ClinicalTrials.gov record
Paclitaxel With or Without Cixutumumab as Second-Line Therapy in Treating Patients With Metastatic Esophageal Cancer or Gastroesophageal Junction Cancer
ClinicalTrials.gov ID: NCT01142388
Public ClinicalTrials.gov record NCT01142388. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Randomized Phase II Study of Paclitaxel With or Without the Anti-IGF-IR mAb Cixutumumab (IMC-A12) as Second Line Treatment for Patients With Metastatic Esophageal or GE Junction Cancer
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This randomized phase II trial studies how well paclitaxel with or without cixutumumab works in treating patients with esophageal cancer or gastroesophageal junction cancer that has spread to other places in the body (metastatic). Drugs used in chemotherapy, such as paclitaxel, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Cixutumumab may kill cancer cells by blocking the action of a protein needed for cancer cell growth. Giving paclitaxel with or without cixutumumab may kill more tumor cells.
Study identification
- NCT ID
- NCT01142388
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 94 participants
Conditions and interventions
Conditions
- Metastatic Esophageal Adenocarcinoma
- Metastatic Esophageal Squamous Cell Carcinoma
- Metastatic Gastroesophageal Junction Adenocarcinoma
- Recurrent Esophageal Adenocarcinoma
- Recurrent Esophageal Carcinoma
- Recurrent Esophageal Squamous Cell Carcinoma
- Recurrent Gastroesophageal Junction Adenocarcinoma
- Stage IV Esophageal Cancer AJCC v7
Interventions
- Cixutumumab Biological
- Laboratory Biomarker Analysis Other
- Paclitaxel Drug
- Pharmacological Study Other
Biological · Other · Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Sep 21, 2010 (Actual)
- Primary completion
- Jul 15, 2014 (Actual)
- Completion
- Mar 31, 2027 (Estimated)
- Last update posted
- Sep 10, 2026
2010 – 2027
United States locations
- U.S. sites
- 232
- U.S. states
- 26
- U.S. cities
- 176
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Mayo Clinic in Arizona | Scottsdale | Arizona | 85259 | — |
| Stanford Cancer Institute Palo Alto | Palo Alto | California | 94304 | — |
| The Medical Center of Aurora | Aurora | Colorado | 80012 | — |
| Boulder Community Foothills Hospital | Boulder | Colorado | 80303 | — |
| Penrose-Saint Francis Healthcare | Colorado Springs | Colorado | 80907 | — |
| AdventHealth Porter | Denver | Colorado | 80210 | — |
| Presbyterian - Saint Lukes Medical Center - Health One | Denver | Colorado | 80218 | — |
| Saint Joseph Hospital - Cancer Centers of Colorado | Denver | Colorado | 80218 | — |
| Rose Medical Center | Denver | Colorado | 80220 | — |
| Western States Cancer Research NCORP | Denver | Colorado | 80222 | — |
| Swedish Medical Center | Englewood | Colorado | 80113 | — |
| Saint Mary's Hospital and Regional Medical Center | Grand Junction | Colorado | 81501 | — |
| Banner North Colorado Medical Center | Greeley | Colorado | 80631 | — |
| CommonSpirit Saint Anthony Hospital Cancer Center | Lakewood | Colorado | 80228 | — |
| AdventHealth Littleton | Littleton | Colorado | 80122 | — |
| Sky Ridge Medical Center | Lone Tree | Colorado | 80124 | — |
| Longmont United Hospital | Longmont | Colorado | 80501 | — |
| Banner North Colorado Medical Center - Loveland Campus | Loveland | Colorado | 80539 | — |
| AdventHealth Parker | Parker | Colorado | 80138 | — |
| Saint Mary Corwin Medical Center | Pueblo | Colorado | 81004 | — |
| North Suburban Medical Center | Thornton | Colorado | 80229 | — |
| Intermountain Health Lutheran Hospital | Wheat Ridge | Colorado | 80401 | — |
| Smilow Cancer Hospital Care Center at Saint Francis | Hartford | Connecticut | 06105 | — |
| Beebe Medical Center | Lewes | Delaware | 19958 | — |
