Safety and Preliminary Efficacy Study of Mesenchymal Precursor Cells (MPCs) in Subjects With Lumbar Back Pain
Public ClinicalTrials.gov record NCT01290367. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Prospective, Double Blind, Controlled Study Evaluating Safety and Preliminary Efficacy of a Single Injection of Adult Mesenchymal Precursor Cells (MPCs) Combined With Hyaluronan in Subjects With Chronic Discogenic Lumbar Back Pain
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to compare two doses of immunoselected, culture-expanded, nucleated, allogeneic adult MPCs when combined with hyaluronic acid to two control intradiscal injections in subjects with chronic low back pain due to moderate Degenerative Disc Disease (DDD) at one lumbar level from L1 to S1. All investigational subjects in this study will undergo injection of either 6 million (M) or 18M cells in a hyaluronic acid carrier into the degenerated lumbar disc's nucleus pulposus. All control subjects will undergo an intradiscal control injection with either saline or hyaluronic acid only
Study identification
- NCT ID
- NCT01290367
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 100 participants
Conditions and interventions
Conditions
Interventions
- Single Dose MPCs Injection Biological
- Single injection of saline solution Procedure
- Single injection of hyaluronic acid Procedure
Biological · Procedure
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jul 31, 2011
- Primary completion
- Jun 30, 2013
- Completion
- Jun 30, 2015
- Last update posted
- Jun 25, 2020
2011 – 2015
United States locations
- U.S. sites
- 13
- U.S. states
- 9
- U.S. cities
- 13
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Arizona Pain Specialists | Scottsdale | Arizona | 85258 | — |
| UC Davis Spine Center | Sacramento | California | 95816 | — |
| The Spine Institute | Santa Monica | California | 90403 | — |
| IPM Medical Group, Inc. | Walnut Creek | California | 94598 | — |
| Denver Spine | Denver | Colorado | 80111 | — |
| Rocky Mountain Associates in Orthopedic Medicine, P.C. | Loveland | Colorado | 80538 | — |
| Emory University School of Medicine | Atlanta | Georgia | 30329 | — |
| Carolina Neurosurgery and Spine Associates | Charlotte | North Carolina | 28204 | — |
| Central Texas Spine Institute | Austin | Texas | 78731 | — |
| Richmond Bone and Joint Clinic, Memorial Hermann Medical Group | Richmond | Texas | 77469 | — |
| Virginia Spine Research Institute, Inc. | Richmond | Virginia | 23235 | — |
| Washington Center for Pain Management | Edmonds | Washington | 98026 | — |
| The Center for Pain Relief, Inc. | Charleston | West Virginia | 25301 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 1 non-U.S. site.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT01290367, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jun 25, 2020 · Synced Sep 7, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT01290367 live on ClinicalTrials.gov.