ClinicalTrials.gov record
Chemotherapy and Pelvic Radiation Therapy With or Without Additional Chemotherapy in Treating Patients With High-Risk Early-Stage Cervical Cancer After Radical Hysterectomy
ClinicalTrials.gov ID: NCT00980954
Public ClinicalTrials.gov record NCT00980954. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Phase III Randomized Study of Concurrent Chemotherapy and Pelvic Radiation Therapy With or Without Adjuvant Chemotherapy in High-Risk Patients With Early-Stage Cervical Carcinoma Following Radical Hysterectomy
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
RATIONALE: Drugs used in chemotherapy, such as cisplatin, paclitaxel, and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Radiation therapy uses high-energy x-rays to kill tumor cells. It is not yet known whether chemotherapy and radiation therapy are more effective when given with or without additional chemotherapy in treating cervical cancer. PURPOSE: This randomized phase III trial is studying chemotherapy and pelvic radiation therapy to see how well they work when given with or without additional chemotherapy in treating patients with high-risk early-stage cervical cancer after radical hysterectomy.
Study identification
- NCT ID
- NCT00980954
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 236 participants
Conditions and interventions
Conditions
Interventions
- carboplatin Drug
- cisplatin Drug
- paclitaxel Drug
- intensity-modulated radiation therapy Radiation
- standard external beam radiation therapy Radiation
- Optional brachytherapy boost Radiation
Drug · Radiation
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- Female
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Sep 2009 (Type not available)
- Primary completion
- Dec 14, 2023 (Actual)
- Completion
- Sep 4, 2025 (Actual)
- Last update posted
- Dec 31, 2025
2009 – 2025
United States locations
- U.S. sites
- 119
- U.S. states
- 36
- U.S. cities
- 101
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham | Birmingham | Alabama | 35294 | — |
| Providence Hospital | Mobile | Alabama | 36608 | — |
| Providence Alaska Medical Center | Anchorage | Alaska | 99508 | — |
| Arizona Center for Cancer Care-Peoria | Peoria | Arizona | 85381 | — |
| Saint Joseph's Hospital and Medical Center | Phoenix | Arizona | 85013 | — |
| Providence Saint Joseph Medical Center/Disney Family Cancer Center | Burbank | California | 91505 | — |
| Mercy San Juan Medical Center | Carmichael | California | 95608 | — |
| City of Hope Medical Center | Duarte | California | 91010 | — |
| Saint Joseph Hospital - Orange | Orange | California | 92868 | — |
| Pomona Valley Hospital Medical Center | Pomona | California | 91767 | — |
| Mercy Cancer Center | Sacramento | California | 95816 | — |
| Mercy General Hospital Radiation Oncology Center | Sacramento | California | 95819 | — |
| University of California At San Diego | San Diego | California | 92103 | — |
| Saint Helena Hospital | St. Helena | California | 94574 | — |
| Penrose-Saint Francis Healthcare | Colorado Springs | Colorado | 80907 | — |
| Hartford Hospital | Hartford | Connecticut | 06102 | — |
| The Hospital of Central Connecticut | New Britain | Connecticut | 06050 | — |
| University of Miami Sylvester Comprehensive Cancer Center at Deerfield Beach | Deerfield Beach | Florida | 33442 | — |
| Memorial Healthcare System - Joe DiMaggio Children's Hospital | Hollywood | Florida | 33021 | — |
| Jackson Memorial Hospital-Holtz Children's Hospital | Miami | Florida | 33136 | — |
| University of Miami Miller School of Medicine-Sylvester Cancer Center | Miami | Florida | 33136 | — |