| Christiana Care Health System-Christiana Hospital | Newark | Delaware | 19718 | — |
| Mayo Clinic in Florida | Jacksonville | Florida | 32224-9980 | — |
| Emory University Hospital/Winship Cancer Institute | Atlanta | Georgia | 30322 | — |
| Lewis Cancer and Research Pavilion at Saint Joseph's/Candler | Savannah | Georgia | 31405 | — |
| Saint Alphonsus Cancer Care Center-Boise | Boise | Idaho | 83706 | — |
| Rush-Copley Medical Center | Aurora | Illinois | 60504 | — |
| MacNeal Hospital and Cancer Center | Berwyn | Illinois | 60402 | — |
| OSF Saint Joseph Medical Center | Bloomington | Illinois | 61701 | — |
| Graham Hospital Association | Canton | Illinois | 61520 | — |
| Memorial Hospital | Carthage | Illinois | 62321 | — |
| Hematology and Oncology Associates | Chicago | Illinois | 60611 | — |
| Northwestern University | Chicago | Illinois | 60611 | — |
| Decatur Memorial Hospital | Decatur | Illinois | 62526 | — |
| Heartland Cancer Research NCORP | Decatur | Illinois | 62526 | — |
| Eureka Hospital | Eureka | Illinois | 61530 | — |
| Illinois CancerCare-Galesburg | Galesburg | Illinois | 61401 | — |
| Ingalls Memorial Hospital | Harvey | Illinois | 60426 | — |
| Mason District Hospital | Havana | Illinois | 62644 | — |
| Hematology Oncology Associates of Illinois-Highland Park | Highland Park | Illinois | 60035 | — |
| Hinsdale Hematology Oncology Associates Incorporated | Hinsdale | Illinois | 60521 | — |
| Duly Health and Care Joliet | Joliet | Illinois | 60435 | — |
| Presence Saint Mary's Hospital | Kankakee | Illinois | 60901 | — |
| AMG Libertyville - Oncology | Libertyville | Illinois | 60048 | — |
| Mcdonough District Hospital | Macomb | Illinois | 61455 | — |
| Trinity Medical Center | Moline | Illinois | 61265 | — |
| DuPage Medical Group-Ogden | Naperville | Illinois | 60563 | — |
| Illinois Cancer Specialists-Niles | Niles | Illinois | 60714 | — |
| Carle BroMenn Medical Center | Normal | Illinois | 61761 | — |
| Carle Cancer Institute Normal | Normal | Illinois | 61761 | — |
| Ottawa Regional Hospital and Healthcare Center | Ottawa | Illinois | 61350 | — |
| OSF Saint Francis Radiation Oncology at Pekin | Pekin | Illinois | 61554 | — |
| Proctor Hospital | Peoria | Illinois | 61614 | — |
| Illinois CancerCare-Peoria | Peoria | Illinois | 61615 | — |
| Methodist Medical Center of Illinois | Peoria | Illinois | 61636 | — |
| OSF Saint Francis Medical Center | Peoria | Illinois | 61637 | — |
| Illinois Valley Hospital | Peru | Illinois | 61354 | — |
| Perry Memorial Hospital | Princeton | Illinois | 61356 | — |
| West Suburban Medical Center | River Forest | Illinois | 60305 | — |
| Swedish American Hospital | Rockford | Illinois | 61104 | — |
| Hematology Oncology Associates of Illinois - Skokie | Skokie | Illinois | 60076 | — |
| Springfield Memorial Hospital | Springfield | Illinois | 62781 | — |
| Carle Cancer Center | Urbana | Illinois | 61801 | — |
| Elkhart General Hospital | Elkhart | Indiana | 46515 | — |
| Indiana University/Melvin and Bren Simon Cancer Center | Indianapolis | Indiana | 46202 | — |
| Richard L. Roudebush Veterans Affairs Medical Center | Indianapolis | Indiana | 46202 | — |
| Sidney and Lois Eskenazi Hospital | Indianapolis | Indiana | 46202 | — |
| IU Health Central Indiana Cancer Centers-East | Indianapolis | Indiana | 46219 | — |
| Community Howard Regional Health | Kokomo | Indiana | 46904 | — |
| IU Health La Porte Hospital | La Porte | Indiana | 46350 | — |
| Franciscan Saint Anthony Health-Michigan City | Michigan City | Indiana | 46360 | — |
| Saint Joseph Regional Medical Center-Mishawaka | Mishawaka | Indiana | 46545 | — |
| IU Health Ball Memorial Hospital | Muncie | Indiana | 47303 | — |
| Memorial Hospital of South Bend | South Bend | Indiana | 46601 | — |
| Northern Indiana Cancer Research Consortium | South Bend | Indiana | 46628 | — |
