A Study to Determine the Effect of Methotrexate (MTX) Dose on Clinical Outcome and Ultrasonographic Signs in Subjects With Moderately to Severely Active Rheumatoid Arthritis (RA) Treated With Adalimumab (MUSICA)
Public ClinicalTrials.gov record NCT01185288. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Multicenter, Double-Blind, Randomized, Parallel-Arm Study to Determine the Effect of Methotrexate Dose on Clinical Outcome and Ultrasonographic Signs in Subjects With Moderately to Severely Active Rheumatoid Arthritis Treated With Adalimumab (MUSICA)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study will investigate the efficacy of both low and high doses of methotrexate (MTX) in combination with open-label adalimumab (ADA) in patients who have had an inadequate response to high dose of MTX. The study will also evaluate the pharmacokinetics and safety of the two regimens of MTX in combination with ADA in participants with rheumatoid arthritis (RA).
Study identification
- NCT ID
- NCT01185288
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 4
- Enrollment
- 309 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Sep 2010 (Type not available)
- Primary completion
- Jan 2013 (Actual)
- Completion
- Jan 2013 (Actual)
- Last update posted
- Mar 18, 2014
2010 – 2013
United States locations
- U.S. sites
- 46
- U.S. states
- 25
- U.S. cities
- 43
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Site Reference ID/Investigator# 38982 | Huntsville | Alabama | 35801 | — |
| Site Reference ID/Investigator# 38686 | Tuscaloosa | Alabama | 35406 | — |
| Site Reference ID/Investigator# 42044 | Mesa | Arizona | 85202 | — |
| Site Reference ID/Investigator# 37983 | Phoenix | Arizona | 85031 | — |
| Site Reference ID/Investigator# 44823 | Little Rock | Arkansas | 72205 | — |
| Site Reference ID/Investigator# 37981 | Hemet | California | 92543 | — |
| Site Reference ID/Investigator# 40208 | Long Beach | California | 90822 | — |
| Site Reference ID/Investigator# 38423 | Sacramento | California | 95816 | — |
| Site Reference ID/Investigator# 38204 | Victorville | California | 92395 | — |
| Site Reference ID/Investigator# 40762 | Walnut Creek | California | 94598 | — |
| Site Reference ID/Investigator# 43049 | Danbury | Connecticut | 06810 | — |
| Site Reference ID/Investigator# 38687 | Jacksonville | Florida | 32209 | — |
| Site Reference ID/Investigator# 40105 | Miami | Florida | 33169 | — |
| Site Reference ID/Investigator# 38083 | Sarasota | Florida | 34239 | — |
| Site Reference ID/Investigator# 38688 | Lawrenceville | Georgia | 30045 | — |
| Site Reference ID/Investigator# 38689 | Meridian | Idaho | 83642 | — |
| Site Reference ID/Investigator# 38085 | Rock Island | Illinois | 61201 | — |
| Site Reference ID/Investigator# 40128 | Springfield | Illinois | 62704 | — |
| Site Reference ID/Investigator# 38981 | Bowling Green | Kentucky | 42101 | — |
| Site Reference ID/Investigator# 38086 | Covington | Louisiana | 70433 | — |
| Site Reference ID/Investigator# 40125 | Fall River | Massachusetts | 02720 | — |
| Site Reference ID/Investigator# 65490 | Las Vegas | Nevada | 89102 | — |
| Site Reference ID/Investigator# 40124 | Clifton | New Jersey | 07012 | — |
| Site Reference ID/Investigator# 38978 | Freehold | New Jersey | 07728 | — |
| Site Reference ID/Investigator# 40123 | Voorhees Township | New Jersey | 08043 | — |
| Site Reference ID/Investigator# 38264 | Smithtown | New York | 11787 | — |
| Site Reference ID/Investigator# 38983 | The Bronx | New York | 10467 | — |
| Site Reference ID/Investigator# 38263 | Asheville | North Carolina | 28803 | — |
| Site Reference ID/Investigator# 38261 | Greenville | North Carolina | 27834 | — |
| Site Reference ID/Investigator# 39024 | Mayfield Village | Ohio | 44143 | — |
| Site Reference ID/Investigator# 40127 | Oklahoma City | Oklahoma | 73104 | — |
| Site Reference ID/Investigator# 38202 | Bend | Oregon | 97701 | — |
| Site Reference ID/Investigator# 39023 | Eugene | Oregon | 97401 | — |
| Site Reference ID/Investigator# 38265 | Duncansville | Pennsylvania | 16635 | — |
| Site Reference ID/Investigator# 38082 | Jackson | Tennessee | 38305 | — |
| Site Reference ID/Investigator# 37980 | Dallas | Texas | 75231 | — |
| Site Reference ID/Investigator# 44888 | Dallas | Texas | 75246 | — |
| Site Reference ID/Investigator# 43050 | Houston | Texas | 77074 | — |
| Site Reference ID/Investigator# 43735 | San Antonio | Texas | 78229 | — |
| Site Reference ID/Investigator# 44344 | Richmond | Virginia | 23294 | — |
| Site Reference ID/Investigator# 40210 | Seattle | Washington | 98101 | — |
| Site Reference ID/Investigator# 38084 | Seattle | Washington | 98122 | — |
| Site Reference ID/Investigator# 38542 | Seattle | Washington | 98133 | — |
| Site Reference ID/Investigator# 38424 | Spokane | Washington | 99204 | — |
| Site Reference ID/Investigator# 38203 | Tacoma | Washington | 98405 | — |
| Site Reference ID/Investigator# 38087 | Franklin | Wisconsin | 53132 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 3 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT01185288, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Mar 18, 2014 · Synced Oct 18, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT01185288 live on ClinicalTrials.gov.