Rates of Gastric Ulcer by Endoscopy in Knee Osteoarthritis Patients Receiving LT-NS001 Versus Naprosyn®
Public ClinicalTrials.gov record NCT01063920. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Double-Blind, Double-Dummy, Randomized, Active-Comparator, Non-Inferiority Study of LT-NS001 Versus Naprosyn® for Twelve Weeks in Osteoarthritis Patients to Compare Endoscopic Gastric Ulcer Rates
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
LT-NS001 is a prodrug of Naproxen, which is inactive as a cox inhibitor while intact and is rapidly metabolized to Naproxen once absorbed. This trial will compare the rate of gastric ulcer by endoscopy over three months in patients with knee osteoarthritis, with patients receiving either LT-NS001 at a dose which provides comparable dose levels of Naproxen, or Naprosyn® 500mg (an approved treatment for OA).
Study identification
- NCT ID
- NCT01063920
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2, Phase 3
- Enrollment
- 534 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 45 Years to 80 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Feb 2010 (Type not available)
- Primary completion
- Nov 2010 (Actual)
- Completion
- Nov 2010 (Actual)
- Last update posted
- Jan 24, 2011
2010
United States locations
- U.S. sites
- 65
- U.S. states
- 23
- U.S. cities
- 54
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Greystone Medical Research, LLC | Birmingham | Alabama | 35242 | — |
| Clinical Research Associates | Huntsville | Alabama | 35801 | — |
| Radiant Research | Chandler | Arizona | 85225 | — |
| Dedicated Clinical Research Inc. | Surprise | Arizona | 85340 | — |
| Radiant Research Inc. | Tucson | Arizona | 85710 | — |
| Adobe Gastroenterology Research, LLC | Tucson | Arizona | 85712 | — |
| Genova Clinical Research Inc. | Tucson | Arizona | 85741 | — |
| Lynn Institute of the Ozarks | Little Rock | Arkansas | 72205 | — |
| Orange County Clinical Trials | Anaheim | California | 92801 | — |
| Theresa Sligh, MD | Burbank | California | 91505 | — |
| Torrance Clinical Research | Lomeita | California | 90274 | — |
| West Gastroenterology Associates | Los Angeles | California | 90045 | — |
| Facey Medical Center | Mission Hills | California | 91345 | — |
| Desert Medical Group | Palm Springs | California | 92262 | — |
| Medical Affiliated Research Center Inc. | San Diego | California | 35801 | — |
| Cynthia Schaeffer, MD | San Diego | California | 92114 | — |
| Medical Associates Research Group | San Diego | California | 92123 | — |
| Lynn Institute of the Rockies | Colorado Springs | Colorado | 80907 | — |
| Rocky Mountain Center for Clinical Research | Wheat Ridge | Colorado | 80033 | — |
| Eastern Clinical Research Unit | Hialeah | Florida | 33013 | — |
| Nature Coast Clinical Research | Inverness | Florida | 33452 | — |
| Drug Study Institute | Jupiter | Florida | 33458 | — |
| University Clinical Research Inc. | Pembroke Pines | Florida | 33024 | — |
| Radiant Research | Pinellas Park | Florida | 33781 | — |
| Accord Clinical Research LLC | Port Orange | Florida | 32129 | — |
| Miami Research Associates | South Miami | Florida | 33143 | — |
| Palm Beach Research Center | West Palm Beach | Florida | 33409 | — |
| Gold Coast Research LLC | Weston | Florida | 33317 | — |
| Thomas Schnitzer, MD | Chicago | Illinois | 60611 | — |
| Welborn Clinic | Evansville | Indiana | 47710 | — |
| MediSphere Medical Research Center LLC | Evansville | Indiana | 47714 | — |
| Venture Resource Group Inc. | Mission | Kansas | 66202 | — |
| Pinnacle Medical Research | Overland Park | Kansas | 66215 | — |
| Delta Research Partners LLC | Bastrop | Louisiana | 71201 | — |
| SNBL Clinical Pharmacology Center | Baltimore | Maryland | 21201 | — |
| Metropolitan Gastroenterolgy Group PC | Chevy Chase | Maryland | 20815 | — |
| Arthritis and Osteoporosis Cener of Maryland | Frederick | Maryland | 21702 | — |
| MidAtlantic Medical Research Centers/Bean Medical Center | Hollywood | Maryland | 20636 | — |
| Dynamic Clinical Research | Kansas City | Missouri | 64114 | — |
| Sundance Clinical Research | St Louis | Missouri | 63141 | — |
| Montana Health Research Institute Inc. | Billings | Montana | 59102 | — |
| Advanced Biomedical Research of America | Las Vegas | Nevada | 89123 | — |
| Affiliated Clinical Research Inc. | Las Vegas | Nevada | 89144 | — |
| Clifton-Wallington Medical Group | Clifton | New Jersey | 07013 | — |
| Research Across America | New York | New York | 10022 | — |
| Allergy Asthma Immunology of Rochester Research Center | Rochester | New York | 14618 | — |
| Carolina Digestive Health Associates PA | Charlotte | North Carolina | 28075 | — |
| Peters Medical Research LLC | High Point | North Carolina | 27262 | — |
| Wake Research Associates | Raleigh | North Carolina | 27612 | — |
| Radiant Research-Akron | Akron | Ohio | 44311 | — |
| Consultants for Clinical Research | Cincinnati | Ohio | 45219 | — |
| Health Research of Oklahoma | Oklahoma City | Oklahoma | 73103 | — |
| Lynn Health Science Institute | Oklahoma City | Oklahoma | 73112 | — |
| Sooner Clinical Research | Oklahoma City | Oklahoma | 73112 | — |
| Clinical Research Associates LLC | Oklahoma City | Oklahoma | 73116 | — |
| Keith Klatt, MD | Portland | Oregon | 97739 | — |
| Altoona Center for Clinical Research | Duncansville | Pennsylvania | 16635 | — |
| Corsicana Medical Research PLLC | Corsicana | Texas | 75110 | — |
| Galenos Research | Dallas | Texas | 75251 | — |
| Clinical Trial Network | Houston | Texas | 77074 | — |
| Houston Endoscopy and Research Center | Houston | Texas | 77079 | — |
| Houston Medical Research Associates | Houston | Texas | 77090 | — |
| Quality Research Inc. | San Antonio | Texas | 78209 | — |
| Arthritis and Osteoporosis Clinic Research Center of Central Texas | Waco | Texas | 76708 | — |
| Physicians Research Options LLC | Draper | Utah | 84020 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT01063920, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jan 24, 2011 · Synced Oct 24, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT01063920 live on ClinicalTrials.gov.