ClinicalTrials.gov record
CAROLINA: Cardiovascular Outcome Study of Linagliptin Versus Glimepiride in Patients With Type 2 Diabetes
ClinicalTrials.gov ID: NCT01243424
Public ClinicalTrials.gov record NCT01243424. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Multicentre, International, Randomised, Parallel Group, Double Blind Study to Evaluate Cardiovascular Safety of Linagliptin Versus Glimepiride in Patients With Type 2 Diabetes Mellitus at High Cardiovascular Risk.
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The aim of the study is to investigate the longterm impact on cardiovascular morbidity and mortality, relevant efficacy parameters (e.g., glycaemic parameters) and safety (e.g., weight and hypoglycaemia) of treatment with linagliptin in patients with type 2 diabetes at elevated cardiovascular risk receiving usual care, and compare outcome against glimepiride.
Study identification
- NCT ID
- NCT01243424
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 6,103 participants
Conditions and interventions
Conditions
Interventions
- linagliptin Drug
- glimepiride Drug
- linagliptin placebo Drug
- glimepiride placebo Drug
Drug
Eligibility (public fields only)
- Age range
- 40 Years to 85 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Nov 11, 2010 (Actual)
- Primary completion
- Aug 21, 2018 (Actual)
- Completion
- Aug 21, 2018 (Actual)
- Last update posted
- Jan 7, 2020
2010 – 2018
United States locations
- U.S. sites
- 177
- U.S. states
- 36
- U.S. cities
- 142
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| North Alabama Research Center, LLC | Athens | Alabama | 35611 | — |
| Alabama Internal Medicine, PC | Birmingham | Alabama | 35235 | — |
| Cahaba Research, Inc. | Birmingham | Alabama | 35242 | — |
| Internal Medicine Center, LLC | Mobile | Alabama | 36608 | — |
| Diagnostic and Medical Clinic | Mobile | Alabama | 36695 | — |
| Extended Arm Physicians, Inc. | Montgomery | Alabama | 36106 | — |
| Office of Dr. Terence T. Hart MD | Tuscumbia | Alabama | 35674 | — |
| Advanced Clinical Research | Pell City | Alaska | 35128 | — |
| Clinical Research Advantage, Inc./Rita B. Chuang, MD, LLC | Mesa | Arizona | 85203 | — |
| Clinical Research Advantage, Inc./Rita B. Chuang, MD, LLC | Mesa | Arizona | 85213 | — |
| Genova Clinical Research | Tucson | Arizona | 85704 | — |
| Quality of Life Medical & Research Center | Tucson | Arizona | 85712 | — |
| Northeast Arkansas Baptist Clinic | Jonesboro | Arkansas | 72404 | — |
| Medical Investigations, Inc | Little Rock | Arkansas | 72205 | — |
| Aureus Research, Inc | Little Rock | Arkansas | 72211 | — |
| Desert Oasis Healthcare | Bermuda Dunes | California | 92203 | — |
| Edinger Medical Group and Research Center | Fountain Valley | California | 92708 | — |
| Clinical Trials of St. Jude Heritage Med. Group | Fullerton | California | 92835 | — |
| Long Beach Center for Clinical Research | Long Beach | California | 90807 | — |
| Office of Dr. Richard S. Cherlin | Los Gatos | California | 95032 | — |
| Providence Clinical Research | North Hollywood | California | 91606 | — |
| Chaparral Medical Group, Inc | Pomona | California | 91767 | — |
| ARI Clinical Trials, Inc | Redondo Beach | California | 90277 | — |
| San Diego Sports Medicine and Family Health Center | San Diego | California | 92120 | — |
| West Coast Research, LLC | San Ramon | California | 94582 | — |
| University of California Los Angeles | Sylmar | California | 91342 | — |
| Metabolic Institute of America | Tarzana | California | 91356 | — |
| Matrix Research Institute | Tustin | California | 92780 | — |
