Tivantinib Plus Erlotinib Versus Placebo Plus Erlotinib for the Treatment of Non-squamous, Non-small-cell Lung Cancer

ClinicalTrials.gov ID: NCT01244191

Public ClinicalTrials.gov record NCT01244191. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Oct 30, 2026, 12:36 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study of ARQ197 Plus Erlotinib Versus Placebo Plus Erlotinib in Previously Treated Subjects With Locally Advanced or Metastatic, Non-Squamous, Non-Small-Cell Lung Cancer (NSCLC)

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

This study is to determine if the combination regimen of tivantinib with erlotinib will improve overall survival relative to erlotinib alone in subjects with locally advanced or metastatic non-squamous, non-small cell lung cancer who have received 1 or 2 prior systemic anti-cancer therapies.

Study identification

NCT ID: NCT01244191
Recruitment status: Terminated
Study type: Interventional
Phase: Phase 3
Lead sponsor: Daiichi Sankyo; Industry
Enrollment: 1,048 participants

Conditions and interventions

Conditions

Non Squamous, Non-small-cell Lung Cancer

Interventions

Drug

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Jan 11, 2011 (Actual)
Primary completion: Dec 15, 2012 (Actual)
Completion: Dec 15, 2012 (Actual)
Last update posted: Apr 6, 2021

2011 – 2012

United States locations

U.S. sites: 111
U.S. states: 27
U.S. cities: 88

Facility	City	State	ZIP	Site status
Not listed	Tucson	Arizona	85704	—
Not listed	Tucson	Arizona	85710	—
Not listed	Tucson	Arizona	85715	—
Not listed	Tucson	Arizona	85724-5024	—
Not listed	Los Angeles	California	90048	—
Not listed	Oxnard	California	—	—
Not listed	Rancho Mirage	California	39800	—
Not listed	Rancho Mirage	California	92270	—
Not listed	Santa Monica	California	90404	—
Not listed	Aurora	Colorado	80012	—
Not listed	Boulder	Colorado	80303	—
Not listed	Colorado Springs	Colorado	80907	—
Not listed	Colorado Springs	Colorado	80909	—
Not listed	Denver	Colorado	80218	—
Not listed	Denver	Colorado	80220	—
Not listed	Lakewood	Colorado	80228	—
Not listed	Littleton	Colorado	80120	—
Not listed	Lone Tree	Colorado	80124	—
Not listed	Longmont	Colorado	80501	—
Not listed	Parker	Colorado	80138	—
Not listed	Thornton	Colorado	80260	—
Not listed	Newark	Delaware	19713	—
Not listed	Fort Myers	Florida	33916	—
Not listed	Miami Beach	Florida	33012	—
Not listed	Pensacola	Florida	32504	—
Not listed	Atlanta	Georgia	30341	—
Not listed	Austell	Georgia	30106	—
Not listed	Carrollton	Georgia	30117	—
Not listed	Cartersville	Georgia	30121	—
Not listed	Douglasville	Georgia	30134	—
Not listed	Marietta	Georgia	30060	—
Not listed	Chicago	Illinois	60637	—
Not listed	Carmel	Indiana	46032	—
Not listed	Fishers	Indiana	46037	—
Not listed	Goshen	Indiana	46526	—
Not listed	Greenfield	Indiana	46140	—
Not listed	Indianapolis	Indiana	46219	—
Not listed	Indianapolis	Indiana	46227	—
Not listed	Indianapolis	Indiana	48202	—
Not listed	Lexington	Kentucky	—	—
Not listed	Louisville	Kentucky	—	—
Not listed	Towson	Maryland	21204	—
Not listed	Boston	Massachusetts	02114	—
Not listed	Minneapolis	Minnesota	55455	—
Not listed	St Louis	Missouri	63110	—
Not listed	Grand Island	Nebraska	68803	—
Not listed	Omaha	Nebraska	68198	—
Not listed	Henderson	Nevada	89052	—
Not listed	Henderson	Nevada	89074	—
Not listed	Las Vegas	Nevada	89128	—
Not listed	Las Vegas	Nevada	89148	—
Not listed	Las Vegas	Nevada	89169	—
Not listed	East Orange	New Jersey	07018	—
Not listed	Albuquerque	New Mexico	87131	—
Not listed	Buffalo	New York	14263	—
Not listed	Goshen	New York	10924	—
Not listed	Latham	New York	—	—
Not listed	New York	New York	10032	—
Not listed	The Bronx	New York	10467	—
Not listed	Cincinnati	Ohio	45242	—
Not listed	Cleveland	Ohio	44195	—
Not listed	Kettering	Ohio	—	—
Not listed	Eugene	Oregon	97401	—
Not listed	Portland	Oregon	97213	—
Not listed	Portland	Oregon	97225	—
Not listed	Portland	Oregon	97227	—
Not listed	Portland	Oregon	97239	—
Not listed	Springfield	Oregon	97477	—
Not listed	Tualatin	Oregon	97062	—
Not listed	Harrisburg	Pennsylvania	17109	—
Not listed	Hershey	Pennsylvania	17033-0850	—
Not listed	Philadelphia	Pennsylvania	19104	—
Not listed	Columbia	South Carolina	29120	—
Not listed	Easley	South Carolina	29640	—
Not listed	Greenville	South Carolina	29601	—
Not listed	Greenville	South Carolina	29605	—
Not listed	Greenville	South Carolina	29615	—
Not listed	Spartanburg	South Carolina	29307	—
Not listed	Bartlett	Tennessee	38138	—
Not listed	Chattanooga	Tennessee	37404	—
Not listed	Germantown	Tennessee	38138	—
Not listed	Knoxville	Tennessee	37909	—
Not listed	Memphis	Tennessee	38104	—
Not listed	Nashville	Tennessee	37203	—
Not listed	Southaven	Tennessee	38671	—
Not listed	Austin	Texas	78705	—
Not listed	Austin	Texas	78731	—
Not listed	Austin	Texas	78745	—
Not listed	Austin	Texas	78758	—
Not listed	Cedar Park	Texas	78731	—
Not listed	Dallas	Texas	75216-9982	—
Not listed	Dallas	Texas	75246	—
Not listed	Fort Worth	Texas	76104	—
Not listed	Fort Worth	Texas	76132	—
Not listed	Kyle	Texas	78640	—
Not listed	Round Rock	Texas	78665	—
Not listed	Round Rock	Texas	78681	—
Not listed	San Marcos	Texas	78666	—
Not listed	Salt Lake City	Utah	84112	—
Not listed	Arlington	Virginia	22205	—
Not listed	Fairfax	Virginia	22031	—
Not listed	Gainesville	Virginia	20155	—
Not listed	Leesburg	Virginia	20176	—
Not listed	Midlothian	Virginia	23112	—
Not listed	Richmond	Virginia	23298	—
Not listed	Winchester	Virginia	22601	—
Not listed	Woodbridge	Virginia	22191	—
Not listed	Seattle	Washington	98104	—
Not listed	Vancouver	Washington	98684	—
Not listed	Vancouver	Washington	98686	—
Not listed	Yakima	Washington	98902	—

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 193 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT01244191, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Apr 6, 2021 · Synced Oct 30, 2026

Open the official record

The complete public registry record, listed eligibility criteria, and available contact information for NCT01244191 live on ClinicalTrials.gov.

View official ClinicalTrials.gov record →