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Completed Phase 3 Interventional Results available

Efficacy and Safety of Azilsartan Medoxomil and Chlorthalidone Compared to Olmesartan Medoxomil and Hydrochlorothiazide in Participants With Moderate to Severe Hypertension.

ClinicalTrials.gov ID: NCT01033071

Public ClinicalTrials.gov record NCT01033071. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

ClinicalTrials.gov public records Last synced Sep 2, 2026, 6:25 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase 3b, Double-Blind, Randomized, 12-Week Efficacy and Safety Study Comparing the TAK-491 Plus Chlorthalidone Fixed-Dose Combination vs Olmesartan Medoxomil-Hydrochlorothiazide in Subjects With Moderate to Severe Hypertension

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

The purpose of this study is to compare the antihypertensive effect of azilsartan medoxomil plus chlorthalidone, once daily (QD), to olmesartan medoxomil plus hydrochlorothiazide in participants with moderate to severe hypertension.

Study identification

NCT ID
NCT01033071
Recruitment status
Completed
Study type
Interventional
Phase
Phase 3
Lead sponsor
Takeda
Industry
Enrollment
1,071 participants

Conditions and interventions

Eligibility (public fields only)

Age range
18 Years and older
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Dec 31, 2009
Primary completion
Sep 30, 2010
Completion
Oct 31, 2010
Last update posted
Feb 6, 2012

2010

United States locations

U.S. sites
84
U.S. states
31
U.S. cities
84
Facility City State ZIP Site status
Not listed Gulf Shores Alabama
Not listed Litchfield Park Arizona
Not listed Mesa Arizona
Not listed Scottsdale Arizona
Not listed Tucson Arizona
Not listed Buena Park California
Not listed Carmichael California
Not listed Greenbrae California
Not listed Irvine California
Not listed Paramount California
Not listed Sacramento California
Not listed San Diego California
Not listed San Francisco California
Not listed Spring Valley California
Not listed Wildomar California
Not listed Colorado Springs Colorado
Not listed Milford Connecticut
Not listed Waterbury Connecticut
Not listed Newark Delaware
Not listed Aventura Florida
Not listed Clearwater Florida
Not listed DeLand Florida
Not listed Fort Lauderdale Florida
Not listed Miami Florida
Not listed Ocala Florida
Not listed Plant City Florida
Not listed Tallahassee Florida
Not listed Tampa Florida
Not listed West Palm Beach Florida
Not listed Winter Haven Florida
Not listed Dunwoody Georgia
Not listed Roswell Georgia
Not listed Suwanee Georgia
Not listed Chicago Illinois
Not listed Melrose Park Illinois
Not listed Naperville Illinois
Not listed Avon Indiana
Not listed Indianapolis Indiana
Not listed Valparaiso Indiana
Not listed Crestview Hills Kentucky
Not listed Lexington Kentucky
Not listed Auburn Maine
Not listed Brockton Massachusetts
Not listed Hyannis Massachusetts
Not listed West Yarmouth Massachusetts
Not listed Ann Arbor Michigan
Not listed City of Saint Peters Missouri
Not listed St Louis Missouri
Not listed Henderson Nevada
Not listed Margate City New Jersey
Not listed Wildwood Crest New Jersey
Not listed Albuquerque New Mexico
Not listed Glens Falls New York
Not listed Boiling Springs North Carolina
Not listed Raleigh North Carolina
Not listed Salisbury North Carolina
Not listed Cincinnati Ohio
Not listed Columbus Ohio
Not listed Willoughby Hills Ohio
Not listed Oklahoma City Oklahoma
Not listed Yukon Oklahoma
Not listed Ashland Oregon
Not listed Portland Oregon
Not listed Bensalem Pennsylvania
Not listed Feasterville Pennsylvania
Not listed Lansdale Pennsylvania
Not listed Pittsburgh Pennsylvania
Not listed Reading Pennsylvania
Not listed Tipton Pennsylvania
Not listed Cranston Rhode Island
Not listed Cumberland Rhode Island
Not listed Mt. Pleasant South Carolina
Not listed Simpsonville South Carolina
Not listed Beaumont Texas
Not listed Dallas Texas
Not listed Houston Texas
Not listed North Richland Hills Texas
Not listed San Antonio Texas
Not listed Magna Utah
Not listed Manassas Virginia
Not listed Lakewood Washington
Not listed Port Orchard Washington
Not listed Madison Wisconsin
Not listed Menomonee Falls Wisconsin

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 10 non-U.S. sites.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT01033071, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Feb 6, 2012 · Synced Sep 2, 2026

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Open the official record

The complete protocol, eligibility criteria, and contact information for NCT01033071 live on ClinicalTrials.gov.

View official ClinicalTrials.gov record →