| Orange County Research Center | Tustin | California | 92780 | — |
| Westlake Medical Research | Westlake Village | California | 91361 | — |
| Clinical Research Advantage, Inc./Rita B. Chuang, MD, LLC | Colorado Springs | Colorado | 80909 | — |
| Clinical Research Advantage, Inc./Rita B. Chuang, MD, LLC | Colorado Springs | Colorado | 80920 | — |
| East Coast Medical Associates | Boca Raton | Florida | 33433 | — |
| Todd Kazdan, DO Family Practice | Davie | Florida | 33314 | — |
| Century Clinical Research, Inc | Daytona Beach | Florida | 32117 | — |
| Doral Research Center | Doral | Florida | 33172 | — |
| Riverside Clinical Research | Edgewater | Florida | 32132 | — |
| Alan Graff, MD, PA | Fort Lauderdale | Florida | 33309 | — |
| M & O Clinical Research, LLC | Fort Lauderdale | Florida | 33316 | — |
| Eastern Research | Hialeah | Florida | 33013 | — |
| Research in Miami Inc | Hialeah | Florida | 33013 | — |
| Jacksonville Impotence Treatment Center | Jacksonville | Florida | 32223 | — |
| East Coast Institute for Research, LLC | Jacksonville | Florida | 32258 | — |
| Care Partners Clinical Research LLC | Jacksonville | Florida | 32277 | — |
| Precision Clinical Research, LLC | Lauderdale Lakes | Florida | 33319 | — |
| Veritas Research Corporation | Miami | Florida | 33126 | — |
| APF Research, LLC | Miami | Florida | 33134 | — |
| Swiss Medical Research | Miami | Florida | 33135 | — |
| University of Miami | Miami | Florida | 33136 | — |
| South Miami Clinical Research | Miami | Florida | 33143 | — |
| Well Pharma Medical Research | Miami | Florida | 33143 | — |
| Advanced Pharma CR, LLC | Miami | Florida | 33147 | — |
| AppleMed Research Group, LLC | Miami | Florida | 33155 | — |
| Kendall South Medical Center, Inc | Miami | Florida | 33185 | — |
| Suncoast Clinical Research, Inc. | New Port Richey | Florida | 34652 | — |
| Advanced Research Institute, Inc | New Port Richey | Florida | 34653 | — |
| Sunshine Research Center | Opa-locka | Florida | 33054 | — |
| Diabetes and Endocrine Center of Orlando | Orlando | Florida | 32803 | — |
| Suncoast Clinical Research | Palm Harbor | Florida | 34684 | — |
| Misal Khan, MD FRCS, ED, PA | Panama City | Florida | 32401 | — |
| Iconic Clinical Trials | Pembroke Pines | Florida | 33024 | — |
| Gulf Region Clinical Research Institute | Pensacola | Florida | 32514 | — |
| St. John's Center for Clinical Research | Ponte Vedra Beach | Florida | 32081 | — |
| Metabolic Research Institute | West Palm Beach | Florida | 33401 | — |
| PMI Health Research Group | Atlanta | Georgia | 30312 | — |
| Atlanta Diabetes Associates | Atlanta | Georgia | 30318 | — |
| Albert F. Johary MD, PC | Dunwoody | Georgia | 30338 | — |
| Georgia Clinical Research, LLC | Snellville | Georgia | 30078 | — |
| Hayden Lake Family Physicians | Hayden Lake | Idaho | 83835 | — |
| Boise Kidney and Hypertension Institute | Meridian | Idaho | 83642 | — |
| Suburban Clinical Research | Bolingbrook | Illinois | 60490 | — |
| Cedar-Crosse Research Center | Chicago | Illinois | 60607 | — |
| John H. Stroger Jr. Hospital of Cook Country | Chicago | Illinois | 60612 | — |
| Apex Medical Research | Chicago | Illinois | 60616 | — |
| Pharmakon Inc | Evergreen Park | Illinois | 60805 | — |
| American Health Network | Avon | Indiana | 46123 | — |
| Investigators Research Group, LLC | Brownsburg | Indiana | 46112 | — |
| American Health Network of Indiana, LLC | Franklin | Indiana | 46131 | — |
| Mapleton Medical Center | Indianapolis | Indiana | 46205 | — |
