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ClinicalTrials.gov record
Completed Phase 3 Interventional Results available

Chemoembolization With or Without Sorafenib Tosylate in Treating Patients With Liver Cancer That Cannot Be Removed by Surgery

ClinicalTrials.gov ID: NCT01004978

Public ClinicalTrials.gov record NCT01004978. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

ClinicalTrials.gov public records Last synced Oct 26, 2026, 3:50 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase III Randomized, Double-Blind Trial of Chemoembolization With or Without Sorafenib in Unresectable Hepatocellular Carcinoma (HCC) in Patients With and Without Vascular Invasion

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

This randomized phase III trial studies chemoembolization and sorafenib tosylate to see how well they work compared with chemoembolization alone in treating patients with liver cancer that cannot be removed by surgery. Drugs used in chemotherapy, such as doxorubicin hydrochloride, mitomycin, and cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Chemoembolization kills tumor cells by carrying drugs directly into blood vessels near the tumor and then blocking the blood flow to allow a higher concentration of the drug to reach the tumor for a longer period of time. Kinase inhibitors, such as sorafenib tosylate may stop the growth of tumor cells by blocking the action of an abnormal protein that signals cancer cells to multiply. It is not yet known whether giving chemoembolization together with sorafenib tosylate is more effective than chemoembolization alone in treating patients with liver cancer.

Study identification

NCT ID
NCT01004978
Recruitment status
Completed
Study type
Interventional
Phase
Phase 3
Enrollment
235 participants

Conditions and interventions

Eligibility (public fields only)

Age range
18 Years and older
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Oct 28, 2009 (Actual)
Primary completion
Feb 11, 2021 (Actual)
Completion
Dec 21, 2022 (Actual)
Last update posted
Jan 3, 2024

