Efficacy And Safety Study Of Tanezumab Subcutaneous Administration In Osteoarthritis - A Subcutaneous/Intravenous Bridging Study
Public ClinicalTrials.gov record NCT01089725. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A PHASE 3, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, MULTICENTER STUDY OF THE ANALGESIC EFFICACY AND SAFETY OF SUBCUTANEOUS ADMINISTRATION OF TANEZUMAB IN PATIENTS WITH OSTEOARTHRITIS OF THE KNEE.
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is an efficacy and safety study of 3 doses (2.5 mg, 5 mg and 10mg) of tanezumab administered subcutaneously versus placebo. This study will also compare a subcutaneous (SC) administration of 10 mg of tanezumab) with an intravenous (IV) administration of 10 mg of tanezumab. Each person will receive an IV infusion and a SC infusion. The study will last 16 weeks for those who wish to enter a 64-week extension study or 24 weeks for those who do not.
Study identification
- NCT ID
- NCT01089725
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 385 participants
Conditions and interventions
Conditions
Interventions
- Placebo IV Biological
- Placebo SC Biological
- Tanezumab SC Biological
- Tanezumab IV Biological
Biological
Eligibility (public fields only)
- Age range
- 18 Years to 99 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 30, 2010 (Actual)
- Primary completion
- Nov 8, 2010 (Actual)
- Completion
- Feb 18, 2011 (Actual)
- Last update posted
- May 5, 2021
2010 – 2011
United States locations
- U.S. sites
- 91
- U.S. states
- 33
- U.S. cities
- 67
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Vaughn H. Mancha, Jr., MD, PC | Montgomery | Alabama | 36117 | — |
| Novara Clinical Research | Mesa | Arizona | 85206 | — |
| Redpoint Research | Phoenix | Arizona | 85029 | — |
| Advanced Clinical Research Institute | Anaheim | California | 92801 | — |
| West Coast Radiology Center | Anaheim | California | 92801 | — |
| Providence Clinical Research | Burbank | California | 91505 | — |
| Valley Research | Fresno | California | 93720 | — |
| Allergy and Rheumatology Medical Clinic, Inc. | La Jolla | California | 92037-1233 | — |
| Triwest Research Associates | La Mesa | California | 91942 | — |
| Synergy Clinical Research Center | National City | California | 91950 | — |
| Benchmark Research | Sacramento | California | 95816 | — |
| Probe Clinical Research Corp. | Santa Ana | California | 92701 | — |
| Trinity Clinical Trials | Santa Ana | California | 92701 | — |
| FMC Clinical Trials | Upland | California | 91786 | — |
| Colorado Hematology | Englewood | Colorado | 80110 | — |
| Colorado Orthopedic Consultants, P.C. | Englewood | Colorado | 80110 | — |
| Stamford Therapeutics Consortium | Stamford | Connecticut | 06905 | — |
| Office of Cynthia Morgan, MD | Washington D.C. | District of Columbia | 20003 | — |
| Innovative Research of West Florida, Inc. | Clearwater | Florida | 33756 | — |
| Nature Coast Clinical Research | Crystal River | Florida | 34429 | — |
| Fleming Island Center for Clinical Research | Fleming Island | Florida | 32003 | — |
| Westside Center for Clinical Research | Jacksonville | Florida | 32205 | — |
| Jacksonville Center for Clinical Research | Jacksonville | Florida | 32216 | — |
| BayCare Outpatient Imaging at Bardmoor | Largo | Florida | 33777 | — |
| Sunshine Research Center | Opa-locka | Florida | 33054 | — |
| DMI Research, Inc. | Pinellas Park | Florida | 33782 | — |
| St. Petersburg Arthritis Center | St. Petersburg | Florida | 33710 | — |
| North Georgia Clinical Research | Woodstock | Georgia | 30189 | — |
| North Georgia Internal Medicine | Woodstock | Georgia | 30189 | — |
| East-West Medical Research Institute | Honolulu | Hawaii | 96814 | — |
| Sonoma Clinical Research, LLC. | Boise | Idaho | 83702 | — |
| Sonora Clinical Research | Boise | Idaho | 83702 | — |
| Apex Medical Research, AMR, Inc. | Chicago | Illinois | 60616 | — |
| Professional Research Network of Kansas, LLC | Wichita | Kansas | 67203 | — |
