Immune Suppression and Ventilator Associated Pneumonias

ClinicalTrials.gov ID: NCT01135277

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Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

Patients in the ICU are already predisposed to nosocomial infections, which are both costly and potentially life threatening, and it appears that the immune paralysis of sepsis may put these patients at greater risk for secondary infections, though this has not been proven conclusively. One measure of this sepsis-induced immune suppression is monocyte deactivation. The investigators hypothesize that, as a cornerstone of the monocytic innate immune response to infection, the inflammasome is critical to monocyte function during sepsis.

Study identification

NCT ID: NCT01135277
Recruitment status: Completed
Study type: Observational
Phase: Not listed
Lead sponsor: Matthew Exline; Other
Enrollment: 50 participants

Conditions and interventions

Conditions

Sepsis

Interventions

Not listed

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Feb 2010 (Type not available)
Primary completion: Nov 2012 (Actual)
Completion: Nov 2012 (Actual)
Last update posted: Sep 11, 2025

2010 – 2012

United States locations

U.S. sites: 1
U.S. states: 1
U.S. cities: 1

Facility	City	State	ZIP	Site status
The Ohio State University	Columbus	Ohio	43221	—

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT01135277, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Sep 11, 2025 · Synced Nov 14, 2026