Investigation of 1.2% Sodium Hyaluronate for Treatment of Painful Chronic Osteoarthritis of the Knee
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Official title
A 26 Week, Double-Blind, Randomized, Placebo-Controlled Study of the Efficacy and Safety of Single Intra-Articular Injection 1.2% Sodium Hyaluronate for Treatment of Painful Osteoarthritis of the Knee, With Optional 26-Week Open-Label Safety Extension
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
Subjects with chronic osteoarthritis of the knee will be assigned to receive an injection of either 1.2% sodium hyaluronate or buffered saline to evaluate its effectiveness and safety for 26 weeks. After 26 weeks, subjects can elect to receive a second injection of 1.2% sodium hyaluronate and be followed for another 26 weeks.
Study identification
- NCT ID
- NCT00988091
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 596 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 40 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Sep 2009 (Type not available)
- Primary completion
- Oct 2010 (Actual)
- Completion
- Apr 2011 (Actual)
- Last update posted
- Jun 15, 2012
2009 – 2011
United States locations
- U.S. sites
- 34
- U.S. states
- 17
- U.S. cities
- 33
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Apex Clinical Trials, LLC | Homewood | Alabama | — | — |
| Tucson Orthopaedic Institute | Tucson | Arizona | — | — |
| St. Joseph's Mercy Clinic | Hot Springs | Arkansas | — | — |
| Rx Medical Research of Arkansas, Inc | Little Rock | Arkansas | — | — |
| Southbay Pharma Research | Buena Park | California | — | — |
| Providence Clinical Research | Burbank | California | — | — |
| Triwest Research Associates | La Mesa | California | — | — |
| UCLA-Division of Rheumatology | Los Angeles | California | — | — |
| Investigational Site | Santa Barbara | California | — | — |
| Colorado Arthritis Center, PC | Englewood | Colorado | — | — |
| Front Range Clinical Research | Wheat Ridge | Colorado | — | — |
| New England Research Associates, LLC | Trumball | Connecticut | — | — |
| International Physicians Research | Aventura | Florida | — | — |
| Investigational Site | Fort Lauderdale | Florida | — | — |
| Sunrise Medical Research | Lauderdale Lakes | Florida | — | — |
| Tri-County Orthopaedic Center | Leesburg | Florida | — | — |
| Clinical Research Center LLC | Wellington | Florida | — | — |
| National Pain Research Institute, LLC | Winter Park | Florida | — | — |
| Georgia Institute for Clinical Research | Marietta | Georgia | — | — |
| Pinnacle Orthopaedics and Sports Medicine | Marietta | Georgia | — | — |
| Lee Research Institute | Shawnee | Kansas | — | — |
| Professional Research Network of Kansas | Wichita | Kansas | — | — |
| New Jersey Physicians, LLC | Passaic | New Jersey | — | — |
| Research Department, Bone & Joint Hospital at St. Anthony | Oklahoma City | Oklahoma | — | — |
| Omega Medical Research | Warwick | Rhode Island | — | — |
| Palmetto Medical Research | Mt. Pleasant | South Carolina | — | — |
| Palmetto Clinical Trial Services, LLC | Simpsonville | South Carolina | — | — |
| Black Hills Orthopedic & Spine Center | Rapid City | South Dakota | — | — |
| Holston Medical Group | Kingsport | Tennessee | — | — |
| McKenzie Medical Center | McKenzie | Tennessee | — | — |
| Texas Orthopedic Specialists, PA | Grapevine | Texas | — | — |
| Memorial Bone & Joint Research Foundation | Houston | Texas | — | — |
| Discovery Clinical Trials (DCT) - Stone Oak, LLC | San Antonio | Texas | — | — |
| Northwest Clinical Research Center | Bellevue | Washington | — | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00988091, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jun 15, 2012 · Synced Nov 13, 2026
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