| Wichita Clinic PA | Wichita | Kansas | 67208 | — |
| Bluegrass Community Research, Inc. | Lexington | Kentucky | 40504 | — |
| BenchMark Research | Metairie | Louisiana | 70006 | — |
| Arthritis Treatment Center | Frederick | Maryland | 21702 | — |
| The Center for Rheumatology and Bone Research | Wheaton | Maryland | 20902 | — |
| Beacon Clinical Research, LLC | Brockton | Massachusetts | 02301 | — |
| Clinical Pharmacology Study Group | Worcester | Massachusetts | 01610 | — |
| Ann Arbor Clinical Reserch | Ann Arbor | Michigan | 48103 | — |
| Troy Internal Medicine, PC | Troy | Michigan | 48098 | — |
| Arthritis Associates, PLLC | Hattiesburg | Mississippi | 39402 | — |
| Billings Clinic Infusion Center | Billings | Montana | 59101 | — |
| Billings Clinic Research Center | Billings | Montana | 59101 | — |
| Physician Research Collaboration, LLC | Lincoln | Nebraska | 68516 | — |
| Midwest Minor Medical | Omaha | Nebraska | 68114 | — |
| Quality Clinical Research, Inc. | Omaha | Nebraska | 68114 | — |
| Midwest Minor Medical | Omaha | Nebraska | 68127 | — |
| Midwest Minor Medical | Omaha | Nebraska | 68144 | — |
| G. Timothy Kelly, MD | Las Vegas | Nevada | 89128 | — |
| Andrew Porges, MD, PC | Roslyn | New York | 11576 | — |
| PMG Research of Charlotte | Charlotte | North Carolina | 28209-3734 | — |
| Greensboro Imaging | Greensboro | North Carolina | 27407 | — |
| Pharmquest | Greensboro | North Carolina | 27408 | — |
| Wake Internal Medicine Consultants, Inc. | Raleigh | North Carolina | 27612 | — |
| Wake Research Associates, LLC | Raleigh | North Carolina | 27612 | — |
| Community Research | Cincinnati | Ohio | 45245 | — |
| Sterling Research Group, Ltd. | Cincinnati | Ohio | 45246 | — |
| LION Research | Norman | Oklahoma | 73069 | — |
| McBride Clinic | Norman | Oklahoma | 73072 | — |
| Health Research Institute | Oklahoma City | Oklahoma | 73109 | — |
| Altoona Center for Clinical Research | Duncansville | Pennsylvania | 16635 | — |
| Lebanon Internal Medicine Associates | Lebanon | Pennsylvania | 17042 | — |
| Founders Research Corporation | Philadelphia | Pennsylvania | 19152 | — |
| Clinical Research Center of Reading, LLP | Wyomissing | Pennsylvania | 19610 | — |
| Coastal Carolina Research Center | Mt. Pleasant | South Carolina | 29464 | — |
| Health Concepts | Rapid City | South Dakota | 57702 | — |
| SoFHA Clinical Research | Johnson City | Tennessee | 37604 | — |
| FutureSearch Trials of Neurology | Austin | Texas | 78731 | — |
| Tekton Research, Inc. | Austin | Texas | 78745 | — |
| Tekton Research, Inc | Austin | Texas | 78745 | — |
| Westbury Medical Clinic | Houston | Texas | 77005 | — |
| Asif Cochinwala, MD, P.A. | Houston | Texas | 77008 | — |
| Accurate Clinical Research | Houston | Texas | 77034 | — |
| Mercury Clinical Research | Houston | Texas | 77036 | — |
| Pioneer Research Solutions, Inc | Houston | Texas | 77036 | — |
| Clinical Trial Network | Houston | Texas | 77074 | — |
| Houston Institute for Clinical Research | Houston | Texas | 77074 | — |
| Little York Medical Center | Houston | Texas | 77093 | — |
| Internist Associates of Texas | Kingwood | Texas | 77339 | — |
| Accurate Clinical Research Inc | Nassau Bay | Texas | 77058 | — |
| Clinical Investigations of Texas, LLC | Plano | Texas | 75075 | — |
| Benchmark Research | San Angelo | Texas | 76904 | — |
| Pioneer Research Solutions, Inc | Sugar Land | Texas | 77479 | — |
| Grayline Clinical Drug Trials | Wichita Falls | Texas | 76309 | — |
| Advanced Clinical Research | West Jordan | Utah | 84088 | — |
| Charlottesville Medical Research | Charlottesville | Virginia | 22911 | — |
| Hypothe Test, LLC | Roanoke | Virginia | 24018 | — |
| Mountain State Clinical Research | Clarksburg | West Virginia | 26301 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT01089725, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 5, 2021 · Synced Oct 20, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT01089725 live on ClinicalTrials.gov.