Investigation of Cortico-Rectal Pathways in Healthy Subjects and Constipated Patients

ClinicalTrials.gov ID: NCT01300897

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Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

Biofeedback therapy improves bowel symptoms and anorectal function in patients with dyssynergic defecation, however its mechanism of action is not known. The investigators hypothesize that biofeedback therapy enhances gut-brain-gut communication by altering cortical processing of information and improving cortically mediated neuromuscular function of the gut. However, in order to better understand these mechanisms in patients, the investigators need to examine and establish normative data and compare findings with healthy subjects. The investigators specific aims are to examine and evaluate the following 40 normal subjects; (1) To evaluate the afferent cortical evoked potentials in response to the electrical stimulation of the anorectum and (2) To evaluate the corticofugal tracts (efferent) by recording the anal and rectal electromyographic responses following noninvasive lumbosacral and transcranial magnetic stimulation.

Study identification

NCT ID: NCT01300897
Recruitment status: Not listed
Study type: Observational
Phase: Not listed
Lead sponsor: Augusta University; Other
Enrollment: 150 participants

Conditions and interventions

Conditions

Interventions

Cortical Evoked Potentials Procedure
Transcranial motor evoked potentials Procedure
Translumbosacral motor evoked potentials Procedure

Procedure

Eligibility (public fields only)

Age range: 18 Years to 85 Years
Sex: All
Healthy volunteers: Accepts healthy volunteers

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Aug 2005 (Actual)
Primary completion: Dec 2015 (Actual)
Completion: Dec 2018 (Estimated)
Last update posted: Jul 23, 2018

2005 – 2018

United States locations

U.S. sites: 1
U.S. states: 1
U.S. cities: 1

Facility	City	State	ZIP	Site status
University of Iowa Hospitals and Clinics	Iowa City	Iowa	52242	—

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT01300897, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Jul 23, 2018 · Synced Nov 14, 2026