A Study of RoActemra/Actemra (Tocilizumab) Versus Adalimumab in Combination With Methotrexate (MTX) in Patients With Moderate to Severe Active Rheumatoid Arthritis And an Inadequate Response to Treatment With Only One Tumor Necrosis Factor (TNF)-Inhibitor
Public ClinicalTrials.gov record NCT01283971. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Open-label, Parallel-group Study of the Reduction of Signs and Symptoms During Treatment With Tocilizumab Versus Adalimumab, Both in Combination With MTX, in Patients With Moderate to Severe Active Rheumatoid Arthritis and an Inadequate Response to Treatment With Only One TNF Inhibitor
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This randomized, parallel-group study will assess the efficacy and safety of RoActemra/Actemra (tocilizumab) versus adalimumab, both in combination with methotrexate (MTX) in patients with moderate to severe active rheumatoid arthritis. Patients, already treated with MTX at stable doses, will be randomized to receive either RoActemra/Actemra 8 mg/kg intravenously (IV) every 4 weeks or adalimumab 40 mg subcutaneous (SC) every 2 weeks. All patients will receive methotrexate (10-25 mg weekly) and folate (at least 5 mg weekly). The anticipated time on study treatment is 24 weeks.
Study identification
- NCT ID
- NCT01283971
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 4
- Enrollment
- 96 participants
Conditions and interventions
Conditions
Interventions
- tocilizumab [RoActemra/Actemra] Drug
- adalimumab Drug
- placebo to tocilizumab Drug
- placebo to adalimumab Drug
- methotrexate Drug
- folate Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Apr 30, 2011
- Primary completion
- Jul 31, 2012
- Completion
- Jul 31, 2012
- Last update posted
- Feb 9, 2014
2011 – 2012
United States locations
- U.S. sites
- 107
- U.S. states
- 32
- U.S. cities
- 98
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Not listed | Huntsville | Alabama | 35801 | — |
| Not listed | Phoenix | Arizona | 85027 | — |
| Not listed | Tucson | Arizona | 85712 | — |
| Not listed | Covina | California | 91723 | — |
| Not listed | Escondido | California | 92025 | — |
| Not listed | Huntington Beach | California | 92646 | — |
| Not listed | La Mesa | California | 91942 | — |
| Not listed | Lakewood | California | 90712 | — |
| Not listed | Long Beach | California | 90806 | — |
| Not listed | Los Angeles | California | 90048 | — |
| Not listed | Sacramento | California | 95816-5119 | — |
| Not listed | San Diego | California | 92108 | — |
| Not listed | Westlake Village | California | 91361 | — |
| Not listed | Whittier | California | 90603 | — |
| Not listed | Whittier | California | 90606 | — |
| Not listed | Bridgeport | Connecticut | 06606 | — |
| Not listed | Hamden | Connecticut | 06518 | — |
| Not listed | Norwich | Connecticut | 06360 | — |
| Not listed | Newark | Delaware | 19713 | — |
| Not listed | Aventura | Florida | 33180 | — |
| Not listed | Fort Lauderdale | Florida | 33334 | — |
| Not listed | Jupiter | Florida | 33458 | — |
| Not listed | Melbourne | Florida | 32901 | — |
| Not listed | Naples | Florida | 34102 | — |
| Not listed | Ocala | Florida | 34474 | — |
| Not listed | Orlando | Florida | 32806 | — |
| Not listed | Ormond Beach | Florida | 32174 | — |
| Not listed | Palm Habor | Florida | 34684 | — |
| Not listed | Palm Harbor | Florida | 34684 | — |
| Not listed | Sarasota | Florida | 34239 | — |
| Not listed | Tamarac | Florida | 33321 | — |
| Not listed | Tampa | Florida | 33609 | — |
| Not listed | Atlanta | Georgia | 30342 | — |
| Not listed | Valdosta | Georgia | 31602 | — |
| Not listed | Idaho Falls | Idaho | 83404 | — |
| Not listed | Chicago | Illinois | 60611 | — |
| Not listed | Maywood | Illinois | 60153 | — |
| Not listed | Moline | Illinois | 61265 | — |
