A Safety and Efficacy Study of Farletuzumab in Participants With Adenocarcinoma of the Lung
Public ClinicalTrials.gov record NCT01218516. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Double-Blind, Placebo-Controlled, Study of the Safety and Efficacy of Farletuzumab in Combination With a Platinum-Containing Doublet in Chemotherapy-Naive Subjects With Stage IV Adenocarcinoma of the Lung (FLAIR)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The primary objective of this study is to compare the effect of farletuzumab versus placebo in combination with either a platinum agent (carboplatin) with paclitaxel or a platinum agent (carboplatin or cisplatin) with pemetrexed followed by farletuzumab or placebo on investigator-assessed progression free survival (PFS) as determined by Response Evaluation Criteria in Solid Tumors (RECIST) v.1.1 or definitive clinical disease progression (eg, new occurrence of positive fluid cytology) in chemotherapy naive participants with folate receptoralpha (FRA)-expressing Stage IV adenocarcinoma of the lung.
Study identification
- NCT ID
- NCT01218516
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 130 participants
Conditions and interventions
Conditions
Interventions
- Farletuzumab Biological
- Placebo Other
- Carboplatin Drug
- Paclitaxel Drug
- Pemetrexed Drug
- Cisplatin Drug
Biological · Other · Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 27, 2011 (Actual)
- Primary completion
- Dec 15, 2012 (Actual)
- Completion
- Nov 1, 2013 (Actual)
- Last update posted
- Aug 20, 2020
2011 – 2013
United States locations
- U.S. sites
- 54
- U.S. states
- 21
- U.S. cities
- 53
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Ironwood Cancer and Research Center | Chandler | Arizona | 85224 | — |
| Arizona Center for Hematology Oncology | Glendale | Arizona | 85306-4666 | — |
| Providence Health System | Beverly Hills | California | 90210-5501 | — |
| Cancer Care Associates of Fresno Medical Group, Inc. | Fresno | California | 93720 | — |
| Medical Oncology Hematology | Gilroy | California | 95020 | — |
| California Cancer Care, Inc. | Greenbrae | California | 94904 | — |
| Moores University of California San Diego Cancer Center | La Jolla | California | 92093 | — |
| Wilshire Medical Oncology Group | La Verne | California | 91750 | — |
| Glendale Adventist Medical Center | Los Angeles | California | 90025 | — |
| Clinical Trials and Research Associates, Inc. | Montebello | California | 90640 | — |
| North Country Oncology-Hematology | Oceanside | California | 92056 | — |
| Pacific Hematology Oncology Associates | San Francisco | California | 94115 | — |
| Central Coast Medical Oncology | Santa Maria | California | 93454 | — |
| Rocky Mountain Cancer Centers, LLP | Denver | Colorado | 80218-1237 | — |
| Hematology Oncology Associates, P.C. | Stamford | Connecticut | 06902-3628 | — |
| Center for Hematology-Oncology | Boca Raton | Florida | 33486 | — |
| Medical Specialists of the Palm Beaches | Deerfield Beach | Florida | 33441 | — |
| Broward General Medical Center | Fort Lauderdale | Florida | 33316 | — |
| Cancer Care of North Florida | Lake City | Florida | 32024 | — |
| Florida Cancer Institute-New Hope | New Port Richey | Florida | 34655 | — |
| Ocala Oncology Center, PL | Ocala | Florida | 34474 | — |
| MD Anderson Cancer Center-Orlando | Orlando | Florida | 32806 | — |
| University Hematology Oncology, Inc. | Centralia | Illinois | 62801 | — |
| University of Chicago Medical Center | Chicago | Illinois | 60637 | — |
| Deaconess Clinic Downtown | Evansville | Indiana | 47713 | — |
| The Community Hospital | Munster | Indiana | 46321 | — |
| Kentucky Cancer Center | Hazard | Kentucky | 41701 | — |
| Baptist Health System, Inc. | Lexington | Kentucky | 40503 | — |
| Christus Saint Frances, Cabrini Hospital, Cabrini Cancer Center | Alexandria | Louisiana | 71301 | — |
| Hematology and Oncology Specialists, LLC | Metairie | Louisiana | 70006 | — |
| National Cancer Institute | Bethesda | Maryland | 20892 | — |
| Maryland Oncology Hematology, P.A. | Columbia | Maryland | 21044 | — |
| Berkshire Hematology Oncology, PC | Pittsfield | Massachusetts | 01201 | — |
| Detroit Clinical Research Center | Farmington Hills | Michigan | 48336 | — |
| Englewood Hospital and Medical Center | Englewood | New Jersey | 07631 | — |
| Queens Hospital Center | Jamaica | New York | 11432 | — |
| Syracuse Veterns Affairs Medical Center | Syracuse | New York | 13210 | — |
| Willamette Valley Cancer Institute and Research Center | Eugene | Oregon | 97401 | — |
| St. Luke's Cancer Center Associates | Bethlehem | Pennsylvania | 18015 | — |
| Gettysburg Cancer Center | Gettysburg | Pennsylvania | 17325 | — |
| Tennessee Oncology, PLLC | Nashville | Tennessee | 37203 | — |
| Texas Oncology - Bedford | Bedford | Texas | 76022 | — |
| University of Texas Medical Branch | Galveston | Texas | 77555 | — |
| Houston Cancer Institute | Houston | Texas | 77055 | — |
| Texas Oncology - Plano East | Plano | Texas | 75075-7787 | — |
| Northwest Cancer Center | Sugar Land | Texas | 77479 | — |
| Texas Oncology - Tyler | Tyler | Texas | 75702-8363 | — |
| Texas Oncology - Waco | Waco | Texas | 76712 | — |
| Virginia Cancer Specialists, PC | Fairfax | Virginia | 22031 | — |
| Delta Hematology Oncology Associates, PC | Portsmouth | Virginia | 23704 | — |
| Virginia Mason Medical Center | Seattle | Washington | 98101 | — |
| Rockwood Cancer Treatment Center | Spokane | Washington | 99204 | — |
| Medical Oncology Associates, PS | Spokane | Washington | 99208 | — |
| Cancer Team Bellin Health | Green Bay | Wisconsin | 54313 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 39 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT01218516, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 20, 2020 · Synced Oct 19, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT01218516 live on ClinicalTrials.gov.