A Pilot Study for Collection of Anti-Influenza A Immune Plasma
Public ClinicalTrials.gov record NCT00984451. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
Background: * The influenza A virus can cause infections that lead to fever, cough, muscle aches, diarrhea, and headaches, and can even be fatal in some people. Seasonal influenza kills an estimated 36,000 people in the United States each year. In addition, more than 200,000 people are hospitalized for flu-related complications. Influenza A has a substantial health effect on every age group. * Currently, treatments are available for influenza A, but there is concern that the rate of complications or even death from this infection is still high despite treatment, and that over time this virus may become resistant to these treatments. Researchers are interested in developing a possible new treatment that uses antibodies against influenza A virus. Objectives: \- To collect plasma (the liquid component of blood containing antibodies) from people who have high levels of antibodies against the influenza A virus because they either have been previously infected with the virus or have been vaccinated against the infection. Eligibility: * Healthy male volunteers between 18 and 60 years of age who are eligible to donate blood. * Individuals must have previously either recovered from influenza infection or have been vaccinated against the infection, and may be subject to other restrictions on participating in National Institutes of Health research studies. Design: * Volunteers will undergo apheresis, an outpatient procedure in which researchers will collect plasma containing antibodies against the influenza virus by drawing blood into a special machine that separates blood cells from the liquid portion under sterile conditions and then returns the blood cells to the donor. * Volunteers will be screened with blood tests to ensure that they are eligible to participate and donate blood. * Volunteers are asked to undergo at least 3 sessions of apheresis; if willing, they can volunteer to participate in up to 20 sessions. * After plasma is collected, it will be tested to ensure that it can be used to safely develop treatments for patients who have influenza A infection.
Study identification
- NCT ID
- NCT00984451
- Recruitment status
- Completed
- Study type
- Observational
- Phase
- Not listed
- Enrollment
- 102 participants
Conditions and interventions
Conditions
Interventions
Biological
Eligibility (public fields only)
- Age range
- 18 Years to 60 Years
- Sex
- Male
- Healthy volunteers
- Accepts healthy volunteers
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Aug 31, 2009
- Primary completion
- Nov 30, 2018
- Completion
- Nov 30, 2018
- Last update posted
- Aug 18, 2019
2009 – 2018
United States locations
- U.S. sites
- 12
- U.S. states
- 9
- U.S. cities
- 10
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| UCLA Care Center | Los Angeles | California | 90095 | — |
| UCLA Pediatric Infectious Diseases | Los Angeles | California | 90095 | — |
| University of Colorado Hospital Blood Donor Center | Aurora | Colorado | 80045 | — |
| Rush University Medical Center | Chicago | Illinois | 60612 | — |
| Johns Hopkins University | Baltimore | Maryland | 21287 | — |
| National Institutes of Health Clinical Center, 9000 Rockville Pike | Bethesda | Maryland | 20892 | — |
| AIDS Clinical Trials Unit, NYU School of Medicine | New York | New York | 10016 | — |
| Cornell Clinical Trials Unit, New York Presbyterian Hospital, Weill Cornell Medical College | New York | New York | 10065 | — |
| Clinical Translational Research Center (CTRC) at UNC Hospitals | Chapel Hill | North Carolina | 27599-7600 | — |
| AIDS Clinical Trial Unit, Holmes Hospital, Div of Infectious Disease, University of Cincinnati College of Medicine | Cincinnati | Ohio | 45267 | — |
| Hospital of the University of Pennsylvania | Philadelphia | Pennsylvania | 19104 | — |
| University of Washington | Seattle | Washington | 98104 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00984451, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 18, 2019 · Synced Sep 4, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT00984451 live on ClinicalTrials.gov.