ClinicalTrials.gov record
A Study of Tocilizumab in Comparison to Etanercept in Participants With Rheumatoid Arthritis and Cardiovascular Disease Risk Factors
ClinicalTrials.gov ID: NCT01331837
Public ClinicalTrials.gov record NCT01331837. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Clinical Outcomes Study to Evaluate the Effects of IL-6 Receptor Blockade With Tocilizumab (TCZ) in Comparison With Etanercept (ETA) on the Rate of Cardiovascular Events in Patients With Moderate to Severe Rheumatoid Arthritis (RA)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This randomized, open-label, parallel-group, multicenter study will evaluate the rate of cardiovascular events with tocilizumab in comparison to etanercept in participants with rheumatoid arthritis (RA). Participants will be randomized to receive intravenous (IV) 8 milligrams per kilogram (mg/kg) tocilizumab every 4 weeks or subcutaneous 50 milligrams (mg) etanercept weekly, with or without non-biologic disease-modifying anti-rheumatic drug (DMARD).
Study identification
- NCT ID
- NCT01331837
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 4
- Enrollment
- 3,080 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 50 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Aug 2, 2011 (Actual)
- Primary completion
- Mar 25, 2016 (Actual)
- Completion
- Mar 25, 2016 (Actual)
- Last update posted
- Jul 13, 2017
2011 – 2016
United States locations
- U.S. sites
- 143
- U.S. states
- 38
- U.S. cities
- 128
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Uni Of Alabama,Birmingham; Medicine - Rheumatology | Birmingham | Alabama | 35294 | — |
| Rheumatology Associates of North Alabama | Huntsville | Alabama | 35801 | — |
| Clinical and Translational Research Center of Alabama, PC | Tuscaloosa | Alabama | 35406 | — |
| Arizona Arthritis & Rheumatology Associates, P.C. | Glendale | Arizona | 85306 | — |
| Arizona Arthritis & Rheumatology Research, Pllc | Paradise Valley | Arizona | 85253 | — |
| Sun Valley Arthritis Center | Peoria | Arizona | 85381 | — |
| Valley Arthritis Care | Phoenix | Arizona | 85027 | — |
| Advanced Arthritis Care & Research | Scottsdale | Arizona | 85258 | — |
| Camp Lowell Medical Specialists | Tucson | Arizona | 85715 | — |
| The University of Arizona | Tucson | Arizona | 85724 | — |
| NEA Baptist Clinic | Jonesboro | Arkansas | 72401 | — |
| OrthoArkansas; Orthopedics & Sports Medicine | Little Rock | Arkansas | 72205 | — |
| Samy Metyas, MD, Inc | Covina | California | 91723 | — |
| Talbert Medical Group | Huntington Beach | California | 92646 | — |
| Allergy & Rheumatology Medical Clinic, Inc | La Jolla | California | 92037 | — |
| Valerius Medical Group | Los Alamitos | California | 90720 | — |
| Clinical Interventions Research Institute | Mission Viejo | California | 92692 | — |
| Dr. Brigid Freyne, MD | Murrieta | California | 92563 | — |
| Sharp Rees-Stealy Medical Group | Poway | California | 92064 | — |
| San Diego Arthritis Med Clnc | San Diego | California | 92108 | — |
| Purushotham & Akther Kotha Inc | San Diego | California | 92120 | — |
| C Michael Neuwelt MD Inc | San Leandro | California | 94578 | — |
| Pacific Arthritis Ctr Med Grp | Santa Maria | California | 93454 | — |
| Orrin M. Troum, Md | Santa Monica | California | 90404 | — |
| Harbor UCLA Medical Center | Torrance | California | 90509 | — |
| Inland Rheumatology; Clinical Trials, Inc. | Upland | California | 91786 | — |
| Medvin Clinical Research | Whittier | California | 90606 | — |
| Arthritis Assoc & Osteoporosis; Ctr of Colorado Springs | Colorado Springs | Colorado | 80920 | — |
| Joao Nascimento | Bridgeport | Connecticut | 06606 | — |
| University of Connecticut Health Center | Farmington | Connecticut | 06030 | — |
| Arthritis & Osteoporosis Center Pc | Hamden | Connecticut | 06518 | — |
| ZASA Clinical Research | Boynton Beach | Florida | 33472 | — |
| DC Health Clinic | Coral Gables | Florida | 33134 | — |
| Tsai, Yong | Daytona Beach | Florida | 32117 | — |
| Jacksonville Center For Clinical Research | Jacksonville | Florida | 32216 | — |
