ClinicalTrials.gov record
Vorinostat, Rituximab, and Combination Chemotherapy in Treating Patients With Newly Diagnosed Stage II, Stage III, or Stage IV Diffuse Large B-Cell Lymphoma
ClinicalTrials.gov ID: NCT00972478
Public ClinicalTrials.gov record NCT00972478. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
ClinicalTrials.gov public records Last synced May 6, 2026, 8:50 AM EDT
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase I/II Trial of Vorinostat (SAHA) (NSC-701852) in Combination With Rituximab-CHOP in Patients With Newly Diagnosed Advanced Stage Diffuse Large B-Cell Lymphoma (DLBCL)
Study identification
- NCT ID
- NCT00972478
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 1, Phase 2
- Lead sponsor
- National Cancer Institute (NCI)
- NIH
- Enrollment
- 83 participants
Conditions and interventions
Conditions
Interventions
- Cyclophosphamide Drug
- Doxorubicin Hydrochloride Drug
- Laboratory Biomarker Analysis Other
- Prednisone Drug
- Rituximab Biological
- Vincristine Sulfate Drug
- Vorinostat Drug
Drug · Other · Biological
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Nov 14, 2010
- Primary completion
- Dec 29, 2015
- Completion
- Mar 5, 2027
- Last update posted
- Apr 27, 2026
2010 – 2027
United States locations
- U.S. sites
- 190
- U.S. states
- 23
- U.S. cities
- 135
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Providence Hospital | Mobile | Alabama | 36608 | — |
| University of Arizona Cancer Center-Orange Grove Campus | Tucson | Arizona | 85704 | — |
| Banner University Medical Center - Tucson | Tucson | Arizona | 85719 | — |
| University of Arizona Cancer Center-North Campus | Tucson | Arizona | 85719 | — |
| Mercy Hospital Fort Smith | Fort Smith | Arkansas | 72903 | — |
| NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro | Jonesboro | Arkansas | 72401 | — |
| NEA Baptist Memorial Hospital | Jonesboro | Arkansas | 72401 | — |
| Kaiser Permanente-Deer Valley Medical Center | Antioch | California | 94531 | — |
| City of Hope Comprehensive Cancer Center | Duarte | California | 91010 | — |
| Kaiser Permanente-Fremont | Fremont | California | 94538 | — |
| Kaiser Permanente-Fresno | Fresno | California | 93720 | — |
| USC / Norris Comprehensive Cancer Center | Los Angeles | California | 90033 | — |
| Kaiser Permanente-Modesto | Modesto | California | 95356 | — |
| Kaiser Permanente-Oakland | Oakland | California | 94611 | — |
| Kaiser Permanente-Redwood City | Redwood City | California | 94063 | — |
| Kaiser Permanente-Richmond | Richmond | California | 94801 | — |
| Kaiser Permanente-Roseville | Roseville | California | 95661 | — |
| Kaiser Permanente-South Sacramento | Sacramento | California | 95823 | — |
| Kaiser Permanente Sacramento Medical Center | Sacramento | California | 95825 | — |
| Kaiser Permanente-San Francisco | San Francisco | California | 94115 | — |
| Kaiser Permanente-Santa Teresa-San Jose | San Jose | California | 95119 | — |
| Kaiser Permanente San Leandro | San Leandro | California | 94577 | — |
| Kaiser Permanente-San Rafael | San Rafael | California | 94903 | — |
| Kaiser Permanente Medical Center - Santa Clara | Santa Clara | California | 95051 | — |
| Kaiser Permanente-Santa Rosa | Santa Rosa | California | 95403 | — |
| Kaiser Permanente-South San Francisco | South San Francisco | California | 94080 | — |
| Kaiser Permanente-Stockton | Stockton | California | 95210 | — |
| Kaiser Permanente Medical Center-Vacaville | Vacaville | California | 95688 | — |
| Kaiser Permanente-Vallejo | Vallejo | California | 94589 | — |
| Kaiser Permanente-Walnut Creek | Walnut Creek | California | 94596 | — |
| Poudre Valley Hospital | Fort Collins | Colorado | 80524 | — |
| Yale University | New Haven | Connecticut | 06520 | — |
| Memorial Health University Medical Center | Savannah | Georgia | 31404 | — |
