Study of Denosumab as Adjuvant Treatment for Women With High Risk Early Breast Cancer Receiving Neoadjuvant or Adjuvant Therapy (D-CARE)
Public ClinicalTrials.gov record NCT01077154. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Double-Blind, Placebo-Controlled, Multi-Center Phase 3 Study of Denosumab as Adjuvant Treatment for Women With Early-Stage Breast Cancer at High Risk of Recurrence (D-CARE)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This randomized phase 3 trial is studying the effect of denosumab to see if it can prevent disease recurrence in the bone or in any other part of the body, when it is given as adjuvant therapy for women with early-stage breast cancer, who are at high risk of disease recurrence.
Study identification
- NCT ID
- NCT01077154
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 4,509 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- Female
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 2, 2010 (Actual)
- Primary completion
- Aug 31, 2017 (Actual)
- Completion
- Mar 26, 2018 (Actual)
- Last update posted
- Sep 28, 2021
2010 – 2018
United States locations
- U.S. sites
- 93
- U.S. states
- 35
- U.S. cities
- 84
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Research Site | Birmingham | Alabama | 35205 | — |
| Research Site | Tucson | Arizona | 85724 | — |
| Research Site | Jonesboro | Arkansas | 72401 | — |
| Research Site | Alhambra | California | 91801 | — |
| Research Site | Anaheim | California | 92801 | — |
| Research Site | Beverly Hills | California | 90211 | — |
| Research Site | Campbell | California | 95008 | — |
| Research Site | Fresno | California | 93720 | — |
| Research Site | Fullerton | California | 92835 | — |
| Research Site | La Verne | California | 91750 | — |
| Research Site | Lancaster | California | 93534 | — |
| Research Site | Long Beach | California | 90813 | — |
| Research Site | Los Angeles | California | 90024 | — |
| Research Site | Los Angeles | California | 90025 | — |
| Research Site | Los Angeles | California | 90095-1772 | — |
| Research Site | Northridge | California | 91328 | — |
| Research Site | Redondo Beach | California | 90277 | — |
| Research Site | Santa Barbara | California | 93105 | — |
| Research Site | Santa Maria | California | 93454 | — |
| Research Site | Torrance | California | 90502 | — |
| Research Site | Denver | Colorado | 80220 | — |
| Research Site | Grand Junction | Colorado | 81501 | — |
| Research Site | New Haven | Connecticut | 06510 | — |
| Research Site | Boynton Beach | Florida | 33435 | — |
| Research Site | Coral Springs | Florida | 33065 | — |
| Research Site | Fort Lauderdale | Florida | 33316 | — |
| Research Site | Hollywood | Florida | 33021 | — |
| Research Site | Jacksonville | Florida | 32256 | — |
| Research Site | Melbourne | Florida | 32901 | — |
| Research Site | Athens | Georgia | 30607 | — |
| Research Site | Niles | Illinois | 60714 | — |
| Research Site | Indianapolis | Indiana | 46260 | — |
| Research Site | Cedar Rapids | Iowa | 52402 | — |
| Research Site | Hutchinson | Kansas | 67502 | — |
| Research Site | Wichita | Kansas | 67214 | — |
| Research Site | Paducah | Kentucky | 42003 | — |
| Research Site | Annapolis | Maryland | 21401 | — |
| Research Site | Baltimore | Maryland | 21201 | — |
| Research Site | Bethesda | Maryland | 20817 | — |
| Research Site | Columbia | Maryland | 21044 | — |
| Research Site | Boston | Massachusetts | 02114 | — |
| Research Site | Danvers | Massachusetts | 01923 | — |
| Research Site | Ann Arbor | Michigan | 48109 | — |
| Research Site | Detroit | Michigan | 48201 | — |
| Research Site | Edina | Minnesota | 55435 | — |
| Research Site | Minneapolis | Minnesota | 55407 | — |
| Research Site | Saint Louis Park | Minnesota | 55426 | — |
| Research Site | Jackson | Mississippi | 39202 | — |
| Research Site | Jefferson City | Missouri | 65109 | — |
| Research Site | Lincoln | Nebraska | 68510 | — |
| Research Site | Henderson | Nevada | 89052 | — |
| Research Site | Lebanon | New Hampshire | 03756-0001 | — |
| Research Site | Denville | New Jersey | 07834 | — |
| Research Site | Hackensack | New Jersey | 07601 | — |
| Research Site | East Setauket | New York | 11733 | — |
| Research Site | New York | New York | 10003 | — |
| Research Site | New York | New York | 10029 | — |
| Research Site | New York | New York | 10032 | — |
| Research Site | Nyack | New York | 10960 | — |
| Research Site | Asheville | North Carolina | 28806 | — |
| Research Site | High Point | North Carolina | 27262 | — |
| Research Site | Cincinnati | Ohio | 45242 | — |
| Research Site | Columbus | Ohio | 43210 | — |
| Research Site | Tulsa | Oklahoma | 74136 | — |
| Research Site | Hershey | Pennsylvania | 17033 | — |
| Research Site | Pittsburgh | Pennsylvania | 15213 | — |
| Research Site | Pawtucket | Rhode Island | 02860 | — |
| Research Site | Charleston | South Carolina | 29414 | — |
| Research Site | Columbia | South Carolina | 29210 | — |
| Research Site | Hilton Head Island | South Carolina | 29926 | — |
| Research Site | Sioux Falls | South Dakota | 57105 | — |
| Research Site | Chattanooga | Tennessee | 37404 | — |
| Research Site | Germantown | Tennessee | 38138 | — |
| Research Site | Nashville | Tennessee | 37203 | — |
| Research Site | Abilene | Texas | 79606-5208 | — |
| Research Site | Corpus Christi | Texas | 78463 | — |
| Research Site | Dallas | Texas | 75230-2510 | — |
| Research Site | Dallas | Texas | 75246 | — |
| Research Site | Dallas | Texas | 75390 | — |
| Research Site | El Paso | Texas | 79902 | — |
| Research Site | Garland | Texas | 75042 | — |
| Research Site | Houston | Texas | 77024 | — |
| Research Site | Houston | Texas | 77030 | — |
| Research Site | Plano | Texas | 75075 | — |
| Research Site | San Antonio | Texas | 78217 | — |
| Research Site | San Antonio | Texas | 78229 | — |
| Research Site | Tyler | Texas | 75702 | — |
| Research Site | Richlands | Virginia | 24641 | — |
| Research Site | Richmond | Virginia | 23230 | — |
| Research Site | Roanoke | Virginia | 24014 | — |
| Research Site | Seattle | Washington | 98109-1023 | — |
| Research Site | Seattle | Washington | 98133 | — |
| Research Site | Tacoma | Washington | 98405 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 366 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT01077154, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 28, 2021 · Synced Oct 23, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT01077154 live on ClinicalTrials.gov.