ClinicalTrials.gov record
Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With Stage IV Melanoma
ClinicalTrials.gov ID: NCT01120275
Public ClinicalTrials.gov record NCT01120275. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Phase II Study of RO4929097 (NSC-749225) in Advanced Melanoma
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This phase II trial is studying how well gamma-secretase/Notch signalling pathway inhibitor RO4929097 works in treating patients with stage IV melanoma. Gamma-secretase/Notch signalling pathway inhibitor RO4929097 may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.
Study identification
- NCT ID
- NCT01120275
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 36 participants
Conditions and interventions
Conditions
Interventions
- gamma-secretase/Notch signalling pathway inhibitor RO4929097 Drug
- laboratory biomarker analysis Other
Drug · Other
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Oct 2010 (Type not available)
- Primary completion
- May 2013 (Actual)
- Completion
- Aug 2015 (Actual)
- Last update posted
- Jun 14, 2016
2010 – 2015
United States locations
- U.S. sites
- 178
- U.S. states
- 29
- U.S. cities
- 127
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Providence Hospital | Mobile | Alabama | 36608 | — |
| Fairbanks Memorial Hospital | Fairbanks | Alaska | 99701 | — |
| University of Arizona Health Sciences Center | Tucson | Arizona | 85724 | — |
| Saint Edward Mercy Medical Center | Fort Smith | Arkansas | 72903 | — |
| University of Arkansas for Medical Sciences | Little Rock | Arkansas | 72205 | — |
| Loma Linda University Medical Center | Loma Linda | California | 92354 | — |
| Fremont - Rideout Cancer Center | Marysville | California | 95901 | — |
| University of California Medical Center At Irvine-Orange Campus | Orange | California | 92868 | — |
| University of California at Davis Cancer Center | Sacramento | California | 95817 | — |
| Tahoe Forest Cancer Center | Truckee | California | 96161 | — |
| University of Colorado Cancer Center - Anschutz Cancer Pavilion | Aurora | Colorado | 80045 | — |
| Denver Veterans Administration Medical Center | Denver | Colorado | 80220 | — |
| Poudre Valley Hospital | Fort Collins | Colorado | 80524 | — |
| Saint Mary's Hospital and Regional Medical Center | Grand Junction | Colorado | 81502 | — |
| Saint Francis Hospital and Medical Center | Hartford | Connecticut | 06105 | — |
| Northeast Georgia Medical Center | Gainesville | Georgia | 30501 | — |
| Oncare Hawaii Inc-POB II | Honolulu | Hawaii | 96813 | — |
| Queen's Medical Center | Honolulu | Hawaii | 96813 | — |
| Straub Clinic and Hospital | Honolulu | Hawaii | 96813 | — |
| University of Hawaii | Honolulu | Hawaii | 96813 | — |
| Oncare Hawaii Inc-Kuakini | Honolulu | Hawaii | 96817 | — |
| The Cancer Center of Hawaii-Liliha | Honolulu | Hawaii | 96817 | — |
| Kapiolani Medical Center for Women and Children | Honolulu | Hawaii | 96826 | — |
| Castle Medical Center | Kailua | Hawaii | 96734 | — |
| Wilcox Memorial Hospital and Kauai Medical Clinic | Lihue | Hawaii | 96766 | — |
| Maui Memorial Medical Center | Wailuku | Hawaii | 96793 | — |
| Pali Momi Medical Center | ‘Aiea | Hawaii | 96701 | — |
| Saint Anthony's Health | Alton | Illinois | 62002 | — |
| University of Chicago | Chicago | Illinois | 60637 | — |
| Decatur Memorial Hospital | Decatur | Illinois | 62526 | — |
| Loyola University Medical Center | Maywood | Illinois | 60153 | — |
