ARQ 197 in Combination With Chemotherapy in Patients With Metastatic Colorectal Cancer
Public ClinicalTrials.gov record NCT01075048. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Placebo-Controlled, Phase 1/2 Study Of ARQ 197 in Combination With Irinotecan and Cetuximab in Subjects With Metastatic Colorectal Cancer With Wild-type KRAS Who Have Received Front-Line Systemic Therapy
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
ARQ 197 or placebo in combination with irinotecan and cetuximab in participants with metastatic colorectal cancer (CRC), in participants with wild-type KRAS alleles who have failed front-line systemic therapy, to evaluate the safety, tolerability, and efficacy of ARQ 197, define the recommended dose for Phase 2. After the recommended dose is determined for Phase 2, participants receive study drug or placebo with irinotecan and cetuximab.
Study identification
- NCT ID
- NCT01075048
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 1, Phase 2
- Enrollment
- 131 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jan 25, 2010
- Primary completion
- Oct 11, 2012
- Completion
- Feb 19, 2015
- Last update posted
- Apr 7, 2021
2010 – 2015
United States locations
- U.S. sites
- 24
- U.S. states
- 15
- U.S. cities
- 24
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Not listed | Beverly Hills | California | 90211-1850 | — |
| Not listed | Encinitas | California | 92024 | — |
| Not listed | Fountain Valley | California | 92708 | — |
| Not listed | Riverside | California | 92501 | — |
| Not listed | Fort Collins | Colorado | 80528 | — |
| Not listed | Norwich | Connecticut | 06360 | — |
| Not listed | Boynton Beach | Florida | 33435 | — |
| Not listed | Fort Myers | Florida | 33916 | — |
| Not listed | Orlando | Florida | 32836 | — |
| Not listed | Centralia | Illinois | 62801 | — |
| Not listed | Metairie | Louisiana | 70006 | — |
| Not listed | Baltimore | Maryland | 21237 | — |
| Not listed | Hagerstown | Maryland | 21740 | — |
| Not listed | Omaha | Nebraska | 68114 | — |
| Not listed | Buffalo | New York | 14263 | — |
| Not listed | Lake Success | New York | 11042 | — |
| Not listed | Canton | Ohio | 44718 | — |
| Not listed | Cincinnati | Ohio | 45242 | — |
| Not listed | Oklahoma City | Oklahoma | 73104 | — |
| Not listed | Charleston | South Carolina | 29403 | — |
| Not listed | Columbia | South Carolina | 29210 | — |
| Not listed | Nashville | Tennessee | 372203 | — |
| Not listed | Houston | Texas | 77030 | — |
| Not listed | Seattle | Washington | 98104 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 16 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT01075048, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 7, 2021 · Synced Sep 5, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT01075048 live on ClinicalTrials.gov.