| Hawaii Cancer Care Inc - Waterfront Plaza | Honolulu | Hawaii | 96813 | — |
| Queen's Medical Center | Honolulu | Hawaii | 96813 | — |
| Straub Clinic and Hospital | Honolulu | Hawaii | 96813 | — |
| University of Hawaii Cancer Center | Honolulu | Hawaii | 96813 | — |
| Hawaii Cancer Care Inc-Liliha | Honolulu | Hawaii | 96817 | — |
| Kuakini Medical Center | Honolulu | Hawaii | 96817 | — |
| Queen's Cancer Center - Kuakini | Honolulu | Hawaii | 96817 | — |
| Kaiser Permanente Moanalua Medical Center | Honolulu | Hawaii | 96819 | — |
| Kapiolani Medical Center for Women and Children | Honolulu | Hawaii | 96826 | — |
| Tripler Army Medical Center | Honolulu | Hawaii | 96859 | — |
| Castle Medical Center | Kailua | Hawaii | 96734 | — |
| Wilcox Memorial Hospital and Kauai Medical Clinic | Lihue | Hawaii | 96766 | — |
| Pali Momi Medical Center | ‘Aiea | Hawaii | 96701 | — |
| Queen's Cancer Center - Pearlridge | ‘Aiea | Hawaii | 96701 | — |
| Northwestern Medicine Cancer Center Delnor | Geneva | Illinois | 60134 | — |
| Loyola University Medical Center | Maywood | Illinois | 60153 | — |
| SSM Health Good Samaritan | Mount Vernon | Illinois | 62864 | — |
| Northwestern Medicine Cancer Center Warrenville | Warrenville | Illinois | 60555 | — |
| Franciscan Saint Francis Health-Beech Grove | Beech Grove | Indiana | 46107 | — |
| Franciscan Health Indianapolis | Indianapolis | Indiana | 46237 | — |
| Reid Health | Richmond | Indiana | 47374 | — |
| Cancer Center of Kansas - Chanute | Chanute | Kansas | 66720 | — |
| Cancer Center of Kansas - Dodge City | Dodge City | Kansas | 67801 | — |
| Cancer Center of Kansas - El Dorado | El Dorado | Kansas | 67042 | — |
| Cancer Center of Kansas - Fort Scott | Fort Scott | Kansas | 66701 | — |
| Saint Rose Ambulatory and Surgery Center | Great Bend | Kansas | 67530 | — |
| HaysMed | Hays | Kansas | 67601 | — |
| Hutchinson Regional Medical Center | Hutchinson | Kansas | 67502 | — |
| Cancer Center of Kansas-Independence | Independence | Kansas | 67301 | — |
| Providence Medical Center | Kansas City | Kansas | 66112 | — |
| University of Kansas Cancer Center | Kansas City | Kansas | 66160 | — |
| Cancer Center of Kansas-Kingman | Kingman | Kansas | 67068 | — |
| Lawrence Memorial Hospital | Lawrence | Kansas | 66044 | — |
| Cancer Center of Kansas-Liberal | Liberal | Kansas | 67905 | — |
| Cancer Center of Kansas - Newton | Newton | Kansas | 67114 | — |
| Menorah Medical Center | Overland Park | Kansas | 66209 | — |
| Saint Luke's South Hospital | Overland Park | Kansas | 66213 | — |
| Cancer Center of Kansas - Parsons | Parsons | Kansas | 67357 | — |
| Mercy Hospital Pittsburg | Pittsburg | Kansas | 66762 | — |
| Kansas City NCI Community Oncology Research Program | Prairie Village | Kansas | 66208 | — |
| Cancer Center of Kansas - Pratt | Pratt | Kansas | 67124 | — |
| Cancer Center of Kansas - Salina | Salina | Kansas | 67401 | — |
| Salina Regional Health Center | Salina | Kansas | 67401 | — |
| University of Kansas Health System Saint Francis Campus | Topeka | Kansas | 66606 | — |
| Cancer Center of Kansas - Wellington | Wellington | Kansas | 67152 | — |
| Associates In Womens Health | Wichita | Kansas | 67208 | — |
| Cancer Center of Kansas-Wichita Medical Arts Tower | Wichita | Kansas | 67208 | — |
| Ascension Via Christi Hospitals Wichita | Wichita | Kansas | 67214 | — |
| Cancer Center of Kansas - Wichita | Wichita | Kansas | 67214 | — |
| Wichita NCI Community Oncology Research Program | Wichita | Kansas | 67214 | — |
| Cancer Center of Kansas - Winfield | Winfield | Kansas | 67156 | — |
| Christus Saint Frances Cabrini Hospital | Alexandria | Louisiana | 71301 | — |
| DeSoto Regional Health System | Mansfield | Louisiana | 71052 | — |
