THE IMPROVE TRIAL: Improving Pain Management and Outcomes With Various Strategies of Patient-Controlled Analgesia (PCA)
Public ClinicalTrials.gov record NCT00999245. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Improving Pain Management and Outcomes With Various Strategies of Patient-Controlled Analgesia (PCA)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
Patient-Controlled Analgesia (PCA) means that the patient is in control of his/her pain medicine. In this study two (2) different treatment plans of Patient-Controlled Analgesia will be used to treat people with sickle cell disease who are admitted to the hospital for a pain crisis. The purpose of this study is to find out if one plan is better than the other in controlling sickle cell pain. If you are eligible for the study, you will be assigned by chance (like flipping a coin) to either get a higher continuous amount of the pain medicine with a smaller amount for pain as you need it, OR to get a smaller continuous amount of pain medicine with a larger amount of pain medicine as you need it. You or your study doctor can not choose which plan you receive, and you will not be told which one you have been assigned to. The doctors and nurses taking care of you will know which plan you are assigned to so they can safely and effectively take care of your pain. Some members of the study team will not know which plan you are on. We will give you morphine sulfate or hydromorphone (dilaudid) for your pain. These medicines are approved by the Food and Drug Administration (FDA) and have been used for a long time to relieve pain. If you have been treated for pain before with hydromorphone (dilaudid) and you prefer it to morphine, then you may choose to get it during the study. If you have not received hydromorphone (dilaudid) before or you do not have a preference then you will be given morphine for pain. The pain medicine will be given through the IV in your arm. You will receive morphine or hydromorphone continuously through the IV and will also be able to use the PCA machine to give yourself extra pain medicine as you need it for pain. You will need to push a button to give yourself extra medicine for pain. The amount of pain medicine you get on these plans is based on how much you weigh.
Study identification
- NCT ID
- NCT00999245
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 38 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 10 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jan 2010 (Type not available)
- Primary completion
- Jun 2010 (Actual)
- Completion
- Jun 2010 (Actual)
- Last update posted
- Apr 18, 2013
2010
United States locations
- U.S. sites
- 28
- U.S. states
- 16
- U.S. cities
- 21
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Children's Hospital and Research Center | Oakland | California | — | — |
| Yale-New Haven Medical Center, | New Haven | Connecticut | — | — |
| A.I. duPont Hospital for Children | Wilmington | Delaware | — | — |
| Children's National Medical Center | Washington D.C. | District of Columbia | — | — |
| Howard University Hospital | Washington D.C. | District of Columbia | — | — |
| Emory University School of Medicine | Atlanta | Georgia | — | — |
| Medical College of Georgia | Augusta | Georgia | — | — |
| Children's Memorial Hospital | Chicago | Illinois | — | — |
| University of Illinois Sickle Cell Center | Chicago | Illinois | — | — |
| Kosair Children's Hospital | Louisville | Kentucky | — | — |
| Children's Hospital at Sinai | Baltimore | Maryland | — | — |
| Johns Hopkins | Baltimore | Maryland | — | — |
| National Institutes of Health Clinical Center | Bethesda | Maryland | — | — |
| Boston Medical Center | Boston | Massachusetts | — | — |
| Children's Hospital Boston | Boston | Massachusetts | — | — |
| University of Mississippi Medical Center | Jackson | Mississippi | — | — |
| Interfaith Medical Center | Brooklyn | New York | — | — |
| New York Methodist Hospital | Brooklyn | New York | — | — |
| The University of North Carolina at Chapel Hill | Chapel Hill | North Carolina | — | — |
| Duke University Medical Center | Durham | North Carolina | — | — |
| Cincinnati Children's Hospital Medical Center | Cincinnati | Ohio | — | — |
| Nationwide Children's Hospital | Columbus | Ohio | — | — |
| Ohio State University | Columbus | Ohio | — | — |
| Children's Hospital of Philadelphia | Philadelphia | Pennsylvania | — | — |
| St. Christopher's Hospital for Children | Philadelphia | Pennsylvania | — | — |
| Children's Hospital of Pittsburgh | Pittsburgh | Pennsylvania | — | — |
| Texas Children's Hospital | Houston | Texas | — | — |
| Virginia Commonwealth University Health Systems | Richmond | Virginia | — | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT00999245, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 18, 2013 · Synced Oct 22, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT00999245 live on ClinicalTrials.gov.