| McFarland Clinic - Ames | Ames | Iowa | 50010 | — |
| Mercy Hospital | Cedar Rapids | Iowa | 52403 | — |
| Oncology Associates at Mercy Medical Center | Cedar Rapids | Iowa | 52403 | — |
| UI Health Care Mission Cancer and Blood - West Des Moines Clinic | Clive | Iowa | 50325 | — |
| Iowa Methodist Medical Center | Des Moines | Iowa | 50309 | — |
| Iowa-Wide Oncology Research Coalition NCORP | Des Moines | Iowa | 50309 | — |
| UI Health Care Mission Cancer and Blood - Des Moines Clinic | Des Moines | Iowa | 50309 | — |
| Mercy Medical Center - Des Moines | Des Moines | Iowa | 50314 | — |
| UI Health Care Mission Cancer and Blood - Laurel Clinic | Des Moines | Iowa | 50314 | — |
| Iowa Lutheran Hospital | Des Moines | Iowa | 50316 | — |
| Mercy Medical Center - North Iowa | Mason City | Iowa | 50401 | — |
| Siouxland Regional Cancer Center | Sioux City | Iowa | 51101 | — |
| Mercy Medical Center-Sioux City | Sioux City | Iowa | 51102 | — |
| Saint Luke's Regional Medical Center | Sioux City | Iowa | 51104 | — |
| Cancer Center of Kansas - Chanute | Chanute | Kansas | 66720 | — |
| Cancer Center of Kansas - Dodge City | Dodge City | Kansas | 67801 | — |
| Cancer Center of Kansas - El Dorado | El Dorado | Kansas | 67042 | — |
| Cancer Center of Kansas - Fort Scott | Fort Scott | Kansas | 66701 | — |
| Cancer Center of Kansas-Independence | Independence | Kansas | 67301 | — |
| Cancer Center of Kansas-Kingman | Kingman | Kansas | 67068 | — |
| Lawrence Memorial Hospital | Lawrence | Kansas | 66044 | — |
| Cancer Center of Kansas-Liberal | Liberal | Kansas | 67905 | — |
| Cancer Center of Kansas - McPherson | McPherson | Kansas | 67460 | — |
| Cancer Center of Kansas - Newton | Newton | Kansas | 67114 | — |
| Cancer Center of Kansas - Parsons | Parsons | Kansas | 67357 | — |
| Cancer Center of Kansas - Pratt | Pratt | Kansas | 67124 | — |
| Cancer Center of Kansas - Salina | Salina | Kansas | 67401 | — |
| Cancer Center of Kansas - Wellington | Wellington | Kansas | 67152 | — |
| Associates In Womens Health | Wichita | Kansas | 67208 | — |
| Cancer Center of Kansas-Wichita Medical Arts Tower | Wichita | Kansas | 67208 | — |
| Ascension Via Christi Hospitals Wichita | Wichita | Kansas | 67214 | — |
| Cancer Center of Kansas - Wichita | Wichita | Kansas | 67214 | — |
| Wichita NCI Community Oncology Research Program | Wichita | Kansas | 67214 | — |
| Cancer Center of Kansas - Winfield | Winfield | Kansas | 67156 | — |
| Mary Bird Perkins Cancer Center | Baton Rouge | Louisiana | 70809 | — |
| Louisiana State University Health Science Center | New Orleans | Louisiana | 70112 | — |
| University Medical Center New Orleans | New Orleans | Louisiana | 70112 | — |
| Johns Hopkins University/Sidney Kimmel Cancer Center | Baltimore | Maryland | 21287 | — |
| Christiana Care - Union Hospital | Elkton | Maryland | 21921 | — |
| Bixby Medical Center | Adrian | Michigan | 49221 | — |
| Hickman Cancer Center | Adrian | Michigan | 49221 | — |
| Michigan Cancer Research Consortium NCORP | Ann Arbor | Michigan | 48106 | — |
| Trinity Health Saint Joseph Mercy Hospital Ann Arbor | Ann Arbor | Michigan | 48106 | — |
| Corewell Health Dearborn Hospital | Dearborn | Michigan | 48124 | — |
| Henry Ford Health Saint John Hospital | Detroit | Michigan | 48236 | — |
| Hurley Medical Center | Flint | Michigan | 48503 | — |
| Genesys Regional Medical Center-West Flint Campus | Flint | Michigan | 48532 | — |
| Allegiance Health | Jackson | Michigan | 49201 | — |
| Bronson Methodist Hospital | Kalamazoo | Michigan | 49007 | — |
| West Michigan Cancer Center | Kalamazoo | Michigan | 49007 | — |
| Beacon Kalamazoo | Kalamazoo | Michigan | 49048 | — |
| University of Michigan Health - Sparrow Lansing | Lansing | Michigan | 48912 | — |
