A Paroxetine- and Placebo-Controlled Study of 50 mg/Day and 100 mg/Day of EB-1010 Among Outpatients With Major Depressive Disorder Who Have Responded Inadequately to Prior Selective Serotonin Reuptake Inhibitors (SSRIs) and Serotonin Norepinephrine Reuptake Inhibitors (SNRIs)
Public ClinicalTrials.gov record NCT01318434. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Double-Blind, Paroxetine- and Placebo-Controlled Study of 50 mg/Day and 100 mg/Day of EB-1010 Among Outpatients With Major Depressive Disorder Who Have Responded Inadequately to Prior Selective Serotonin Reuptake Inhibitors (SSRIs) and Serotonin Norepinephrine Reuptake Inhibitors (SNRIs) (Triple Reuptake Inhibitor Anti-Depressant Effects - TRIADE Study)
Study identification
- NCT ID
- NCT01318434
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2, Phase 3
- Lead sponsor
- Euthymics BioScience, Inc.
- Industry
- Enrollment
- 342 participants
Conditions and interventions
Conditions
Interventions
- EB-1010 25mg BID Drug
- EB-1010 50mg BID Drug
- Placebo Drug
- SSRI Active Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years to 65 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jan 31, 2011
- Primary completion
- Jan 31, 2013
- Completion
- Jan 31, 2013
- Last update posted
- Dec 3, 2015
2011 – 2013
United States locations
- U.S. sites
- 43
- U.S. states
- 21
- U.S. cities
- 42
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Pacific Clinical Research Medical Group | Arcadia | California | 91007 | — |
| Southwest Research, Inc. | Beverly Hills | California | 90210 | — |
| Synergy Clinical Research Center | National City | California | 91950 | — |
| Clinical Innovations, Inc. | Santa Ana | California | 92705 | — |
| Pacific Clinical Research Medical Group | Upland | California | 91786 | — |
| Radiant Research, Inc. | Denver | Colorado | 80239 | — |
| Comprehensive Psychiatric Care | Norwich | Connecticut | 06360 | — |
| Sanitas Research | Coral Gables | Florida | 33134 | — |
| Clinical Neuroscience Solution, Inc. | Jacksonville | Florida | 32216 | — |
| Florida Clinical Research Center | Maitland | Florida | 32751 | — |
| Clinical Neuroscience Solutions, Inc | Orlando | Florida | 32806 | — |
| Medical Research Group of Central Florida | Sanford | Florida | 32771 | — |
| Atlanta Center for Medical Research | Atlanta | Georgia | 30308 | — |
| AMR Baber Research | Naperville | Illinois | 60563 | — |
| Psychiatric Medicine Associates | Stokie | Illinois | 60076 | — |
| Lake Charles Clinical Trials | Lake Charles | Louisiana | 70601 | — |
| Clinical Insights | Glen Burnie | Maryland | 21061 | — |
| Cambridge Health Alliance | Cambridge | Massachusetts | 02139 | — |
| AccelRx Research | Fall River | Massachusetts | 02721 | — |
| St Charles Psychiatric Associates | Saint Charles | Missouri | 63301 | — |
| Global Medical Institutes | Princeton | New Jersey | 08540 | — |
| CRI Worldwide, LLC | Willingboro | New Jersey | 08046 | — |
| Mount Sinai School of Medicine | New York | New York | 10029 | — |
| Behavioral Medical Research of Staten Island | Staten Island | New York | 10305 | — |
| Community Research | Cincinnati | Ohio | 45227 | — |
| Midwest Clinical Research Center | Dayton | Ohio | 45417 | — |
| North Star Medical Research | Middleburg Heights | Ohio | 44130 | — |
| Neurology and Neuroscience Center of Ohio | Toledo | Ohio | 43623 | — |
| SP Research, PLLC | Oklahoma City | Oklahoma | 73112 | — |
| Lehigh Valley Hospital | Allentown | Pennsylvania | 18103 | — |
| Southeastern PA Medical Institute | Broomall | Pennsylvania | 19008 | — |
| Suburban Research Associates | Media | Pennsylvania | 19063 | — |
| University of Pennsylvania | Philadelphia | Pennsylvania | 19104 | — |
| CRI Worldwide | Philadelphia | Pennsylvania | 19139 | — |
| Scranton Counseling Center | Scranton | Pennsylvania | 18503 | — |
| Radiant Research | Greer | South Carolina | 29651 | — |
| Clinical NeuroScience Solutions, Inc. | Memphis | Tennessee | 38119 | — |
| Vanderbilt University Medical Center | Nashville | Tennessee | 37212 | — |
| FutureSearch Trials of Dallas | Dallas | Texas | 75231 | — |
| Radiant Research, Inc. | Murray | Utah | 84123 | — |
| Aspen Clinical Research | Orem | Utah | 84058 | — |
| VCU | Richmond | Virginia | 23219 | — |
| Dean Foundation for Health, Research & Education | Middleton | Wisconsin | 53562 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT01318434, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Dec 3, 2015 · Synced May 16, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT01318434 live on ClinicalTrials.gov.