ClinicalTrials.gov record
Lisinopril or Coreg CR® in Reducing Side Effects in Women With Breast Cancer Receiving Trastuzumab
ClinicalTrials.gov ID: NCT01009918
Public ClinicalTrials.gov record NCT01009918. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Phase II Placebo-controlled Trial of Lisinopril and Coreg CR® to Reduce Cardiotoxicity in Patients With Breast Cancer Receiving (Neo)Adjuvant Chemotherapy With Trastuzumab (Herceptin®)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
RATIONALE: Lisinopril or Coreg CR®, may help reduce side effects caused by trastuzumab. It is not yet known whether lisinopril or Coreg CR® are more effective than a placebo in reducing side effects caused by trastuzumab. PURPOSE: This phase II trial is studying lisinopril and Coreg CR® to see how well they work compared with a placebo in reducing side effects in patients with HER2-positive breast cancer receiving trastuzumab.
Study identification
- NCT ID
- NCT01009918
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 468 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 2010 (Type not available)
- Primary completion
- Aug 2017 (Actual)
- Completion
- Nov 2018 (Actual)
- Last update posted
- Mar 30, 2021
2010 – 2018
United States locations
- U.S. sites
- 174
- U.S. states
- 29
- U.S. cities
- 145
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Todd Cancer Institute at Long Beach Memorial Medical Center | Long Beach | California | 90806 | — |
| Olive View - UCLA Medical Center Foundation | Sylmar | California | 91342 | — |
| Aurora Presbyterian Hospital | Aurora | Colorado | 80012 | — |
| Boulder Community Hospital | Boulder | Colorado | 80301-9019 | — |
| Penrose Cancer Center at Penrose Hospital | Colorado Springs | Colorado | 80933 | — |
| St. Anthony Central Hospital | Denver | Colorado | 80204 | — |
| Porter Adventist Hospital | Denver | Colorado | 80210 | — |
| Presbyterian - St. Luke's Medical Center | Denver | Colorado | 80218 | — |
| St. Joseph Hospital | Denver | Colorado | 80218 | — |
| Rose Medical Center | Denver | Colorado | 80220 | — |
| CCOP - Colorado Cancer Research Program | Denver | Colorado | 80222 | — |
| Swedish Medical Center | Englewood | Colorado | 80110 | — |
| North Colorado Medical Center | Greeley | Colorado | 80631 | — |
| Littleton Adventist Hospital | Littleton | Colorado | 80122 | — |
| Sky Ridge Medical Center | Lone Tree | Colorado | 80124 | — |
| Hope Cancer Care Center at Longmont United Hospital | Longmont | Colorado | 80501 | — |
| McKee Medical Center | Loveland | Colorado | 80539 | — |
| Parker Adventist Hospital | Parker | Colorado | 80138 | — |
| St. Mary - Corwin Regional Medical Center | Pueblo | Colorado | 81004 | — |
| Exempla Lutheran Medical Center | Wheat Ridge | Colorado | 80033 | — |
| Ella Milbank Foshay Cancer Center at Jupiter Medical Center | Jupiter | Florida | 33458 | — |
| Lakeland Regional Cancer Center at Lakeland Regional Medical Center | Lakeland | Florida | 33805 | — |
| CCOP - Mount Sinai Medical Center | Miami Beach | Florida | 33140 | — |
| MBCCOP - Medical College of Georgia Cancer Center | Augusta | Georgia | 30912 | — |
| Nancy N. and J. C. Lewis Cancer and Research Pavilion at St. Joseph's/Candler | Savannah | Georgia | 31405 | — |
| Illinois CancerCare - Bloomington | Bloomington | Illinois | 61701 | — |
| Illinois CancerCare - Canton | Canton | Illinois | 61520 | — |
| Illinois CancerCare - Carthage | Carthage | Illinois | 62321 | — |
| Resurrection Medical Center | Chicago | Illinois | 60631 | — |
| Louis A. Weiss Memorial Hospital | Chicago | Illinois | 60640 | — |
| Decatur Memorial Hospital Cancer Care Institute | Decatur | Illinois | 62526 | — |
| Illinois CancerCare - Eureka | Eureka | Illinois | 61530 | — |
| Galesburg Clinic, PC | Galesburg | Illinois | 61401 | — |