2009 – 2022

United States locations

U.S. sites
281
U.S. states
45
U.S. cities
186
Facility City State ZIP Site status
University of Alabama at Birmingham Cancer Center Birmingham Alabama 35233 —
University of South Alabama Mitchell Cancer Institute Mobile Alabama 36688 —
Mayo Clinic in Arizona Scottsdale Arizona 85259 —
University of Arizona Cancer Center-Orange Grove Campus Tucson Arizona 85704 —
Banner University Medical Center - Tucson Tucson Arizona 85719 —
University of Arizona Cancer Center-North Campus Tucson Arizona 85719 —
John L McClellan Memorial Veterans Hospital Little Rock Arkansas 72205 —
University of Arkansas for Medical Sciences Little Rock Arkansas 72205 —
Marin Cancer Care Inc Greenbrae California 94904 —
USC / Norris Comprehensive Cancer Center Los Angeles California 90033 —
Saint Joseph Hospital - Orange Orange California 92868 —
Stanford Cancer Institute Palo Alto Palo Alto California 94304 —
Zuckerberg San Francisco General Hospital San Francisco California 94110 —
UCSF Medical Center-Mount Zion San Francisco California 94115 —
UCHealth University of Colorado Hospital Aurora Colorado 80045 —
UCHealth Memorial Hospital Central Colorado Springs Colorado 80909 —
Porter Adventist Hospital Denver Colorado 80210 —
Saint Mary's Hospital and Regional Medical Center Grand Junction Colorado 81501 —
Smilow Cancer Hospital Care Center at Saint Francis Hartford Connecticut 06105 —
Yale University New Haven Connecticut 06520 —
Beebe Medical Center Lewes Delaware 19958 —
Christiana Care Health System-Christiana Hospital Newark Delaware 19718 —
Veterans Affairs Medical Center -Washington DC Washington D.C. District of Columbia 20422 —
Mayo Clinic in Florida Jacksonville Florida 32224-9980 —
Lakeland Regional Health Hollis Cancer Center Lakeland Florida 33805 —
Emory University Hospital/Winship Cancer Institute Atlanta Georgia 30322 —
Medical Center of Central Georgia Macon Georgia 31201 —
Hawaii Cancer Care Inc - Waterfront Plaza Honolulu Hawaii 96813 —
Queen's Medical Center Honolulu Hawaii 96813 —
University of Hawaii Cancer Center Honolulu Hawaii 96813 —
Hawaii Cancer Care Inc-Liliha Honolulu Hawaii 96817 —
Queen's Cancer Center - Kuakini Honolulu Hawaii 96817 —
The Cancer Center of Hawaii-Liliha Honolulu Hawaii 96817 —
Kapiolani Medical Center for Women and Children Honolulu Hawaii 96826 —
Castle Medical Center Kailua Hawaii 96734 —
Wilcox Memorial Hospital and Kauai Medical Clinic Lihue Hawaii 96766 —
Pali Momi Medical Center ‘Aiea Hawaii 96701 —
Saint Alphonsus Cancer Care Center-Boise Boise Idaho 83706 —
Saint Luke's Cancer Institute - Boise Boise Idaho 83712 —
Saint Luke's Cancer Institute - Fruitland Fruitland Idaho 83619 —
Saint Luke's Cancer Institute - Meridian Meridian Idaho 83642 —
Saint Luke's Cancer Institute - Nampa Nampa Idaho 83686 —
Saint Luke's Cancer Institute - Twin Falls Twin Falls Idaho 83301 —
Saint Joseph Medical Center Bloomington Illinois 61701 —
Illinois CancerCare-Bloomington Bloomington Illinois 61704 —
Graham Hospital Association Canton Illinois 61520 —
Illinois CancerCare-Canton Canton Illinois 61520 —
Illinois CancerCare-Carthage Carthage Illinois 62321 —
Memorial Hospital Carthage Illinois 62321 —
Hematology and Oncology Associates Chicago Illinois 60611 —
Northwestern University Chicago Illinois 60611 —
John H Stroger Jr Hospital of Cook County Chicago Illinois 60612 —
University of Illinois Chicago Illinois 60612 —
Swedish Covenant Hospital Chicago Illinois 60625 —
University of Chicago Comprehensive Cancer Center Chicago Illinois 60637 —
Heartland Cancer Research NCORP Decatur Illinois 62526 —
Eureka Hospital Eureka Illinois 61530 —
Illinois CancerCare-Eureka Eureka Illinois 61530 —
Saint Francis Hospital Evanston Illinois 60202 —
Illinois CancerCare-Galesburg Galesburg Illinois 61401 —
Ingalls Memorial Hospital Harvey Illinois 60426 —
Illinois CancerCare-Havana Havana Illinois 62644 —
Mason District Hospital Havana Illinois 62644 —
Hematology Oncology Associates of Illinois-Highland Park Highland Park Illinois 60035 —
Edward Hines Jr VA Hospital Hines Illinois 60141 —
Hinsdale Hematology Oncology Associates Incorporated Hinsdale Illinois 60521 —
Midwest Center for Hematology Oncology Joliet Illinois 60432 —
Presence Saint Mary's Hospital Kankakee Illinois 60901 —
Illinois CancerCare-Kewanee Clinic Kewanee Illinois 61443 —
AMITA Health Adventist Medical Center La Grange Illinois 60525 —
AMG Libertyville - Oncology Libertyville Illinois 60048 —
