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Completed Phase 3 Interventional Results available

Cardiovascular Risk Reduction Study (Reduction in Recurrent Major CV Disease Events)

ClinicalTrials.gov ID: NCT01327846

Public ClinicalTrials.gov record NCT01327846. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

ClinicalTrials.gov public records Last synced Oct 29, 2026, 4:16 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Randomized, Double-blind, Placebo-controlled, Event-driven Trial of Quarterly Subcutaneous Canakinumab in the Prevention of Recurrent Cardiovascular Events Among Stable Post-myocardial Infarction Patients With Elevated hsCRP

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

Main Study (CACZ885M2301): The purpose of the pivotal phase of this trial was to test the hypothesis that canakinumab treatment of patients with myocardial infarction (MI) at least one month prior to study entry and elevated hsCRP could prevent recurrent cardiovascular events. The purpose of the extension phase of the main study is to collect additional long-term safety data on continued exposure to canakinumab in patients who participated in the pivotal phase. Sub-study 1 (CACZ885M2301S1): The purpose of this sub-study was to evaluate the effect of quarterly subcutaneous canakinumab treatment for 24 months comparted with placebo on the carotid plaque burden measured by integrated vascular MRI in patients enrolled in the CACZ885M2301 study (CANTOS). Sub-study 2 (CACZ885M2301S2): The purpose of this CANTOS sub-study was to determine whether, in patients with type 2 diabetes participating in the CANTOS main study, canakinumab compared to placebo, on top of standard of care could increase insulin secretion and insulin sensitivity.

Study identification

NCT ID
NCT01327846
Recruitment status
Completed
Study type
Interventional
Phase
Phase 3
Lead sponsor
Novartis Pharmaceuticals
Industry
Enrollment
10,066 participants

Conditions and interventions

Interventions

Drug

Eligibility (public fields only)

Age range
18 Years and older
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Apr 11, 2011 (Actual)
Primary completion
Mar 28, 2017 (Actual)
Completion
Apr 14, 2019 (Actual)
Last update posted
Jan 22, 2020

