Prevention of Cardiac Allograft Vasculopathy Using Rituximab (Rituxan) Therapy in Cardiac Transplantation
Public ClinicalTrials.gov record NCT01278745. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Prevention of Cardiac Allograft Vasculopathy Using Rituximab (Rituxan) Therapy in Cardiac Transplantation (CTOT-11)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
All people who have a heart transplant are at risk for developing cardiac allograft vasculopathy (CAV). CAV means narrowing of the heart transplant vessels, which is associated with poor heart transplant function. People who develop antibodies after transplant have a higher risk of developing CAV. Infections, high cholesterol, and rejection also increase the risk of developing CAV. People who develop CAV usually have to receive another transplant.
Study identification
- NCT ID
- NCT01278745
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 362 participants
Conditions and interventions
Interventions
- Rituximab induction/conventional immunosuppression (tacrolimus, MMF, and steroid taper) Biological
- Rituximab placebo/conventional immunosuppression (tacrolimus, MMF, and steroid taper) Drug
Biological · Drug
Eligibility (public fields only)
- Age range
- 18 Years to 75 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Sep 2011 (Type not available)
- Primary completion
- Oct 2015 (Actual)
- Completion
- Oct 2015 (Actual)
- Last update posted
- Sep 24, 2026
2011 – 2015
United States locations
- U.S. sites
- 24
- U.S. states
- 12
- U.S. cities
- 19
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Cedars Sinai Heart Institute | Beverly Hills | California | 90211 | — |
| Ronald Regan UCLA Medical Center | Los Angeles | California | 90095 | — |
| Stanford University/Palo Alto VA | Palo Alto | California | 94304 | — |
| University of California San Francisco | San Francisco | California | 94143-0124 | — |
| Stanford University | Stanford | California | 94305 | — |
| Northwestern University | Chicago | Illinois | 60611 | — |
| University of Maryland | Baltimore | Maryland | 21201 | — |
| Tufts Medical Center | Boston | Massachusetts | 02111 | — |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | — |
| Brigham and Women's Hospital | Boston | Massachusetts | 02115 | — |
| Minneapolis Heart Institute | Minneapolis | Minnesota | 55407 | — |
| University of Minnesota | Minneapolis | Minnesota | 55455 | — |
| Mount Sinai School of Medicine | New York | New York | 10029 | — |
| Columbia University Medical Center | New York | New York | 10032' | — |
| Cleveland Clinic Foundation | Cleveland | Ohio | 44195 | — |
| Drexel University College of Medicine | Philadelphia | Pennsylvania | 19102 | — |
| University of Pennsylvania | Philadelphia | Pennsylvania | 19104 | — |
| Allegheny General Hospital | Pittsburgh | Pennsylvania | 15212 | — |
| Medical University of South Carolina | Charleston | South Carolina | 29425 | — |
| Medical City Dallas Hospital/CRSTI | Dallas | Texas | 75230 | — |
| The Methodist Hospital | Houston | Texas | 77030 | — |
| Intermountain Medical Center | Murray | Utah | 84157 | — |
| University of Utah | Salt Lake City | Utah | 84132-2401 | — |
| University of Wisconsin | Madison | Wisconsin | 53792 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT01278745, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 24, 2026 · Synced Oct 20, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT01278745 live on ClinicalTrials.gov.