| Baptist Hospital of Miami | Miami | Florida | 33176 | — |
| Florida Hospital | Orlando | Florida | 32803 | — |
| Grady Health System | Atlanta | Georgia | 30303 | — |
| Northside Hospital | Atlanta | Georgia | 30342 | — |
| Northeast Georgia Medical Center | Gainesville | Georgia | 30501 | — |
| Memorial Health University Medical Center | Savannah | Georgia | 31403 | — |
| Saint Joseph's-Candler Health System | Savannah | Georgia | 31405 | — |
| Queen's Medical Center | Honolulu | Hawaii | 96813 | — |
| University of Hawaii | Honolulu | Hawaii | 96813 | — |
| Saint Alphonsus Regional Medical Center | Boise | Idaho | 83706 | — |
| Northwestern University | Chicago | Illinois | 60611 | — |
| Rush University Medical Center | Chicago | Illinois | 60612 | — |
| OSF Saint Francis Medical Center | Peoria | Illinois | 61637 | — |
| Saint Vincent Anderson Regional Hospital/Cancer Center | Anderson | Indiana | 46016 | — |
| Saint Francis Hospital and Health Centers | Beech Grove | Indiana | 46107 | — |
| Franciscan Saint Margaret Health-Hammond Campus | Hammond | Indiana | 46320 | — |
| Franciscan Saint Francis Health-Indianapolis | Indianapolis | Indiana | 46237 | — |
| Michiana Hematology Oncology PC-Mishawaka | Mishawaka | Indiana | 46545-1470 | — |
| University of Iowa Hospitals and Clinics | Iowa City | Iowa | 52242 | — |
| Mercy Medical Center - North Iowa | Mason City | Iowa | 50401 | — |
| University of Kansas Medical Center | Kansas City | Kansas | 66160 | — |
| Kansas City Cancer Centers-Southwest | Overland Park | Kansas | 66210 | — |
| Via Christi Regional Medical Center | Wichita | Kansas | 67214 | — |
| University of Maryland/Greenebaum Cancer Center | Baltimore | Maryland | 21201 | — |
| Greater Baltimore Medical Center | Baltimore | Maryland | 21204 | — |
| Sinai Hospital of Baltimore | Baltimore | Maryland | 21215 | — |
| Central Maryland Radiation Oncology in Howard County | Columbia | Maryland | 21044 | — |
| Holy Cross Hospital | Silver Spring | Maryland | 20910 | — |
| Hickman Cancer Center | Adrian | Michigan | 49221 | — |
| Saint John Hospital and Medical Center | Detroit | Michigan | 48236 | — |
| West Michigan Cancer Center | Kalamazoo | Michigan | 49007 | — |
| Saint Joseph Mercy Port Huron | Port Huron | Michigan | 48060 | — |
| Saint John Macomb-Oakland Hospital | Warren | Michigan | 48093 | — |
| Abbott-Northwestern Hospital | Minneapolis | Minnesota | 55407 | — |
| Mayo Clinic | Rochester | Minnesota | 55905 | — |
| University of Mississippi Medical Center | Jackson | Mississippi | 39216 | — |
| Kansas City Cancer Center - South | Kansas City | Missouri | 64131 | — |
| Kansas City Cancer Centers - North | Kansas City | Missouri | 64154 | — |
| Kansas City Cancer Center-Lee's Summit | Lee's Summit | Missouri | 64064 | — |
| Phelps County Regional Medical Center | Rolla | Missouri | 65401 | — |
| Mercy Hospital Springfield | Springfield | Missouri | 65804 | — |
| CoxHealth South Hospital | Springfield | Missouri | 65807 | — |
| Saint John's Mercy Medical Center | St Louis | Missouri | 63141 | — |
| Nebraska Methodist Hospital | Omaha | Nebraska | 68114 | — |
| The Nebraska Medical Center | Omaha | Nebraska | 68198 | — |
| Elliot Hospital | Manchester | New Hampshire | 03103 | — |
| Cooper Hospital University Medical Center | Camden | New Jersey | 08103 | — |
| Morristown Memorial Hospital | Morristown | New Jersey | 07962 | — |
| Fox Chase Cancer Center at Virtua Memorial Hospital of Burlington County | Mount Holly | New Jersey | 08060 | — |
| UMDNJ - New Jersey Medical School | Newark | New Jersey | 07103 | — |
| MD Anderson Cancer Center at Cooper-Voorhees | Voorhees Township | New Jersey | 08043 | — |