2011 – 2019

United States locations

U.S. sites
315
U.S. states
47
U.S. cities
251
Facility City State ZIP Site status
Novartis Investigative Site Athens Alabama 35611 —
Novartis Investigative Site Birmingham Alabama 35235-3424 —
Novartis Investigative Site Birmingham Alabama 35243 —
Novartis Investigative Site Birmingham Alabama 35294-2041 —
Novartis Investigative Site Fairhope Alabama 36532 —
Novartis Investigative Site Huntsville Alabama 35801 —
Novartis Investigative Site Mobile Alabama 36604 —
Novartis Investigative Site Mobile Alabama 36608 —
Novartis Investigative Site Mobile Alabama 36617-2293 —
Novartis Investigative Site Anchorage Alaska 99508 —
Novartis Investigative Site Chandler Arizona 85224 —
Novartis Investigative Site Glendale Arizona 85306 —
Novartis Investigative Site Phoenix Arizona 85018 —
Novartis Investigative Site Phoenix Arizona 85032 —
Novartis Investigative Site Hot Springs Arkansas 71913 —
Novartis Investigative Site Jonesboro Arkansas 72401 —
Novartis Investigative Site Little Rock Arkansas 72204 —
Novartis Investigative Site Beverly Hills California 90211 —
Novartis Investigative Site Carmichael California 95608 —
Novartis Investigative Site Escondido California 92025 —
Novartis Investigative Site Fullerton California 92835 —
Novartis Investigative Site Huntington Beach California 92647 —
Novartis Investigative Site Lancaster California 93534 —
Novartis Investigative Site Loma Linda California 92354 —
Novartis Investigative Site Loma Linda California 92357 —
Novartis Investigative Site Long Beach California 90806 —
Novartis Investigative Site Los Angeles California 90033 —
Novartis Investigative Site Los Angeles California 90073 —
Novartis Investigative Site Los Gatos California 95032 —
Novartis Investigative Site Mission Viejo California 92691 —
Novartis Investigative Site Newport Beach California 92663 —
Novartis Investigative Site Northridge California 91325 —
Novartis Investigative Site Oceanside California 92056 —
Novartis Investigative Site Orangevale California 95662 —
Novartis Investigative Site Palm Springs California 92262 —
Novartis Investigative Site Pasadena California 91105 —
Novartis Investigative Site Pomona California 91767 —
Novartis Investigative Site Sacramento California 95816 —
Novartis Investigative Site Sacramento California 95819 —
Novartis Investigative Site San Diego California 92101 —
Novartis Investigative Site San Diego California 92120 —
Novartis Investigative Site San Diego California 92128 —
Novartis Investigative Site San Diego California 92161 —
Novartis Investigative Site San Francisco California 94143-0792 —
Novartis Investigative Site Santa Ana California 92704 —
Novartis Investigative Site Santa Rosa California 95405 —
Novartis Investigative Site Torrance California 90502 —
Novartis Investigative Site Tustin California 92780 —
Novartis Investigative Site Visalia California 93291 —
Novartis Investigative Site Walnut Creek California 94598 —
Novartis Investigative Site Aurora Colorado 80012 —
Novartis Investigative Site Colorado Springs Colorado 80907 —
Novartis Investigative Site Denver Colorado 80204-4507 —
Novartis Investigative Site Denver Colorado 80206 —
Novartis Investigative Site Denver Colorado 80218 —
Novartis Investigative Site Denver Colorado 80220 —
Novartis Investigative Site Norwich Connecticut 06360 —
Novartis Investigative Site Newark Delaware 19713 —
Novartis Investigative Site Washington D.C. District of Columbia 20010 —
Novartis Investigative Site Washington D.C. District of Columbia 20037 —
Novartis Investigative Site Clearwater Florida 33756 —
Novartis Investigative Site Coral Springs Florida 33065 —
Novartis Investigative Site Davie Florida 33324 —
Novartis Investigative Site Daytona Beach Florida 32114 —
Novartis Investigative Site DeFuniak Springs Florida 32435 —
Novartis Investigative Site Doral Florida 33136 —
Novartis Investigative Site Hialeah Florida 33012 —
Novartis Investigative Site Hollywood Florida 33021 —
Novartis Investigative Site Hollywood Florida 33312 —
Novartis Investigative Site Jacksonville Florida 32204 —
Novartis Investigative Site Jacksonville Florida 32209-6511 —
Novartis Investigative Site Jacksonville Florida 32216 —
Novartis Investigative Site Jacksonville Florida 32223 —
Novartis Investigative Site Jacksonville Beach Florida 32050 —
Novartis Investigative Site Jupiter Florida 33458 —
Novartis Investigative Site Miami Florida 33126 —
Novartis Investigative Site Miami Florida 33135 —
