Selexipag (ACT-293987) in Pulmonary Arterial Hypertension
Public ClinicalTrials.gov record NCT01106014. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Multicenter, Double-blind, Placebo-controlled Phase 3 Study Assessing the Safety and Efficacy of Selexipag on Morbidity and Mortality in Patients With Pulmonary Arterial Hypertension
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The AC-065A302 (GRIPHON) study is an event-driven Phase 3 study to demonstrate the effect of selexipag on time to first morbidity or mortality event in patients with pulmonary arterial hypertension.
Study identification
- NCT ID
- NCT01106014
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 1,156 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 75 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 1, 2009 (Actual)
- Primary completion
- Apr 1, 2014 (Actual)
- Completion
- Oct 1, 2014 (Actual)
- Last update posted
- Oct 27, 2025
2009 – 2014
United States locations
- U.S. sites
- 43
- U.S. states
- 22
- U.S. cities
- 35
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of South Alabama | Mobile | Alabama | 36617 | — |
| The University of Arizona, Clinical and Translational Science (CATS) Research Center | Tucson | Arizona | 85704 | — |
| University of California San Diego Medical Center (La Jolla) | La Jolla | California | 92037 | — |
| Cedars-Sinai Medical Center | Los Angeles | California | 90048 | — |
| GLVA Healthcare Center | Los Angeles | California | 90073 | — |
| University of California, Davis, UC Davis Medical Center | Sacramento | California | 95817 | — |
| LIU Center for Pulmonary Hypertension | Torrance | California | 90502-2006 | — |
| Lung Health & Sleep Emhancement Center, LLC | Newark | Delaware | 19713 | — |
| Emory University School of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine | Atlanta | Georgia | 30322 | — |
| Georgia Health Sciences University | Augusta | Georgia | 30912-3135 | — |
| Georgia Clinical Research | Austell | Georgia | 30106 | — |
| Clarian North Hospital | Carmel | Indiana | 46032 | — |
| University of Iowa Hospitals & Clinics | Iowa City | Iowa | 52242 | — |
| Kentuckiana Pulmonary Associates | Louisville | Kentucky | 40202 | — |
| LSU Health Science Center - New Orleans | New Orleans | Louisiana | 70112 | — |
| Johns Hopkins University School of Medicine | Baltimore | Maryland | 21205 | — |
| Tufts Medical Center | Boston | Massachusetts | 02111 | — |
| Massachusetts General Hospital - Pulmonary Critical Care Unit | Boston | Massachusetts | 02114 | — |
| Massachusetts General Hospital-Pulmonary Critical Care Unit | Boston | Massachusetts | 02114 | — |
| Boston University School of Medicine / Boston University Medical Center | Boston | Massachusetts | 02118 | — |
| University of Michigan | Ann Arbor | Michigan | 48109 | — |
| Henry Ford Hospital | Detroit | Michigan | 48202 | — |
| Beaumont Hospital | Troy | Michigan | 48307 | — |
| Washington University School of Medicine | St Louis | Missouri | 63110 | — |
| Newark Beth Isreal Medical Center-Department of Pulmonary Medicine | Newark | New Jersey | 07112 | — |
| Columbia University Medical Center, Pediatric Cardiology | New York | New York | 10032 | — |
| Montefiore Medical Center, Weiler Division | The Bronx | New York | 10461 | — |
| Duke University Medical Center | Durham | North Carolina | 27710-0001 | — |
| The Lindner Clinical Trial Center | Cincinnati | Ohio | 45219-2906 | — |
| University of Cincinnati | Cincinnati | Ohio | 45267 | — |
| University Hospitals Case Medical Center | Cleveland | Ohio | 44106 | — |
| The Ohio State University Medical Center | Columbus | Ohio | 43221 | — |
| Oregon Pulmonary Associates, PC | Portland | Oregon | 97225 | — |
| Central Bucks Specialists | Doylestown | Pennsylvania | 18901 | — |
| Penn Presbyterian Medical Center | Philadelphia | Pennsylvania | 19104 | — |
| Thomas Jefferson University Hospital | Philadelphia | Pennsylvania | 19107 | — |
| Vanderbilt Medical Center | Nashville | Tennessee | 37232-2386 | — |
| UT Southwestern Medical Center at Dallas | Dallas | Texas | 75390 | — |
| Baylor College of Medicine | Houston | Texas | 77030 | — |
| University of Texas-Houston Health Center Department of Pulmonary & Critical Care | Houston | Texas | 77030 | — |
| University of Wisconsin Hospital-Department of Medicine | Madison | Wisconsin | 53792 | — |
| St. Luke's Medical Center | Milwaukee | Wisconsin | 53215 | — |
| Froedtert Hospital - Medical College of Wisconsin | Milwaukee | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 139 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT01106014, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 27, 2025 · Synced Oct 17, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT01106014 live on ClinicalTrials.gov.