ClinicalTrials.gov record
Safety and Efficacy Study of MDV3100 in Patients With Castration-Resistant Prostate Cancer Who Have Been Previously Treated With Docetaxel-based Chemotherapy
ClinicalTrials.gov ID: NCT00974311
Public ClinicalTrials.gov record NCT00974311. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Affirm: A Multinational Phase 3, Randomized, Double-blind, Placebo-controlled Efficacy And Safety Study Of Oral Mdv3100 In Patients With Progressive Castration-resistant Prostate Cancer Previously Treated With Docetaxel Based Chemotherapy
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is a phase 3 study to compare the clinical benefit of MDV3100 versus placebo in patients with castration-resistant prostate cancer who have been previously treated with docetaxel-based chemotherapy.
Study identification
- NCT ID
- NCT00974311
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 1,199 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- Male
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Sep 30, 2009 (Actual)
- Primary completion
- Sep 15, 2011 (Actual)
- Completion
- Nov 2, 2017 (Actual)
- Last update posted
- Dec 11, 2018
2009 – 2017
United States locations
- U.S. sites
- 98
- U.S. states
- 26
- U.S. cities
- 62
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham | Birmingham | Alabama | 35233 | — |
| University of Alabama at Birmingham | Birmingham | Alabama | 35294 | — |
| Mayo Clinic Hospital | Phoenix | Arizona | 85054 | — |
| Premiere Oncology of Arizona | Scottsdale | Arizona | 85258 | — |
| Mayo Clinic Arizona | Scottsdale | Arizona | 85259 | — |
| Tower Cancer Research Foundation, Tower Hematology Oncology Medical Group | Beverly Hills | California | 90211-1850 | — |
| USC Westside Prostate Cancer Center | Beverly Hills | California | 90211 | — |
| City of Hope | Duarte | California | 91010 | — |
| Cancer Center Oncology Medical Group | La Mesa | California | 91942 | — |
| LAC & USC Medical Center | Los Angeles | California | 90033 | — |
| USC/Norris Comprehensive Cancer Center | Los Angeles | California | 90033 | — |
| Ronald Reagan UCLA Medical Center | Los Angeles | California | 90095-6984 | — |
| UCLA | Los Angeles | California | 90095 | — |
| c/o Prostate Oncology Specialist, Inc. | Marina del Rey | California | 90292 | — |
| North County Oncology Medical Clinic, Inc, | Oceanside | California | 92056 | — |
| Medical Oncology Associates - SD | San Diego | California | 92123 | — |
| Sharp Memorial Hospital Investigational Pharmacy | San Diego | California | 92123 | — |
| Sharp Rees-Stealy | San Diego | California | 92123 | — |
| UCSF Helen Diller Family Comprehensive Cancer Center | San Francisco | California | 94115 | — |
| City of Hope Medical Group | South Pasadena | California | 91030 | — |
| Stanford Hospital and Clinics Research Pharmacy | Stanford | California | 94305 | — |
| Stanford University Medical Center | Stanford | California | 94305 | — |
| Research Pharmacist | Aurora | Colorado | 80045 | — |
| University of Colorado Denver, Anschutz Cancer Pavilion | Aurora | Colorado | 80045 | — |
| C/O: Thomas Ferencz R.Ph., BCOP | New Haven | Connecticut | 06510 | — |
| Yale University School of Med | New Haven | Connecticut | 06520 | — |
| George Washington University-Medical Faculty Associates | Washington D.C. | District of Columbia | 20037 | — |
| Palm Beach Cancer Institute | Atlantis | Florida | 33462 | — |
| Palm Beach Cancer Institute | Palm Beach Gardens | Florida | 33410 | — |
| Palm Beach Cancer Institute | Wellington | Florida | 33414 | — |
| Palm Beach Cancer Institute | West Palm Beach | Florida | 33401 | — |
| Peachtree Hematology-Oncology Consultants, P.C. | Atlanta | Georgia | 30318 | — |
| University of Chicago Medical Center | Chicago | Illinois | 60637 | — |
| University of Chicago | Chicago | Illinois | 60637 | — |
| The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | Baltimore | Maryland | 21231 | — |
| The Johns Hopkins Hospital | Baltimore | Maryland | 21287 | — |
| Massachusetts General Hospital (MGH) | Boston | Massachusetts | 02114 | — |
| Brigham & Women's Hospital (BWH) | Boston | Massachusetts | 02115 | — |
| Beth Israel Deaconess Medical Center | Boston | Massachusetts | 02215 | — |
| Dana-Farber Cancer Institute | Boston | Massachusetts | 02215 | — |
| Karmanos Cancer Institute | Detroit | Michigan | 48201 | — |