| Pharmax Research Clinic Inc. | Miami | Florida | 33126 | — |
| Arthritis/Osteoporosis Treatment Center | Orange Park | Florida | 32073 | — |
| Arthritis Rsrch of Florida, Inc. | Palm Harbor | Florida | 34684 | — |
| Baptist Hospital Clinical Research | Pensacola | Florida | 32501 | — |
| Lovelace Scientific Resources | Sarasota | Florida | 34292 | — |
| Centre for Arthritis and Rheumatic Diseases | South Miami | Florida | 33143 | — |
| Pinellas Medical Research, LLC | St. Petersburg | Florida | 33708 | — |
| SW Florida Clinical Research | Tampa | Florida | 33609 | — |
| Healthpoint Medical group, Inc | Tampa | Florida | 33614 | — |
| Emory Uni ; Division of Rheumatology | Atlanta | Georgia | 30303 | — |
| Arthritis & Rheumatology of Georgia | Atlanta | Georgia | 30342 | — |
| North Georgia Rheumatology | Duluth | Georgia | 30096 | — |
| Harbin Clinic | Rome | Georgia | 30165 | — |
| St. Joseph'S/Candler Health System, Inc.; Office of Research | Savannah | Georgia | 31405 | — |
| Sonora Clinical Research | Boise | Idaho | 83702 | — |
| St. Luke's Intermountain Research Center | Boise | Idaho | 83702 | — |
| Selah Medical Ctr | Boise | Idaho | 83704 | — |
| Coeur D'Alene Arthritis Clinic | Coeur d'Alene | Idaho | 83814 | — |
| Idaho Arthritis Center | Meridian | Idaho | 83642 | — |
| University of Illinois at Chicago | Chicago | Illinois | 60612 | — |
| Apex Medical Research, AMR, Inc. | Chicago | Illinois | 60616 | — |
| Methodist Medical Center of Ilinois | Peoria | Illinois | 61602 | — |
| Northern Indiana Research Alliance | Fort Wayne | Indiana | 46804 | — |
| Diagnostic Rheumatology & Research | Indianapolis | Indiana | 46227 | — |
| Memorial Medical Group Clinical Research | South Bend | Indiana | 46601 | — |
| Graves Gilbert Clinic | Bowling Green | Kentucky | 42101 | — |
| Research Integrity | Owensboro | Kentucky | 42303 | — |
| Arthritis & Diabetes Clinic, Inc | Monroe | Louisiana | 71203 | — |
| Ochsner Health System | New Orleans | Louisiana | 70121 | — |
| Rheumatology Associates of Baltimore | Baltimore | Maryland | 21286 | — |
| Osteoporosis & Clinical Trials Center | Hagerstown | Maryland | 21740 | — |
| Center For Rheumatology & Bone Research | Wheaton | Maryland | 20902 | — |
| Phase Iii Clinical Research | Fall River | Massachusetts | 02720 | — |
| UMass Memorial Medical Center | Worcester | Massachusetts | 01605 | — |
| Clinical Pharmacology Study Group | Worcester | Massachusetts | 01610 | — |
| Hurley Research Center | Flint | Michigan | 48503 | — |
| Rheumatology, P.C.; Medical Arts Building | Kalamazoo | Michigan | 49009 | — |
| Advanced Rheumatology, PC | Lansing | Michigan | 48910 | — |
| Northern Michigan Regional Hospital | Petoskey | Michigan | 49770 | — |
| St. Paul Rheumatology | Eagan | Minnesota | 55121 | — |
| Va Medical Center | Minneapolis | Minnesota | 55417 | — |
| Mayo Clinic Rochester | Rochester | Minnesota | 55905 | — |
| Jackson Arthritis Clinic | Flowood | Mississippi | 39232 | — |
| North Mississippi Med Clinics, Inc. | Tupelo | Mississippi | 38801 | — |
| Glacier View Research Institute | Kalispell | Montana | 59901 | — |
| Univ of Nebraska Medical Ctr | Omaha | Nebraska | 68198 | — |
| Advanced Biomedical Research of America | Las Vegas | Nevada | 89123 | — |
| Innovative Health Research | Las Vegas | Nevada | 89128 | — |
| Dartmouth-Hitchcock Medical Center, Rheumatology 5C | Lebanon | New Hampshire | 03756 | — |
| Nashua Rheumatology - Foundation Medical Partners | Nashua | New Hampshire | 03060 | — |
| Summit Medical Group | Berkeley Heights | New Jersey | 07922 | — |
| Rheumatology Associates Of New Jersey | Teaneck | New Jersey | 07666 | — |
| Arthritis Rheumatic & Back Disease Associates | Voorhees Township | New Jersey | 08043 | — |
| Albuquerque Center For Rheumatology | Albuquerque | New Mexico | 87102 | — |
| Arthritis and Osteoporosis Associates of New Mexico | Las Cruces | New Mexico | 88011 | — |
| Arthritis & Osteoporosis Medical Associates, Pllc | Brooklyn | New York | 11201 | — |