Illinois CancerCare-Macomb Macomb Illinois 61455 —
Mcdonough District Hospital Macomb Illinois 61455 —
Loyola University Medical Center Maywood Illinois 60153 —
Holy Family Medical Center Monmouth Illinois 61462 —
Illinois CancerCare-Monmouth Monmouth Illinois 61462 —
Illinois Cancer Specialists-Niles Niles Illinois 60714 —
Bromenn Regional Medical Center Normal Illinois 61761 —
Carle Cancer Institute Normal Normal Illinois 61761 —
Illinois CancerCare-Community Cancer Center Normal Illinois 61761 —
Illinois CancerCare-Ottawa Clinic Ottawa Illinois 61350 —
Ottawa Regional Hospital and Healthcare Center Ottawa Illinois 61350 —
Illinois CancerCare-Pekin Pekin Illinois 61554 —
OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center Pekin Illinois 61554 —
Pekin Hospital Pekin Illinois 61554 —
Proctor Hospital Peoria Illinois 61614 —
Illinois CancerCare-Peoria Peoria Illinois 61615 —
Methodist Medical Center of Illinois Peoria Illinois 61636 —
OSF Saint Francis Medical Center Peoria Illinois 61637 —
Illinois CancerCare-Peru Peru Illinois 61354 —
Illinois Valley Hospital Peru Illinois 61354 —
Illinois CancerCare-Princeton Princeton Illinois 61356 —
Perry Memorial Hospital Princeton Illinois 61356 —
West Suburban Medical Center River Forest Illinois 60305 —
Swedish American Hospital Rockford Illinois 61104 —
SwedishAmerican Regional Cancer Center/ACT Rockford Illinois 61114 —
Hematology Oncology Associates of Illinois - Skokie Skokie Illinois 60076 —
Illinois CancerCare-Spring Valley Spring Valley Illinois 61362 —
Medical Oncology and Hematology Associates-West Des Moines Clive Iowa 50325 —
Iowa Methodist Medical Center Des Moines Iowa 50309 —
Iowa-Wide Oncology Research Coalition NCORP Des Moines Iowa 50309 —
Medical Oncology and Hematology Associates-Des Moines Des Moines Iowa 50309 —
Mercy Medical Center - Des Moines Des Moines Iowa 50314 —
Mission Cancer and Blood - Laurel Des Moines Iowa 50314 —
Iowa Lutheran Hospital Des Moines Iowa 50316 —
HaysMed University of Kansas Health System Hays Kansas 67601 —
Hutchinson Regional Medical Center Hutchinson Kansas 67502 —
University of Kansas Cancer Center-West Kansas City Kansas 66112 —
University of Kansas Cancer Center Kansas City Kansas 66160 —
Menorah Medical Center Overland Park Kansas 66209 —
University of Kansas Cancer Center-Overland Park Overland Park Kansas 66210 —
Saint Luke's South Hospital Overland Park Kansas 66213 —
Ascension Via Christi - Pittsburg Pittsburg Kansas 66762 —
Kansas City NCI Community Oncology Research Program Prairie Village Kansas 66208 —
Salina Regional Health Center Salina Kansas 67401 —
Advent Health - Shawnee Mission Medical Center Shawnee Mission Kansas 66204 —
University of Kansas Health System Saint Francis Campus Topeka Kansas 66606 —
University of Kentucky/Markey Cancer Center Lexington Kentucky 40536 —
Ochsner Medical Center Jefferson New Orleans Louisiana 70121 —
LSU Health Sciences Center at Shreveport Shreveport Louisiana 71103 —
Saint Agnes Hospital Baltimore Maryland 21229 —
Johns Hopkins University/Sidney Kimmel Cancer Center Baltimore Maryland 21287 —
Christiana Care - Union Hospital Elkton Maryland 21921 —
Tufts Medical Center Boston Massachusetts 02111 —
Boston Medical Center Boston Massachusetts 02118 —
Lahey Hospital and Medical Center Burlington Massachusetts 01805 —
Michigan Cancer Research Consortium NCORP Ann Arbor Michigan 48106 —
Saint Joseph Mercy Hospital Ann Arbor Michigan 48106 —
University of Michigan Comprehensive Cancer Center Ann Arbor Michigan 48109 —
Beaumont Hospital - Dearborn Dearborn Michigan 48124 —
Ascension Saint John Hospital Detroit Michigan 48236 —
Hurley Medical Center Flint Michigan 48503 —
Genesys Regional Medical Center-West Flint Campus Flint Michigan 48532 —
Allegiance Health Jackson Michigan 49201 —
Bronson Methodist Hospital Kalamazoo Michigan 49007 —
West Michigan Cancer Center Kalamazoo Michigan 49007 —
Borgess Medical Center Kalamazoo Michigan 49048 —
Sparrow Hospital Lansing Michigan 48912 —
Trinity Health Saint Mary Mercy Livonia Hospital Livonia Michigan 48154 —
UP Health System Marquette Marquette Michigan 49855 —
Saint Joseph Mercy Oakland Pontiac Michigan 48341 —
Lake Huron Medical Center Port Huron Michigan 48060 —
Ascension Saint Mary's Hospital Saginaw Michigan 48601 —
Ascension Providence Hospitals - Southfield Southfield Michigan 48075 —
Saint John Macomb-Oakland Hospital Warren Michigan 48093 —
Fairview Ridges Hospital Burnsville Minnesota 55337 —