| Illinois CancerCare - Havana | Havana | Illinois | 62644 | — |
| Illinois CancerCare - Kewanee Clinic | Kewanee | Illinois | 61443 | — |
| La Grange Memorial Hospital | La Grange | Illinois | 60525 | — |
| Illinois CancerCare - Macomb | Macomb | Illinois | 61455 | — |
| Illinois CancerCare - Monmouth | Monmouth | Illinois | 61462 | — |
| Good Samaritan Regional Health Center | Mount Vernon | Illinois | 62864 | — |
| Illinois CancerCare - Community Cancer Center | Normal | Illinois | 61761 | — |
| Advocate Christ Medical Center | Oak Lawn | Illinois | 60453-2699 | — |
| Oncology Hematology Associates of Central Illinois, PC - Ottawa | Ottawa | Illinois | 61350 | — |
| Illinois CancerCare - Pekin | Pekin | Illinois | 61603 | — |
| CCOP - Illinois Oncology Research Association | Peoria | Illinois | 61615 | — |
| Illinois CancerCare - Peru | Peru | Illinois | 61354 | — |
| Illinois CancerCare - Princeton | Princeton | Illinois | 61356 | — |
| West Suburban Center for Cancer Care | River Forest | Illinois | 60305 | — |
| Regional Cancer Center at Memorial Medical Center | Springfield | Illinois | 62781-0001 | — |
| Bloomington Hospital Regional Cancer Institute | Bloomington | Indiana | 47403 | — |
| Elkhart Clinic, LLC | Elkhart | Indiana | 46514-2098 | — |
| Michiana Hematology-Oncology, PC - Elkhart | Elkhart | Indiana | 46514 | — |
| Elkhart General Hospital | Elkhart | Indiana | 46515 | — |
| St. Francis Hospital Cancer Care Services | Indianapolis | Indiana | 46237 | — |
| Howard Community Hospital | Kokomo | Indiana | 46904 | — |
| Center for Cancer Therapy at LaPorte Hospital and Health Services | La Porte | Indiana | 46350 | — |
| Michiana Hematology-Oncology, PC - South Bend | Mishawaka | Indiana | 46545-1470 | — |
| Saint Joseph Regional Medical Center | Mishawaka | Indiana | 46545-1470 | — |
| Michiana Hematology Oncology PC - Plymouth | Plymouth | Indiana | 46563 | — |
| Reid Hospital & Health Care Services | Richmond | Indiana | 47374 | — |
| CCOP - Northern Indiana CR Consortium | South Bend | Indiana | 46601 | — |
| Memorial Hospital of South Bend | South Bend | Indiana | 46601 | — |
| Michiana Hematology Oncology PC - La Porte | Westville | Indiana | 46391 | — |
| Cedar Rapids Oncology Associates | Cedar Rapids | Iowa | 52403 | — |
| Medical Oncology and Hematology Associates - West Des Moines | Clive | Iowa | 50325 | — |
| CCOP - Iowa Oncology Research Association | Des Moines | Iowa | 50309 | — |
| Medical Oncology and Hematology Associates at John Stoddard Cancer Center | Des Moines | Iowa | 50309 | — |
| Medical Oncology and Hematology Associates at Mercy Cancer Center | Des Moines | Iowa | 50314 | — |
| Covenant Cancer Treatment Center | Waterloo | Iowa | 50702 | — |
| Lucille P. Markey Cancer Center at University of Kentucky | Lexington | Kentucky | 40536-0093 | — |
| MBCCOP - LSU Health Sciences Center | New Orleans | Louisiana | 70112 | — |
| Mercy Hospital | Portland | Maine | 04101 | — |
| Mercy Medical Center | Baltimore | Maryland | 21202 | — |
| Alvin and Lois Lapidus Cancer Institute at Sinai Hospital | Baltimore | Maryland | 21215 | — |
| Suburban Hospital | Bethesda | Maryland | 20814 | — |
| Jordan Hospital Club Cancer Center | Plymouth | Massachusetts | 02360 | — |
| Battle Creek Health System Cancer Care Center | Battle Creek | Michigan | 49017 | — |
| Bay Regional Medical Center | Bay City | Michigan | 48708 | — |
| Mecosta County Medical Center | Big Rapids | Michigan | 49307 | — |
| Barbara Ann Karmanos Cancer Institute | Detroit | Michigan | 48201-1379 | — |
| Singh and Arora Hematology Oncology, PC | Flint | Michigan | 48532 | — |
| Butterworth Hospital at Spectrum Health | Grand Rapids | Michigan | 49503 | — |
| Lacks Cancer Center at Saint Mary's Health Care | Grand Rapids | Michigan | 49503 | — |
| West Michigan Cancer Center | Kalamazoo | Michigan | 49007-3731 | — |