Novartis Investigative Site Miami Florida 33155 —
Novartis Investigative Site Miami Florida 33176 —
Novartis Investigative Site Miami Beach Florida 33140 —
Novartis Investigative Site Naples Florida 34119 —
Novartis Investigative Site Orlando Florida 32822 —
Novartis Investigative Site Pembroke Pines Florida 33024 —
Novartis Investigative Site Pinellas Park Florida 33781 —
Novartis Investigative Site Port Charlotte Florida 33952 —
Novartis Investigative Site Port Orange Florida 32127 —
Novartis Investigative Site Sarasota Florida 34239 —
Novartis Investigative Site South Miami Florida 33143 —
Novartis Investigative Site Tampa Florida 33613 —
Novartis Investigative Site Tampa Florida 33624 —
Novartis Investigative Site Wellington Florida 33449 —
Novartis Investigative Site Athens Georgia 30606 —
Novartis Investigative Site Augusta Georgia 30904 —
Novartis Investigative Site Covington Georgia 30014 —
Novartis Investigative Site Cumming Georgia 30041 —
Novartis Investigative Site Decatur Georgia 30033 —
Novartis Investigative Site Decatur Georgia 30035 —
Novartis Investigative Site Duluth Georgia 30096 —
Novartis Investigative Site Macon Georgia 31201 —
Novartis Investigative Site Roswell Georgia 30076 —
Novartis Investigative Site Savannah Georgia 31406 —
Novartis Investigative Site Thomasville Georgia 31792 —
Novartis Investigative Site Honolulu Hawaii 96814 —
Novartis Investigative Site Coeur d'Alene Idaho 83814 —
Novartis Investigative Site Chicago Illinois 60611 —
Novartis Investigative Site Jerseyville Illinois 62052 —
Novartis Investigative Site Lombard Illinois 60148 —
Novartis Investigative Site Melrose Park Illinois 60160 —
Novartis Investigative Site Peoria Illinois 61602 —
Novartis Investigative Site Evansville Indiana 47712 —
Novartis Investigative Site Evansville Indiana 47714 —
Novartis Investigative Site Ames Iowa 50010 —
Novartis Investigative Site Waterloo Iowa 50702 —
Novartis Investigative Site Kansas City Kansas 66160 —
Novartis Investigative Site Overland Park Kansas 66204 —
Novartis Investigative Site Topeka Kansas 66606 —
Novartis Investigative Site Wichita Kansas 67207 —
Novartis Investigative Site Wichita Kansas 67214 —
Novartis Investigative Site Lexington Kentucky 40509 —
Novartis Investigative Site Louisville Kentucky 40206 —
Novartis Investigative Site Madisonville Kentucky 42431 —
Novartis Investigative Site Owensboro Kentucky 42303 —
Novartis Investigative Site Baton Rouge Louisiana 70808 —
Novartis Investigative Site Baton Rouge Louisiana 70816 —
Novartis Investigative Site Covington Louisiana 70433 —
Novartis Investigative Site Houma Louisiana 70360 —
Novartis Investigative Site Lafayette Louisiana 70501 —
Novartis Investigative Site Lafayette Louisiana 70508 —
Novartis Investigative Site Mandeville Louisiana 70471 —
Novartis Investigative Site Metairie Louisiana 70001 —
Novartis Investigative Site Metairie Louisiana 70006 —
Novartis Investigative Site Minden Louisiana 71055 —
Novartis Investigative Site New Orleans Louisiana 70115 —
Novartis Investigative Site New Orleans Louisiana 70119 —
Novartis Investigative Site Opelousas Louisiana 70570 —
Novartis Investigative Site Shreveport Louisiana 71101 —
Novartis Investigative Site Shreveport Louisiana 71103 —
Novartis Investigative Site Slidell Louisiana 70458 —
Novartis Investigative Site Winnsboro Louisiana 71295 —
Novartis Investigative Site Zachary Louisiana 70791 —
Novartis Investigative Site Portland Maine 04102 —
Novartis Investigative Site Baltimore Maryland 21204 —
Novartis Investigative Site Beltsville Maryland 20705 —
Novartis Investigative Site Columbia Maryland 21044 —
Novartis Investigative Site Burlington Massachusetts 01803 —
Novartis Investigative Site Fall River Massachusetts 02720 —
Novartis Investigative Site Haverhill Massachusetts 01830 —
Novartis Investigative Site Ann Arbor Michigan 48106 —
Novartis Investigative Site Chelsea Michigan 48118 —
Novartis Investigative Site Detroit Michigan 48202 —
Novartis Investigative Site Grand Blanc Michigan 48439 —
Novartis Investigative Site Kalamazoo Michigan 49008 —
Novartis Investigative Site Midland Michigan 48640 —
Novartis Investigative Site Novi Michigan 48374 —
Novartis Investigative Site Petoskey Michigan 49770 —
Novartis Investigative Site Royal Oak Michigan 48073 —
Novartis Investigative Site Saginaw Michigan 48601 —
Novartis Investigative Site Wyoming Michigan 49519 —
Novartis Investigative Site Bloomington Minnesota 55420 —
Novartis Investigative Site Duluth Minnesota 55805 —
