Apitox, Honeybee Toxin for Pain and Inflammation of Osteoarthritis
Public ClinicalTrials.gov record NCT01112722. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Multicenter, Randomized, Double Blind, Active Controlled, Parallel Group, Clinical Study, to Evaluate the Safety and Efficacy of Apitox vs Histamine in Subjects With Refractory Osteoarthritis Pain and Inflammation of the Knee
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The study will identify the efficacy of Apitox, purified honeybee toxin, in 330 patients with diagnosed osteoarthritis of the knee. The subjects will be evaluated for relief of pain using Western Ontario and McMaster Osteoarthritis Index (WOMAC) and Physician and Patient Global Assessments and primary efficacy measure of relief of pain and inflammation over a 12 week treatment period after randomization into the trial. Secondary efficacy is improvement of mobility Treatment effect will be compared in a 2-1 Apitox vs active control
Study identification
- NCT ID
- NCT01112722
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 363 participants
Conditions and interventions
Conditions
Interventions
- Apitox, purified honeybee toxin, lyophilized in saline Biological
- histamine Biological
Biological
Eligibility (public fields only)
- Age range
- 30 Years to 85 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 2013 (Type not available)
- Primary completion
- Nov 2016 (Actual)
- Completion
- Dec 2016 (Actual)
- Last update posted
- Dec 13, 2016
2013 – 2016
United States locations
- U.S. sites
- 15
- U.S. states
- 9
- U.S. cities
- 14
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Functional Research LLC | Gulf Shores | Alabama | 36542 | — |
| Tucson Orthopaedic Institute | Tucson | Arizona | 87512 | — |
| SC Clinical Research Inc. | Garden Grove | California | 92844 | — |
| Axis Clinical Trials | Los Angeles | California | 90036 | — |
| Westlake Medical Research | Thousand Oaks | California | 91360 | — |
| SC Clinical Research Inc. | Upland | California | 91786 | — |
| Schrock Orthopedics Research | Fort Lauderdale | Florida | 33316 | — |
| AppleMed Research Inc. | Miami | Florida | 33155 | — |
| Radiant Research Inc. | Pinellas Park | Florida | 33781 | — |
| Beacon Clinical | Brockton | Massachusetts | 02301 | — |
| Radiant Research Inc Columbus | Columbus | Ohio | 43212 | — |
| Hillcrest Clinical Research | Olahoma City | Oklahoma | 73119 | — |
| PMG Research of Knoxville | Knoxville | Tennessee | 37912 | — |
| PMG Research of Knoxville | Knoxville | Tennessee | 37938 | — |
| Tekton Research | Austin | Texas | 78745 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT01112722, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Dec 13, 2016 · Synced Nov 3, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT01112722 live on ClinicalTrials.gov.