| Trinity Health Saint Mary Mercy Livonia Hospital | Livonia | Michigan | 48154 | — |
| Mercy Memorial Hospital | Monroe | Michigan | 48162 | — |
| Toledo Clinic Cancer Centers-Monroe | Monroe | Michigan | 48162 | — |
| Trinity Health Saint Joseph Mercy Oakland Hospital | Pontiac | Michigan | 48341 | — |
| Lake Huron Medical Center | Port Huron | Michigan | 48060 | — |
| MyMichigan Medical Center Saginaw | Saginaw | Michigan | 48601 | — |
| Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center | Saint Joseph | Michigan | 49085 | — |
| Corewell Health Lakeland Hospitals - Saint Joseph Hospital | Saint Joseph | Michigan | 49085 | — |
| Henry Ford Health Warren Hospital | Warren | Michigan | 48093 | — |
| Essentia Health Saint Joseph's Medical Center | Brainerd | Minnesota | 56401 | — |
| Fairview Ridges Hospital | Burnsville | Minnesota | 55337 | — |
| Mercy Hospital | Coon Rapids | Minnesota | 55433 | — |
| Essentia Health Cancer Center | Duluth | Minnesota | 55805 | — |
| Essentia Health Saint Mary's Medical Center | Duluth | Minnesota | 55805 | — |
| Miller-Dwan Hospital | Duluth | Minnesota | 55805 | — |
| Fairview Southdale Hospital | Edina | Minnesota | 55435 | — |
| Unity Hospital | Fridley | Minnesota | 55432 | — |
| Hutchinson Area Health Care | Hutchinson | Minnesota | 55350 | — |
| Minnesota Oncology Hematology PA-Maplewood | Maplewood | Minnesota | 55109 | — |
| Saint John's Hospital - Healtheast | Maplewood | Minnesota | 55109 | — |
| Abbott-Northwestern Hospital | Minneapolis | Minnesota | 55407 | — |
| Hennepin County Medical Center | Minneapolis | Minnesota | 55415 | — |
| New Ulm Medical Center | New Ulm | Minnesota | 56073 | — |
| North Memorial Medical Health Center | Robbinsdale | Minnesota | 55422 | — |
| Mayo Clinic in Rochester | Rochester | Minnesota | 55905 | — |
| Metro Minnesota Community Oncology Research Consortium | Saint Louis Park | Minnesota | 55416 | — |
| Park Nicollet Clinic - Saint Louis Park | Saint Louis Park | Minnesota | 55416 | — |
| Regions Hospital | Saint Paul | Minnesota | 55101 | — |
| United Hospital | Saint Paul | Minnesota | 55102 | — |
| Saint Francis Regional Medical Center | Shakopee | Minnesota | 55379 | — |
| Lakeview Hospital | Stillwater | Minnesota | 55082 | — |
| Ridgeview Medical Center | Waconia | Minnesota | 55387 | — |
| Rice Memorial Hospital | Willmar | Minnesota | 56201 | — |
| Minnesota Oncology Hematology PA-Woodbury | Woodbury | Minnesota | 55125 | — |
| Nebraska Cancer Research Center | Lincoln | Nebraska | 68510 | — |
| Missouri Valley Cancer Consortium | Omaha | Nebraska | 68106 | — |
| Alegent Health Immanuel Medical Center | Omaha | Nebraska | 68122 | — |
| Alegent Health Bergan Mercy Medical Center | Omaha | Nebraska | 68124 | — |
| Alegent Health Lakeside Hospital | Omaha | Nebraska | 68130 | — |
| Cooper Hospital University Medical Center | Camden | New Jersey | 08103 | — |
| Veterans Adminstration New Jersey Health Care System | East Orange | New Jersey | 07018-1095 | — |
| CentraState Medical Center | Freehold | New Jersey | 07728 | — |
| The Cancer Institute of New Jersey Hamilton | Hamilton | New Jersey | 08690 | — |
| Rutgers Cancer Institute of New Jersey | New Brunswick | New Jersey | 08903 | — |
| Rutgers New Jersey Medical School | Newark | New Jersey | 07101 | — |
| Newark Beth Israel Medical Center | Newark | New Jersey | 07112 | — |
| New York Oncology Hematology PC - Albany Medical Center | Albany | New York | 12208 | — |
| Essentia Health Cancer Center-South University Clinic | Fargo | North Dakota | 58103 | — |
| Summa Health System - Akron Campus | Akron | Ohio | 44304 | — |
| Toledo Clinic Cancer Centers-Bowling Green | Bowling Green | Ohio | 43402 | — |
| Cleveland Clinic Mercy Hospital | Canton | Ohio | 44708 | — |
| MetroHealth Medical Center | Cleveland | Ohio | 44109 | — |