| Ochsner LSU Health Monroe Medical Center | Monroe | Louisiana | 71202 | — |
| Overton Brooks Veteran's Administration Medical Center | Shreveport | Louisiana | 71101 | — |
| LSU Health Sciences Center at Shreveport | Shreveport | Louisiana | 71103 | — |
| Highland Clinic | Shreveport | Louisiana | 71105 | — |
| Boston Medical Center | Boston | Massachusetts | 02118 | — |
| Lahey Hospital and Medical Center | Burlington | Massachusetts | 01805 | — |
| Bronson Battle Creek | Battle Creek | Michigan | 49017 | — |
| Spectrum Health Big Rapids Hospital | Big Rapids | Michigan | 49307 | — |
| Cancer Research Consortium of West Michigan NCORP | Grand Rapids | Michigan | 49503 | — |
| Corewell Health Grand Rapids Hospitals - Butterworth Hospital | Grand Rapids | Michigan | 49503 | — |
| Trinity Health Grand Rapids Hospital | Grand Rapids | Michigan | 49503 | — |
| Trinity Health Muskegon Hospital | Muskegon | Michigan | 49444 | — |
| Corewell Health Reed City Hospital | Reed City | Michigan | 49677 | — |
| Munson Medical Center | Traverse City | Michigan | 49684 | — |
| University Health Truman Medical Center | Kansas City | Missouri | 64108 | — |
| Saint Luke's Hospital of Kansas City | Kansas City | Missouri | 64111 | — |
| Saint Joseph Health Center | Kansas City | Missouri | 64114 | — |
| North Kansas City Hospital | Kansas City | Missouri | 64116 | — |
| Heartland Hematology and Oncology Associates Incorporated | Kansas City | Missouri | 64118 | — |
| Research Medical Center | Kansas City | Missouri | 64132 | — |
| Saint Luke's East - Lee's Summit | Lee's Summit | Missouri | 64086 | — |
| Liberty Hospital | Liberty | Missouri | 64068 | — |
| Mercy Clinic-Rolla-Cancer and Hematology | Rolla | Missouri | 65401 | — |
| Heartland Regional Medical Center | Saint Joseph | Missouri | 64506 | — |
| Cancer Research for the Ozarks NCORP | Springfield | Missouri | 65804 | — |
| Mercy Hospital Springfield | Springfield | Missouri | 65804 | — |
| Mercy Infusion Center - Chippewa | St Louis | Missouri | 63109 | — |
| Mercy Hospital Saint Louis | St Louis | Missouri | 63141 | — |
| Billings Clinic Cancer Center | Billings | Montana | 59101 | — |
| Saint Vincent Healthcare | Billings | Montana | 59101 | — |
| Montana Cancer Consortium NCORP | Billings | Montana | 59102 | — |
| Saint Vincent Frontier Cancer Center | Billings | Montana | 59102 | — |
| Bozeman Health Deaconess Hospital | Bozeman | Montana | 59715 | — |
| Saint James Community Hospital and Cancer Treatment Center | Butte | Montana | 59701 | — |
| Benefis Sletten Cancer Institute | Great Falls | Montana | 59405 | — |
| Great Falls Clinic | Great Falls | Montana | 59405 | — |
| Saint Peter's Community Hospital | Helena | Montana | 59601 | — |
| Glacier Oncology PLLC | Kalispell | Montana | 59901 | — |
| Logan Health Medical Center | Kalispell | Montana | 59901 | — |
| Montana Cancer Specialists | Missoula | Montana | 59802 | — |
| Saint Patrick Hospital - Community Hospital | Missoula | Montana | 59802 | — |
| Arnot Ogden Medical Center/Falck Cancer Center | Elmira | New York | 14905 | — |
| Interlakes Foundation Inc-Rochester | Rochester | New York | 14623 | — |
| University of Rochester | Rochester | New York | 14642 | — |
| Wayne Memorial Hospital | Goldsboro | North Carolina | 27534 | — |
| Margaret R Pardee Memorial Hospital | Hendersonville | North Carolina | 28791 | — |
| AdventHealth Hendersonville | Hendersonville | North Carolina | 28792 | — |
| Iredell Memorial Hospital | Statesville | North Carolina | 28677 | — |
| Southeast Clinical Oncology Research Consortium NCORP | Winston-Salem | North Carolina | 27104 | — |
| Mary Rutan Hospital | Bellefontaine | Ohio | 43311 | — |
| Adena Regional Medical Center | Chillicothe | Ohio | 45601 | — |
| University of Cincinnati Cancer Center-UC Medical Center | Cincinnati | Ohio | 45219 | — |
