Pioglitazone in Early Parkinson's Disease
Public ClinicalTrials.gov record NCT01280123. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Multi-Center, Double-Blind, Placebo-Controlled Phase II Study of Pioglitazone in Early Parkinson's Disease
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is a multi-center, double-blind, placebo controlled clinical trial of two dosages of oral pioglitazone (15 milligram(mg) and 45 milligram (mg)) for safety, tolerability, and futility. Subjects who are on stable dose of rasagiline 1 mg/day or selegiline 10 mg/day for at least 8 weeks but no more than 8 months, will be randomized to one of two dosages of oral pioglitazone (15 mg and 45 mg) or matching placebo. The study will measure disease progression by the change in total Unified Parkinson's Disease Rating Scale (UPDRS) score between the baseline visit and 44 weeks.
Study identification
- NCT ID
- NCT01280123
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 210 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 30 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 2011 (Type not available)
- Primary completion
- May 2014 (Actual)
- Completion
- May 2014 (Actual)
- Last update posted
- Oct 14, 2015
2011 – 2014
United States locations
- U.S. sites
- 38
- U.S. states
- 26
- U.S. cities
- 35
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Univeristy of Alabama at Birmingham | Birmingham | Alabama | 35294-0017 | — |
| Barrow Neurological Institute | Phoenix | Arizona | 85013 | — |
| The Parkinson's & Movement Disorder Institute | Fountain Valley | California | 92708 | — |
| University of Southern California | Los Angeles | California | 90083 | — |
| University of California San Fransisco | San Francisco | California | 94143-0114 | — |
| Univeristy of Colorado Denver | Aurora | Colorado | 80045 | — |
| University of Florida | Gainsville | Florida | 32610 | — |
| University of Florida, Jacksonville | Jacksonville | Florida | 32209 | — |
| University of Miami | Miami | Florida | 33136 | — |
| University of South Florida | Tampa | Florida | 33606 | — |
| Emory University School of Medicine | Atlanta | Georgia | 30329 | — |
| Medical College of Georgia | Augusta | Georgia | 30912 | — |
| Pacific Health Research & Education Institute | Honolulu | Hawaii | 96819 | — |
| Northwestern University | Chicago | Illinois | 60611 | — |
| Rush University Medical Center | Chicago | Illinois | 60612 | — |
| University of Kansas Medical Center | Kansas City | Kansas | 66160 | — |
| University of Kentucky | Lexington | Kentucky | 40536 | — |
| Ochsner Clinic Foundation | New Orleans | Louisiana | 70121 | — |
| LSU Health Science Center Shreveport | Shreveport | Louisiana | 71103 | — |
| Johns Hopkins University | Baltimore | Maryland | 21287-0875 | — |
| Brigham & Women's Hospital | Boston | Massachusetts | 02115 | — |
| Beth Israel Deaconess Medical Center | Boston | Massachusetts | 02215 | — |
| University of Michigan | Ann Arbor | Michigan | 48109-5316 | — |
| Michigan State University | East Lansing | Michigan | 48824 | — |
| Struthers Parkinson's Center | Golden Valley | Minnesota | 55427 | — |
| Washington University | St Louis | Missouri | 63110 | — |
| Dartmouth Hitchcock Medical Center | Lebanon | New Hampshire | 03756 | — |
| SUNY Downstate Medical Center | Brooklyn | New York | 11203-2098 | — |
| North Shore - LIJ Health System | Manhasset | New York | 11030 | — |
| Duke University | Durham | North Carolina | 27705 | — |
| Oregon Health & Science University | Portland | Oregon | 97239-3098 | — |
| Thomas Jefferson University | Philadelphia | Pennsylvania | 19107 | — |
| University of Pennsylvania | Philadelphia | Pennsylvania | 19107 | — |
| Medical University of South Carolina | Charleston | South Carolina | 29401 | — |
| Vanderbilt University | Nashville | Tennessee | 37232 | — |
| University of Texas Southwestern Medical Center | Dallas | Texas | 75390-9036 | — |
| University of Vermont | Burlington | Vermont | 05405 | — |
| University of Virginia | Charlottesville | Virginia | 22903 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT01280123, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 14, 2015 · Synced Oct 20, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT01280123 live on ClinicalTrials.gov.