| American Health Network, LLC | Indianapolis | Indiana | 46254 | — |
| McKinley Research, LLC | Mishawaka | Indiana | 46545 | — |
| American Health Network of Indiana, LLC | Muncie | Indiana | 47304 | — |
| MCM Clinical Research, LLC | Florence | Kentucky | 41042 | — |
| Kentucky Diabetes Endocrinology Center | Lexington | Kentucky | 40503 | — |
| Four Rivers Clinical Research, Inc | Paducah | Kentucky | 42003 | — |
| Crescent City Clinical Research | Metairie | Louisiana | 70006 | — |
| Acadia Clinical Research, LLC | Bangor | Maine | 04401 | — |
| Office of Dr. Stephen R. Smith, MD | Baltimore | Maryland | 21234 | — |
| Endocrine and Metabolic Consultants | Rockville | Maryland | 20852 | — |
| Tristan Medical Enterprises, PC dba Regeneris | North Attleboro | Massachusetts | 02760 | — |
| ClinSite, LLC | Canton | Michigan | 48187 | — |
| Apex Medical Research, AMR Inc | Flint | Michigan | 48504 | — |
| Westside Family Medical Center, PC | Kalamazoo | Michigan | 49009 | — |
| Tri City Medical Centers, PC | Livonia | Michigan | 48152 | — |
| KMED Research | Saint Clair Shores | Michigan | 48081 | — |
| Tri-County Research, Inc | Sterling Heights | Michigan | 48310 | — |
| Medical Research Associates | Traverse City | Michigan | 49684 | — |
| Oakland Medical Research Center | Troy | Michigan | 48085 | — |
| Park Nicollet Institute | Minneapolis | Minnesota | 55416 | — |
| The Center for Clinical Trials, Inc. | Biloxi | Mississippi | 39531 | — |
| Mercy Health Research | St Louis | Missouri | 63141 | — |
| Quality Clinical Research | Omaha | Nebraska | 68114 | — |
| Clinical Research Advantage, Inc./Rita B. Chuang, MD, LLC | Henderson | Nevada | 89052 | — |
| Clinical Research of South Nevada | Las Vegas | Nevada | 89121 | — |
| Palm Medical Research Center | Las Vegas | Nevada | 89148 | — |
| Atco Medical Associates, PC | Atco | New Jersey | 08004 | — |
| Summit Medical Group | Clifton | New Jersey | 07012 | — |
| USMA Clinical Research | Elizabeth | New Jersey | 07201 | — |
| Central Jersey Medical Research | Elizabeth | New Jersey | 07202 | — |
| Albany Medical Center / Albany Medical College | Albany | New York | 12206 | — |
| Endocrine Associates of Long Island, PC | Smithtown | New York | 11787 | — |
| Southgate Medical Group/ Southgate Medical Park | West Seneca | New York | 14224 | — |
| OnSite Clinical Solutions, LLC | Asheville | North Carolina | 28801 | — |
| Kernodle Clinic West | Burlington | North Carolina | 27215 | — |
| The University of North Carolina at Chapel Hill | Chapel Hill | North Carolina | 27517 | — |
| Internal Medicine Research | Charlotte | North Carolina | 28204 | — |
| Gaffney Health Services | Charlotte | North Carolina | 28205 | — |
| Durham Internal Medicine Associates | Durham | North Carolina | 27704 | — |
| Sentara Family Medicine | Elizabeth City | North Carolina | 27909 | — |
| PMG Research of Raleigh, LLC | Raleigh | North Carolina | 27609 | — |
| Carolina Research Center, Inc | Shelby | North Carolina | 28150 | — |
| Piedmont Healthcare | Statesville | North Carolina | 28625 | — |
| PMG Research of Wilmington, LLC | Wilmington | North Carolina | 28401 | — |
| Community Health Care of Manchester | Akron | Ohio | 44319 | — |
| Community Medical Associates, LLC | Austintown | Ohio | 44515 | — |
| Harrison Community Research Center | Cadiz | Ohio | 43907 | — |
| Medical Frontiers, LLC | Carlisle | Ohio | 45005 | — |
| Genoa Medical Center | Genoa | Ohio | 43430 | — |
| Office of Dr. Craig S. Thompson, MD, LLC | Marion | Ohio | 43302 | — |
| RAS Health Limited | Marion | Ohio | 43302 | — |