Novartis Investigative Site Edina Minnesota 55435 —
Novartis Investigative Site Fridley Minnesota 55432 —
Novartis Investigative Site Minneapolis Minnesota 55433 —
Novartis Investigative Site Robbinsdale Minnesota 55422 —
Novartis Investigative Site Saint Cloud Minnesota 56303 —
Novartis Investigative Site Saint Paul Minnesota 55102 —
Novartis Investigative Site Hattiesburg Mississippi 39401 —
Novartis Investigative Site Jackson Mississippi 39209 —
Novartis Investigative Site Picayune Mississippi 39466 —
Novartis Investigative Site Columbia Missouri 65212 —
Novartis Investigative Site Kansas City Missouri 64111 —
Novartis Investigative Site Springfield Missouri 65807 —
Novartis Investigative Site St Louis Missouri 63110 —
Novartis Investigative Site St Louis Missouri 63128 —
Novartis Investigative Site St Louis Missouri 63141 —
Novartis Investigative Site Grand Island Nebraska 68803 —
Novartis Investigative Site Lincoln Nebraska 68516 —
Novartis Investigative Site Omaha Nebraska 68114 —
Novartis Investigative Site Omaha Nebraska 68131 —
Novartis Investigative Site Omaha Nebraska 68134 —
Novartis Investigative Site Las Vegas Nevada 89118 —
Novartis Investigative Site Nashua New Hampshire 03060 —
Novartis Investigative Site Camden New Jersey 08103 —
Novartis Investigative Site Freehold New Jersey 07728 —
Novartis Investigative Site Lodi New Jersey 07644 —
Novartis Investigative Site New Brunswick New Jersey 08901 —
Novartis Investigative Site Ocean City New Jersey 07712 —
Novartis Investigative Site Pomona New Jersey 08240 —
Novartis Investigative Site Ridgewood New Jersey 07450 —
Novartis Investigative Site Westwood New Jersey 07675 —
Novartis Investigative Site Albuquerque New Mexico 87102 —
Novartis Investigative Site Binghamton New York 13901 —
Novartis Investigative Site Endwell New York 13760 —
Novartis Investigative Site Kew Gardens New York 11415 —
Novartis Investigative Site Mineola New York 11501 —
Novartis Investigative Site New York New York 10003 —
Novartis Investigative Site New York New York 10016 —
Novartis Investigative Site New York New York 10035 —
Novartis Investigative Site Rochester New York 14609 —
Novartis Investigative Site Rochester New York 14621 —
Novartis Investigative Site Asheboro North Carolina 27204 —
Novartis Investigative Site Charlotte North Carolina 28277 —
Novartis Investigative Site Greensboro North Carolina 27401 —
Novartis Investigative Site Greensboro North Carolina 27410 —
Novartis Investigative Site Greenville North Carolina 27834 —
Novartis Investigative Site Hickory North Carolina 28601 —
Novartis Investigative Site Mooresville North Carolina 28117 —
Novartis Investigative Site Pinehurst North Carolina 28374 —
Novartis Investigative Site Salisbury North Carolina 28144 —
Novartis Investigative Site Sanford North Carolina 27330 —
Novartis Investigative Site Statesville North Carolina 28625 —
Novartis Investigative Site Winston-Salem North Carolina 27103 —
Novartis Investigative Site Winston-Salem North Carolina 27106 —
Novartis Investigative Site Fargo North Dakota 58122 —
Novartis Investigative Site Grand Forks North Dakota 58201 —
Novartis Investigative Site Akron Ohio 44309 —
Novartis Investigative Site Cincinnati Ohio 45219 —
Novartis Investigative Site Cincinnati Ohio 45245 —
Novartis Investigative Site Cleveland Ohio 44109-1998 —
Novartis Investigative Site Columbus Ohio 43235 —
Novartis Investigative Site Dayton Ohio 45402 —
Novartis Investigative Site Marion Ohio 43302 —
Novartis Investigative Site Bartlesville Oklahoma 74006 —
Novartis Investigative Site Oklahoma City Oklahoma 73120 —
Novartis Investigative Site Tulsa Oklahoma 74133 —
Novartis Investigative Site Bend Oregon 97701 —
Novartis Investigative Site Portland Oregon 97225 —
Novartis Investigative Site Abington Pennsylvania 19001 —
Novartis Investigative Site Altoona Pennsylvania 16602 —
Novartis Investigative Site Beaver Pennsylvania 15009 —
Novartis Investigative Site Bridgeville Pennsylvania 15017 —
Novartis Investigative Site Camp Hill Pennsylvania 17011 —
Novartis Investigative Site Erie Pennsylvania 16507 —
Novartis Investigative Site Hershey Pennsylvania 17033 —
Novartis Investigative Site Pittsburgh Pennsylvania 15216 —
Novartis Investigative Site Pittsburgh Pennsylvania 15236 —
Novartis Investigative Site Pittsburgh Pennsylvania 15243 —
Novartis Investigative Site Pottstown Pennsylvania 19464 —
Novartis Investigative Site Uniontown Pennsylvania 15401 —
