A Study of Response-Guided Duration of Combination Therapy With GS-9451, Pegasys® and Copegus® With and Without Tegobuvir (GS-9190) in Previously Untreated Subjects With Genotype 1 Chronic Hepatitis C
Public ClinicalTrials.gov record NCT01271790. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2b, Randomized, Double-Blind, Placebo-Controlled Trial Evaluating 16 and 24 Weeks of Four-Drug Regimen and 24 Weeks of a Three-Drug Regimen of GS-9451, Peginterferon Alfa 2a (PEG, Pegasys®) and Ribavirin (RBV, Copegus®) With and Without Tegobuvir (GS-9190) Followed by Response Guided PEG and RBV in Treatment Naïve Subjects With Chronic Genotype 1 Hepatitis C Virus Infection (Protocol No. GS US 196 0140
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This phase 2b study will evaluate the efficacy and safety of 16 and 24 weeks of a 4-drug regimen with GS-9451 and Tegobuvir and 24 weeks of a 3-drug regimen of GS-9451 without Tegobuvir, all with Peginterferon Alfa-2a (Pegasys®) and Ribavirin (Copegus®).
Study identification
- NCT ID
- NCT01271790
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 245 participants
Conditions and interventions
Conditions
Interventions
- Tegobuvir (GS-9190) Drug
- GS-9451 Drug
- Pegasys® Biological
- Copegus® Drug
- Tegobuvir placebo Drug
- GS-9451 placebo Drug
Drug · Biological
Eligibility (public fields only)
- Age range
- 18 Years to 70 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Oct 2010 (Type not available)
- Primary completion
- Jan 2013 (Actual)
- Completion
- Sep 2013 (Actual)
- Last update posted
- Feb 6, 2014
2010 – 2013
United States locations
- U.S. sites
- 85
- U.S. states
- 29
- U.S. cities
- 65
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Digestive Health Specialists of the Southeast | Dothan | Alabama | 36305 | — |
| Alabama Liver and Digestive Specialists | Montgomery | Alabama | 36116 | — |
| Mayo Clinic | Phoenix | Arizona | 85054 | — |
| University of Arizona | Tucson | Arizona | 85724 | — |
| Pacific Oaks Medical Group | Beverly Hills | California | 90211 | — |
| eStudySite | Chula Vista | California | 91911 | — |
| Scripps Clinic | La Jolla | California | 92037 | — |
| eStudySite | La Mesa | California | 91942 | — |
| Cedars-Sinai Medical Center | Los Angeles | California | 90048 | — |
| Synergy Clinical Research Center | National City | California | 91950 | — |
| eStudySite | Oceanside | California | 92056 | — |
| RESEARCH and EDUCATION, INC | San Diego | California | 92015 | — |
| Medical Associates Research Group | San Diego | California | 92123 | — |
| Kaiser Permanente | San Diego | California | 92154 | — |
| California Pacific Medical Center | San Francisco | California | 94115 | — |
| San Francisco Veterans Affairs Medical Center | San Francisco | California | 94121 | — |
| University of Colorado Denver | Aurora | Colorado | 80045 | — |
| South Denver Gastroenterology | Englewood | Colorado | 80110 | — |
| Washington Hospital Center | Washington D.C. | District of Columbia | 20010 | — |
| Bach and Godofsky Infectious Diseases | Bradenton | Florida | 34209 | — |
| Avail Clinical Research, LLC | DeLand | Florida | 32720 | — |
| University of Florida | Gainesville | Florida | 32610 | — |
| Palmetto Research | Hialeah | Florida | 33016 | — |
| University of Miami | Miami | Florida | 33136 | — |
| Scientific Clinical Research, Inc c/o Segal Institute for Clinical Research | North Miami | Florida | 33161 | — |
| Orlando Immunology Center | Orlando | Florida | 32803 | — |
| Florida Hospital | Orlando | Florida | 32804 | — |
| South Florida Center of Gastroenterology, LLC | Wellington | Florida | 33414 | — |
| Atlanta Gastroenterology Associates | Atlanta | Georgia | 30308 | — |
| Emory University, Infectious Disease Clinic | Atlanta | Georgia | 30308 | — |
| Liver Center of Atlanta | Atlanta | Georgia | 30309 | — |
| Dekalb Gastroenterology | Decatur | Georgia | 30033 | — |
| Infectious Disease Specialists of Atlanta | Decatur | Georgia | 30033 | — |
