ClinicalTrials.gov record
Intensity-Modulated Radiation Therapy and Paclitaxel With or Without Pazopanib Hydrochloride in Treating Patients With Anaplastic Thyroid Cancer
ClinicalTrials.gov ID: NCT01236547
Public ClinicalTrials.gov record NCT01236547. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
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Official title
A Randomized Phase II Study of Concurrent Intensity Modulated Radiation Therapy (IMRT), Paclitaxel and Pazopanib (NSC 737754)/Placebo, for the Treatment of Anaplastic Thyroid Cancer
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This randomized phase II trial studies the side effects and how well intensity-modulated radiation therapy (IMRT) and paclitaxel with or without pazopanib hydrochloride works in treating patients with anaplastic thyroid cancer. Specialized radiation therapy that delivers a high dose of radiation directly to the tumor may kill more tumor cells and cause less damage to normal tissue. Drugs used in chemotherapy, such as paclitaxel, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Pazopanib hydrochloride may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. It is not yet known whether radiation therapy and paclitaxel are more effective when given with pazopanib hydrochloride in treating thyroid cancer.
Study identification
- NCT ID
- NCT01236547
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 123 participants
Conditions and interventions
Conditions
Interventions
- Intensity-Modulated Radiation Therapy Radiation
- Paclitaxel Drug
- Pazopanib Hydrochloride Drug
- Placebo Administration Other
Radiation · Drug · Other
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Oct 28, 2010 (Actual)
- Primary completion
- Mar 9, 2020 (Actual)
- Completion
- May 20, 2022 (Actual)
- Last update posted
- Jul 19, 2022
2010 – 2022
United States locations
- U.S. sites
- 130
- U.S. states
- 27
- U.S. cities
- 103
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham Cancer Center | Birmingham | Alabama | 35233 | — |
| The Kirklin Clinic at Acton Road | Birmingham | Alabama | 35243 | — |
| Cancer Center at Saint Joseph's | Phoenix | Arizona | 85004 | — |
| Saint Joseph's Hospital and Medical Center | Phoenix | Arizona | 85013 | — |
| Arizona Oncology-Deer Valley Center | Phoenix | Arizona | 85027 | — |
| Arizona Oncology Services Foundation | Scottsdale | Arizona | 85260 | — |
| Sutter Cancer Centers Radiation Oncology Services-Auburn | Auburn | California | 95603 | — |
| Alta Bates Summit Medical Center-Herrick Campus | Berkeley | California | 94704 | — |
| Mills-Peninsula Medical Center | Burlingame | California | 94010 | — |
| Sutter Cancer Centers Radiation Oncology Services-Cameron Park | Cameron Park | California | 95682 | — |
| Eden Hospital Medical Center | Castro Valley | California | 94546 | — |
| Sutter Cancer Centers Radiation Oncology Services-Roseville | Roseville | California | 95661 | — |
| Sutter Medical Center Sacramento | Sacramento | California | 95816 | — |
| California Pacific Medical Center-Pacific Campus | San Francisco | California | 94115 | — |
| UCSF Medical Center-Mount Zion | San Francisco | California | 94115 | — |
| UCSF Medical Center-Parnassus | San Francisco | California | 94143 | — |
| Sutter Cancer Centers Radiation Oncology Services-Vacaville | Vacaville | California | 95687 | — |
| Sutter Solano Medical Center/Cancer Center | Vallejo | California | 94589 | — |
| Christiana Gynecologic Oncology LLC | Newark | Delaware | 19713 | — |
| Delaware Clinical and Laboratory Physicians PA | Newark | Delaware | 19713 | — |
| Helen F Graham Cancer Center | Newark | Delaware | 19713 | — |
| Medical Oncology Hematology Consultants PA | Newark | Delaware | 19713 | — |
| Christiana Care Health System-Christiana Hospital | Newark | Delaware | 19718 | — |
| Beebe Health Campus | Rehoboth Beach | Delaware | 19971 | — |
| Christiana Care Health System-Wilmington Hospital | Wilmington | Delaware | 19801 | — |
| Mayo Clinic in Florida | Jacksonville | Florida | 32224-9980 | — |