| Not listed | Springfield | Illinois | 62704 | — |
| Not listed | Fort Wayne | Indiana | 46804 | — |
| Not listed | South Bend | Indiana | 46601 | — |
| Not listed | Lexington | Kentucky | 40515 | — |
| Not listed | Baton Rouge | Louisiana | 70808 | — |
| Not listed | Monroe | Louisiana | 71203 | — |
| Not listed | Annapolis | Maryland | 21401 | — |
| Not listed | Cumberland | Maryland | 21502 | — |
| Not listed | Frederick | Maryland | 21702 | — |
| Not listed | Hagerstown | Maryland | 21740 | — |
| Not listed | Fall River | Massachusetts | 02720 | — |
| Not listed | Worcester | Massachusetts | 01610 | — |
| Not listed | Battle Creek | Michigan | 49015 | — |
| Not listed | Lansing | Michigan | 48910 | — |
| Not listed | Petoskey | Michigan | 49770 | — |
| Not listed | Saint Claire Shores | Michigan | 48081 | — |
| Not listed | Biloxi | Mississippi | 39531 | — |
| Not listed | Flowood | Mississippi | 39232 | — |
| Not listed | Tupelo | Mississippi | 38802 | — |
| Not listed | Springfield | Missouri | 65807 | — |
| Not listed | St Louis | Missouri | 63117 | — |
| Not listed | Reno | Nevada | 89502 | — |
| Not listed | Clifton | New Jersey | 07012 | — |
| Not listed | Manalapan | New Jersey | 07726 | — |
| Not listed | New Brunswick | New Jersey | 08903 | — |
| Not listed | Brooklyn | New York | 11201 | — |
| Not listed | New York | New York | 10016 | — |
| Not listed | New York | New York | 10029-6574 | — |
| Not listed | Syracuse | New York | 13210 | — |
| Not listed | Charlotte | North Carolina | 28204 | — |
| Not listed | Charlotte | North Carolina | 28210 | — |
| Not listed | Greensboro | North Carolina | 27408 | — |
| Not listed | Greenville | North Carolina | 27834 | — |
| Not listed | Raleigh | North Carolina | 27617 | — |
| Not listed | Washington | North Carolina | 27889 | — |
| Not listed | Cleveland | Ohio | 44195 | — |
| Not listed | Middleburg Heights | Ohio | 44130 | — |
| Not listed | Toledo | Ohio | 43606 | — |
| Not listed | Oklahoma City | Oklahoma | 73109 | — |
| Not listed | Lake Oswego | Oregon | 97035 | — |
| Not listed | Duncansville | Pennsylvania | 16635 | — |
| Not listed | Philadelphia | Pennsylvania | 19152 | — |
| Not listed | Pittsburgh | Pennsylvania | 15237 | — |
| Not listed | Pittsburgh | Pennsylvania | 15261 | — |
| Not listed | Willow Grove | Pennsylvania | 19090 | — |
| Not listed | Wynnewood | Pennsylvania | 19096 | — |
| Not listed | Wyomissing | Pennsylvania | 19610 | — |
| Not listed | Charleston | South Carolina | 29406 | — |
| Not listed | Myrtle Beach | South Carolina | 29572 | — |
| Not listed | Jackson | Tennessee | 38305 | — |
| Not listed | Memphis | Tennessee | 38104 | — |
| Not listed | Memphis | Tennessee | 38119 | — |
| Not listed | Austin | Texas | 78731 | — |
| Not listed | Carrollton | Texas | 75007 | — |
| Not listed | Corpus Christi | Texas | 78404 | — |
| Not listed | Houston | Texas | 77004 | — |
| Not listed | Houston | Texas | 77034 | — |
| Not listed | Houston | Texas | 77070 | — |
| Not listed | Houston | Texas | 77074 | — |
| Not listed | Mesquite | Texas | 75150 | — |
| Not listed | San Antonio | Texas | 78217 | — |
| Not listed | San Antonio | Texas | 78258 | — |
| Not listed | Sugar Land | Texas | 77479 | — |
| Not listed | Arlington | Virginia | 22205 | — |
| Not listed | Kennewick | Washington | 99336 | — |
| Not listed | Spokane | Washington | 99204 | — |
| Not listed | Tacoma | Washington | 98405 | — |
| Not listed | Clarksburg | West Virginia | 26301 | — |
| Not listed | Franklin | Wisconsin | 53132 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 63 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT01283971, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Feb 9, 2014 · Synced Sep 24, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT01283971 live on ClinicalTrials.gov.