| Good Samaritan Regional Health Center | Mount Vernon | Illinois | 62864 | — |
| Memorial Medical Center | Springfield | Illinois | 62781-0001 | — |
| Saint Francis Hospital and Health Centers | Beech Grove | Indiana | 46107 | — |
| Reid Hospital and Health Care Services | Richmond | Indiana | 47374 | — |
| Genesis Medical Center - East Campus | Davenport | Iowa | 52803 | — |
| Hays Medical Center | Hays | Kansas | 67601 | — |
| Promise Regional Medical Center-Hutchinson | Hutchinson | Kansas | 65702 | — |
| University of Kansas Medical Center | Kansas City | Kansas | 66160 | — |
| Lawrence Memorial Hospital | Lawrence | Kansas | 66044 | — |
| Menorah Medical Center | Overland Park | Kansas | 66209 | — |
| Saint Luke's South Hospital | Overland Park | Kansas | 66213 | — |
| Via Christi Hospital-Pittsburg | Pittsburg | Kansas | 66762 | — |
| Kansas City CCOP | Prairie Village | Kansas | 66208 | — |
| Salina Regional Health Center | Salina | Kansas | 67401 | — |
| Shawnee Mission Medical Center | Shawnee Mission | Kansas | 66204 | — |
| Saint Francis Hospital and Medical Center - Topeka | Topeka | Kansas | 66606 | — |
| Wesley Medical Center | Wichita | Kansas | 67214 | — |
| University of Kentucky | Lexington | Kentucky | 40536 | — |
| Louisiana State University Sciences Center- Monroe | Monroe | Louisiana | 71210 | — |
| Highland Clinic | Shreveport | Louisiana | 71105 | — |
| Louisiana State University Health Sciences Center Shreveport | Shreveport | Louisiana | 71130 | — |
| Sinai Hospital of Baltimore | Baltimore | Maryland | 21215 | — |
| Saint Joseph Mercy Hospital | Ann Arbor | Michigan | 48106-0995 | — |
| Michigan Cancer Research Consortium Community Clinical Oncology Program | Ann Arbor | Michigan | 48106 | — |
| University of Michigan | Ann Arbor | Michigan | 48109 | — |
| Bronson Battle Creek | Battle Creek | Michigan | 49017 | — |
| Spectrum Health Big Rapids Hospital | Big Rapids | Michigan | 49307 | — |
| Oakwood Hospital | Dearborn | Michigan | 48124 | — |
| Wayne State University/Karmanos Cancer Institute | Detroit | Michigan | 48201 | — |
| Saint John Hospital and Medical Center | Detroit | Michigan | 48236 | — |
| Hurley Medical Center | Flint | Michigan | 48502 | — |
| Genesys Regional Medical Center-West Flint Campus | Flint | Michigan | 48532 | — |
| Grand Rapids Clinical Oncology Program | Grand Rapids | Michigan | 49503 | — |
| Mercy Health Saint Mary's | Grand Rapids | Michigan | 49503 | — |
| Spectrum Health at Butterworth Campus | Grand Rapids | Michigan | 49503 | — |
| Allegiance Health | Jackson | Michigan | 49201 | — |
| Sparrow Hospital | Lansing | Michigan | 48912 | — |
| Saint Mary Mercy Hospital | Livonia | Michigan | 48154 | — |
| Mercy Health Mercy Campus | Muskegon | Michigan | 49444 | — |
| Saint Joseph Mercy Oakland | Pontiac | Michigan | 48341-2985 | — |
| Saint Joseph Mercy Port Huron | Port Huron | Michigan | 48060 | — |
| William Beaumont Hospital-Royal Oak | Royal Oak | Michigan | 48073 | — |
| Saint Mary's of Michigan | Saginaw | Michigan | 48601 | — |
| Munson Medical Center | Traverse City | Michigan | 49684 | — |
| Saint John Macomb-Oakland Hospital | Warren | Michigan | 48093 | — |
| Metro Health Hospital | Wyoming | Michigan | 49519 | — |
| Central Care Cancer Center-Carrie J Babb Cancer Center | Bolivar | Missouri | 65613 | — |
| CoxHealth Cancer Center | Branson | Missouri | 65616 | — |
| Saint Francis Medical Center | Cape Girardeau | Missouri | 63703 | — |