Mercy Hospital Coon Rapids Minnesota 55433 —
Fairview Southdale Hospital Edina Minnesota 55435 —
Unity Hospital Fridley Minnesota 55432 —
Hutchinson Area Health Care Hutchinson Minnesota 55350 —
Minnesota Oncology Hematology PA-Maplewood Maplewood Minnesota 55109 —
Saint John's Hospital - Healtheast Maplewood Minnesota 55109 —
Abbott-Northwestern Hospital Minneapolis Minnesota 55407 —
Hennepin County Medical Center Minneapolis Minnesota 55415 —
North Memorial Medical Health Center Robbinsdale Minnesota 55422 —
Metro Minnesota Community Oncology Research Consortium Saint Louis Park Minnesota 55416 —
Park Nicollet Clinic - Saint Louis Park Saint Louis Park Minnesota 55416 —
Regions Hospital Saint Paul Minnesota 55101 —
United Hospital Saint Paul Minnesota 55102 —
Saint Francis Regional Medical Center Shakopee Minnesota 55379 —
Ridgeview Medical Center Waconia Minnesota 55387 —
Rice Memorial Hospital Willmar Minnesota 56201 —
Minnesota Oncology Hematology PA-Woodbury Woodbury Minnesota 55125 —
University of Mississippi Medical Center Jackson Mississippi 39216 —
Veterans Administration Columbia Missouri 65201 —
Truman Medical Centers Kansas City Missouri 64108 —
Saint Luke's Hospital of Kansas City Kansas City Missouri 64111 —
Saint Joseph Health Center Kansas City Missouri 64114 —
North Kansas City Hospital Kansas City Missouri 64116 —
Heartland Hematology and Oncology Associates Incorporated Kansas City Missouri 64118 —
Kansas City Veterans Affairs Medical Center Kansas City Missouri 64128 —
The University of Kansas Cancer Center-South Kansas City Missouri 64131 —
Research Medical Center Kansas City Missouri 64132 —
University of Kansas Cancer Center - North Kansas City Missouri 64154 —
University of Kansas Cancer Center - Lee's Summit Lee's Summit Missouri 64064 —
Saint Luke's East - Lee's Summit Lee's Summit Missouri 64086 —
Heartland Regional Medical Center Saint Joseph Missouri 64506 —
Saint Joseph Oncology Inc Saint Joseph Missouri 64507 —
Washington University School of Medicine St Louis Missouri 63110 —
Billings Clinic Cancer Center Billings Montana 59101 —
Northern Rockies Radiation Oncology Center Billings Montana 59101 —
Saint Vincent Healthcare Billings Montana 59101 —
Montana Cancer Consortium NCORP Billings Montana 59102 —
Saint Vincent Frontier Cancer Center Billings Montana 59102 —
Bozeman Deaconess Hospital Bozeman Montana 59715 —
Saint James Community Hospital and Cancer Treatment Center Butte Montana 59701 —
Benefis Healthcare- Sletten Cancer Institute Great Falls Montana 59405 —
Berdeaux, Donald MD (UIA Investigator) Great Falls Montana 59405 —
Great Falls Clinic Great Falls Montana 59405 —
Northern Montana Hospital Havre Montana 59501 —
Saint Peter's Community Hospital Helena Montana 59601 —
Glacier Oncology PLLC Kalispell Montana 59901 —
Kalispell Medical Oncology Kalispell Montana 59901 —
Kalispell Regional Medical Center Kalispell Montana 59901 —
Montana Cancer Specialists Missoula Montana 59802 —
Saint Patrick Hospital - Community Hospital Missoula Montana 59802 —
Community Medical Hospital Missoula Montana 59804 —
Guardian Oncology and Center for Wellness Missoula Montana 59804 —
CHI Health Saint Francis Grand Island Nebraska 68803 —
Great Plains Health Callahan Cancer Center North Platte Nebraska 69101 —
Nebraska Methodist Hospital Omaha Nebraska 68114 —
University of Nebraska Medical Center Omaha Nebraska 68198 —
Renown Regional Medical Center Reno Nevada 89502 —
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center Lebanon New Hampshire 03756 —
Cooper Hospital University Medical Center Camden New Jersey 08103 —
Virtua Memorial Mount Holly New Jersey 08060 —
Rutgers New Jersey Medical School Newark New Jersey 07101 —
MD Anderson Cancer Center at Cooper-Voorhees Voorhees Township New Jersey 08043 —
Virtua Voorhees Voorhees Township New Jersey 08043 —
University of New Mexico Cancer Center Albuquerque New Mexico 87102 —
Veteran Affairs New York Harbor Healthcare System-Brooklyn Campus Brooklyn New York 11209 —
Maimonides Medical Center Brooklyn New York 11219 —
Mount Sinai Union Square New York New York 10003 —
Veterans Affairs New York Harbor Healthcare System-Manhattan Campus New York New York 10010 —
Laura and Isaac Perlmutter Cancer Center at NYU Langone New York New York 10016 —
Mount Sinai West New York New York 10019 —
UNC Lineberger Comprehensive Cancer Center Chapel Hill North Carolina 27599 —
Novant Health Presbyterian Medical Center Charlotte North Carolina 28204 —