| Great Lakes Cancer Institute - Lapeer Campus | Lapeer | Michigan | 48446 | — |
| Clemens Regional Medical Center | Mount Clemens | Michigan | 48043 | — |
| Mercy General Health Partners | Muskegon | Michigan | 49444 | — |
| Northern Michigan Hospital | Petoskey | Michigan | 49770 | — |
| Lakeland Regional Cancer Care Center - St. Joseph | Saint Joseph | Michigan | 49085 | — |
| Lakeside Cancer Specialists, PLLC | Saint Joseph | Michigan | 49085 | — |
| Providence Cancer Institute at Providence Hospital - Southfield Campus | Southfield | Michigan | 48075 | — |
| Munson Medical Center | Traverse City | Michigan | 49684 | — |
| Fairview Ridges Hospital | Burnsville | Minnesota | 55337 | — |
| Mercy and Unity Cancer Center at Mercy Hospital | Coon Rapids | Minnesota | 55433 | — |
| Fairview Southdale Hospital | Edina | Minnesota | 55435 | — |
| Mercy and Unity Cancer Center at Unity Hospital | Fridley | Minnesota | 55432 | — |
| Hutchinson Area Health Care | Hutchinson | Minnesota | 55350 | — |
| HealthEast Cancer Care at St. John's Hospital | Maplewood | Minnesota | 55109 | — |
| Virginia Piper Cancer Institute at Abbott - Northwestern Hospital | Minneapolis | Minnesota | 55407 | — |
| Hennepin County Medical Center - Minneapolis | Minneapolis | Minnesota | 55415 | — |
| Humphrey Cancer Center at North Memorial Outpatient Center | Robbinsdale | Minnesota | 55422-2900 | — |
| CCOP - Metro-Minnesota | Saint Louis Park | Minnesota | 55416 | — |
| Park Nicollet Cancer Center | Saint Louis Park | Minnesota | 55416 | — |
| Regions Hospital Cancer Care Center | Saint Paul | Minnesota | 55101 | — |
| United Hospital | Saint Paul | Minnesota | 55102 | — |
| St. Francis Cancer Center at St. Francis Medical Center | Shakopee | Minnesota | 55379 | — |
| Lakeview Hospital | Stillwater | Minnesota | 55082 | — |
| Ridgeview Medical Center | Waconia | Minnesota | 55387 | — |
| Willmar Cancer Center at Rice Memorial Hospital | Willmar | Minnesota | 56201 | — |
| Minnesota Oncology - Woodbury | Woodbury | Minnesota | 55125 | — |
| Central Care Cancer Center | Bolivar | Missouri | 65613 | — |
| Southeast Cancer Center | Cape Girardeau | Missouri | 63703 | — |
| Saint Luke's Hospital | Chesterfield | Missouri | 63017 | — |
| Goldschmidt Cancer Center | Jefferson City | Missouri | 65109 | — |
| Freeman Cancer Institute | Joplin | Missouri | 64804 | — |
| Missouri Baptist Cancer Center | St Louis | Missouri | 63131 | — |
| Mercy Hospital St. Louis | St Louis | Missouri | 63141 | — |
| CCOP - Montana Cancer Consortium | Billings | Montana | 59101 | — |
| Hematology-Oncology Centers of the Northern Rockies - Billings | Billings | Montana | 59102 | — |
| Billings Clinic - Downtown | Billings | Montana | 59107-7000 | — |
| Bozeman Deaconess Cancer Center | Bozeman | Montana | 59715 | — |
| Big Sky Oncology | Great Falls | Montana | 59405-5309 | — |
| Sletten Cancer Institute at Benefis Healthcare | Great Falls | Montana | 59405 | — |
| Kalispell Regional Medical Center | Kalispell | Montana | 59901 | — |
| Montana Cancer Specialists at Montana Cancer Center | Missoula | Montana | 59807-7877 | — |
| Good Samaritan Cancer Center at Good Samaritan Hospital | Kearney | Nebraska | 68848-1990 | — |
| Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center | Lebanon | New Hampshire | 03756-0002 | — |
| Foundation Medical Partners | Nashua | New Hampshire | 03060 | — |
| Oncology Center at St. Joseph Hospital | Nashua | New Hampshire | 03060 | — |
| Dizzy Gillespie Cancer Institute at Englewood Hospital and Medical Center | Englewood | New Jersey | 07631 | — |
| Monmouth Medical Center | Long Branch | New Jersey | 07740-6395 | — |
| UMDNJ University Hospital | Newark | New Jersey | 07103 | — |
| Franklin & Edith Scarpa Regional Cancer Center at South Jersey Healthcare | Vineland | New Jersey | 08360 | — |