| Moffitt Cancer Center | Tampa | Florida | 33612 | — |
| Emory University Hospital Midtown | Atlanta | Georgia | 30308 | — |
| Emory University Hospital/Winship Cancer Institute | Atlanta | Georgia | 30322 | — |
| Radiation Oncology Associates PC | Fort Wayne | Indiana | 46804 | — |
| Parkview Hospital Randallia | Fort Wayne | Indiana | 46805 | — |
| University of Kansas Cancer Center | Kansas City | Kansas | 66160 | — |
| The James Graham Brown Cancer Center at University of Louisville | Louisville | Kentucky | 40202 | — |
| Mary Bird Perkins Cancer Center | Baton Rouge | Louisiana | 70809 | — |
| Touro Infirmary | New Orleans | Louisiana | 70115 | — |
| Greater Baltimore Medical Center | Baltimore | Maryland | 21204 | — |
| Sinai Hospital of Baltimore | Baltimore | Maryland | 21215 | — |
| Boston Medical Center | Boston | Massachusetts | 02118 | — |
| Henry Ford Cancer Institute-Downriver | Brownstown | Michigan | 48183 | — |
| Henry Ford Macomb Hospital-Clinton Township | Clinton Township | Michigan | 48038 | — |
| Henry Ford Medical Center-Fairlane | Dearborn | Michigan | 48126 | — |
| Henry Ford Hospital | Detroit | Michigan | 48202 | — |
| West Michigan Cancer Center | Kalamazoo | Michigan | 49007 | — |
| Henry Ford Medical Center-Columbus | Novi | Michigan | 48377 | — |
| Henry Ford West Bloomfield Hospital | West Bloomfield | Michigan | 48322 | — |
| Fairview Ridges Hospital | Burnsville | Minnesota | 55337 | — |
| Mercy Hospital | Coon Rapids | Minnesota | 55433 | — |
| Fairview Southdale Hospital | Edina | Minnesota | 55435 | — |
| Unity Hospital | Fridley | Minnesota | 55432 | — |
| Minnesota Oncology Hematology PA-Maplewood | Maplewood | Minnesota | 55109 | — |
| Abbott-Northwestern Hospital | Minneapolis | Minnesota | 55407 | — |
| Hennepin County Medical Center | Minneapolis | Minnesota | 55415 | — |
| North Memorial Medical Health Center | Robbinsdale | Minnesota | 55422 | — |
| Mayo Clinic in Rochester | Rochester | Minnesota | 55905 | — |
| Metro Minnesota Community Oncology Research Consortium | Saint Louis Park | Minnesota | 55416 | — |
| Park Nicollet Clinic - Saint Louis Park | Saint Louis Park | Minnesota | 55416 | — |
| Regions Hospital | Saint Paul | Minnesota | 55101 | — |
| United Hospital | Saint Paul | Minnesota | 55102 | — |
| Ridgeview Medical Center | Waconia | Minnesota | 55387 | — |
| Rice Memorial Hospital | Willmar | Minnesota | 56201 | — |
| University of Mississippi Medical Center | Jackson | Mississippi | 39216 | — |
| Billings Clinic Cancer Center | Billings | Montana | 59101 | — |
| Memorial Sloan Kettering Basking Ridge | Basking Ridge | New Jersey | 07920 | — |
| New York-Presbyterian/Brooklyn Methodist Hospital | Brooklyn | New York | 11215 | — |
| Memorial Sloan Kettering Commack | Commack | New York | 11725 | — |
| Memorial Sloan Kettering Westchester | Harrison | New York | 10604 | — |
| Memorial Sloan Kettering Cancer Center | New York | New York | 10065 | — |
| Memorial Sloan Kettering Sleepy Hollow | Sleepy Hollow | New York | 10591 | — |
| Memorial Sloan Kettering Nassau | Uniondale | New York | 11553 | — |
| UNC Lineberger Comprehensive Cancer Center | Chapel Hill | North Carolina | 27599 | — |
| Summa Health System - Akron Campus | Akron | Ohio | 44304 | — |
| Summa Health System - Barberton Campus | Barberton | Ohio | 44203 | — |
| University of Cincinnati Cancer Center-UC Medical Center | Cincinnati | Ohio | 45219 | — |
| Case Western Reserve University | Cleveland | Ohio | 44106 | — |
| Cleveland Clinic Foundation | Cleveland | Ohio | 44195 | — |
| Ohio State University Comprehensive Cancer Center | Columbus | Ohio | 43210 | — |
| Mercy Cancer Center-Elyria | Elyria | Ohio | 44035 | — |
| Summa Health Medina Medical Center | Medina | Ohio | 44256 | — |
| UH Seidman Cancer Center at Lake Health Mentor Campus | Mentor | Ohio | 44060 | — |
| UH Seidman Cancer Center at Southwest General Hospital | Middleburg Heights | Ohio | 44130 | — |
| University Hospitals Parma Medical Center | Parma | Ohio | 44129 | — |