Rutherford Hospital Rutherfordton North Carolina 28139 —
Southeast Clinical Oncology Research Consortium NCORP Winston-Salem North Carolina 27104 —
Wake Forest University Health Sciences Winston-Salem North Carolina 27157 —
University of Cincinnati Cancer Center-UC Medical Center Cincinnati Ohio 45219 —
Case Western Reserve University Cleveland Ohio 44106 —
MetroHealth Medical Center Cleveland Ohio 44109 —
Cleveland Clinic Foundation Cleveland Ohio 44195 —
Ohio State University Comprehensive Cancer Center Columbus Ohio 43210 —
ProMedica Flower Hospital Sylvania Ohio 43560 —
University of Toledo Toledo Ohio 43614 —
Mercy Health - Saint Anne Hospital Toledo Ohio 43623 —
University of Oklahoma Health Sciences Center Oklahoma City Oklahoma 73104 —
Oklahoma Cancer Specialists and Research Institute-Tulsa Tulsa Oklahoma 74146 —
Legacy Mount Hood Medical Center Gresham Oregon 97030 —
Legacy Good Samaritan Hospital and Medical Center Portland Oregon 97210 —
Legacy Emanuel Hospital and Health Center Portland Oregon 97227 —
Legacy Meridian Park Hospital Tualatin Oregon 97062 —
Saint Luke's University Hospital-Bethlehem Campus Bethlehem Pennsylvania 18015 —
Geisinger Medical Center Danville Pennsylvania 17822 —
Thomas Jefferson University Hospital Philadelphia Pennsylvania 19107 —
Fox Chase Cancer Center Philadelphia Pennsylvania 19111 —
Einstein Medical Center Philadelphia Philadelphia Pennsylvania 19141 —
Roger Williams Medical Center Providence Rhode Island 02908 —
AnMed Health Cancer Center Anderson South Carolina 29621 —
AnMed Health Hospital Anderson South Carolina 29621 —
Medical University of South Carolina Charleston South Carolina 29425 —
Prisma Health Cancer Institute - Easley Easley South Carolina 29640 —
Greenville Health System Cancer Institute-Andrews Greenville South Carolina 29601 —
Saint Francis Hospital Greenville South Carolina 29601 —
Prisma Health Cancer Institute - Greer Greer South Carolina 29650 —
Spartanburg Medical Center Spartanburg South Carolina 29303 —
Jackson-Madison County General Hospital Jackson Tennessee 38301 —
University of Tennessee - Knoxville Knoxville Tennessee 37920 —
The Don and Sybil Harrington Cancer Center Amarillo Texas 79106 —
Dell Seton Medical Center at The University of Texas Austin Texas 78701 —
University of Texas Medical Branch Galveston Texas 77555-0565 —
Huntsman Cancer Institute/University of Utah Salt Lake City Utah 84112 —
Bon Secours Saint Francis Medical Center Midlothian Virginia 23114 —
Bon Secours Saint Mary's Hospital Richmond Virginia 23226 —
Hunter Holmes McGuire Veterans Administration Medical Center Richmond Virginia 23249 —
Virginia Commonwealth University/Massey Cancer Center Richmond Virginia 23298 —
MultiCare Auburn Medical Center Auburn Washington 98001 —
Highline Medical Center-Main Campus Burien Washington 98166 —
Providence Regional Cancer System-Centralia Centralia Washington 98531 —
Providence Regional Cancer Partnership Everett Washington 98201 —
Saint Francis Hospital Federal Way Washington 98003 —
Saint Clare Hospital Lakewood Washington 98499 —
Providence - Saint Peter Hospital Olympia Washington 98506-5166 —
MultiCare Good Samaritan Hospital Puyallup Washington 98372 —
Virginia Mason Medical Center Seattle Washington 98101 —
Kaiser Permanente Washington Seattle Washington 98112 —
MultiCare Allenmore Hospital Tacoma Washington 98405 —
MultiCare Tacoma General Hospital Tacoma Washington 98405 —
Northwest NCI Community Oncology Research Program Tacoma Washington 98405 —
Saint Joseph Medical Center Tacoma Washington 98405 —
Legacy Salmon Creek Hospital Vancouver Washington 98686 —
West Virginia University Healthcare Morgantown West Virginia 26506 —
Princeton Community Hospital Princeton West Virginia 24740 —
University of Wisconsin Carbone Cancer Center Madison Wisconsin 53792 —
Marshfield Medical Center-Marshfield Marshfield Wisconsin 54449 —
Medical College of Wisconsin Milwaukee Wisconsin 53226 —
Rocky Mountain Oncology Casper Wyoming 82609 —
Welch Cancer Center Sheridan Wyoming 82801 —

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT01004978, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Jan 3, 2024 · Synced Oct 26, 2026

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Open the official record

The complete public registry record, listed eligibility criteria, and available contact information for NCT01004978 live on ClinicalTrials.gov.

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