| Lovelace Medical Center - Downtown | Albuquerque | New Mexico | 87102 | — |
| Presbyterian Cancer Treatment Center at Presbyterian Kaseman Hospital | Albuquerque | New Mexico | 87110 | — |
| University of New Mexico Cancer Center | Albuquerque | New Mexico | 87131-5636 | — |
| Bassett Healthcare Regional Cancer Program at Mary Imogene Bassett Hospital | Cooperstown | New York | 13326 | — |
| Charles R. Wood Cancer Center at Glens Falls Hospital | Glens Falls | New York | 12801 | — |
| Nalitt Cancer Institute at Staten Island University Hospital | Staten Island | New York | 10305 | — |
| Park Ridge Health | Henderson | North Carolina | 28792 | — |
| McDowell Cancer Center at Akron General Medical Center | Akron | Ohio | 44307 | — |
| Summa Center for Cancer Care at Akron City Hospital | Akron | Ohio | 44309-2090 | — |
| Aultman Cancer Center at Aultman Hospital | Canton | Ohio | 44710-1799 | — |
| David L. Rike Cancer Center at Miami Valley Hospital | Dayton | Ohio | 45409 | — |
| Samaritan North Cancer Care Center | Dayton | Ohio | 45415 | — |
| CCOP - Dayton | Dayton | Ohio | 45420 | — |
| Blanchard Valley Medical Associates | Findlay | Ohio | 45840 | — |
| Middletown Regional Hospital | Franklin | Ohio | 45005-1066 | — |
| Wayne Hospital | Greenville | Ohio | 45331 | — |
| Charles F. Kettering Memorial Hospital | Kettering | Ohio | 45429 | — |
| UVMC Cancer Care Center at Upper Valley Medical Center | Troy | Ohio | 45373-1300 | — |
| United States Air Force Medical Center - Wright-Patterson | Wright-Patterson Air Force Base | Ohio | 45433-5529 | — |
| Ruth G. McMillan Cancer Center at Greene Memorial Hospital | Xenia | Ohio | 45385 | — |
| Cancer Care Associates - Norman | Norman | Oklahoma | 73071 | — |
| Cancer Care Associates - Mercy Campus | Oklahoma City | Oklahoma | 73120 | — |
| Natalie Warren Bryant Cancer Center at St. Francis Hospital | Tulsa | Oklahoma | 74136 | — |
| Geisinger Cancer Institute at Geisinger Health | Danville | Pennsylvania | 17822-0001 | — |
| Geisinger Hazleton Cancer Center | Hazleton | Pennsylvania | 18201 | — |
| Joan Karnell Cancer Center at Pennsylvania Hospital | Philadelphia | Pennsylvania | 19107 | — |
| Cancer Center at Phoenixville Hospital | Phoenixville | Pennsylvania | 19460 | — |
| Guthrie Cancer Center at Guthrie Clinic Sayre | Sayre | Pennsylvania | 18840 | — |
| Geisinger Medical Group - Scenery Park | State College | Pennsylvania | 16801 | — |
| Frank M. and Dorothea Henry Cancer Center at Geisinger Wyoming Valley Medical Center | Wilkes-Barre | Pennsylvania | 18711 | — |
| Keyserling Cancer Center at Beaufort Memorial Hospital | Beaufort | South Carolina | 29902 | — |
| St. Francis Hospital | Greenville | South Carolina | 29601 | — |
| Gibbs Cancer Center - Pelham | Greer | South Carolina | 29651 | — |
| Rapid City Regional Hospital | Rapid City | South Dakota | 57701 | — |
| Martha Jefferson Hospital Cancer Care Center | Charlottesville | Virginia | 22901 | — |
| Green Bay Oncology, Limited at St. Vincent Hospital Regional Cancer Center | Green Bay | Wisconsin | 54301-3526 | — |
| Green Bay Oncology, Limited at St. Mary's Hospital | Green Bay | Wisconsin | 54303 | — |
| Mercy Regional Cancer Center | Janesville | Wisconsin | 53547 | — |
| Gundersen Lutheran Center for Cancer and Blood | La Crosse | Wisconsin | 54601 | — |
| D.N. Greenwald Center | Mukwonago | Wisconsin | 53149 | — |
| Regional Cancer Center at Oconomowoc Memorial Hospital | Oconomowoc | Wisconsin | 53066 | — |
| Waukesha Memorial Hospital Regional Cancer Center | Waukesha | Wisconsin | 53188 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT01009918, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Mar 30, 2021 · Synced Oct 23, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT01009918 live on ClinicalTrials.gov.