| Weisberg Cancer Treatment Center | Farmington Hills | Michigan | 48334 | — |
| Mayo Clinic | Rochester | Minnesota | 55905 | — |
| Siteman Cancer Center | City of Saint Peters | Missouri | 63376 | — |
| Siteman Cancer Center-West County | Creve Coeur | Missouri | 63141 | — |
| Barnes-Jewish Hospital | St Louis | Missouri | 63110-1094 | — |
| Washington University School of Medicine | St Louis | Missouri | 63110 | — |
| Comprehensive Cancer Centers of Nevada | Las Vegas | Nevada | 89128 | — |
| Nevada Cancer Institute, an affiliate of the UC San Diego Health System | Las Vegas | Nevada | 89135 | — |
| Comprehensive Cancer Centers of Nevada | Las Vegas | Nevada | 89169 | — |
| New Mexico Oncology Hematology Consultants, Ltd. | Albuquerque | New Mexico | 87109 | — |
| Roswell Park Cancer Institute | Buffalo | New York | 14263 | — |
| Weill Cornell Medical College-New York Presbyterian Hospital | New York | New York | 10021 | — |
| Memorial Sloan-Kettering Cancer Center | New York | New York | 10065 | — |
| Weill Cornell Medical College-New York Presbyterian Hospital | New York | New York | 10065 | — |
| Duke University Medical Center | Durham | North Carolina | 27710 | — |
| Pharmaceutical Research Services | Durham | North Carolina | 27710 | — |
| Portland VA Medical Center | Portland | Oregon | 97239 | — |
| UPMC Cancer Centers | McKeesport | Pennsylvania | 15132 | — |
| Hospital of the University of Pennsylvania | Philadelphia | Pennsylvania | 19104 | — |
| Fox Chase Cancer Center | Philadelphia | Pennsylvania | 19111 | — |
| University of Pittsburgh Cancer Institute | Pittsburgh | Pennsylvania | 15232 | — |
| UPMC Cancer Centers | Pittsburgh | Pennsylvania | 15237 | — |
| VA Pittsburgh Healthcare System | Pittsburgh | Pennsylvania | 15240 | — |
| Hollings Cancer Center | Charleston | South Carolina | 29425 | — |
| Medical University of South Carolina (MUSC) | Charleston | South Carolina | 29425 | — |
| Carolina Urologic Research Center | Myrtle Beach | South Carolina | 29572 | — |
| Grand Strand Urology | Myrtle Beach | South Carolina | 29572 | — |
| Tennessee Oncology, PLLC | Chattanooga | Tennessee | 37404 | — |
| Tennessee Oncology, PLLC | Dickson | Tennessee | 37055 | — |
| Tennessee Oncology, PLLC | Franklin | Tennessee | 37067 | — |
| Tennessee Oncology, PLLC | Gallatin | Tennessee | 37066 | — |
| Tennessee Oncology, PLLC | Hermitage | Tennessee | 37076 | — |
| Tennessee Oncology, PLLC | Lebanon | Tennessee | 37087 | — |
| Tennessee Oncology, PLLC | Murfreesboro | Tennessee | 37129 | — |
| Tennessee Oncology, PLLC | Nashville | Tennessee | 37203 | — |
| The Sarah Cannon Research Institute | Nashville | Tennessee | 37203 | — |
| Tennessee Oncology, PLLC | Nashville | Tennessee | 37205 | — |
| Tennessee Oncology, PLLC | Nashville | Tennessee | 37207 | — |
| Tennessee Oncology, PLLC | Nashville | Tennessee | 37211 | — |
| Vanderbilt University Medical Center | Nashville | Tennessee | 37232-5536 | — |
| Tennessee Oncology, PLLC | Smyrna | Tennessee | 37167 | — |
| Parkland Health and Hospital System | Dallas | Texas | 75235 | — |
| Texas Oncology, Sammons Cancer Center | Dallas | Texas | 75246 | — |
| UT Southwestern Medical Center at Dallas | Dallas | Texas | 75390 | — |
| Virginia Oncology Associates | Chesapeake | Virginia | 23320 | — |
| Virginia Oncology Associates | Hampton | Virginia | 23666 | — |
| Virginia Cancer Institute | Mechanicsville | Virginia | 23116-1844 | — |
| Virginia Cancer Institute | Midlothian | Virginia | 23114 | — |
| Virginia Oncology Associates | Newport News | Virginia | 23606 | — |
| Virginia Oncology Associates | Norfolk | Virginia | 23502 | — |
| Virginia Cancer Institute | Richmond | Virginia | 23230 | — |
| Virginia Cancer Institute | Richmond | Virginia | 23235-4730 | — |
| Virginia Oncology Associates | Virginia Beach | Virginia | 23456 | — |
| Virginia Oncology Associates | Williamsburg | Virginia | 23188 | — |
| Seattle Cancer Care Alliance | Seattle | Washington | 98109 | — |
| University of Washington Medical Center | Seattle | Washington | 98195 | — |
| University of Wisconsin Hospital and Clinics | Madison | Wisconsin | 53792 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 151 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00974311, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Dec 11, 2018 · Synced Oct 31, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00974311 live on ClinicalTrials.gov.