| SUNY Downstate Medical Center. | Brooklyn | New York | 11203 | — |
| DiGiovanna Inst for Med Ed&Res | North Massapequa | New York | 11758 | — |
| Southern Tier Arthritis & Rheumatism | Olean | New York | 14760 | — |
| Arthritis Health Associates; Clinical Research | Syracuse | New York | 13210 | — |
| Asheville Arthritis & Osteoporosis Center, PA | Asheville | North Carolina | 28803 | — |
| Joint & Muscle Research Institute | Charlotte | North Carolina | 28204 | — |
| Carolina Bone & Joint P.A. | Charlotte | North Carolina | 28210 | — |
| Durham Rheumatology | Durham | North Carolina | 27704 | — |
| PMG Research of Hickory LLC | Hickory | North Carolina | 28602 | — |
| Shanahan Rheumatology & Immunology, PLLC | Raleigh | North Carolina | 27617 | — |
| Specialty Medical Clinic and Research Center | Sanford | North Carolina | 27330 | — |
| Carolina Arthritis Associates, Pa | Wilmington | North Carolina | 28401 | — |
| Trinity Health Center | Minot | North Dakota | 58701 | — |
| Cincinnati Rheumatic Disease Study Group | Cincinnati | Ohio | 45219 | — |
| University Hospitals Case Medical Center | Cleveland | Ohio | 44109 | — |
| Ohio State Univ Med Center | Columbus | Ohio | 43210 | — |
| Columbus Arthritis Center | Columbus | Ohio | 43215 | — |
| Clinical Research Source, Inc. | Toledo | Ohio | 43606 | — |
| Toledo Clinic | Toledo | Ohio | 43623 | — |
| Lynn Health Science Institute | Oklahoma City | Oklahoma | 73112 | — |
| Altoona Center For Clinical Research | Duncansville | Pennsylvania | 16635 | — |
| Penn State Milton S. Hershey Medical Center | Hershey | Pennsylvania | 17033 | — |
| Ilumina Clinical Associates | Indiana | Pennsylvania | 15701 | — |
| PMA Medical Specialists | Limerick | Pennsylvania | 19468 | — |
| Pivotal Clinical Research, Llc | Perkasie | Pennsylvania | 18944 | — |
| Arthritis Group | Philadelphia | Pennsylvania | 19152 | — |
| University of Pittsburgh Medical Center Health System; Infectious Disease | Pittsburgh | Pennsylvania | 15213-2582 | — |
| Allegheny Rheumatology | Wexford | Pennsylvania | 15090 | — |
| Clinical Research Center of Reading | Wyomissing | Pennsylvania | 19610 | — |
| Pennsylvania Regional Center for Arthritis and Osteoporosis Research | Wyomissing | Pennsylvania | 19610 | — |
| Columbia Arthritis Center (Partnership Practice) | Columbia | South Carolina | 29204 | — |
| South Carolina Research Center | Myrtle Beach | South Carolina | 29572 | — |
| Brown Clinic | Watertown | South Dakota | 57201 | — |
| Ramesh Gupta - PP | Memphis | Tennessee | 38119 | — |
| Amarillo Center For Clinical Research | Amarillo | Texas | 79124 | — |
| Adriana Pop-Moody MD Clinic PA | Corpus Christi | Texas | 78404 | — |
| Metroplex Clinical Research | Dallas | Texas | 75231 | — |
| Leading Edge Research, PA; Office of Dr. Burbano | Fort Worth | Texas | 76109 | — |
| Rheumatic Disease Clin Res Ctr | Houston | Texas | 77004 | — |
| Houston Inst. For Clinical Research | Houston | Texas | 77074 | — |
| Southwest Rheumatology | Mesquite | Texas | 75150 | — |
| Leading Edge Research, PA; Office of Dr. Burbano | Richardson | Texas | 75080 | — |
| Texas Arthritis Research Center | San Antonio | Texas | 78217 | — |
| Arthritis & Osteoporosis Clinic | Waco | Texas | 76710 | — |
| Arthritis and Rheumatic Disease Associates | Burke | Virginia | 22015 | — |
| Sentara Medical Group | Norfolk | Virginia | 23510 | — |
| Apex Clinical Research | Kennewick | Washington | 99336 | — |
| Seattle Rheumatology Associates | Seattle | Washington | 98104 | — |
| Office of George Krick, Md | Tacoma | Washington | 98405 | — |
| Rheum & Pulmonary Clinic | Beckley | West Virginia | 25801 | — |
| Mountain State Clinical Research | Clarksburg | West Virginia | 26301 | — |
| Arthritis Centre; Suite 103 | Racine | Wisconsin | 53406 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 285 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT01331837, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jul 13, 2017 · Synced Oct 25, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT01331837 live on ClinicalTrials.gov.