| State University of New York Downstate Medical Center | Brooklyn | New York | 11203 | — |
| Memorial Sloan-Kettering Cancer Center | New York | New York | 10065 | — |
| Highland Hospital | Rochester | New York | 14620 | — |
| University of Rochester | Rochester | New York | 14642 | — |
| Montefiore Medical Center-Weiler Division | The Bronx | New York | 10461 | — |
| Montefiore Medical Center | The Bronx | New York | 10467-2490 | — |
| Carolinas Medical Center | Charlotte | North Carolina | 28203 | — |
| Summa Akron City Hospital/Cooper Cancer Center | Akron | Ohio | 44304 | — |
| Akron General Medical Center | Akron | Ohio | 44307 | — |
| Summa Barberton Hospital | Barberton | Ohio | 44203 | — |
| University of Cincinnati | Cincinnati | Ohio | 45267 | — |
| Case Western Reserve University | Cleveland | Ohio | 44106 | — |
| Arthur G. James Cancer Hospital and Solove Research Institute at Ohio State University Medical Center | Columbus | Ohio | 43210 | — |
| Summa Health Center at Lake Medina | Medina | Ohio | 44256 | — |
| UHHS-Chagrin Highlands Medical Center | Orange | Ohio | 44122 | — |
| Southern Ohio Medical Center | Portsmouth | Ohio | 45662 | — |
| Robinson Radiation Oncology | Ravenna | Ohio | 44266 | — |
| Cancer Care Center, Incorporated | Salem | Ohio | 44460 | — |
| Ireland Cancer Center at Firelands Regional Medical Center | Sandusky | Ohio | 44870 | — |
| Flower Hospital | Sylvania | Ohio | 43560 | — |
| University of Toledo | Toledo | Ohio | 43614 | — |
| UHHS-Westlake Medical Center | Westlake | Ohio | 44145 | — |
| Cancer Treatment Center | Wooster | Ohio | 44691 | — |
| University of Oklahoma Health Sciences Center | Oklahoma City | Oklahoma | 73104 | — |
| Providence Portland Medical Center | Portland | Oregon | 97213 | — |
| Providence Saint Vincent Medical Center | Portland | Oregon | 97225 | — |
| Delaware County Memorial Hospital | Drexel Hill | Pennsylvania | 19026 | — |
| Reading Hospital | West Reading | Pennsylvania | 19611 | — |
| Lankenau Hospital | Wynnewood | Pennsylvania | 19096 | — |
| Women and Infants Hospital | Providence | Rhode Island | 02905 | — |
| Rapid City Regional Hospital | Rapid City | South Dakota | 57701 | — |
| Sanford Cancer Center-Oncology Clinic | Sioux Falls | South Dakota | 57104 | — |
| University of Tennessee - Knoxville | Knoxville | Tennessee | 37920 | — |
| University of Texas Southwestern Medical Center | Dallas | Texas | 75390 | — |
| M D Anderson Cancer Center | Houston | Texas | 77030 | — |
| Methodist Hospital | Houston | Texas | 77030 | — |
| Intermountain Medical Center | Murray | Utah | 84157 | — |
| McKay-Dee Hospital Center | Ogden | Utah | 84403 | — |
| Huntsman Cancer Institute/University of Utah | Salt Lake City | Utah | 84112 | — |
| Dixie Medical Center Regional Cancer Center | St. George | Utah | 84770 | — |
| Seattle Cancer Care Alliance | Seattle | Washington | 98109 | — |
| North Star Lodge Cancer Center at Yakima Valley Memorial Hospital | Yakima | Washington | 98902 | — |
| Wheeling Hospital | Wheeling | West Virginia | 26003 | — |
| Saint Vincent Hospital | Green Bay | Wisconsin | 54301 | — |
| Aurora Saint Luke's Medical Center | Milwaukee | Wisconsin | 53215 | — |
| Froedtert and the Medical College of Wisconsin | Milwaukee | Wisconsin | 53226 | — |
| Aurora West Allis Medical Center | West Allis | Wisconsin | 53227 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 6 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00980954, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Dec 31, 2025 · Synced Oct 21, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00980954 live on ClinicalTrials.gov.