Comparing the Efficacy, Safety, and Tolerability of Combination Antivirals (Amantadine, Ribavirin, Oseltamivir) Versus Oseltamivir for the Treatment of Influenza in Adults at Risk for Complications
Public ClinicalTrials.gov record NCT01227967. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized Double-Blind Phase 2 Study Comparing the Efficacy, Safety, and Tolerability of Combination Antivirals (Amantadine, Ribavirin, Oseltamivir) Versus Oseltamivir for the Treatment of Influenza in Adults at Risk for Complications
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
Seasonal influenza is responsible for many hospitalizations and deaths each year, despite effective antiviral treatments. Some individuals have medical conditions such as heart or lung diseases that make them particularly at risk of severe influenza infections that may result in hospitalization or death. Oseltamivir (Tamiflu) is used most often to treat flu, but there are still many hospitalizations, complications, and deaths even with treatment. This study evaluated the use of combination antivirals (amantadine, oseltamivir, and ribavirin) compared to oseltamivir alone in the treatment of influenza in an at-risk population.
Study identification
- NCT ID
- NCT01227967
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 881 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Sep 2010 (Type not available)
- Primary completion
- May 2, 2016 (Actual)
- Completion
- Mar 30, 2017 (Actual)
- Last update posted
- Feb 4, 2019
2010 – 2017
United States locations
- U.S. sites
- 69
- U.S. states
- 23
- U.S. cities
- 61
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Simon Williamson Clinic | Birmingham | Alabama | 35211 | — |
| East Valley Family Physicians | Chandler | Arizona | 85224 | — |
| Thomas Lenzmeier Family Practice | Glendale | Arizona | 85308 | — |
| Central Phoenix Medical Center | Phoenix | Arizona | 85020 | — |
| WCCT Global LLC | Costa Mesa | California | 92626 | — |
| Advanced Rx Clinical Research | Garden Grove | California | 92843 | — |
| Torrance Clinical Research Institute, Inc. | Lomita | California | 90717 | — |
| University of Southern California | Los Angeles | California | 90033 | — |
| University of California at San Diego | San Diego | California | 92103 | — |
| Westlake Medical Research (CA) | Thousand Oaks | California | 91360 | — |
| Los Angeles BioMedical Research Institute | Torrance | California | 90502 | — |
| Empire Clinical Research | Upland | California | 91786 | — |
| University of Colorado | Aurora | Colorado | 80045 | — |
| Centennial - IMMUNOe International Research | Centennial | Colorado | 80112 | — |
| University of Florida | Gainesville | Florida | 32610 | — |
| Best Quality Research Inc. | Hialeah | Florida | 33016 | — |
| San Marcus Research Clinic, Inc. | Miami | Florida | 33015 | — |
| Medical Consulting Center | Miami | Florida | 33125 | — |
| Suncoast Research Group, LLC | Miami | Florida | 33135 | — |
| University of Miami | Miami | Florida | 33136 | — |
| DMI Research, Inc. | Pinellas Park | Florida | 33782 | — |
| Northwestern University | Chicago | Illinois | 60611 | — |
| Sneeze, Wheeze & Itch Associates, LLC | Normal | Illinois | 61761 | — |
| Ridge Family Practice | Council Bluffs | Iowa | 51503 | — |
| University of Iowa | Iowa City | Iowa | 52246 | — |
| Research Integrity, LLC | Owensboro | Kentucky | 42303 | — |
| Horizon Research Group, of Opelousas, LLC | Eunice | Louisiana | 70535 | — |
| Centex Studies Inc. - Dr. Seep | Lake Charles | Louisiana | 70601 | — |
| NIH Clinical Center | Bethesda | Maryland | 20892 | — |
| Boston Medical Center | Boston | Massachusetts | 02111 | — |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | — |
| Brigham and Women's Hospital | Boston | Massachusetts | 02115 | — |
| UMass Medical School | Worcester | Massachusetts | 01655 | — |
| Henry Ford Health Systems | Detroit | Michigan | 48202 | — |
| Bronson Methodist Hospital | Kalamazoo | Michigan | 49007 | — |
| West Florissant Internists | Bridgeton | Missouri | 63044 | — |
| Clinical Research Advantage/ Skyline Medical Center | Elkhorn | Nebraska | 68022 | — |
| Prairie Fields Family Medicine | Fremont | Nebraska | 68025 | — |
| Southwest Family Physicians | Omaha | Nebraska | 68124 | — |
| New Jersey Medical School | Newark | New Jersey | 07103 | — |
| Icahn School of Medicine at Mount Sinai | New York | New York | 10029 | — |
| University of Rochester Medical Center | Rochester | New York | 14642 | — |
| James J. Peters, VA Medical Center | The Bronx | New York | 10468 | — |
| University of North Carolina-Chapel Hill | Chapel Hill | North Carolina | 27514 | — |
| Duke University | Durham | North Carolina | 27710 | — |
| Clinical Research Solutions - Dr. Panuto | Middleburg Heights | Ohio | 44130 | — |
| University of Pennsylvania | Philadelphia | Pennsylvania | 19104 | — |
| University of Pittsburgh | Pittsburgh | Pennsylvania | 15213 | — |
| Montgomery Medical | Smithfield | Pennsylvania | 15478 | — |
| Health Concepts | Rapid City | South Dakota | 57702 | — |
| Clinical Research Solutions - Dr. Bart | Columbia | Tennessee | 38401 | — |
| Clinical Research Solutions - Dr. Slandzicki | Franklin | Tennessee | 37064 | — |
| Clinical Research Solutions - Dr. Hoppers | Jackson | Tennessee | 38305 | — |
| Holston Medical Group | Kingsport | Tennessee | 37660 | — |
| Clinical Research Solutions - Dr. Rowe | Nashville | Tennessee | 37211 | — |
| Clinical Research Solutions - Dr. Dar | Smyrna | Tennessee | 37167 | — |
| University of Texas Tech Amarillo | Amarillo | Texas | 79106 | — |
| Family Medicine Associates of Texas | Carrollton | Texas | 75010 | — |
| 3rd Coast Research Associates | Corpus Christi | Texas | 78413 | — |
| University of Texas at Houston | Houston | Texas | 77030 | — |
| Centex Studies Inc. - Dr. Pouzar | Houston | Texas | 77062 | — |
| Pioneer Research Solutions, Inc. | Houston | Texas | 77098 | — |
| Texas Tech HSC | Lubbock | Texas | 79430 | — |
| Centex Studies Inc. - Dr. Garcia | Pharr | Texas | 78577 | — |
| Village Health Partners | Plano | Texas | 75024 | — |
| Endeavor Clinical Trials | San Antonio | Texas | 78229 | — |
| Bandera Family Healthcare Research | San Antonio | Texas | 78249 | — |
| University of Virginia | Charlottesville | Virginia | 22908 | — |
| Virginia Commonwealth University | Richmond | Virginia | 23298 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 22 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT01227967, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Feb 4, 2019 · Synced Oct 18, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT01227967 live on ClinicalTrials.gov.