| North Coast Cancer Care-Clyde | Clyde | Ohio | 43410 | — |
| Hematology Oncology Center Incorporated | Elyria | Ohio | 44035 | — |
| Mercy Cancer Center-Elyria | Elyria | Ohio | 44035 | — |
| Saint Rita's Medical Center | Lima | Ohio | 45801 | — |
| Lima Memorial Hospital | Lima | Ohio | 45804 | — |
| Saint Luke's Hospital | Maumee | Ohio | 43537 | — |
| Toledo Clinic Cancer Centers-Maumee | Maumee | Ohio | 43537 | — |
| Fisher-Titus Medical Center | Norwalk | Ohio | 44857 | — |
| Saint Charles Hospital | Oregon | Ohio | 43616 | — |
| Toledo Clinic Cancer Centers-Oregon | Oregon | Ohio | 43616 | — |
| North Coast Cancer Care | Sandusky | Ohio | 44870 | — |
| ProMedica Flower Hospital | Sylvania | Ohio | 43560 | — |
| Mercy Hospital of Tiffin | Tiffin | Ohio | 44883 | — |
| ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital | Toledo | Ohio | 43606 | — |
| Mercy Health - Saint Vincent Hospital | Toledo | Ohio | 43608 | — |
| University of Toledo | Toledo | Ohio | 43614 | — |
| Toledo Community Hospital Oncology Program CCOP | Toledo | Ohio | 43617 | — |
| Mercy Health - Saint Anne Hospital | Toledo | Ohio | 43623 | — |
| Toledo Clinic Cancer Centers-Toledo | Toledo | Ohio | 43623 | — |
| Fulton County Health Center | Wauseon | Ohio | 43567 | — |
| Saint Luke's University Hospital-Bethlehem Campus | Bethlehem | Pennsylvania | 18015 | — |
| Bryn Mawr Hospital | Bryn Mawr | Pennsylvania | 19010 | — |
| Butler Memorial Hospital | Butler | Pennsylvania | 16001 | — |
| Geisinger Medical Center | Danville | Pennsylvania | 17822 | — |
| Geisinger Medical Center-Cancer Center Hazleton | Hazleton | Pennsylvania | 18201 | — |
| Paoli Memorial Hospital | Paoli | Pennsylvania | 19301 | — |
| Thomas Jefferson University Hospital | Philadelphia | Pennsylvania | 19107 | — |
| Fox Chase Cancer Center | Philadelphia | Pennsylvania | 19111 | — |
| UPMC Hillman Cancer Center | Pittsburgh | Pennsylvania | 15232 | — |
| Pottstown Hospital | Pottstown | Pennsylvania | 19464 | — |
| Hematology and Oncology Associates of North East Pennsylvania | Scranton | Pennsylvania | 18508 | — |
| Geisinger Medical Group | State College | Pennsylvania | 16801 | — |
| Reading Hospital | West Reading | Pennsylvania | 19611 | — |
| Geisinger Wyoming Valley/Henry Cancer Center | Wilkes-Barre | Pennsylvania | 18711 | — |
| Lankenau Medical Center | Wynnewood | Pennsylvania | 19096 | — |
| Main Line Health NCORP | Wynnewood | Pennsylvania | 19096 | — |
| Jackson-Madison County General Hospital | Jackson | Tennessee | 38301 | — |
| Fredericksburg Oncology Inc | Fredericksburg | Virginia | 22401 | — |
| Wheeling Hospital/Schiffler Cancer Center | Wheeling | West Virginia | 26003 | — |
| Aspirus Cancer Care-Antigo-Volm Cancer Center | Antigo | Wisconsin | 54409 | — |
| Saint Vincent Hospital Cancer Center Green Bay | Green Bay | Wisconsin | 54301 | — |
| University of Wisconsin Carbone Cancer Center - Johnson Creek | Johnson Creek | Wisconsin | 53038 | — |
| Gundersen Lutheran Medical Center | La Crosse | Wisconsin | 54601 | — |
| SSM Health Dean Medical Group - South Madison Campus | Madison | Wisconsin | 53715 | — |
| University of Wisconsin Carbone Cancer Center - University Hospital | Madison | Wisconsin | 53792 | — |
| Holy Family Memorial Hospital | Manitowoc | Wisconsin | 54221 | — |
| Bay Area Medical Center | Marinette | Wisconsin | 54143 | — |
| HSHS Saint Nicholas Hospital | Sheboygan | Wisconsin | 53081 | — |
| Aspirus Cancer Care-Wausau | Wausau | Wisconsin | 54401 | — |
| Aspirus Cancer Care - Wisconsin Rapids | Wisconsin Rapids | Wisconsin | 54494 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT01142388, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 10, 2026 · Synced Oct 22, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT01142388 live on ClinicalTrials.gov.