| Truman Medical Center | Kansas City | Missouri | 64108 | — |
| Saint Luke's Cancer Institute | Kansas City | Missouri | 64111 | — |
| Saint Luke's Hospital of Kansas City | Kansas City | Missouri | 64111 | — |
| Saint Joseph Health Center | Kansas City | Missouri | 64114 | — |
| North Kansas City Hospital | Kansas City | Missouri | 64116 | — |
| Research Medical Center | Kansas City | Missouri | 64132 | — |
| Saint Luke's East - Lee's Summit | Lee's Summit | Missouri | 64086 | — |
| Liberty Hospital | Liberty | Missouri | 64068 | — |
| Heartland Regional Medical Center | Saint Joseph | Missouri | 64506 | — |
| Ozark Health Ventures LLC dba Cancer Research for The Ozarks Springfield | Springfield | Missouri | 65802 | — |
| Mercy Hospital Springfield | Springfield | Missouri | 65804 | — |
| CoxHealth South Hospital | Springfield | Missouri | 65807 | — |
| Saint Louis Cancer and Breast Institute-South City | St Louis | Missouri | 63109 | — |
| Saint John's Mercy Medical Center | St Louis | Missouri | 63141 | — |
| Saint Louis-Cape Girardeau CCOP | St Louis | Missouri | 63141 | — |
| Montana Cancer Consortium CCOP | Billings | Montana | 59101 | — |
| Saint Vincent Healthcare | Billings | Montana | 59101 | — |
| Hematology-Oncology Centers of the Northern Rockies PC | Billings | Montana | 59102 | — |
| Billings Clinic | Billings | Montana | 59107-7000 | — |
| Bozeman Deaconess Cancer Center | Bozeman | Montana | 59715 | — |
| Bozeman Deaconess Hospital | Bozeman | Montana | 59715 | — |
| Benefis Healthcare- Sletten Cancer Institute | Great Falls | Montana | 59405 | — |
| Great Falls Clinic | Great Falls | Montana | 59405 | — |
| Saint Peter's Community Hospital | Helena | Montana | 59601 | — |
| Glacier Oncology PLLC | Kalispell | Montana | 59901 | — |
| Kalispell Regional Medical Center | Kalispell | Montana | 59901 | — |
| Montana Cancer Specialists | Missoula | Montana | 59802 | — |
| Saint Patrick Hospital - Community Hospital | Missoula | Montana | 59802 | — |
| University Medical Center of Southern Nevada | Las Vegas | Nevada | 89102 | — |
| Nevada Cancer Research Foundation CCOP | Las Vegas | Nevada | 89106 | — |
| University of Rochester | Rochester | New York | 14642 | — |
| Mission Hospital-Memorial Campus | Asheville | North Carolina | 28801 | — |
| Novant Health Presbyterian Medical Center | Charlotte | North Carolina | 28204 | — |
| Wayne Memorial Hospital | Goldsboro | North Carolina | 27534 | — |
| Margaret R Pardee Memorial Hospital | Hendersonville | North Carolina | 28791 | — |
| Iredell Memorial Hospital | Statesville | North Carolina | 28677 | — |
| Mary Rutan Hospital | Bellefontaine | Ohio | 43311 | — |
| Adena Regional Medical Center | Chillicothe | Ohio | 45601 | — |
| Good Samaritan Hospital - Cincinnati | Cincinnati | Ohio | 45220 | — |
| University of Cincinnati | Cincinnati | Ohio | 45267 | — |
| Riverside Methodist Hospital | Columbus | Ohio | 43214 | — |
| Columbus CCOP | Columbus | Ohio | 43215 | — |
| Grant Medical Center | Columbus | Ohio | 43215 | — |
| Mount Carmel Health Center West | Columbus | Ohio | 43222 | — |
| Doctors Hospital | Columbus | Ohio | 43228 | — |
| Grandview Hospital | Dayton | Ohio | 45405 | — |
| Good Samaritan Hospital - Dayton | Dayton | Ohio | 45406 | — |
| Miami Valley Hospital | Dayton | Ohio | 45409 | — |
| Samaritan North Health Center | Dayton | Ohio | 45415 | — |
| Dayton CCOP | Dayton | Ohio | 45420 | — |
| Grady Memorial Hospital | Delaware | Ohio | 43015 | — |
