Safety and Efficacy Study of SYN115 in Parkinson's Patients Using Levodopa to Treat End of Dose Wearing Off
Public ClinicalTrials.gov record NCT01283594. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Double-blind, Randomized, Placebo-controlled Study of the Safety and Efficacy of SYN115 as Adjunctive Therapy in Levodopa-treated Parkinson's Subjects With End of Dose Wearing Off
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this research study is to test the effect of SYN115 compared to placebo (a "sugar pill" that looks like SYN115 but does not include active drug) on movement during the "on" and "off" states as well as other symptoms that some patients with Parkinson's disease experience. This study will also look at whether or not patients with Parkinson's disease experience "side-effects" with SYN115.
Study identification
- NCT ID
- NCT01283594
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2, Phase 3
- Enrollment
- 420 participants
Conditions and interventions
Conditions
Interventions
- Tozadenant (SYN115) 60 mg BID Drug
- Placebo Drug
- Levodopa (L-dopa) Drug
- Tozadenant (SYN115) 120 mg BID Drug
- Tozadenant (SYN115) 180 mg BID Drug
- Tozadenant (SYN115) 240 mg BID Drug
Drug
Eligibility (public fields only)
- Age range
- 30 Years to 80 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 2011 (Type not available)
- Primary completion
- Oct 2012 (Actual)
- Completion
- Oct 2012 (Actual)
- Last update posted
- Jan 17, 2019
2011 – 2012
United States locations
- U.S. sites
- 40
- U.S. states
- 24
- U.S. cities
- 40
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Not listed | Birmingham | Alabama | 35005 | — |
| Not listed | La Jolla | California | 92037 | — |
| Not listed | Loma Linda | California | 92318 | — |
| Not listed | Los Angeles | California | 90001 | — |
| Not listed | Oxnard | California | 93030 | — |
| Not listed | San Francisco | California | 94016 | — |
| Not listed | Denver | Colorado | 80014 | — |
| Not listed | Manchester | Connecticut | 06040 | — |
| Not listed | New Haven | Connecticut | 06501 | — |
| Not listed | Boca Raton | Florida | 33427 | — |
| Not listed | Gainesville | Florida | 32601 | — |
| Not listed | Miami | Florida | 33101 | — |
| Not listed | Tampa | Florida | 33601 | — |
| Not listed | Weston | Florida | 33326 | — |
| Not listed | Atlanta | Georgia | 30301 | — |
| Not listed | Augusta | Georgia | 30901 | — |
| Not listed | Boise | Idaho | 83701 | — |
| Not listed | Springfield | Illinois | 62629 | — |
| Not listed | Indianapolis | Indiana | 46077 | — |
| Not listed | Des Moines | Iowa | 50047 | — |
| Not listed | Kansas City | Kansas | 66012 | — |
| Not listed | Lexington | Kentucky | 40502 | — |
| Not listed | Baltimore | Maryland | 21201 | — |
| Not listed | West Bloomfield | Michigan | 48302 | — |
| Not listed | Minneapolis | Minnesota | 55111 | — |
| Not listed | Commack | New York | 11725 | — |
| Not listed | New York | New York | 10001 | — |
| Not listed | Durham | North Carolina | 27517 | — |
| Not listed | Cincinnati | Ohio | 41073 | — |
| Not listed | Cleveland | Ohio | 44101 | — |
| Not listed | Columbus | Ohio | 43004 | — |
| Not listed | Toledo | Ohio | 43460 | — |
| Not listed | Tulsa | Oklahoma | 74008 | — |
| Not listed | Allentown | Pennsylvania | 18001 | — |
| Not listed | Philadelphia | Pennsylvania | 19019 | — |
| Not listed | Charleston | South Carolina | 29401 | — |
| Not listed | Dallas | Texas | 75001 | — |
| Not listed | Houston | Texas | 77001 | — |
| Not listed | Roanoke | Virginia | 24001 | — |
| Not listed | Milwaukee | Wisconsin | 53201 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 21 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT01283594, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jan 17, 2019 · Synced Oct 17, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT01283594 live on ClinicalTrials.gov.