Global Study Looking at the Combination of RAD001 Plus Best Supportive Care (BSC) and Placebo Plus BSC to Treat Patients With Advanced Hepatocellular Carcinoma.
Public ClinicalTrials.gov record NCT01035229. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized Phase III, Double-blind, Placebo-controlled, Multi-center Study to Evaluate the Efficacy and Safety of Everolimus (RAD001) in Adult Patients With Advanced Hepatocellular Carcinoma After Failure of Sorafenib Treatment - The EVOLVE-1 Study
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to compare treatment with RAD001 plus best supportive care (BSC) to placebo plus BSC in patients with advanced HCC whose disease progressed while on or after sorafenib treatment or who are intolerant to sorafenib.
Study identification
- NCT ID
- NCT01035229
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 546 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Apr 2010 (Type not available)
- Primary completion
- Oct 2013 (Actual)
- Completion
- Oct 2013 (Actual)
- Last update posted
- Sep 22, 2016
2010 – 2013
United States locations
- U.S. sites
- 19
- U.S. states
- 14
- U.S. cities
- 18
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Highlands Oncology Group Dept of Highlands Oncology Grp | Fayetteville | Arkansas | 72703 | — |
| Compassionate Cancer Care Medical Group CCCMG | Fountain Valley | California | 92708 | — |
| University of California San Diego - Moores Cancer Center SC - 3 | La Jolla | California | 92093-0658 | — |
| California Pacific Medical Center California Pacific Med | San Francisco | California | 94120-7999 | — |
| Rocky Mountain Cancer Centers RMCC - Denver-Midtown (4) | Greenwood Village | Colorado | — | — |
| Queen's Medical Center Queens Cancer Center | Honolulu | Hawaii | 96817 | — |
| The Sidney Kimmel Cancer Center at Johns Hopkins Hospital Dept. of SKCC @ JHU | Baltimore | Maryland | 21287-0013 | — |
| Massachusetts General Hospital Dept. of Mass General Hospital | Boston | Massachusetts | 02114 | — |
| Midwest Cancer Care Physicians Research Medical Center | Kansas City | Missouri | 64131 | — |
| VA Sierra Nevada Health Care System Dept. of VA Sierra Nevada HCS | Reno | Nevada | 89502 | — |
| University of Rochester Medical Center Rochester | Rochester | New York | 14642 | — |
| Northwest Cancer Specialists Rose Quarter Cancer Center | Portland | Oregon | 97210 | — |
| St. Luke's Hospital and Health Network St. Luke's Cancer Network (2) | Bethlehem | Pennsylvania | — | — |
| Texas Cancer Center - Abilene | Abilene | Texas | 79606 | — |
| Methodist Charlton Cancer Center Methodist | Dallas | Texas | 75237 | — |
| University of Texas Southwestern Medical Center DeptofSimmons Cancer Center(3) | Dallas | Texas | 75390-8527 | — |
| Cancer Care Centers of South Texas / HOAST CCC of So. TX- San Antonio | San Antonio | Texas | 78229 | — |
| Blue Ridge Research Center at Roanoke Neurological Center Blue Ridge Cancer Care | Roanoke | Virginia | 24018 | — |
| University of Washington Cancer Care SC | Seattle | Washington | 98109-1023 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 112 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT01035229, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 22, 2016 · Synced Oct 18, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT01035229 live on ClinicalTrials.gov.