| Blanchard Valley Hospital | Findlay | Ohio | 45840 | — |
| Atrium Medical Center-Middletown Regional Hospital | Franklin | Ohio | 45005-1066 | — |
| Wayne Hospital | Greenville | Ohio | 45331 | — |
| Kettering Medical Center | Kettering | Ohio | 45429 | — |
| Fairfield Medical Center | Lancaster | Ohio | 43130 | — |
| Marietta Memorial Hospital | Marietta | Ohio | 45750 | — |
| Knox Community Hospital | Mount Vernon | Ohio | 43050 | — |
| Licking Memorial Hospital | Newark | Ohio | 43055 | — |
| Springfield Regional Medical Center | Springfield | Ohio | 45505 | — |
| Upper Valley Medical Center | Troy | Ohio | 45373 | — |
| Saint Ann's Hospital | Westerville | Ohio | 43081 | — |
| Clinton Memorial Hospital | Wilmington | Ohio | 45177 | — |
| Greene Memorial Hospital | Xenia | Ohio | 45385 | — |
| Genesis HealthCare System | Zanesville | Ohio | 43701 | — |
| Adventist Medical Center | Portland | Oregon | 97216 | — |
| SWOG | Portland | Oregon | 97239 | — |
| AnMed Health Hospital | Anderson | South Carolina | 29621 | — |
| McLeod Regional Medical Center | Florence | South Carolina | 29506 | — |
| Spartanburg Regional Medical Center | Spartanburg | South Carolina | 29303 | — |
| Upstate Carolina CCOP | Spartanburg | South Carolina | 29303 | — |
| Wellmont Holston Valley Hospital and Medical Center | Kingsport | Tennessee | 37660 | — |
| Thompson Cancer Survival Center | Knoxville | Tennessee | 37916 | — |
| Danville Regional Medical Center | Danville | Virginia | 24541 | — |
| Memorial Hospital Of Martinsville | Martinsville | Virginia | 24115 | — |
| Cancer Care Center at Island Hospital | Anacortes | Washington | 98221 | — |
| PeaceHealth Saint Joseph Medical Center | Bellingham | Washington | 98225 | — |
| Harrison HealthPartners Hematology and Oncology-Bremerton | Bremerton | Washington | 98310 | — |
| Highline Medical Center-Main Campus | Burien | Washington | 98166 | — |
| Columbia Basin Hematology and Oncology PLLC | Kennewick | Washington | 99336 | — |
| Evergreen Hospital Medical Center | Kirkland | Washington | 98033 | — |
| Skagit Valley Hospital | Mount Vernon | Washington | 98274 | — |
| Harrison HealthPartners Hematology and Oncology-Poulsbo | Poulsbo | Washington | 98370 | — |
| Virginia Mason CCOP | Seattle | Washington | 98101 | — |
| Harborview Medical Center | Seattle | Washington | 98104 | — |
| Minor and James Medical PLLC | Seattle | Washington | 98104 | — |
| Pacific Medical Center-First Hill | Seattle | Washington | 98104 | — |
| Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium | Seattle | Washington | 98109 | — |
| Group Health Cooperative-Seattle | Seattle | Washington | 98112 | — |
| Swedish Medical Center-First Hill | Seattle | Washington | 98122-4307 | — |
| The Polyclinic | Seattle | Washington | 98122 | — |
| University of Washington Medical Center | Seattle | Washington | 98195 | — |
| United General Hospital | Sedro-Woolley | Washington | 98284 | — |
| Cancer Care Northwest - Spokane South | Spokane | Washington | 99202 | — |
| Evergreen Hematology and Oncology PS | Spokane | Washington | 99218 | — |
| Wenatchee Valley Medical Center | Wenatchee | Washington | 98801 | — |
| Rocky Mountain Oncology | Casper | Wyoming | 82609 | — |
| Welch Cancer Center | Sheridan | Wyoming | 82801 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT01120275, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jun 14, 2016 · Synced Oct 21, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT01120275 live on ClinicalTrials.gov.