Novartis Investigative Site Cumberland Rhode Island 02864-1410 —
Novartis Investigative Site Providence Rhode Island 02904 —
Novartis Investigative Site Providence Rhode Island 02906 —
Novartis Investigative Site Anderson South Carolina 29621 —
Novartis Investigative Site Columbia South Carolina 29201 —
Novartis Investigative Site Fort Mill South Carolina 29707 —
Novartis Investigative Site Greenville South Carolina 29605 —
Novartis Investigative Site Greer South Carolina 29651 —
Novartis Investigative Site Moncks Corner South Carolina 29461 —
Novartis Investigative Site Mt. Pleasant South Carolina 29464 —
Novartis Investigative Site North Myrtle Beach South Carolina 29582 —
Novartis Investigative Site Orangeburg South Carolina 29115 —
Novartis Investigative Site Varnville South Carolina 29944 —
Novartis Investigative Site Rapid City South Dakota 57701 —
Novartis Investigative Site Sioux Falls South Dakota 57104 —
Novartis Investigative Site Germantown Tennessee 38138 —
Novartis Investigative Site Greenville Tennessee 37745 —
Novartis Investigative Site Jackson Tennessee 38305 —
Novartis Investigative Site Johnson City Tennessee 37604 —
Novartis Investigative Site Knoxville Tennessee 37917 —
Novartis Investigative Site Knoxville Tennessee 37920 —
Novartis Investigative Site Knoxville Tennessee 37934 —
Novartis Investigative Site Memphis Tennessee 38120 —
Novartis Investigative Site Allen Texas 75002-3688 —
Novartis Investigative Site Beaumont Texas 77701 —
Novartis Investigative Site Beaumont Texas 77702 —
Novartis Investigative Site Bedford Texas 76021 —
Novartis Investigative Site Brownsville Texas 78520 —
Novartis Investigative Site Dallas Texas 75204 —
Novartis Investigative Site Dallas Texas 75226 —
Novartis Investigative Site Dallas Texas 75231 —
Novartis Investigative Site Gonzales Texas 78629 —
Novartis Investigative Site Greenville Texas 75401 —
Novartis Investigative Site Houston Texas 77025 —
Novartis Investigative Site Houston Texas 77030 —
Novartis Investigative Site Houston Texas 77055 —
Novartis Investigative Site Houston Texas 77064 —
Novartis Investigative Site Houston Texas 77070 —
Novartis Investigative Site Houston Texas 77081 —
Novartis Investigative Site Irving Texas 75039 —
Novartis Investigative Site Lake Jackson Texas 77566 —
Novartis Investigative Site Leander Texas 78641 —
Novartis Investigative Site Livingston Texas 77351 —
Novartis Investigative Site Lufkin Texas 75904 —
Novartis Investigative Site Marshall Texas 75670 —
Novartis Investigative Site McAllen Texas 78501 —
Novartis Investigative Site McKinney Texas 75069 —
Novartis Investigative Site Odessa Texas 79761 —
Novartis Investigative Site San Antonio Texas 78212 —
Novartis Investigative Site San Antonio Texas 78229-3900 —
Novartis Investigative Site San Antonio Texas 78229-4801 —
Novartis Investigative Site San Antonio Texas 78229 —
Novartis Investigative Site San Antonio Texas 78234 —
Novartis Investigative Site San Antonio Texas 78238-7676 —
Novartis Investigative Site San Antonio Texas 78258 —
Novartis Investigative Site Sugar Land Texas 77479 —
Novartis Investigative Site Temple Texas 76508 —
Novartis Investigative Site Tomball Texas 77375 —
Novartis Investigative Site Waco Texas 76710 —
Novartis Investigative Site Webster Texas 77598 —
Novartis Investigative Site Bountiful Utah 84010 —
Novartis Investigative Site Layton Utah 84041 —
Novartis Investigative Site Salt Lake City Utah 84102 —
Novartis Investigative Site Salt Lake City Utah 84107 —
Novartis Investigative Site Salt Lake City Utah 84124 —
Novartis Investigative Site Burke Virginia 22015 —
Novartis Investigative Site Danville Virginia 24541 —
Novartis Investigative Site Hopewell Virginia 23860 —
Novartis Investigative Site Richmond Virginia 23249 —
Novartis Investigative Site Richmond Virginia 23298 —
Novartis Investigative Site Port Orchard Washington 98366 —
Novartis Investigative Site Renton Washington 98057 —
Novartis Investigative Site Seattle Washington 98104 —
Novartis Investigative Site Seattle Washington 98122 —
Novartis Investigative Site Tacoma Washington 98405 —
Novartis Investigative Site Madison Wisconsin 53713 —

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 816 non-U.S. sites.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT01327846, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Jan 22, 2020 · Synced Oct 29, 2026

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Open the official record

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