| Advanced Medical Research, LLC | Maumee | Ohio | 43537 | — |
| Pharmacotherapy Research Associates, Inc | Zanesville | Ohio | 43701 | — |
| Infinity Research Group, LLC | Oklahoma City | Oklahoma | 73103 | — |
| Castlerock Clinical Research Consultants, LLC | Tulsa | Oklahoma | 74136 | — |
| Oregon Medical Group | Eugene | Oregon | 97401 | — |
| Harleysville Medical Associates | Harleysville | Pennsylvania | 19438 | — |
| Detweiler Family Medicine & Associates, PC | Lansdale | Pennsylvania | 19446 | — |
| Temple University School of Medicine | Philadelphia | Pennsylvania | 19140 | — |
| Warminster Medical Associates, PC | Warminster | Pennsylvania | 18974 | — |
| New England Center for Clinical Research, Inc | Cranston | Rhode Island | 02920 | — |
| Hartwell Research Group, LLC | Anderson | South Carolina | 29621 | — |
| Paris View Family Practice | Greenville | South Carolina | 29601 | — |
| Mountain View Clinical Research | Greer | South Carolina | 29651 | — |
| South Carolina Nephrology and Hypertension Center, Inc | Orangeburg | South Carolina | 29118 | — |
| Carolina Diabetes & Kidney Center | Sumter | South Carolina | 29150 | — |
| PMG Research of Bristol | Bristol | Tennessee | 37620 | — |
| University Diabetes and Endocrine Consultants | Chattanooga | Tennessee | 37411 | — |
| University of Tennessee | Memphis | Tennessee | 38163 | — |
| Trinity Clinical Research, LLC | Tullahoma | Tennessee | 37388 | — |
| KRK Medical Research | Arlington | Texas | 76012 | — |
| Austin Center for Clinical Research | Austin | Texas | 78758 | — |
| Punzi Medical Center | Carrollton | Texas | 75006 | — |
| Dallas Diabetes and Endocrine Center | Dallas | Texas | 75230 | — |
| Baylor Endocrine Center | Dallas | Texas | 75246 | — |
| University of Texas Southwestern Medical Center | Dallas | Texas | 75390-8858 | — |
| Jacon Medical Research Associates, LLC | Houston | Texas | 77030 | — |
| JVC Family Medicine | Houston | Texas | 77040 | — |
| Clinical Trial Network | Houston | Texas | 77074 | — |
| Endocrine and Psychiastry Center | Houston | Texas | 77095 | — |
| Pioneer Research Solutions, Inc. | Houston | Texas | 77099 | — |
| Midland Clinical Research Center | Midland | Texas | 79707 | — |
| Hill Country Medical Associates | New Braunfels | Texas | 78130 | — |
| Naidu Clinic | Odessa | Texas | 79761 | — |
| The Methodist Hospital d/b/a HMRI CCAT at Pearland | Pearland | Texas | 77584 | — |
| Village Health Partners | Plano | Texas | 75024 | — |
| Sun Research Institute | San Antonio | Texas | 78215 | — |
| Northeast Clinical Research of San Antonio, LLC | Schertz | Texas | 78154 | — |
| Kenneth Otah and Associates | Sugar Land | Texas | 77478 | — |
| PHS Clinical Trials | Midvale | Utah | 84047 | — |
| Highland Clinical Research | Salt Lake City | Utah | 84124 | — |
| Burke Internal Medicine and Research | Burke | Virginia | 22015 | — |
| Ettrick Health Center | Ettrick | Virginia | 23803 | — |
| Manassas Clinical Research Center | Manassas | Virginia | 20110 | — |
| Clinical Research Partners, LLC | Richmond | Virginia | 23220 | — |
| Richmond Family Practice | Richmond | Virginia | 23220 | — |
| Larry D Stonesifer, MD Inc., PS | Federal Way | Washington | 98003 | — |
| Premier Clinical Research | Spokane | Washington | 99204 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 436 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT01243424, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jan 7, 2020 · Synced Oct 21, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT01243424 live on ClinicalTrials.gov.