| UH Seidman Cancer Center at Firelands Regional Medical Center | Sandusky | Ohio | 44870 | — |
| University of Cincinnati Cancer Center-West Chester | West Chester | Ohio | 45069 | — |
| University of Oklahoma Health Sciences Center | Oklahoma City | Oklahoma | 73104 | — |
| UPMC-Heritage Valley Health System Beaver | Beaver | Pennsylvania | 15009 | — |
| UPMC Cancer Centers - Arnold Palmer Pavilion | Greensburg | Pennsylvania | 15601 | — |
| Penn State Milton S Hershey Medical Center | Hershey | Pennsylvania | 17033-0850 | — |
| UPMC-Johnstown/John P. Murtha Regional Cancer Center | Johnstown | Pennsylvania | 15901 | — |
| UPMC Cancer Center at UPMC McKeesport | McKeesport | Pennsylvania | 15132 | — |
| UPMC-Coraopolis/Heritage Valley Radiation Oncology | Moon Township | Pennsylvania | 15108 | — |
| UPMC Cancer Center-Natrona Heights | Natrona Heights | Pennsylvania | 15065 | — |
| UPMC Jameson | New Castle | Pennsylvania | 16105 | — |
| Thomas Jefferson University Hospital | Philadelphia | Pennsylvania | 19107 | — |
| UPMC-Presbyterian Hospital | Pittsburgh | Pennsylvania | 15213 | — |
| UPMC-Saint Margaret | Pittsburgh | Pennsylvania | 15215 | — |
| UPMC-Shadyside Hospital | Pittsburgh | Pennsylvania | 15232 | — |
| UPMC Jefferson Regional Radiation Oncology | Pittsburgh | Pennsylvania | 15236 | — |
| UPMC-Passavant Hospital | Pittsburgh | Pennsylvania | 15237 | — |
| UPMC-Saint Clair Hospital Cancer Center | Pittsburgh | Pennsylvania | 15243 | — |
| UPMC Cancer Center at UPMC Northwest | Seneca | Pennsylvania | 16346 | — |
| UPMC Uniontown Hospital Radiation Oncology | Uniontown | Pennsylvania | 15401 | — |
| UPMC Washington Hospital Radiation Oncology | Washington | Pennsylvania | 15301 | — |
| Prisma Health Cancer Institute - Spartanburg | Boiling Springs | South Carolina | 29316 | — |
| Prisma Health Cancer Institute - Faris | Greenville | South Carolina | 29605 | — |
| Prisma Health Cancer Institute - Eastside | Greenville | South Carolina | 29615 | — |
| Prisma Health Cancer Institute - Greer | Greer | South Carolina | 29650 | — |
| Prisma Health Cancer Institute - Seneca | Seneca | South Carolina | 29672 | — |
| Parkland Memorial Hospital | Dallas | Texas | 75235 | — |
| UT Southwestern/Simmons Cancer Center-Dallas | Dallas | Texas | 75390 | — |
| M D Anderson Cancer Center | Houston | Texas | 77030 | — |
| American Fork Hospital / Huntsman Intermountain Cancer Center | American Fork | Utah | 84003 | — |
| Sandra L Maxwell Cancer Center | Cedar City | Utah | 84720 | — |
| Logan Regional Hospital | Logan | Utah | 84321 | — |
| Intermountain Medical Center | Murray | Utah | 84107 | — |
| McKay-Dee Hospital Center | Ogden | Utah | 84403 | — |
| Utah Valley Regional Medical Center | Provo | Utah | 84604 | — |
| Utah Cancer Specialists-Salt Lake City | Salt Lake City | Utah | 84106 | — |
| LDS Hospital | Salt Lake City | Utah | 84143 | — |
| Saint George Regional Medical Center | St. George | Utah | 84770 | — |
| Sentara Cancer Institute at Sentara CarePlex Hospital | Hampton | Virginia | 23666 | — |
| Sentara Norfolk General Hospital | Norfolk | Virginia | 23507 | — |
| Sentara Virginia Beach General Hospital | Virginia Beach | Virginia | 23454 | — |
| Green Bay Oncology at Saint Vincent Hospital | Green Bay | Wisconsin | 54301-3526 | — |
| Saint Vincent Hospital Cancer Center Green Bay | Green Bay | Wisconsin | 54301 | — |
| Green Bay Oncology Limited at Saint Mary's Hospital | Green Bay | Wisconsin | 54303 | — |
| Saint Vincent Hospital Cancer Center at Saint Mary's | Green Bay | Wisconsin | 54303 | — |
| University of Wisconsin Carbone Cancer Center | Madison | Wisconsin | 53792 | — |
| Holy Family Memorial Hospital | Manitowoc | Wisconsin | 54221 | — |
| Bay Area Medical Center | Marinette | Wisconsin | 54143 | — |
| Medical College of Wisconsin | Milwaukee | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT01236547, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jul 19, 2022 · Synced Nov 5, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT01236547 live on ClinicalTrials.gov.