A Safety and Efficacy Study of Oral MDV3100 in Chemotherapy-Naive Patients With Progressive Metastatic Prostate Cancer
Public ClinicalTrials.gov record NCT01212991. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
PREVAIL: A MULTINATIONAL PHASE 3, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED EFFICACY AND SAFETY STUDY OF ORAL MDV3100 IN CHEMOTHERAPY-NAÏVE PATIENTS WITH PROGRESSIVE METASTATIC PROSTATE CANCER WHO HAVE FAILED ANDROGEN DEPRIVATION THERAPY
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to determine the benefit of enzalutamide versus placebo as assessed by overall survival and progression-free survival in patients with progressive metastatic prostate cancer who have failed androgen deprivation therapy but not yet received chemotherapy.
Study identification
- NCT ID
- NCT01212991
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 1,717 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- Male
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Sep 16, 2010 (Actual)
- Primary completion
- Sep 30, 2013 (Actual)
- Completion
- Feb 14, 2019 (Actual)
- Last update posted
- Mar 17, 2020
2010 – 2019
United States locations
- U.S. sites
- 65
- U.S. states
- 21
- U.S. cities
- 37
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham | Birmingham | Alabama | 35249 | — |
| University of Alabama at Birmingham | Birmingham | Alabama | 35294 | — |
| The University of Arizona Cancer Center-North Campus | Tucson | Arizona | 85719 | — |
| The University of Arizona Cancer Certer-North Campus | Tucson | Arizona | 85719 | — |
| Cancer Center Oncology Medical Group | La Mesa | California | 91942 | — |
| Keck Hospital of USC | Los Angeles | California | 90033 | — |
| LAC&USC Medical Center | Los Angeles | California | 90033 | — |
| USC/Norris Comprehensive Cancer Center / Investigational Drug Services | Los Angeles | California | 90033 | — |
| USC/Norris Comprehensive Cancer Center | Los Angeles | California | 90033 | — |
| Ronald Reagan UCLA Medical Center Drug Information Center Department of Pharmaceutical Services | Los Angeles | California | 90095 | — |
| UCLA Clark Urology Clinic | Los Angeles | California | 90095 | — |
| North County Oncology Medical Clinic, Inc | Oceanside | California | 92056 | — |
| UC Davis Medical Center | Sacramento | California | 95817 | — |
| University of California Davis Comprehensive Cancer Center | Sacramento | California | 95817 | — |
| Medical Oncology Associates-SD | San Diego | California | 92123 | — |
| Sharp Memorial Hospital Investigational Pharmacy | San Diego | California | 92123 | — |
| Sharp Rees-Stealy | San Diego | California | 92123 | — |
| Stanford University Medical Center | Stanford | California | 94305 | — |
| Anschutz Cancer Center Pavilion Pharmacy | Aurora | Colorado | 80045 | — |
| University of Colorado Hospital, Anschutz Cancer Pavilion | Aurora | Colorado | 80045 | — |
| Lynn Cancer Institute Center for Hematology Oncology | Boca Raton | Florida | 33486 | — |
| Northwestern Medical Faculty Foundation | Chicago | Illinois | 60611 | — |
| Northwestern Memorial Hospital | Chicago | Illinois | 60611 | — |
| Jewish Hospital & St. Mary's Healthcare, Inc. | Louisville | Kentucky | 40245 | — |
| Brigham & Women's Hospital | Boston | Massachusetts | 02115 | — |
| Beth Israel Deaoness Medical Center | Boston | Massachusetts | 02215 | — |
| Dana Farber Cancer Institute | Boston | Massachusetts | 02215 | — |
| Karmanos Cancer Institute | Detroit | Michigan | 48201 | — |
| Karmanos Cancer Institute Weisberg Cancer Treatment Center | Farmington Hills | Michigan | 48334 | — |
| Mayo Clinic | Rochester | Minnesota | 55905 | — |
| Barnes-Jewish St. Peters Hospital | City of Saint Peters | Missouri | 63376 | — |
| Barnes-Jewish West County Hospital | Creve Coeur | Missouri | 63141 | — |
| BJH Pharmacy | St Louis | Missouri | 63108 | — |
| Barnes-Jewish Hospital | St Louis | Missouri | 63110 | — |
| Washington University School of Medicine | St Louis | Missouri | 63110 | — |
| Nebraska Methodist Hospital | Omaha | Nebraska | 68114 | — |
| The Mount Sinai Medical Center | New York | New York | 10029 | — |
| Memorial Sloan-Kettering Cancer Center | New York | New York | 10065 | — |
| Cancer Centers of North Carolina | Cary | North Carolina | 27518 | — |
| Levine Cancer Institute | Charlotte | North Carolina | 28203 | — |
| Levine Cancer Institute - Main | Charlotte | North Carolina | 28204 | — |
| Levine Cancer Institute - Southpark | Charlotte | North Carolina | 28211 | — |
| Levine Cancer Institute - University | Charlotte | North Carolina | 28262 | — |
| Levine Cancer Institute - Ballantyne | Charlotte | North Carolina | 28277 | — |
| Duke University Medical Center | Durham | North Carolina | 27710 | — |
| Investigational Chemotherapy Services | Durham | North Carolina | 27710 | — |
| Cancer Centers of North Carolina | Raleigh | North Carolina | 27607 | — |
| Portland VA Medical Center Laboratory | Portland | Oregon | 97239 | — |
| Abramson Cancer Center of the University of Pennsylvania at Perelman Center for Advanced Medicine | Philadelphia | Pennsylvania | 19104 | — |
| UPMC Presbyterian | Pittsburgh | Pennsylvania | 15213 | — |
| UPMC Hillman Cancer Center | Pittsburgh | Pennsylvania | 15232 | — |
| Hematology / Oncology MUSC Hollings Cancer Center | Charleston | South Carolina | 29425 | — |
| Medical University of South Carolina - Urology Services | Charleston | South Carolina | 29425 | — |
| MUSC Department of Radiology | Charleston | South Carolina | 29425 | — |
| MUSC Urology Ambulatory Care | Charleston | South Carolina | 29425 | — |
| MUSC Hematology / Oncology Medical Specialty Associates, East Cooper Medical Arts Center 3rd Floor | Mt. Pleasant | South Carolina | 29464 | — |
| MUSC Urology Medical Specialty Associates, East Cooper Medical Arts Center 3rd Floor | Mt. Pleasant | South Carolina | 29464 | — |
| UT Southwestern Medical Center at Dallas | Dallas | Texas | 75390 | — |
| Virginia Oncology Associates | Hampton | Virginia | 23666 | — |
| Virginia Oncology Associates | Newport News | Virginia | 23606 | — |
| Virginia Oncology Associates | Norfolk | Virginia | 23502 | — |
| Virginia Oncology Associates | Virginia Beach | Virginia | 23456 | — |
| Seattle Cancer Care Alliance | Seattle | Washington | 98109 | — |
| University of Washington Medical Center | Seattle | Washington | 98195 | — |
| University of Wisconsin Hospital and Clinics | Madison | Wisconsin | 53792 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 204 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT01212991, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Mar 17, 2020 · Synced Oct 30, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT01212991 live on ClinicalTrials.gov.