| Northwestern Memorial Hospital | Chicago | Illinois | 60611 | — |
| University of Chicago | Chicago | Illinois | 60637 | — |
| Indiana University | Indianapolis | Indiana | 46202 | — |
| IGRF | Indianapolis | Indiana | 46237 | — |
| Graves Gilbert Clinic | Bowling Green | Kentucky | 42101 | — |
| University of Louisville | Louisville | Kentucky | 40202 | — |
| Gastroenterology Associates, LLC | Baton Rouge | Louisiana | 70809 | — |
| Digestive Disease Associates, PA | Baltimore | Maryland | 21229 | — |
| Johns Hopkins University | Baltimore | Maryland | 21287 | — |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | — |
| Beth Israel Deaconess Medical Center | Boston | Massachusetts | 02115 | — |
| Partners in Internal Medicine, P.C. | Worcester | Massachusetts | 01608 | — |
| Henry Ford Health System-Columbus center | Novi | Michigan | 48377 | — |
| MN Gastroenterology, P.A. | Plymouth | Minnesota | 55446 | — |
| Gastrointestinal Associates, PA | Jackson | Mississippi | 39202 | — |
| Digestive Health Specialists, PA | Tupelo | Mississippi | 38801 | — |
| Saint Louis University | St Louis | Missouri | 63104 | — |
| Comprehensive Clinical Research | Berlin | New Jersey | 08009 | — |
| ID Care 105 | Hillsborough | New Jersey | 08844 | — |
| Atlantic Research Affiliates, LLC | Morristown | New Jersey | 07960 | — |
| University of Medicine and Dentistry of New Jersey | Newark | New Jersey | 07103 | — |
| UNM Health Sciences Center | Albuquerque | New Mexico | 87106 | — |
| Binghamton Gastroenterology | Binghamton | New York | 13903 | — |
| North Shore University Hospital | Manhasset | New York | 11030 | — |
| Concorde Medical Group | New York | New York | 10016 | — |
| NYU Hepatology Associates | New York | New York | 10016 | — |
| Cornell University Gastroenterology & Hepatology | New York | New York | 10021 | — |
| Mount Sinai Medical Center | New York | New York | 10029 | — |
| Columbia University Medical Center | New York | New York | 10032 | — |
| Asheville Gastroenterology Associates, P.A. | Asheville | North Carolina | 28801 | — |
| Duke University Medical Center | Durham | North Carolina | 27710 | — |
| Consultants for Clinical | Cincinnati | Ohio | 45219 | — |
| University of Cincinnati | Cincinnati | Ohio | 45267 | — |
| University Hospitals Case Medical Center | Cleveland | Ohio | 44106 | — |
| Options Health Research, LLC | Tulsa | Oklahoma | 74104 | — |
| Albert Einstein Medical Center | Philadelphia | Pennsylvania | 19141 | — |
| Memphis Gastroenterology Group | Germantown | Tennessee | 38138 | — |
| James H. Quillen VA Medical Center | Mountain Home | Tennessee | 37684 | — |
| Columbia Medical Group, The Frist Clinic | Nashville | Tennessee | 37203 | — |
| The North Texas Research Institute | Arlington | Texas | 76012 | — |
| UT Southwestern Medical Center at Dallas | Dallas | Texas | 75390-8887 | — |
| Kelsey Research Foundation | Houston | Texas | 77005 | — |
| Advanced Liver Therapies | Houston | Texas | 77030 | — |
| Research Specialists of Texas | Houston | Texas | 77030 | — |
| Amcare Research Inc. | Houston | Texas | 77090 | — |
| Alamo Medical Research | San Antonio | Texas | 78215 | — |
| Brooke Army Medical Center | San Antonio | Texas | 78234 | — |
| Metropolitan Research | Fairfax | Virginia | 22031 | — |
| Liver Institute of Virginia, Bon Secours | Newport News | Virginia | 23602 | — |
| Digestive and Liver Disease Specialists | Norfolk | Virginia | 23502 | — |
| Virginia Mason Medical Center, Digestive Disease Institute | Seattle | Washington | 98101 | — |
| University of Wisconsin Hospital & Clinics | Madison | Wisconsin | 53792 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 59 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT01271790, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Feb 6, 2014 · Synced Oct 18, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT01271790 live on ClinicalTrials.gov.