A Study to Evaluate the Efficacy and Safety of Arbaclofen Placarbil (XP19986) as Adjunctive Therapy in Subjects With Gastroesophageal Reflux Disease (GERD)

ClinicalTrials.gov ID: NCT00978016

Public ClinicalTrials.gov record NCT00978016. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Sep 2, 2026, 2:02 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Dose-Response Efficacy and Safety Study of Arbaclofen Placarbil (XP19986) as Adjunctive Therapy in Subjects With Gastroesophageal Reflux Disease (GERD) Who Are Incomplete Responders to a Proton Pump Inhibitor (PPI)

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

The purpose of the study is to evaluate efficacy and safety of arbaclofen placarbil (XP19986) versus placebo as adjunctive therapy in subjects with troublesome GERD symptoms despite therapy with approved doses of a Proton Pump Inhibitor (PPI).

Study identification

NCT ID: NCT00978016
Recruitment status: Completed
Study type: Interventional
Phase: Phase 2
Lead sponsor: XenoPort, Inc.; Industry
Enrollment: 460 participants

Conditions and interventions

Conditions

Gastroesophageal Reflux Disease

Interventions

Drug

Eligibility (public fields only)

Age range: 18 Years to 65 Years
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Aug 31, 2009
Primary completion: Nov 30, 2010
Completion: Nov 30, 2010
Last update posted: Feb 20, 2021

2009 – 2010

United States locations

U.S. sites: 62
U.S. states: 26
U.S. cities: 59

Facility	City	State	ZIP	Site status
Not listed	Huntsville	Alabama	35801	—
Not listed	Chandler	Arizona	85224	—
Not listed	Mesa	Arizona	85203	—
Not listed	Mesa	Arizona	85213	—
Not listed	Scottsdale	Arizona	85251	—
Not listed	Tucson	Arizona	85715	—
Not listed	Sherwood	Arkansas	72120	—
Not listed	Anaheim	California	92801	—
Not listed	Lancaster	California	93534	—
Not listed	Mission Hills	California	91345	—
Not listed	Sacramento	California	95821	—
Not listed	San Diego	California	92103	—
Not listed	San Diego	California	92120	—
Not listed	Stanford	California	94305	—
Not listed	Westlake Village	California	91361	—
Not listed	Colorado Springs	Colorado	80909	—
Not listed	Lafayette	Colorado	80026	—
Not listed	Lakewood	Colorado	80215	—
Not listed	Littleton	Colorado	80120	—
Not listed	Milford	Connecticut	06460	—
Not listed	Waterbury	Connecticut	06708	—
Not listed	Jupiter	Florida	33458	—
Not listed	Pembroke Pines	Florida	33024	—
Not listed	Atlanta	Georgia	30342	—
Not listed	Clive	Iowa	50325	—
Not listed	Lexington	Kentucky	40504	—
Not listed	Madisonville	Kentucky	42431	—
Not listed	Baton Rouge	Louisiana	70808	—
Not listed	Metairie	Louisiana	70006	—
Not listed	Monroe	Louisiana	71201	—
Not listed	Shreveport	Louisiana	71103	—
Not listed	Annapolis	Maryland	21401	—
Not listed	Hagerstown	Maryland	21742	—
Not listed	Brockton	Massachusetts	02301	—
Not listed	Ann Arbor	Michigan	48109	—
Not listed	Egg Harbor	New Jersey	08234	—
Not listed	Binghamton	New York	13903	—
Not listed	Brooklyn	New York	11214	—
Not listed	Great Neck	New York	11021	—
Not listed	Johnson City	New York	11042	—
Not listed	Lake Success	New York	11042	—
Not listed	Charlotte	North Carolina	28209	—
Not listed	Fayetteville	North Carolina	28304	—
Not listed	Greensboro	North Carolina	27403	—
Not listed	Raleigh	North Carolina	27612	—
Not listed	Fargo	North Dakota	58104	—
Not listed	Columbus	Ohio	43215	—
Not listed	Norman	Oklahoma	73071	—
Not listed	Pittsburgh	Pennsylvania	15243	—
Not listed	Uniontown	Pennsylvania	15401	—
Not listed	Chattanooga	Tennessee	37421	—
Not listed	Germantown	Tennessee	38138	—
Not listed	Bellaire	Texas	77401	—
Not listed	Lake Jackson	Texas	77566	—
Not listed	San Antonio	Texas	78209	—
Not listed	San Antonio	Texas	78215	—
Not listed	Logan	Utah	84405	—
Not listed	Ogden	Utah	84405	—
Not listed	Salt Lake City	Utah	84107	—
Not listed	Charlottesville	Virginia	22911	—
Not listed	Christiansburg	Virginia	24073	—
Not listed	Waukesha	Wisconsin	53188	—

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 2 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT00978016, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Feb 20, 2021 · Synced Sep 2, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT00978016 live on ClinicalTrials.gov.

View official ClinicalTrials.gov record →