43015 | — |
| Blanchard Valley Hospital | Findlay | Ohio | 45840 | — |
| Atrium Medical Center-Middletown Regional Hospital | Franklin | Ohio | 45005-1066 | — |
| Wayne Hospital | Greenville | Ohio | 45331 | — |
| Kettering Medical Center | Kettering | Ohio | 45429 | — |
| Fairfield Medical Center | Lancaster | Ohio | 43130 | — |
| Marietta Memorial Hospital | Marietta | Ohio | 45750 | — |
| Knox Community Hospital | Mount Vernon | Ohio | 43050 | — |
| Licking Memorial Hospital | Newark | Ohio | 43055 | — |
| Southern Ohio Medical Center | Portsmouth | Ohio | 45662 | — |
| Springfield Regional Medical Center | Springfield | Ohio | 45504 | — |
| Upper Valley Medical Center | Troy | Ohio | 45373 | — |
| Saint Ann's Hospital | Westerville | Ohio | 43081 | — |
| Wright-Patterson Medical Center | Wright-Patterson Air Force Base | Ohio | 45433 | — |
| Greene Memorial Hospital | Xenia | Ohio | 45385 | — |
| Genesis Healthcare System Cancer Care Center | Zanesville | Ohio | 43701 | — |
| Saint Charles Health System | Bend | Oregon | 97701 | — |
| AnMed Health Cancer Center | Anderson | South Carolina | 29621 | — |
| AnMed Health Hospital | Anderson | South Carolina | 29621 | — |
| Saint Francis Hospital | Greenville | South Carolina | 29601 | — |
| Spartanburg Medical Center | Spartanburg | South Carolina | 29303 | — |
| Cancer Care Center at Island Hospital | Anacortes | Washington | 98221 | — |
| PeaceHealth Saint Joseph Medical Center | Bellingham | Washington | 98225 | — |
| Highline Medical Center-Main Campus | Burien | Washington | 98166 | — |
| Swedish Cancer Institute-Edmonds | Edmonds | Washington | 98026 | — |
| Swedish Cancer Institute-Issaquah | Issaquah | Washington | 98029 | — |
| Kadlec Clinic Hematology and Oncology | Kennewick | Washington | 99336 | — |
| Skagit Valley Hospital | Mount Vernon | Washington | 98274 | — |
| Harrison HealthPartners Hematology and Oncology-Poulsbo | Poulsbo | Washington | 98370 | — |
| Harborview Medical Center | Seattle | Washington | 98104 | — |
| Minor and James Medical PLLC | Seattle | Washington | 98104 | — |
| Fred Hutchinson Cancer Center | Seattle | Washington | 98109 | — |
| Kaiser Permanente Washington | Seattle | Washington | 98112 | — |
| Swedish Medical Center-First Hill | Seattle | Washington | 98122 | — |
| University of Washington Medical Center - Montlake | Seattle | Washington | 98195 | — |
| PeaceHealth United General Medical Center | Sedro-Woolley | Washington | 98284 | — |
| Saint Joseph Medical Center Hematology and Oncology - Silverdale | Silverdale | Washington | 98383 | — |
| Cancer Care Northwest - Spokane South | Spokane | Washington | 99202 | — |
| Evergreen Hematology and Oncology PS | Spokane | Washington | 99218 | — |
| Wenatchee Valley Hospital and Clinics | Wenatchee | Washington | 98801 | — |
| Rocky Mountain Oncology | Casper | Wyoming | 82609 | — |
| Welch Cancer Center | Sheridan | Wyoming | 82801 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00972478, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 9, 2026 · Synced Oct 19, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00972478 live on ClinicalTrials.gov.