| Riverside Methodist Hospital | Columbus | Ohio | 43214 | — |
| Columbus NCI Community Oncology Research Program | Columbus | Ohio | 43215 | — |
| Grant Medical Center | Columbus | Ohio | 43215 | — |
| Mount Carmel Health Center West | Columbus | Ohio | 43222 | — |
| Doctors Hospital | Columbus | Ohio | 43228 | — |
| Grandview Hospital | Dayton | Ohio | 45405 | — |
| Good Samaritan Hospital - Dayton | Dayton | Ohio | 45406 | — |
| Miami Valley Hospital | Dayton | Ohio | 45409 | — |
| Miami Valley Hospital North | Dayton | Ohio | 45415 | — |
| Dayton NCI Community Oncology Research Program | Dayton | Ohio | 45459 | — |
| Grady Memorial Hospital | Delaware | Ohio | 43015 | — |
| Blanchard Valley Hospital | Findlay | Ohio | 45840 | — |
| Atrium Medical Center-Middletown Regional Hospital | Franklin | Ohio | 45005-1066 | — |
| Wayne Hospital | Greenville | Ohio | 45331 | — |
| Kettering Medical Center | Kettering | Ohio | 45429 | — |
| Fairfield Medical Center | Lancaster | Ohio | 43130 | — |
| Marietta Memorial Hospital | Marietta | Ohio | 45750 | — |
| Knox Community Hospital | Mount Vernon | Ohio | 43050 | — |
| Licking Memorial Hospital | Newark | Ohio | 43055 | — |
| Southern Ohio Medical Center | Portsmouth | Ohio | 45662 | — |
| Springfield Regional Medical Center | Springfield | Ohio | 45504 | — |
| Upper Valley Medical Center | Troy | Ohio | 45373 | — |
| Saint Ann's Hospital | Westerville | Ohio | 43081 | — |
| Wright-Patterson Medical Center | Wright-Patterson Air Force Base | Ohio | 45433 | — |
| Greene Memorial Hospital | Xenia | Ohio | 45385 | — |
| Genesis Healthcare System Cancer Care Center | Zanesville | Ohio | 43701 | — |
| Saint Charles Health System | Bend | Oregon | 97701 | — |
| AnMed Health Cancer Center | Anderson | South Carolina | 29621 | — |
| AnMed Health Hospital | Anderson | South Carolina | 29621 | — |
| Saint Francis Hospital | Greenville | South Carolina | 29601 | — |
| Spartanburg Medical Center | Spartanburg | South Carolina | 29303 | — |
| Cancer Care Center at Island Hospital | Anacortes | Washington | 98221 | — |
| PeaceHealth Saint Joseph Medical Center | Bellingham | Washington | 98225 | — |
| Highline Medical Center-Main Campus | Burien | Washington | 98166 | — |
| Swedish Cancer Institute-Edmonds | Edmonds | Washington | 98026 | — |
| Swedish Cancer Institute-Issaquah | Issaquah | Washington | 98029 | — |
| Kadlec Clinic Hematology and Oncology | Kennewick | Washington | 99336 | — |
| Skagit Valley Hospital | Mount Vernon | Washington | 98274 | — |
| Harrison HealthPartners Hematology and Oncology-Poulsbo | Poulsbo | Washington | 98370 | — |
| Harborview Medical Center | Seattle | Washington | 98104 | — |
| Minor and James Medical PLLC | Seattle | Washington | 98104 | — |
| Fred Hutchinson Cancer Center | Seattle | Washington | 98109 | — |
| Kaiser Permanente Washington | Seattle | Washington | 98112 | — |
| Swedish Medical Center-First Hill | Seattle | Washington | 98122 | — |
| University of Washington Medical Center - Montlake | Seattle | Washington | 98195 | — |
| PeaceHealth United General Medical Center | Sedro-Woolley | Washington | 98284 | — |
| Saint Michael Cancer Center | Silverdale | Washington | 98383 | — |
| Cancer Care Northwest - Spokane South | Spokane | Washington | 99202 | — |
| Evergreen Hematology and Oncology PS | Spokane | Washington | 99218 | — |
| Wenatchee Valley Hospital and Clinics | Wenatchee | Washington | 98801 | — |
| Rocky Mountain Oncology | Casper | Wyoming | 82609 | — |
| Welch Cancer Center | Sheridan | Wyoming | 82801 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00972478, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 27, 2026 · Synced May 6, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT00972478 live on ClinicalTrials.gov.